In vivo genotoxicity evaluation of lung cells from Fischer 344 rats following 28 days of inhalation exposure to MWCNTs, plus 28 days and 90 days post-exposure

References

• Ahn KH, Kim SM, Yu IJ. (2011). Multi-walled carbon nanotube (MWCNT) dispersion and aerosolization with hot water atomization without addition of any surfactant. Safety Health Work 2:65–9
   PubMedGoogle Scholar
• Card JW, Carey MA, Bradbury JA, et al. (2006). Gender differences in murine airway responsiveness and lipopolysaccharide-induced inflammation. J Immunol 177:621–30
   PubMed Web of Science ®Google Scholar
• Card JW, Zeldin DC, Bonner JC, Nestman ER. (2008). Pulmonary applications and toxicity of engineered nanoparticles. Am J Physiol 295:L400–11
   PubMed Web of Science ®Google Scholar
• Cortez BA, Machado-Santelli GM. (2008). Chrysotile effects on human lung cell carcinoma in culture: 3-D reconstruction and DNA quantification by image analysis. BMC Cancer 8:181
   PubMedGoogle Scholar
• Davis JM. (1994). The role of clearance and dissolution in determining the durability or biopersistence of mineral fibers. Environ Health Perspect 102:113–17
   PubMed Web of Science ®Google Scholar
• Degano B, Prevost MC, Berger P, et al. (2001). Estradiol decreases the acetylcholine-elicited airway reactivity in ovariectomized rats through an increase in epithelial acetylcholinesterase activity. Am J Respir Crit Care Med 164:1849–54
   PubMed Web of Science ®Google Scholar
• Donaldson K, Aitken R, Tran L, et al. (2006). Toxicology of carbon nanotubes. Toxicol Sci 92:5–22
   PubMed Web of Science ®Google Scholar
• Donaldson K, Poland CA. (2012). Inhaled nanoparticles and lung cancer – what we can learn from conventional particle toxicology. Swiss Med Wkly 142:w13547
   PubMedGoogle Scholar
• Elgrabli D, Floriaani M, Abella-Gallart S, et al. (2008). Biodistribution and clearance of instilled carbon nanotubes in rat lung. Part Fibre Toxicol 5:20
   PubMed Web of Science ®Google Scholar
• Endo M, Strano MS, Ajayan PM. (2008). Potential applications of carbon nanotubes. Carbon Nanotubes 111:13–61
   Google Scholar
• Fischer HC, Chan WC. (2007). Nanotoxicity: the growing need for in vivo study. Curr Opin Biotechnol 18:565–71
   PubMed Web of Science ®Google Scholar
• Fujitani Y, Furuyama A, Hirano S. (2009). Generation of airborne multi-walled carbon nanotubes for inhalation studies. Aerosol Sci Technol 43:881–90
   Web of Science ®Google Scholar
• Gwinn MR, Vallyathan V. (2006). Nanoparticles: health effects – pros and cons. Environ Health Perspect 114:1818–25
   PubMed Web of Science ®Google Scholar
• Han JH, Lee EJ, Lee JH, et al. (2008). Monitoring multiwalled carbon nanotube exposure in carbon nanotube research facility. Inhal Toxicol 20:741–9
   PubMed Web of Science ®Google Scholar
• Huang YY, Terentjev EM. (2008). Dispersion and rheology of carbon nanotubes in polymers. Int J Mater Form 1:63–74
   Web of Science ®Google Scholar
• Iijima AS. (1991). Helical microtubules of graphite carbon. Nature 354:54–9
   Web of Science ®Google Scholar
• Kim JS, Lee K, Lee YH, et al. (2011). Aspect ratio has no effect on genotoxicity of multi-wall carbon nanotubes. Arch Toxicol 85:775–86
   PubMed Web of Science ®Google Scholar
• Kim JS, Song KS, Lee JK, et al. (2012a). Toxicogenomic comparison of multi-wall carbon nanotubes (MWCNTs) and asbestos. Arch Toxicol 86:553–62
   PubMed Web of Science ®Google Scholar
• Kim JS, Sung JH, Song KS, et al. (2012b). Persistent DNA damage measured by comet assay of Sprague Dawley rat lung cells after five days of inhalation exposure and 1 month post-exposure to dispersed multi-wall carbon nanotubes (MWCNTs) generated by new MWCNT aerosol generation system. Toxicol Sci 128:439–48
