Ozone exposure enhances mast-cell inflammation in asthmatic airways despite inhaled corticosteroid therapy

References

• Alexis, N., Urch, B., Tarlo, S., Corey, P., Pengelly, D., O’Byrne, P., and Silverman, F. 2000. Cyclooxygenase metabolites play a different role in ozone-induced pulmonary function decline in asthmatics compared to normals. Inhal. Toxicol. 12 (12): 1205–1224.
   PubMed Web of Science ®Google Scholar
• Alexis, N.E., Lay, J.C., Haczku, A., Gong, H., Linn, W., Hazucha, M.J., Harris, B., Tal-Singer, R., and Peden, D.B. 2008. Fluticasone propionate protects against ozone-induced airway inflammation and modified immune cell activation markers in healthy volunteers. Environ. Health Perspect. 116 (6): 799–805.
   PubMed Web of Science ®Google Scholar
• Aris, R.M., Christian, D., Hearne, P.Q., Kerr, K., Finkbeiner, W.E., and Balmes, J.R. 1993. Ozone-induced airway inflammation in human subjects as determined by airway lavage and biopsy. Am. Rev. Respir. Dis. 148 (5): 1363–1372.
   PubMed Web of Science ®Google Scholar
• Balmes, J.R., Aris, R.M., Chen, L.L., Scannell, C., Tager, I.B., Finkbeiner, W., Christian, D., Kelly, T., Hearne, P.Q., Ferrando, R., and Welch, B. 1997. Effects of ozone on normal and potentially sensitive human subjects. Part I: Airway inflammation and responsiveness to ozone in normal and asthmatic subjects. Res. Rep. Health Effects Inst. (78): 1–37.
   PubMedGoogle Scholar
• Basha, M.A., Gross, K.B., Gwizdala, C.J., Haidar, A.H., and Popovich, J., Jr. 1994. Bronchoalveolar lavage neutrophilia in asthmatic and healthy volunteers after controlled exposure to ozone and filtered purified air. Chest 106 (6): 1757–1765.
   PubMed Web of Science ®Google Scholar
• Becky Kelly, EA., Busse, W.W., and Jarjour, N.N. 2000. Inhaled budesonide decreases airway inflammatory response to allergen. Am. J. Respir. Crit. Care Med. 162 (3 Pt 1): 883–890.
   PubMed Web of Science ®Google Scholar
• Berry, M.A., Hargadon, B., Shelley, M., Parker, D., Shaw, D.E., Green, R.H., Bradding, P., Brightling, C.E., Wardlaw, A.J., and Pavord, I.D. 2006. Evidence of a role of tumor necrosis factor alpha in refractory asthma. N. Engl. J. Med. 354 (7): 697–708.
   PubMed Web of Science ®Google Scholar
• Blomberg, A., Mudway, I.S., Nordenhall, C., Hedenstrom, H., Kelly, F.J., Frew, A.J., Holgate, S.T., and Sandstrom, T. 1999. Ozone-induced lung function decrements do not correlate with early airway inflammatory or antioxidant responses. Eur. Respir. J. 13 (6): 1418–1428.
   PubMed Web of Science ®Google Scholar
• Bosson, J., Stenfors, N., Bucht, A., Frew, A., Helleday, R., Holgate, S., Kelly, F., Pourazar, J., Sandström, T., Wilson, S., and Blomberg, A. 2003. Ozone induced bronchial epithelial cytokine expression differs between healthy and asthmatic subjects. Clin. Exp. Allergy 33: 777–782.
   PubMed Web of Science ®Google Scholar
• Bradding, P., Roberts, J.A., Britten, K.M., Montefort, S., Djukanovic, R., Mueller, R., Heusser, C.H., Howarth, P.H., and Holgate, S.T. 1994. Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: Evidence for the human mast cell as a source of these cytokines. Am. J. Respir. Cell Mol. Biol. 10 (5): 471–480.
   PubMed Web of Science ®Google Scholar
• Britten, K.M., Howarth, P.H., and Roche, W.R. 1993. Immunohistochemistry on resin sections: a comparison of resin embedding techniques for small mucosal biopsies. Biotech. Histochem. 68 (5): 271–280.
   PubMed Web of Science ®Google Scholar
• Carlson, M., Hakansson, L., Peterson, C., Stalenheim, G., and Venge, P. 1991. Secretion of granule proteins from eosinophils and neutrophils is increased in asthma. J. Allergy Clin. Immunol. 87 (1 Pt 1): 27–33.
