Comparative effects of inhaled diesel exhaust and ambient fine particles on inflammation, atherosclerosis, and vascular dysfunction

References

• Adar SD, Gold DR, Coull BA, Schwartz J, Stone PH, Suh H. 2007. Focused exposures to airborne traffic particles and heart rate variability in the elderly. Epidemiology 2007;18:95–103.
   PubMed Web of Science ®Google Scholar
• Air Quality Expert Group. 2005. Particulate Matter in the United Kingdom. London: Defra.
   Google Scholar
• Araujo JA, Barajas B, Kleinman M, Wang X, Bennett BJ, Gong KW, Navab M, Harkema J, Sioutas C, Lusis AJ, Nel AE. 2008. Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circ Res 102:589–596.
   PubMed Web of Science ®Google Scholar
• Batalha JR, Saldiva PH, Clarke RW, Coull BA, Stearns RC, Lawrence J, Murthy GK, Koutrakis P, Godleski JJ. 2002. Concentrated ambient air particles induce vasoconstriction of small pulmonary arteries in rats. Environ Health Perspect 110:1191–1197.
   PubMed Web of Science ®Google Scholar
• Boren, HG. 1964. Carbon as a carrier gas mechanism for irritant gases. Arch Environ Health 8:127–132.
   Google Scholar
• Brook RD, Brook JR, Urch B, Vincent R, Rajagopalan S, Silverman F. 2002. Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults. Circulation 105:1534–1536.
   PubMed Web of Science ®Google Scholar
• Brook RD, Franklin B, Cascio W, Hong Y, Howard G, Lipsett M, et al. 2004. Air pollution and cardiovascular disease: A statement for healthcare professionals from the expert panel on population and prevention science of the American Heart Association. Circulation 109:2655–2671.
   PubMed Web of Science ®Google Scholar
• Campen MJ, Babu NS, Helms GA, Pett S, Wernly J, Mehran R, et al. 2005. Nonparticulate components of diesel exhaust promote constriction in coronary arteries from ApoE−/– mice. Toxicol Sci 88:95–102.
   PubMed Web of Science ®Google Scholar
• Campen MJ, McDonald JD, Reed MD, Seagrave J. 2006. Fresh gasoline emissions, not paved road dust, alter cardiac repolarization in ApoE−/− mice. Cardiovasc Toxicol 6:199–210.
   PubMed Web of Science ®Google Scholar
• Campen MJ, Lund AK, Knuckles TL, Conklin DJ, Bishop B, Young D, Seilkop S, Seagrave J, Reed MD, McDonald JD. 2010. Inhaled diesel emissions alter atherosclerotic plaque composition in ApoE(−/−) mice. Toxicol Appl Pharmacol 242:310–317.
   PubMed Web of Science ®Google Scholar
• Chen LC, Hwang JS. 2005. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice, IV. Characterization of acute and chronic effects of ambient air fine particulate matter exposures on heart-rate variability. Inhal Toxicol 17:209–216.
   PubMed Web of Science ®Google Scholar
• Chen LC, Nadziejko C. 2005. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice, V: CAPs exacerbate aortic plaque development in hyperlipidemic mice. Inhal Toxicol 17:217–224.
   PubMed Web of Science ®Google Scholar
• Chen LC, Thurston G, Schlesinger R. 2006. Acid aerosols as a health hazard. In: Ayres J, Maynard R, Richards R, eds. Air Pollution and Health. London: Imperial College Press, Chapter 5.
   Google Scholar
• Cheng TJ, Hwang JS, Wang PY, Tsai CF, Chen CY, Lin SH, et al. 2003. Effects of concentrated ambient particles on heart rate and blood pressure in pulmonary hypertensive rats. Environ Health Perspect 111:147–150.
   PubMed Web of Science ®Google Scholar
• Cherng TW, Campen MJ, Knuckles TL, Gonzalez Bosc L, Kanagy NL. 2009. Impairment of coronaryendothelial cell ET(B) receptor function after short-term inhalation exposure to whole diesel emissions. Am J Physiol Regul Integr Comp Physiol 297:R640–R647.
   Google Scholar
• Devlin RB, Ghio AJ, Kehrl H, Sanders G, Cascio W. 2003. Elderly humans exposed to concentrated air pollution particles have decreased heart rate variability. Eur Respir J S40:76s–80s.
   Google Scholar
• Dockery DW, Pope CA, Xu X, Spengler JD, Ware JH, Fay ME, et al. 1993. An association between air pollution and mortality in six U.S. cities. N Engl J Med 329:1753–1759.