   PubMed Web of Science ®Google Scholar
• Kisin ER, Murray AR, Sargent L, et al. (2011). Genotoxicity of carbon nanofibers: are they potentially more or less dangerous than carbon nanotubes or asbestos? Toxicol Appl Pharmacol 252:1–10
   PubMed Web of Science ®Google Scholar
• Kline JN, Cowden JD, Hunninghake GW, et al. (1999). Variable airway responsiveness to inhaled lipopolysaccharide. Am J Respir Crit Care Med 160:297–303
   PubMed Web of Science ®Google Scholar
• Kumaravel TS, Jha AN. (2006). Reliable Comet assay measurements for detecting DNA damage induced by ionising radiation and chemicals. Mutat Res 605:7–16
   PubMed Web of Science ®Google Scholar
• Lee JH, Lee SB, Bae GN, et al. (2010). Exposure assessment of carbon nanotube manufacturing workplaces. Inhal Toxicol 22:369–81
   PubMed Web of Science ®Google Scholar
• Ligeiro de Oliveira AP, Oliveira-Filho RM, da Silva ZS, et al. (2004). Regulation of allergic lung inflammation in rats: interaction between estradiol and corticosterone. Neuroimmunomodulation 11:20–7
   PubMed Web of Science ®Google Scholar
• Lin Y, Taylor S, Li H, et al. (2004). Advances towards bioapplications of carbon nanotubes. J Mater Chem 14:527–41
   Web of Science ®Google Scholar
• Liu Y, Zhao Y, Sun B, Chen C. (2012). Understanding the toxicity of carbon nanotubes. Acc Chem Res 46:702–13
   Google Scholar
• Ma-Hock L, Treumann S, Strauss V, et al. (2009). Inhalation toxicity of multiwall carbon nanotubes in rats exposed for 3 months. Tox Sci 112:468–81
   PubMed Web of Science ®Google Scholar
• Manning CB, Vallyathan V, Mossman BT. (2002). Diseases caused by asbestos: mechanisms of injury and disease development. Int Immunopharmacol 2:191–200
   PubMed Web of Science ®Google Scholar
• Mercer RR, Scabilloni JF, Hubbs AF, et al. (2013). Distribution and fibrotic response following inhalation exposure to multi-walled carbon nanotubes. Particle Fibre Toxicol 10:33
   PubMed Web of Science ®Google Scholar
• Mossman BT, Kamp DW, Weitzman SA. (1996). Mechanisms of carcinogenesis and clinical features of asbestos-associated cancers. Cancer Invest 14:464–78
   Web of Science ®Google Scholar
• Murphy FA, Poland CA, Duffin R, et al. (2011). Length-dependent retention of carbon nanotubes in the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura. Am J Pathol 178:2587–600
   PubMed Web of Science ®Google Scholar
• Murphy FA, Schinwald A, Poland CA, Donaldson K. (2012). The mechanism of pleural inflammation by long carbon nanotubes: interaction of long fibres with macrophages stimulates them to amplify pro-inflammatory responses in mesothelial cells. Part Fibre Toxicol 9:8
   PubMed Web of Science ®Google Scholar
• Norris RL, Eagleshan GK, Shaw GR, et al. (2001). A sensitive and specific assay for glutathione with potential application to glutathione disulfide, using high-performance liquid chromatography-tandem mass spectrophotometry. J Chromatog B 762:17–23
   PubMed Web of Science ®Google Scholar
• OECD (Organization for Economic Cooperation and Development). (2009). OECD guidelines for testing of chemicals, OECD Guideline 412. Subacute Inhalation Toxicity: 28-Day Study. Paris, France: OECD
   Google Scholar
• Pacurari M, Castranova V, Vallyathan V. (2010). Single-and multi-wall carbon nanotubes versus asbestos: are the carbon nanotubes a new health risk to humans? J Toxicol Environ Health A 73:378–95
   PubMed Web of Science ®Google Scholar
• Pauluhn J. (2010). Subchronic 13-week inhalation exposure of rats to multiwalled carbon nanotubes: toxic effects are determined by density of agglomerate structures, not fibrillar structures. Tox Sci 113:226–42
   PubMed Web of Science ®Google Scholar
