Implication of PDGF signaling in cigarette smoke-induced pulmonary arterial hypertension in rat

References

• Andrae J, Gallini R, Betsholtz C. 2008. Role of platelet-derived growth factors in physiology and medicine. Genes Dev 22:1276–1312.
   PubMed Web of Science ®Google Scholar
• Arcot SS, Lipke DW, Gillespie MN, Olson JW. 1993. Alterations of growth factor transcripts in rat lungs during development of monocrotaline-induced pulmonary hypertension. Biochem Pharmacol 46:1086–1091.
   PubMed Web of Science ®Google Scholar
• Barst RJ. 2005. PDGF signaling in pulmonary arterial hypertension. J Clin Invest 115:2691–2694.
   PubMed Web of Science ®Google Scholar
• Basciani S, Mariani S, Arizzi M, Brama M, Ricci A, Betsholtz C, Bondjers C, Ricci G, Catizone A, Galdieri M, Spera G, Gnessi L. 2004. Expression of platelet-derived growth factor (PDGF) in the epididymis and analysis of the epididymal development in PDGF-A, PDGF-B, and PDGF receptor β deficient mice. Biol Reprod 70:168–177.
   PubMed Web of Science ®Google Scholar
• Betsholtz C, Lindblom P, Bjarnegard M, Enge M, Gerhardt H, Lindahl P. 2004. Role of platelet-derived growth factor in mesangium development and vasculopathies: lessons from platelet-derived growth factor and platelet-derived growth factor receptor mutations in mice. Curr Opin Nephrol Hypertens 13:45–52.
   PubMed Web of Science ®Google Scholar
• Bonner JC. 2004. Regulation of PDGF and its receptors in fibrotic diseases. Cytokine Growth Factor Rev 15:255–273.
   PubMed Web of Science ®Google Scholar
• Cao Y, Cao R, Hedlund EM. 2008. R Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathways. J Mol Med 86:785–789.
   PubMed Web of Science ®Google Scholar
• Carraway MS, Ghio AJ, Suliman HB, Carter JD, Whorton AR, Piantadosi CA. 2002. Carbon monoxide promotes hypoxic pulmonary vascular remodeling. Am J Physiol Lung Cell Mol Physiol 282:L693–L702.
   PubMed Web of Science ®Google Scholar
• Carty CS, Huribal M, Marsan BU, Ricotta JJ, Dryjski M. 1997. Nicotine and its metabolite cotinine are mitogenic for human vascular smooth muscle cells. J Vasc Surg 25:682–688.
   PubMed Web of Science ®Google Scholar
• De Cunto G, Cardini S, Cirino G, Geppetti P, Lungarella G, Lucattelli M. 2011. Pulmonary hypertension in smoking mice over-expressing protease-activated receptor-2. Eur Respir J 37:823–834.
   PubMed Web of Science ®Google Scholar
• Farooqi AA, Waseem S, Riaz AM, Dilawar BA, Mukhtar S, Minhaj S, Waseem MS, Daniel S, Malik BA, Nawaz A, Bhatti S. 2011. PDGF: the nuts and bolts of signalling toolbox. Tumour Biol 32:1057–1070.
   PubMed Web of Science ®Google Scholar
• Garat CV, Crossno JT Jr, Sullivan TM, Reusch JE, Klemm DJ. 2010. Thiazolidinediones prevent PDGF-BB-induced CREB depletion in pulmonary artery smooth muscle cells by preventing upregulation of casein kinase 2 α’ catalytic subunit. J Cardiovasc Pharmacol 55:469–480.
   PubMed Web of Science ®Google Scholar
• Ghofrani HA, Seeger W, Grimminger F. 2005. Imatinib for the treatment of pulmonary arterial hypertension. N Engl J Med 353:1412–1413.
   PubMed Web of Science ®Google Scholar
• Grimminger F, Schermuly RT. 2010. PDGF receptor and its antagonists: role in treatment of PAH. Adv Exp Med Biol 661:435–446.
   PubMed Web of Science ®Google Scholar
• Han SX, He GM, Wang T, Chen L, Ning YY, Luo F, An J, Yang T, Dong JJ, Liao ZL, Xu D, Wen FQ. 2010. Losartan attenuates chronic cigarette smoke exposure-induced pulmonary arterial hypertension in rats: possible involvement of angiotensin-converting enzyme-2. Toxicol Appl Pharmacol 245:100–107.
   PubMed Web of Science ®Google Scholar
• Heldin CH, Westermark B. 1999. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 79:1283–1316.
   PubMed Web of Science ®Google Scholar
• Humbert M, Morrell NW, Archer SL, Stenmark KR, MacLean MR, Lang IM, Christman BW, Weir EK, Eickelberg O., Voelkel NFRabinovitch M. 2004. Cellular and molecular pathobiology of pulmonary arterial hypertension. J Am Coll Cardiol 43:13S–24S.
   PubMed Web of Science ®Google Scholar
• Jankov RP, Kantores C, Belcastro R, Yi S, Ridsdale RA, Post M, Tanswell AK. 2005. A role for platelet-derived growth factor β-receptor in a newborn rat model of endothelin-mediated pulmonary vascular remodeling. Am J Physiol Lung Cell Mol Physiol 288:L1162–L1170.
   PubMed Web of Science ®Google Scholar
• Jawien A, Bowen-Pope DF, Lindner V, Schwartz SM, Clowes AW. 1992. Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty. J Clin Invest 89:507–511.
   PubMed Web of Science ®Google Scholar
• Jeffery TK, Wanstall JC. 2001. Pulmonary vascular remodeling: a target for therapeutic intervention in pulmonary hypertension. Pharmacol Ther 92:1–20.