   PubMed Web of Science ®Google Scholar
• Floyd HS, Chen LC, Vallanat B, and Dreher K. 2009. Fine ambient air particular matter exposure induces molecular alterations indicative of cardiovascular disease progression in atherosclerotic susceptible mice. Inhal Toxicol 21:394–403.
   PubMed Web of Science ®Google Scholar
• Frampton MW, Stewart JC, Oberdorster G, Morrow PE, Chalupa D, Pietropaoli AP, Frasier LM, Speers DM, Cox C, Huang LS, Utell MJ. 2006. Inhalation of ultrafine particles alters blood leukocyte expression of adhesion molecules in humans. Environ Health Perspect 114:51–58.
   PubMed Web of Science ®Google Scholar
• Geller MD, Sardar SB, Phuleria H, Fine PM, Sioutas C. 2005. Measurements of particle number and mass concentrations and size distributions in a tunnel environment. Environ Sci Technol 39:8653–8663.
   PubMed Web of Science ®Google Scholar
• Godleski JJ, Verrier RL, Koutrakis P, Catalano P, Coull B, Reinisch U, et al. 2000. Mechanisms of morbidity and mortality from exposure to ambient air particles. Res Rep Health Eff Inst. 91:5–88; discussion 89–103.
   PubMedGoogle Scholar
• Gong H, Linn WS, Sioutas C, Terrell SL, Clark KW, Anderson KR, et al. 2003. Controlled exposures ofhealthy and asthmatic volunteers to concentrated ambient fine particles in Los Angeles. Inhal Toxicol 15:305–325.
   PubMed Web of Science ®Google Scholar
• Goto Y, Hogg JC, Shih CH, Ishii H, Vincent R, van Eeden SF. 2004. Exposure to ambient particles accelerates monocyte release from bone marrow in atherosclerotic rabbits. Am J Physiol Lung Cell Mol Physiol 287:L79–L85.
   Google Scholar
• Health Effects Institute. 1995. Diesel Exhaust: A Critical Analysis of Emissions, Exposure, and Health Effects. Cambridge, MA: Health Effects Institute.
   Google Scholar
• Hoek G, Brunekreef B, Goldbohm S, Fischer P, van den Brandt PA. 2002. Association between mortality and indicators of traffic-related air pollution in the Netherlands: A cohort study. Lancet 360:1203–1209.
   PubMed Web of Science ®Google Scholar
• Hoffmann B, Moebus S, Möhlenkamp S, Stang A, Lehmann N, Dragano N, et al. 2007. Recall Study Investigative Group. Residential exposure to traffic is associated with coronary atherosclerosis. Circulation 116:489–96.
   PubMed Web of Science ®Google Scholar
• Ishihara Y, Kagawa J. 2003. Chronic diesel exhaust exposures of rats demonstrate concentration and time-dependent effects on pulmonary inflammation. Inhal Toxicol 15:473–492.
   PubMed Web of Science ®Google Scholar
• Kilburn KH, McKenzie WN. 1978. Leukocyte recruitment to airways by aldehyde-carbon combinations that mimic cigarette smoke. Lab. Invest 38:134–143.
   PubMed Web of Science ®Google Scholar
• Knuckles TL, Lund AK, Lucas SN, Campen MJ. 2008. Diesel exhaust exposure enhances venoconstriction via uncoupling of eNOS. Toxicol Appl Pharmacol 230:346–351.
   PubMed Web of Science ®Google Scholar
• Kunzli N, Jerrett M, Mack WJ, Beckerman B, LaBree L, Gilliland F, et al. 2005. Ambient air pollution and atherosclerosis in Los Angeles. Environ Health Perspect 113:201–206.
   PubMed Web of Science ®Google Scholar
• Lanki T, de Hartog JJ, Heinrich J, Hoek G, Janssen NA, Peters A, et al. 2006. Can we identify sources of fine particles responsible for exercise-induced ischemia on days with elevated air pollution? The ULTRA study. Environ Health Perspect 114:655–660.
   PubMed Web of Science ®Google Scholar
• Libby P. Inflammation in atherosclerosis. 2002. Nature 420:868–874.
   PubMed Web of Science ®Google Scholar
• Lund AK, Knuckles TL, Obot Akata C, Shohet R, McDonald JD, Gigliotti A, Seagrave JC, Campen MJ. 2007. Gasoline exhaust emissions induce vascular remodeling pathways involved in atherosclerosis. Toxicol Sci 95:485–494.
   PubMed Web of Science ®Google Scholar
• Lund AK, Lucero J, Lucas S, Madden MC, McDonald JD, Seagrave JC, Knuckles  TL, Campen MJ. 2009. Vehicular emissions induce vascular MMP-9 expression and activity associated with endothelin-1-mediated pathways. Arterioscler Thromb Vasc Biol. 2009;29:511–517.
