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Original Article

Development of an in Situ Isolated Porcine Liver Perfusion Model for Tightly Controlled Physiologic and Pharmacologic Studies

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Pages 131-147 | Received 02 Aug 1995, Accepted 28 Nov 1995, Published online: 09 Jul 2009

References

  • Swindle MM. Swine as replacements for dogs in the surgical teaching and research laboratory. Lab Anim Sci. 1984; 34: 383–385
  • Bhatnagar MK, Shahidi E, Singh A. Histology of piglet liver. Swine in Biomedical Research, M Tumbleson. Plenum, New York 1986; Vol 2: 759–766
  • Singh A, Shahidi E. Ultrastructure of piglet liver. Swine in Biomedical Research, M Tumbleson. Plenum, New York 1986; Vol 1: 77–87
  • Swindle MM. Porcine models in surgical research: an overview. Swine in Biomedical Research, M Tumbleson. Plenum, New York 1986; Vol 1: 235–242
  • Eiseman B, Liem DS, Raffucci F. Heterologous liver perfusion in treatment of hepatic failure. Ann Surg. 1965; 162: 329–345
  • Ham JM, Pirola RC, Elmslie RG. Function of the isolated perfused pig liver. Surg Gynecol Obstet. 1969; 129: 470–474
  • Hickman R, Saunders SJ, Simson E, Terblanche J. Perfusion of the isolated pig liver: functional assessment under control normothermic conditions. Br J Surg. 1971; 58: 33–38
  • Ikeda T, Yanaga K, Lebeau G, Higashi H, Kakizoe S, Starzl T. Hemodynamic and biochemical changes during normothermic and hypothermic sanguinous perfusion of the porcine hepatic graft. Transplantation 1990; 50: 564–567
  • Yanaga K, Makowka L, Lebeau G. A new liver perfusion and preservation system for transplantation research in large animals. J Invest Surg. 1990; 3: 65–75
  • Nagano K, Gelman S, Bradley EL, Parks D. Hypothermia, hepatic oxygen supply-demand, and ischemia-reperfusion injury in pigs. Am J Physiol. 1990; 258: G910–G918
  • Royblat L, Gelman S, Bradley EL, Henderson T, Parks D. Dopamine and hepatic oxygen supply-demand relationship. Can J Physiol Pharm. 1990; 68: 1165–1169
  • Fath J, Parkes B, Sorensen V. Fasted state impedes recovery of porcine hepatic oxygen consumption after warm hepatic ischemia. Surgery 1991; 110: 742–752
  • Paulsen AW, Klintmalm GBG. Direct measurement of hepatic blood flow in native and transplanted organs, with accompanying systemic hemodynamics. Hepatology. 1992; 16: 1–12
  • West JB, Wagner PD. Pulmonary gas exchange. Bioengineering Aspects of the Lung, JB West. Dekker, New York 1977; 361–457
  • Bloor CM, White FC, Lammers RJ. Cardiac ischemia and coronary blood flow in swine. Swine in Cardiovascular Research, HC Stanton, HJ Mersmann. CRC Press, Boca Raton, FL 1986; Vol 2: 87–104
  • Buckley NM, Gootman PM, Yellin EL, Brazeau P. Age related cardiovascular effects of catecholamines in anesthetized piglets. Circ Res. 1979; 45: 282–292
  • Scott D, McIntosh GH. Changes in blood composition and in urinary mineral excretion in the pig in response to acute acid base disturbance. Quart J Exp Physiol. 1975; 60: 131–140
  • Lautt WW. Role and control of the hepatic artery. Hepatic Circulation in Health and Disease, WW Lautt. Raven, New York 1981; 203–226
  • Greenway CV, Stark RD. Hepatic vascular bed. Physiol Rev. 1971; 51: 23–65
  • Mandelbaum I, Berry J, Silbert M, Burns WH, Rothe C. Regional blood flow during pulsatile and nonpulsatile perfusion. Arch Surg. 1965; 91: 771–774

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