   PubMed Web of Science ®Google Scholar
• Lahm T, Crisostomo PR, Markel TA, Wang M, Lillemoe KD, Meldrum DR. 2007. The critical role of vascular endothelial growth factor in pulmonary vascular remodeling after lung injury. Shock 28:4–14.
   PubMed Web of Science ®Google Scholar
• Millette E, Rauch BH, Kenagy RD, Daum GClowes AW. 2006. Platelet-derived growth factor-BB transactivates the fibroblast growth factor receptor to induce proliferation in human smooth muscle cells. Trends Cardiovasc Med 16:25–28.
   PubMed Web of Science ®Google Scholar
• Oltmanns U, Chung KF, Walters M, John M, Mitchell JA. 2005. Cigarette smoke induces IL-8, but inhibits eotaxin and RANTES release from airway smooth muscle. Respir Res 6:74.
   PubMed Web of Science ®Google Scholar
• Ou XM, Wen FQ, Uhal BD, Feng YL, Huang XY, Wang T, Wang K, Liu DS, Wang X, Chen L. 2009. Simvastatin attenuates experimental small airway remodelling in rats. Respirology 14:734–745.
   PubMed Web of Science ®Google Scholar
• Overbeek MJ, Boonstra A, Voskuyl AE, Vonk MC, Vonk-Noordegraaf A, van Berkel MP, Mooi WJ, Dijkmans BA, Hondema LS, Smit EF, Grünberg K. 2011. Platelet-derived growth factor receptor-ß and epidermal growth factor receptor in pulmonary vasculature of systemic sclerosis-associated pulmonary arterial hypertension versus idiopathic pulmonary arterial hypertension and pulmonary veno-occlusive disease: a case-control study. Arthritis Res Ther 13:R61.
   PubMed Web of Science ®Google Scholar
• Patterson KC, Weissmann A, Ahmadi T, Farber HW. 2006. Imatinib mesylate in the treatment of refractory idiopathic pulmonary arterial hypertension. Ann Intern Med 145:152–153.
   PubMed Web of Science ®Google Scholar
• Perros F, Montani D, Dorfmüller P, Durand-Gasselin I, Tcherakian C, Le Pavec J, Mazmanian M, Fadel E, Mussot S, Mercier O, Hervé P, Emilie D, Eddahibi S, Simonneau G, Souza R, Humbert M. 2008. Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med 178:81–88.
   PubMed Web of Science ®Google Scholar
• Pestana IA, Vazquez-Padron RI, Aitouche A, Pham SM. 2005. Nicotinic and PDGF-receptor function are essential for nicotine-stimulated mitogenesis in human vascular smooth muscle cells. J Cell Biochem 96:986–995.
   PubMed Web of Science ®Google Scholar
• Pietra GG, Capron F, Stewart S, Leone O, Humbert M, Robbins IM, Reid LMTuder RM. 2004. Pathologic assessment of vasculopathies in pulmonary hypertension. J Am Coll Cardiol 43:25S–32S.
   PubMed Web of Science ®Google Scholar
• Rabinovitch M. 2008. Molecular pathogenesis of pulmonary arterial hypertension. J Clin Invest 118:2372–2379.
   PubMed Web of Science ®Google Scholar
• Sakao S, Tatsumi K, Voelkel NF. 2010. Reversible or irreversible remodeling in pulmonary arterial hypertension. Am J Respir Cell Mol Biol 43:629–634.
   PubMed Web of Science ®Google Scholar
• Schermuly RT, Dony E, Ghofrani HA, Pullamsetti S, Savai R, Roth M, Sydykov A, Lai YJ, Weissmann N, Seeger W, Grimminger F. 2005. Reversal of experimental pulmonary hypertension by PDGF inhibition. J Clin Invest 115:2811–2821.
   PubMed Web of Science ®Google Scholar
• Souza R, Sitbon O, Parent F, Simonneau G, Humbert M. 2006. Long term imatinib treatment in pulmonary arterial hypertension. Thorax 61:736.
   PubMed Web of Science ®Google Scholar
• Uutela M, Laurén J, Bergsten E, Li X, Horelli-Kuitunen N, Eriksson U, Alitalo K. 2001. Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFD genes. Circulation 103:2242–2247.
   PubMed Web of Science ®Google Scholar
• Villablanca AC. 1998. Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitro. J Appl Physiol 84:2089–2098.
   PubMed Web of Science ®Google Scholar
• Voelkel NF, Vandivier RW, Tuder RM. 2006. Vascular endothelial growth factor in the lung. Am J Physiol Lung Cell Mol Physiol 290:L209–L221.
   PubMed Web of Science ®Google Scholar
• Wright JL, Levy RD, Churg A. 2005. Pulmonary hypertension in chronic obstructive pulmonary disease: current theories of pathogenesis and their implications for treatment. Thorax 60:605–609.
   PubMed Web of Science ®Google Scholar
• Yamabe H, Osawa H, Kaizuka M, Tsunoda S, Shirato K, Tateyama F, Okumura K. 2000. Platelet-derived growth factor, basic fibroblast growth factor, and interferon gamma increase type IV collagen production in human fetal mesangial cells via a transforming growth factor-β-dependent mechanism. Nephrol Dial Transplant 15:872–876.
   PubMed Web of Science ®Google Scholar
• Yi ES, Lee H, Yin S, Piguet P, Sarosi I, Kaufmann S, Tarpley J, Wang NS, Ulich TR. 1996. Platelet-derived growth factor causes pulmonary cell proliferation and collagen deposition in vivo. Am J Pathol 149:539–548.
   PubMed Web of Science ®Google Scholar