Considerations for the design and technical setup of a human whole-body exposure chamber

References

• Breuer D, Maybaum B, Gusbeth K, Rosenthal S, Seifert M. 2005. Round robin test to determine volatile inorganic acids (HCl and HNO3) (in German). Gefahrstoffe Reinh Luft 65:122–127.
   Web of Science ®Google Scholar
• Bornschein S, Hausteiner C, Römmelt H, Nowak D, Förstl H, Zilker T. 2008. Double-blind placebo-controlled provocation study in patients with subjective Multiple Chemical Sensitivity (MCS) and matched control subjects. Clin Toxicol (Phila) 46:443–449.
   PubMed Web of Science ®Google Scholar
• Committee for European Normalization (CEN). 2006. CEN/TR 15281: Guidance on inerting for the prevention of explosions. Brussels, Belgium. Available from www.cenorm.be
   Google Scholar
• DIN EN 779. (2002). Particulate air filters for general ventilation – Determination of the filtration performance; German version: Berlin: Beuth.
   Google Scholar
• Eduard W, Kruse K, Skogstad A, Nilsen T, Synnes O, Kongerud J, Heldal KK. 2008. Generation and homogeneity of aerosols in a human whole-body inhalation chamber. Ann Occup Hyg 52:545–554.
   PubMedGoogle Scholar
• Fiedler N, Kelly-McNeil K, Mohr S, Lehrer P, Opiekun RE, Lee C, Wainman T, Hamer R, Weisel C, Edelberg R, Lioy PJ. 2000. Controlled human exposure to methyl tertiary butyl ether in gasoline: Symptoms, psychophysiologic and neurobehavioral responses of self-reported sensitive persons. Environ Health Perspect 108:753–763.
   PubMed Web of Science ®Google Scholar
• Fiedler N, Laumbach R, Kelly-McNeil K, Lioy P, Fan ZH, Zhang J, Ottenweller J, Ohman-Strickland P, Kipen H. 2005. Health effects of a mixture of indoor air volatile organics, their ozone oxidation products, and stress. Environ Health Perspect 113:1542–1548.
   PubMed Web of Science ®Google Scholar
• Fiedler N, Kelly-McNeil K, Ohman-Strickland P, Zhang J, Ottenweller J, Kipen HM. 2008. Negative affect and chemical intolerance as risk factors for building-related symptoms: A controlled exposure study. Psychosom Med 70:254–262.
   PubMed Web of Science ®Google Scholar
• GESTIS-database on hazardous substances: GESTIS is the Information system on hazardous substances of the German Social Accident Insurance (in German). St. Augustin, Germany. Available from www.dguv.de/ifa/stoffdatenbank
   Google Scholar
• Hall. L. 2010. Grantees grapple with harmonizing air pollution studies. Environmental factors. Available from www.niehs.nih.gov/news/newsletter/2010/may/spotlight-harmonizing.cfm
   Google Scholar
• Hammad YY, Pieretti LF. 2011. Performance of a human inhalation challenge exposure system. I. Gases. Inhal Toxicol 23:331–338.
   PubMed Web of Science ®Google Scholar
• Hempel-Jørgensen A, Kjaergaard SK, Môlhave L, Hudnell HK. 1999. Time course of sensory eye irritation in humans exposed to N-butanol and 1-octene. Arch Environ Health 54:86–94.
   PubMedGoogle Scholar
• Hornuss C, Praun S, Villinger J, Dornauer A, Moehnle P, Dolch M, Weninger E, Chouker A, Feil C, Briegel J, Thiel M, Schelling G. 2007. Real-time monitoring of propofol in expired air in humans undergoing total intravenous anesthesia. Anesthesiology 106:665–674.
   PubMed Web of Science ®Google Scholar
• Ichitsubo H, Yamada Y, Shimo M, Koizumi A. 2004. Development of a radon-aerosol chamber at NIRS–general design and aerosol performance. J Aerosol Sci 35:217–232.