   PubMed Web of Science ®Google Scholar
• Devlin, R.B., McDonnell, W.F., Becker, S., Madden, M.C., McGee, M.P., Perez, R., Hatch, G., House, D.E., and Koren, H.S. 1996. Time-dependent changes of inflammatory mediators in the lungs of humans exposed to 0.4 ppm ozone for 2 hr: A comparison of mediators found in bronchoalveolar lavage fluid 1 and 18 hr after exposure. Toxicol. Appl. Pharmacol. 138 (1): 176–185.
   PubMed Web of Science ®Google Scholar
• Djukanovic, R., Wilson, J.W., Britten, K.M., Wilson, S.J., Walls, A.F., Roche, W.R., Howarth, P.H., and Holgate, S.T. 1992. Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am. Rev. Respir. Dis. 145 (3): 669–674.
   PubMed Web of Science ®Google Scholar
• Gong, H., Jr., McManus, M.S., and Linn, W.S. 1997. Attenuated response to repeated daily ozone exposures in asthmatic subjects. Arch. Environ. Health 52 (1): 34–41.
   PubMedGoogle Scholar
• Hiltermann, J.T., Lapperre, T.S., van Bree, L., Steerenberg, P.A., Brahim, J.J., Sont, J.K., Sterk, P.J., Hiemstra, P.S., and Stolk, J. 1999. Ozone-induced inflammation assessed in sputum and bronchial lavage fluid from asthmatics: A new noninvasive tool in epidemiologic studies on air pollution and asthma. Free Radical Biol. Med. 27 (11–12): 1448–1454.
   PubMed Web of Science ®Google Scholar
• Hiltermann, T.J., Peters, E.A., Alberts, B., Kwikkers, K., Borggreven, P.A., Hiemstra, P.S., Dijkman, J.H., van Bree, LA, and Stolk, J. 1998. Ozone-induced airway hyperresponsiveness in patients with asthma: Role of neutrophil-derived serine proteinases. Free Radic. Biol. Med. 24 (6): 952–958.
   PubMed Web of Science ®Google Scholar
• Hiltermann, T.J., Stolk, J., Hiemstra, P.S., Fokkens, P.H., Rombout, P.J., Sont, J.K., Sterk, P.J., and Dijkman, J.H. 1995. Effect of ozone exposure on maximal airway narrowing in non-asthmatic and asthmatic subjects. Clin. Sci. (Colch.) 89 (6): 619–624.
   Google Scholar
• Holz, O., Jorres, R.A., Timm, P., Mucke, M., Richter, K., Koschyk, S., and Magnussen, H. 1999. Ozone-induced airway inflammatory changes differ between individuals and are reproducible. Am. J. Respir. Crit. Care Med. 159 (3): 776–784.
   PubMed Web of Science ®Google Scholar
• Holz, O., Tal-Singer, R., Kanniess, F., Simpson, K.J., Gibson, A., Vessey, R.S., Janicki, S., Magnussen, H., Jorres, R.A., and Richter, K. 2005. Validation of the human ozone challenge model as a tool for assessing anti-inflammatory drugs in early development. J. Clin. Pharmacol. 45 (5): 498–503.
   PubMed Web of Science ®Google Scholar
• Horstman, D.H., Ball, B.A., Brown, J., Gerrity, T., and Folinsbee, L.J. 1995. Comparison of pulmonary responses of asthmatic and nonasthmatic subjects performing light exercise while exposed to a low level of ozone. Toxicol. Ind. Health 11 (4): 369–385.
   PubMed Web of Science ®Google Scholar
• Howarth, P.H., Babu, K.S., Arshad, H.S., Lau, L., Buckley, M., McConnell, W., Beckett, P., Al, A.M., Chauhan, A., Wilson, S.J., Reynolds, A., Davies, D.E., and Holgate, S.T. 2005. Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma. Thorax 60 (12): 1012–1018.
   PubMed Web of Science ®Google Scholar
• Jenkins, H.S., Devalia, J.L., Mister, R.L., Bevan, A.M., Rusznak, C., and Davies, R.J. 1999. The effect of exposure to ozone and nitrogen dioxide on the airway response of atopic asthmatics to inhaled allergen. Am. J. Respir. Crit Care Med. 160 (1): 33–39.
   PubMed Web of Science ®Google Scholar
• Jorres, R., Nowak, D., and Magnussen, H. 1996. The effect of ozone exposure on allergen responsiveness in subjects with asthma or rhinitis. Am. J. Respir. Crit. Care Med. 153 (1): 56–64.
