Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 24, 2012 - Issue 9
220
Views
11
CrossRef citations to date
0
Altmetric
Research Article

Transcriptomics analysis of lungs and peripheral blood of crystalline silica-exposed rats

, , , , , , , , , , , & show all
Pages 570-579 | Received 04 Apr 2012, Accepted 24 May 2012, Published online: 03 Aug 2012

References

  • Absher MP, Hemenway DR, Leslie KO, Trombley L, Vacek P. 1992. Intrathoracic distribution and transport of aerosolized silica in the rat. Exp Lung Res 18:743–757.
  • Antonini JM, Roberts JR. 2007. Chromium in stainless steel welding fume suppresses lung defense responses against bacterial infection in rats. J Immunotoxicol 4:117–127.
  • Barbarin V, Nihoul A, Misson P, Arras M, Delos M, Leclercq I, Lison D, Huaux F. 2005. The role of pro- and anti-inflammatory responses in silica-induced lung fibrosis. Respir Res 6:112.
  • Benjamini Y, Hochberg Y. 1995. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser 57:289–300.
  • Bushel PR, Heinloth AN, Li J, Huang L, Chou JW, Boorman GA, Malarkey DE, Houle CD, Ward SM, Wilson RE, Fannin RD, Russo MW, Watkins PB, Tennant RW, Paules RS. 2007. Blood gene expression signatures predict exposure levels. Proc Natl Acad Sci USA 104:18211–18216.
  • Campo GM, Avenoso A, D’Ascola A, Scuruchi M, Prestipino V, Nastasi G, Calatroni A, Campo S. 2012. The inhibition of hyaluronan degradation reduced pro-inflammatory cytokines in mouse synovial fibroblasts subjected to collagen-induced arthritis. J Cell Biochem 113:1852–1867.
  • Cantin AM, Larivée P, Martel M, Bégin R. 1992. Hyaluronan (hyaluronic acid) in lung lavage of asbestos-exposed humans and sheep. Lung 170:211–220.
  • Carter JM, Driscoll KE. 2001. The role of inflammation, oxidative stress, and proliferation in silica-induced lung disease: a species comparison. J Environ Pathol Toxicol Oncol 20 Suppl 1:33–43.
  • Cassel SL, Eisenbarth SC, Iyer SS, Sadler JJ, Colegio OR, Tephly LA, Carter AB, Rothman PB, Flavell RA, Sutterwala FS. 2008. The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci USA 105:9035–9040.
  • Castranova V, Porter D, Millecchia L, Ma JY, Hubbs AF, Teass A. 2002. Effect of inhaled crystalline silica in a rat model: time course of pulmonary reactions. Mol Cell Biochem 234-235:177–184.
  • Castranova V. 2004. Signaling pathways controlling the production of inflammatory mediators in response to crystalline silica exposure: role of reactive oxygen/nitrogen species. Free Radic Biol Med 37:916–925.
  • Chen GY, Nuñez G. 2010. Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol 10:826–837.
  • Cooper GS, Miller FW, Germolec DR. 2002. Occupational exposures and autoimmune diseases. Int Immunopharmacol 2:303–313.
  • DiMatteo M, Reasor MJ. 1997. Modulation of silica-induced pulmonary toxicity by dexamethasone-containing liposomes. Toxicol Appl Pharmacol 142:411–421.
  • Eklund A, Tornling G, Blaschke E, Curstedt T. 1991. Extracellular matrix components in bronchoalveolar lavage fluid in quartz exposed rats. Br J Ind Med 48:776–782.
  • Erdely A, Liston A, Salmen-Muniz R, Hulderman T, Young SH, Zeidler-Erdely PC, Castranova V, Simeonova PP. 2011. Identification of systemic markers from a pulmonary carbon nanotube exposure. J Occup Environ Med 53:S80–S86.
  • Franchi L, Eigenbrod T, Núñez G. 2009. Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation. J Immunol 183:792–796.
  • Fraser JR, Laurent TC, Laurent UB. 1997. Hyaluronan: its nature, distribution, functions and turnover. J Intern Med 242:27–33.
  • Fubini B, Hubbard A. 2003. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis. Free Radic Biol Med 34:1507–1516.
  • Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JY, Zhang J. 2004. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 5:R80.
  • Haslinger B, Mandl-Weber S, Sellmayer A, Sitter T. 2001. Hyaluronan fragments induce the synthesis of MCP-1 and IL-8 in cultured human peritoneal mesothelial cells. Cell Tissue Res 305:79–86.
  • Heinloth AN, Irwin RD, Boorman GA, Nettesheim P, Fannin RD, Sieber SO, Snell ML, Tucker CJ, Li L, Travlos GS, Vansant G, Blackshear PE, Tennant RW, Cunningham ML, Paules RS. 2004. Gene expression profiling of rat livers reveals indicators of potential adverse effects. Toxicol Sci 80:193–202.
  • Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E. 2008. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 9:847–856.
  • IARC. 1997. International Agency for Research on Cancer, Monograph on the evaluation of carcinogenic risk to human, 68:1–475.
  • Jiang D, Liang J, Fan J, Yu S, Chen S, Luo Y, Prestwich GD, Mascarenhas MM, Garg HG, Quinn DA, Homer RJ, Goldstein DR, Bucala R, Lee PJ, Medzhitov R, Noble PW. 2005. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med 11:1173–1179.
  • Kreiss K, Zhen B. 1996. Risk of silicosis in a Colorado mining community. Am J Ind Med 30:529–539.