   Web of Science ®Google Scholar
• Krug N, Hohlfeld JM, Larbig M, Buckendahl A, Badorrek P, Geldmacher H, Behnke W, Dunkhorst W, Windt H, Loedding B, Luettig B, Koch W. 2003. Validation of an environmental exposure unit for controlled human inhalation studies with grass pollen in patients with seasonal allergic rhinitis. Clin Exp Allergy 33:1667–1674.
   PubMed Web of Science ®Google Scholar
• Kuprov RY, Buck D, Pope CA 3rd, Eatough DJ, Hansen JC. 2011. Design and characterization of a two-stage human subject exposure chamber. J Air Waste Manag Assoc 61:864–871.
   PubMedGoogle Scholar
• Lidén C, Lundgren L, Skare L, Lidén G, Tornling G, Krantz S. 1998. A new whole-body exposure chamber for human skin and lung challenge experiments – the generation of wheat flour aerosols. Ann Occup Hyg 42:541–547.
   PubMedGoogle Scholar
• Lundgren L, Skare L, Lidén C, Tornling G. 2006. Large organic aerosols in a dynamic and continuous whole-body exposure chamber tested on humans and on a heated mannequin. Ann Occup Hyg 50:705–715.
   PubMed Web of Science ®Google Scholar
• Marczynski B, Czuppon AB, Hoffarth HP, Marek W, Baur X. 1992. DNA damage in human white blood cells after inhalative exposure to methylenediphenyl diisocyanate (MDI) – case report. Toxicol Lett 60:131–138.
   PubMed Web of Science ®Google Scholar
• Monsé C, Broding HC, Hoffmeyer F, Jettkant B, Berresheim H, Brüning T, Bünger J, Sucker K. 2010. Use of test gas generator for dynamic dilution olfactometry to assess odour and irritation thresholds for single compounds. Chem Senses 35:523–530
   PubMed Web of Science ®Google Scholar
• Morin K, Rakatansky H, Riddick FA Jr, Morse LJ, O’Bannon JM 3rd, Goldrich MS, Ray P, Weiss M, Sade RM, Spillman MA. 2002. Managing conflicts of interest in the conduct of clinical trials. JAMA 287:78–84.
   PubMed Web of Science ®Google Scholar
• Rudell B, Sandström T, Hammarström U, Ledin ML, Hörstedt P, Stjernberg N. 1994. Evaluation of an exposure setup for studying effects of diesel exhaust in humans. Int Arch Occup Environ Health 66:77–83.
   PubMed Web of Science ®Google Scholar
• Salvi S, Blomberg A, Rudell B, Kelly F, Sandström T, Holgate ST, Frew A. 1999. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J Respir Crit Care Med 159:702–709.
   PubMed Web of Science ®Google Scholar
• Schnuch A, Oppel E, Oppel T, Römmelt H, Kramer M, Riu E, Darsow U, Przybilla B, Nowak D, Jörres RA. 2010. Experimental inhalation of fragrance allergens in predisposed subjects: Effects on skin and airways. Br J Dermatol 162:598–606.
   PubMed Web of Science ®Google Scholar
• Søstrand P, Kongerud J, Eduard W, Nilsen T, Skogland M, Boe J. 1997. A test chamber for experimental hydrogen fluoride exposure in humans. Am Ind Hyg Assoc J 58:521–525.
   PubMedGoogle Scholar
• Suarez JC, Warmath DS, Koetz KP, Hood AF, Thompson ML, Kendal-Reed MS, Walker DB, Walker JC. 2005. Single-pass environmental chamber for quantifying human responses to airborne chemicals. Inhal Toxicol 17:169–175.
   PubMed Web of Science ®Google Scholar
• van Thriel C, Schäper M, Kleinbeck S, Kiesswetter E, Blaszkewicz M, Golka K, Nies E, Raulf-Heimsoth M, Brüning T. 2010. Sensory and pulmonary effects of acute exposure to sulfur dioxide (SO2). Toxicol Lett 196:42–50.
   PubMed Web of Science ®Google Scholar
• van Thriel C, Seeber A, Kiesswetter E, Blaszkewicz M, Golka K, Wiesmüller GA. 2003. Physiological and psychological approaches to chemosensory effects of solvents. Toxicol Lett 140–141:261–271.
   PubMed Web of Science ®Google Scholar