   PubMed Web of Science ®Google Scholar
• Kehrl, H.R., Peden, D.B., Ball, B., Folinsbee, L.J., and Horstman, D. 1999. Increased specific airway reactivity of persons with mild allergic asthma after 7.6 hours of exposure to 0.16 ppm ozone. J. Allergy Clin. Immunol. 104 (6): 1198–1204.
   PubMed Web of Science ®Google Scholar
• Kleeberger, S.R., Ohtsuka, Y., Zhang, L.Y., and Longphre, M. 2001. Airway responses to chronic ozone exposure are partially mediated through mast cells. J. Appl. Physiol 90 (2): 713–723.
   PubMed Web of Science ®Google Scholar
• Kleeberger, S.R., Seiden, J.E., Levitt, R.C., and Zhang, L.Y. 1993. Mast cells modulate acute ozone-induced inflammation of the murine lung. Am. Rev. Respir. Dis. 148 (5): 1284–1291.
   PubMed Web of Science ®Google Scholar
• Koenig, J.Q., Covert, D.S., Marshall, S.G., van Belle, G., and Pierson, W.E. 1987. The effects of ozone and nitrogen dioxide on pulmonary function in healthy and in asthmatic adolescents. Am. Rev. Respir. Dis. 136 (5): 1152–1157.
   PubMed Web of Science ®Google Scholar
• Koren, H.S., Devlin, R.B., Graham, D.E., Mann, R., McGee, M.P., Horstman, D.H., Kozumbo, W.J., Becker, S., House, D.E., and McDonnell, W.F. 1989. Ozone-induced inflammation in the lower airways of human subjects. Am. Rev. Respir. Dis. 139 (2): 407–415.
   PubMed Web of Science ®Google Scholar
• Kreit, J.W., Gross, K.B., Moore, T.B., Lorenzen, T.J., D’Arcy, J., and Eschenbacher, W.L. 1989. Ozone-induced changes in pulmonary function and bronchial responsiveness in asthmatics. J. Appl. Physiol 66 (1): 217–222.
   PubMed Web of Science ®Google Scholar
• Krishna, M.T., Blomberg, A., Biscione, G.L., Kelly, F., Sandstrom, T., Frew, A., and Holgate, S. 1997. Short-term ozone exposure upregulates P-selectin in normal human airways. Am. J. Respir. Crit Care Med. 155 (5): 1798–1803.
   PubMed Web of Science ®Google Scholar
• Krishna, M.T., Madden, J., Teran, L.M., Biscione, G.L., Lau, L.C., Withers, N.J., Sandstrom, T., Mudway, I., Kelly, F.J., Walls, A., Frew, A.J., and Holgate, S.T. 1998. Effects of 0.2 ppm ozone on biomarkers of inflammation in bronchoalveolar lavage fluid and bronchial mucosa of healthy subjects. Eur. Respir. J. 11 (6): 1294–1300.
   PubMed Web of Science ®Google Scholar
• Linn, W.S., Shamoo, D.A., Anderson, K.R., Peng, R.C., Avol, E.L., and Hackney, J.D. 1994. Effects of prolonged, repeated exposure to ozone, sulfuric acid, and their combination in healthy and asthmatic volunteers. Am. J. Respir. Crit Care Med. 150 (2): 431–440.
   PubMed Web of Science ®Google Scholar
• Montuschi, P., Nightingale, J.A., Kharitonov, S.A., and Barnes, P.J. 2002. Ozone-induced increase in exhaled 8-isoprostane in healthy subjects is resistant to inhaled budesonide. Free Radic. Biol. Med. 33 (10): 1403–1408.
   PubMed Web of Science ®Google Scholar
• Mudway, I.S., Stenfors, N., Blomberg, A., Helleday, R., Dunster, C., Marklund, S.L., Frew, A.J., Sandstrom, T., and Kelly, F.J. 2001. Differences in basal airway antioxidant concentrations are not predictive of individual responsiveness to ozone: A comparison of healthy and mild asthmatic subjects. Free Radical Biol. Med. 31 (8): 962–974.
   PubMed Web of Science ®Google Scholar
• National Institutes of Health and National Heart LaBI 1995. Global strategy for asthma management and prevention. NHLBI/WHO Workshop.