   PubMed Web of Science ®Google Scholar
• Maciejczyk P, Chen LC. 2005. Effects of subchronic exposures to CAPs in mice: VIII. Source-related daily variations in in vitro responses to CAPs. Inhal Toxicol 17:243–253.
   PubMed Web of Science ®Google Scholar
• Maciejczyk P, Zhong M, Li Q, Xiong J, Nadziejko C, Chen LC. 2005. Effects of subchronic exposures to CAPs in mice: II. The design of a CAPs exposure system for biometric telemetry monitoring. Inhal Toxicol 17:189–197.
   PubMed Web of Science ®Google Scholar
• Madden MC, Richards JE, Dailey LA, Hatch GE, Ghio AJ. 2000. Effect of ozone on diesel exhaust particle toxicity in rat lung. Toxicol Appl Pharmacol 168:140–148.
   PubMed Web of Science ®Google Scholar
• Magari SR, Schwartz J, Williams PL, Hauser R, Smith TJ, Christiani DC. 2002. The association of particulate air metal concentrations with heart rate variability. Environ Health Perspect 110:875–880.
   PubMed Web of Science ®Google Scholar
• McDonald JD, Barr EB, White RK. 2004. Design, characterization, and evaluation of a small-scale diesel exhaust exposure system. Aerosol Sci Technol 38:62–78.
   Web of Science ®Google Scholar
• Miller KA, Siscovick DS, Sheppard L, Shepherd K, Sullivan JH, Anderson GL, et al. 2007. Long-term exposure to air pollution and incidence of cardiovascular events in women. N Engl J Med 356:447–458.
   PubMed Web of Science ®Google Scholar
• Mills NL, Törnqvist H, Gonzalez MC, Vink E, Robinson SD, Söderberg S, et al. 2007a. Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease. N Engl J Med 357:1075–1082.
   PubMed Web of Science ®Google Scholar
• Mills NL, Törnqvist H, Robinson SD, Gonzalez MC, Söderberg S, Sandström T, Blomberg A, Newby DE, Donaldson K. 2007b. Air pollution and atherothrombosis. Inhal Toxicol 19(S1):81–89.
   PubMedGoogle Scholar
• Nadziejko C, Fang K, Chen LC, Gordon T, Nãdas A. 2003. Quantitative analysis of cardiac data from rats monitored by telemetry: Reducing within- and between-animal variability. Cardiovasc Toxicol 2:237–244.
   Google Scholar
• Nurkiewicz TR, Porter DW, Barger M, Castranova V, Boegehold MA. 2004. Particulate matter exposure impairs systemic microvascular endothelium-dependent dilation. Environ Health Perspect 112:1299–1306.
   PubMed Web of Science ®Google Scholar
• Palinski W, Ord VA, Plump AS, Breslow JL, Steinberg D, Witztum JL. 1994. ApoE-deficient mice are a model of liproprotein oxidation in atherogenesis. Arterioscler Thromb 14:605–616.
   PubMed Web of Science ®Google Scholar
• Peters A, Dockery DW, Muller JE, Mittleman MA. 2001. Increased particulate air pollution and the triggering of myocardial infarction. Circulation 103:2810–2815.
   PubMed Web of Science ®Google Scholar
• Peters A, von Klot S, Heier M, Trentinaglia I, Hörmann A, Wichmann HE, et al. 2004. Exposure to traffic and the onset of myocardial infarction. N Engl J Med 351:1721–1730.
   PubMed Web of Science ®Google Scholar
• Pope CA, Burnett RT, Thurston GD, Thun MJ, Calle EE, Krewski D, et al. 2004. Cardiovascular mortality and long-term exposure to particulate air pollution: Epidemiological evidence of general pathophysiological pathways of disease. Circulation 109:71–77.
   PubMed Web of Science ®Google Scholar
• Peretz A, Sullivan JH, Leotta DF, Trenga CA, Sands FN, Allen J, Carlsten C, Wilkinson CW, Gill EA, Kaufman JD. 2008. Diesel exhaust inhalation elicits acute vasoconstriction in vivo. Environ Health Perspect 116:937–942.
   PubMed Web of Science ®Google Scholar
• Prieditis H, Adamson IY. 2002. Comparative pulmonary toxicity of various soluble metals found in urban population dusts. Exp Lung Res 28:563–576.
   PubMed Web of Science ®Google Scholar
• Riediker M, Cascio WE, Griggs TR, Herbst MC, Bromberg PA, Neas L, et al. 2004. Particulate matter exposure in cars is associated with cardiovascular effects in healthy young men. Am J Respir Crit Care Med 169:934–940.