  • Linch KD, Miller WE, Althouse RB, Groce DW, Hale JM. 1998. Surveillance of respirable crystalline silica dust using OSHA compliance data (1979-1995). Am J Ind Med 34:547–558.
  • Lobenhofer EK, Auman JT, Blackshear PE, Boorman GA, Bushel PR, Cunningham ML, Fostel JM, Gerrish K, Heinloth AN, Irwin RD, Malarkey DE, Merrick BA, Sieber SO, Tucker CJ, Ward SM, Wilson RE, Hurban P, Tennant RW, Paules RS. 2008. Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype. Genome Biol 9:R100.
  • McKinney W, Chen B, Frazer D. 2009. Computer controlled multi-walled carbon nanotube inhalation exposure system. Inhal Toxicol 21:1053–1061.
  • Miller BG, Hagen S, Love RG, Soutar CA, Cowie HA, Kidd MW, Robertson A. 1998. Risks of silicosis in coalworkers exposed to unusual concentrations of respirable quartz. Occup Environ Med 55:52–58.
  • Mundt KA, Birk T, Parsons W, Borsch-Galetke E, Siegmund K, Heavner K, Guldner K. 2011. Respirable crystalline silica exposure-response evaluation of silicosis morbidity and lung cancer mortality in the German porcelain industry cohort. J Occup Environ Med 53:282–289.
  • Nasrullah M, Mazurek JM, Wood JM, Bang KM, Kreiss K. 2011. Silicosis mortality with respiratory tuberculosis in the United States, 1968-2006. Am J Epidemiol 174:839–848.
  • NIOSH. 2002. Hazard Review: Health Effects of Occupational Exposures to Respirable Crystalline Silica. US Department of Health and Human Services (NIOSH) Publication No. 2002-129, Available at: http://www.cdc.gov/niosh/docs/2002-129/02-129a.html.
  • O’Reilly KM, Phipps RP, Thatcher TH, Graf BA, Van Kirk J, Sime PJ. 2005. Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 288:L1010–L1016.
  • Parks CG, Conrad K, Cooper GS. 1999. Occupational exposure to crystalline silica and autoimmune disease. Environ Health Perspect 107 Suppl 5:793–802.
  • Porter DW, Ramsey D, Hubbs AF, Battelli L, Ma J, Barger M, Landsittel D, Robinson VA, McLaurin J, Khan A, Jones W, Teass A, Castranova V. 2001. Time course of pulmonary response of rats to inhalation of crystalline silica: histological results and biochemical indices of damage, lipidosis, and fibrosis. J Environ Pathol Toxicol Oncol 20 Suppl 1:1–14.
  • Porter DW, Millecchia L, Robinson VA, Hubbs A, Willard P, Pack D, Ramsey D, McLaurin J, Khan A, Landsittel D, Teass A, Castranova V. 2002. Enhanced nitric oxide and reactive oxygen species production and damage after inhalation of silica. Am J Physiol Lung Cell Mol Physiol 283:L485–L493.
  • Porter DW, Hubbs AF, Mercer R, Robinson VA, Ramsey D, McLaurin J, Khan A, Battelli L, Brumbaugh K, Teass A, Castranova V. 2004. Progression of lung inflammation and damage in rats after cessation of silica inhalation. Toxicol Sci 79:370–380.
  • Raghavachari N, Xu X, Munson PJ, Gladwin MT. 2009. Characterization of whole blood gene expression profiles as a sequel to globin mRNA reduction in patients with sickle cell disease. PLoS ONE 4:e6484.
  • Sanderson W. 1986. The US population-at-risk to occupational respiratory diseases. In: Merchant JA, Editor, Occupational Respiratory Diseases. Washington, DC: DHHS (NIOSH) publication, pp 86–102.
  • Sato T, Shimosato T, Alvord WG, Klinman DM. 2008. Suppressive oligodeoxynucleotides inhibit silica-induced pulmonary inflammation. J Immunol 180:7648–7654.
  • Sellamuthu R, Umbright C, Roberts JR, Chapman R, Young SH, Richardson D, Leonard H, McKinney W, Chen B, Frazer D, Li S, Kashon M, Joseph P. 2011a. Blood gene expression profiling detects silica exposure and toxicity. Toxicol Sci 122:253–264.
  • Sellamuthu R, Umbright C, Li S, Kashon M, Joseph P. 2011b. Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling. Inhal Toxicol 23:927–937.
  • Sellamuthu R, Umbright C, Roberts JR, Cumpston A, McKinney W, Chen BT, Frazer D, Li S, Kashon M, Joseph P. 2012. Molecular insights into the progression of crystalline silica-induced pulmonary toxicity in rats. J Appl Toxicol (in press).
  • Smyth GK. 2004. Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3:Article3.
  • Steenland K, Mannetje A, Boffetta P, Stayner L, Attfield M, Chen J, Dosemeci M, DeKlerk N, Hnizdo E, Koskela R, Checkoway H; International Agency for Research on Cancer. 2001. Pooled exposure-response analyses and risk assessment for lung cancer in 10 cohorts of silica-exposed workers: an IARC multicentre study. Cancer Causes Control 12:773–784.
  • Thakur SA, Beamer CA, Migliaccio CT, Holian A. 2009. Critical role of MARCO in crystalline silica-induced pulmonary inflammation. Toxicol Sci 108:462–471.
  • Tzircotis G, Thorne RF, Isacke CM. 2005. Chemotaxis towards hyaluronan is dependent on CD44 expression and modulated by cell type variation in CD44-hyaluronan binding. J Cell Sci 118:5119–5128.
  • Umbright C, Sellamuthu R, Li S, Kashon M, Luster M, Joseph P. 2010. Blood gene expression markers to detect and distinguish target organ toxicity. Mol Cell Biochem 335:223–234.
  • Xiang M, Fan J. 2010. Pattern recognition receptor-dependent mechanisms of acute lung injury. Mol Med 16:69–82.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.