   Google Scholar
• Newson, E.J., Krishna, M.T., Lau, L.C., Howarth, P.H., Holgate, S.T., and Frew, A.J. 2000. Effects of short-term exposure to 0.2 ppm ozone on biomarkers of inflammation in sputum, exhaled nitric oxide, and lung function in subjects with mild atopic asthma. J. Occup. Environ. Med. 42 (3): 270–277.
   PubMed Web of Science ®Google Scholar
• Newton, R., Barnes, P.J., and Adcock, I.M. 1998. Asthma: Basic mechanisms and clinical management (3rd ed). In Transcription factors, eds R, Newton, PJ, Barnes, and IM, Adcock, 459–474. London: Academic Press Limited.
   Google Scholar
• Nightingale, J.A., Rogers, D.F., and Barnes, P.J. 1999. Effect of inhaled ozone on exhaled nitric oxide, pulmonary function, and induced sputum in normal and asthmatic subjects. Thorax 54 (12): 1061–1069.
   PubMed Web of Science ®Google Scholar
• Nightingale, J.A., Rogers, D.F., Fan, C.K., and Barnes, P.J. 2000. No effect of inhaled budesonide on the response to inhaled ozone in normal subjects. Am. J. Respir. Crit Care Med. 161 (2 Pt 1): 479–486.
   PubMed Web of Science ®Google Scholar
• Norzila, M.Z., Fakes, K., Henry, R.L., Simpson, J., and Gibson, P.G. 2000. Interleukin-8 secretion and neutrophil recruitment accompanies induced sputum eosinophil activation in children with acute asthma. Am. J. Respir. Crit. Care Med. 161 (3 Pt 1): 769–774.
   PubMed Web of Science ®Google Scholar
• Pauwels, RA, Buist, AS, Calverley, PM, Jenkins, CR, and Hurd, SS 2001. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am. J. Respir. Crit Care Med. 163 (5): 1256–1276.
   PubMedGoogle Scholar
• Pearlman, D.S. 1999. Pathophysiology of the inflammatory response. J. Allergy Clin. Immunol. 104 (4 Pt 1): S132–S137.
   Web of Science ®Google Scholar
• Peden, D.B., Boehlecke, B., Horstman, D., and Devlin, R. 1997. Prolonged acute exposure to 0.16 ppm ozone induces eosinophilic airway inflammation in asthmatic subjects with allergies. J. Allergy Clin. Immunol. 100 (6 Pt 1): 802–808.
   PubMed Web of Science ®Google Scholar
• Scannell, C., Chen, L., Aris, R.M., Tager, I., Christian, D., Ferrando, R., Welch, B., Kelly, T., and Balmes, J.R. 1996. Greater ozone-induced inflammatory responses in subjects with asthma. Am. J. Respir. Crit Care Med. 154 (1): 24–29.
   PubMed Web of Science ®Google Scholar
• Stenfors, N., Pourazar, J., Blomberg, A., Krishna, M.T., Mudway, I., Helleday, R., Kelly, F.J., Frew, A.J., and Sandstrom, T. 2002. Effect of ozone on bronchial mucosal inflammation in asthmatic and healthy subjects. Respir. Med. 96 (5): 352–358.
   PubMed Web of Science ®Google Scholar
• Torres, A., Utell, M.J., Morow, P.E., Voter, K.Z., Whitin, J.C., Cox, C., Looney, R.J., Speers, D.M., Tsai, Y., and Frampton, M.W. 1997. Airway inflammation in smokers and nonsmokers with varying responsiveness to ozone. Am. J. Respir. Crit. Care Med. 156 (3 Pt 1): 728–736.
   PubMed Web of Science ®Google Scholar
• Vagaggini, B., Carnevali, S., Macchioni, P., Taccola, M., Fornai, E., Bacci, E., Bartoli, M.L., Cianchetti, S., Dente, F.L., Di Franco, A, Giannini, D., and Paggiaro, P.L. 1999. Airway inflammatory response to ozone in subjects with different asthma severity. Eur. Respir. J. 13 (2): 274–280.
   PubMed Web of Science ®Google Scholar
• Vagaggini, B., Taccola, M., Conti, I., Carnevali, S., Cianchetti, S., Bartoli, M.L., Bacci, E., Dente, F.L., Di Franco, A., Giannini, D., and Paggiaro, P.L. 2001. Budesonide reduces neutrophilic but not functional airway response to ozone in mild asthmatics. Am. J. Respir. Crit. Care Med. 164 (12): 2172–2176.
   PubMed Web of Science ®Google Scholar