   PubMed Web of Science ®Google Scholar
• Rossi G, Vigotti MA, Zanobetti A, Repetto F, Gianelle V, Schwartz J. 1999. Air pollution and cause-specific mortality in Milan, Italy, 1980–1989. Arch Environ Health 54:158–164.
   PubMed Web of Science ®Google Scholar
• Saber AT, Jacobsen NR, Bornholdt J, Kjaer SL, Dybdahl M, Risom L, Loft S, Vogel U, Wallin H. 2006. Cytokine expression in mice exposed to diesel exhaust particles by inhalation. Role of tumor necrosis factor. Part Fibre Toxicol 20:4.
   Google Scholar
• Saber AT, Halappanavar S, Folkmann JK, Bornholdt J, Boisen AM, Møller P, Williams A, Yauk C, Vogel U, Loft S, Wallin H. 2009. Lack of acute phase response in the livers of mice exposed to diesel exhaust particles or carbon black by inhalation. Part Fibre Toxicol 6:12.
   PubMed Web of Science ®Google Scholar
• Saldiva PHN, Clarke RW, Coull BA, Stearns RC, Lawrence J, Krishna-Murthy GG, et al. 2002. Lung inflammation induced by concentrated ambient air particles is related to particle composition. Am J Respir Crit Care Med 165:1610–1617.
   PubMed Web of Science ®Google Scholar
• Salvi S, Blomberg A, Rudell B, Kelly F, Sandstrom T, Holgate ST, Frew A. 1999. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J Respir Crit Care Med 159:702–709.
   PubMed Web of Science ®Google Scholar
• Schwartz J, Litonjua A, Suh H, Verrier M, Zanobetti A, Syring M, et al. 2005. Traffic related pollution and heart rate variability in a panel of elderly subjects. Thorax 60:455–461.
   PubMed Web of Science ®Google Scholar
• Sun Q, Wang A, Jin X, Natanzon A, Duquaine D, Brook RD, et al. 2005. Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model. JAMA 294:3003–3010.
   PubMed Web of Science ®Google Scholar
• Suwa T, Hogg JC, Quinlan KB, Ohgami A, Vincent R, van Eeden SF. 2002. Particulate air pollution induces progression of atherosclerosis. J Am Coll Cardiol 39:935–42.
   PubMed Web of Science ®Google Scholar
• Törnqvist H, Mills NL, Gonzalez M, Miller MR, Robinson SD, Megson  IL, Macnee W, Donaldson K, Söderberg S, Newby DE, Sandström T, Blomberg  A. 2007. Persistent endothelial dysfunction in humans after diesel exhaust inhalation. Am J Respir Crit Care Med 2007;176:395–400.
   PubMed Web of Science ®Google Scholar
• Tsakadze NL, Srivastava S, Awe SO, Adeagbo ASO, Bhatnagar A, D’Souza SE. 2003. Acrolein-induced vasomotor responses of rat aorta. Am J Physiol Heart Circ Physiol 285:H727–H734.
   Google Scholar
• Utell MJ, Frampton MW. 2000. Acute health effects of ambient air pollution: The ultrafine particle hypothesis. J Aerosol Med 13:355–359.
   PubMedGoogle Scholar
• US EPA. 2002. Health assessment document for diesel engine exhaust. Washington, DC: EPA. 600/8-90/057F. http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=29060&CFID=6037651&CFTOKEN=47408256. Accessed August 21, 2008.
   Google Scholar
• US EPA. 2006. 40 CFR Part 50, Appendix L, Quality Assurance Document 2.12 or Quality Assurance Guidance Document, Method Compendium, PM2.5 Mass Weighing Laboratory Standard Operating Procedures for the Performance Evaluation Program.
   Google Scholar
• US EPA. 2006. National Ambient Air Quality Standards (NAAQS). Available at: http://www.epa.gov/air/criteria.html. Accessed August 21, 2008.
   Google Scholar
• US EPA. 2006. National-scale Air Toxics Assessment for 1999: Estimated emissions, concentrations and risk. National Air Toxics Assessment. www.epa.gov/ttn/atw/nata1999/natafinalfact.html. Accessed August 21, 2008.
   Google Scholar
• Wellenius GA, Saldiva PH, Batalha JR, Krishna Murthy GG, Coull BA, Verrier  RL, Godleski JJ. 2002. Electrocardiographic changes during exposure to residual oil fly ash (ROFA) particles in a rat model of myocardial infarction. Toxicol Sci 66:327–335.
   PubMed Web of Science ®Google Scholar
• Wilson MR, Lightbody JH, Donaldson K, Sales J, Stone V. 2002. Interactions between ultrafine particles and transition metals in vivo and in vitro. Toxicol Appl Pharmacol 184:172–179.
   PubMed Web of Science ®Google Scholar