• Porter DW, Hubbs AF, Mercer RR, et al. (2010). Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes. Toxicology 269:136–47
   PubMed Web of Science ®Google Scholar
• Pott F. (1978). Some aspect on the dosimetry of the carcinogenic potency of asbestos and other fibrous dusts. Staub-Reinhalt Luft 38:486–90
   Web of Science ®Google Scholar
• Pott F, Friedrichs KH. (1972). Tumoren der Ratte nach i.p. Injektion faserförmiger Stäube. Naturwissenschaften 59:318–32
   PubMed Web of Science ®Google Scholar
• Riganti C, Aldieri E, Bergandi L, et al. (2003). Long and short fiber amosite asbestos alters at a different extent the redox metabolism in human lung epithelial cells. Toxicol Appl Pharmacol 193:106–15
   PubMed Web of Science ®Google Scholar
• Sargent LM, Reynolds SH, Castranova V. (2010). Potential pulmonary effects of engineered carbon nanotubes: in vitro genotoxic effects. Nanotoxicology 4: 396–408
   PubMed Web of Science ®Google Scholar
• Sargent LM, Shevedova AA, Hubbs AF, et al. (2009). Induction of aneuploidy by single-walled carbon nanotubes. Environ Molec Mutagen 50:708–17
   PubMed Web of Science ®Google Scholar
• Schins RP, Knaapen AM. (2007). Genotoxicity of poorly soluble particles. Inhal Toxicol 19:189–98
   PubMed Web of Science ®Google Scholar
• Sharma CS, Sarkar S, Periyakaruppan A, et al. (2007). Single-walled carbon nanotubes induce oxidative stress in rat lung epithelial cells. J Nanosci Nanotechnol 7:2466–72
   PubMed Web of Science ®Google Scholar
• Sharma V, Singh P, Pandey AK, Dhawan A. (2012). Induction of oxidative stress, DNA damage and apoptosis in mouse liver after sub-acute oral exposure to zinc oxide nanoparticles. Mutat Res 745:84–91
   PubMed Web of Science ®Google Scholar
• Shirai M, Sato A, Chida K. (1995). The influence of ovarian hormones on the granulomatous inflammatory process in the rat lung. Eur Respir J 8:272–7
   PubMedGoogle Scholar
• Shvedova AA, Castranova V, Kisin ER, et al. (2003). Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J Toxicol Environ Health A 66:1909–26
   PubMed Web of Science ®Google Scholar
• Singh NP, McCoy MT, Tice RR, Schneider EL. (1988). A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184–91
   PubMed Web of Science ®Google Scholar
• Stanton MF, Laynard M, Tegeris A, et al. (1977). Carcinogenicity of fibrous glass: pleural response in the rat in relation to fiber dimension. J Natl Cancer Inst 58:587–603
   PubMed Web of Science ®Google Scholar
• Stanton MF, Wrench C. (1972). Mechanisms of mesothelioma induction with asbestos and fibrous glass. J Natl Cancer Inst 48:797–821
   PubMed Web of Science ®Google Scholar
• Stem ST, McNeil SE. (2008). Nanotechnology safety concerns revisited. Toxicol Sci 101:4–21
   PubMed Web of Science ®Google Scholar
• Sung JH, Ji JH, Park JD, et al. (2009). Subchronic inhalation toxicity of silver nanoparticles. Toxicol Sci 108:452–61
   PubMed Web of Science ®Google Scholar
• Svensson S, Olin AC, Lärstad M, et al. (2004). Determination of hydrogen peroxide in exhaled breath condensate by flow injection analysis with fluorescence detection. J Chromatogr B Analyt Technol Biomed Life Sci 809:199–203
   PubMed Web of Science ®Google Scholar
• Tenne R, Remskar M, Enyashin A, Seifert G. (2008). Inorganic nanotubes and fullerene-like structures (IF). Carbon Nanotubes 111:631–71
   Google Scholar
• Uno Y. (2006). Understanding of genotoxic mechanism of action for carcinogen risk assessment to humans: a commentary to the discussion at the 4th International Workshop on Genotoxicity Testing (IWGT). Genes Environ 28:38–9
   Google Scholar
• Vallyathan V, Mega JF, Shi X, Dalal NS. (1992). Enhanced generation of free radicals from phagocytes induced by mineral dusts. Am J Respir Cell Biol 6:404–41
   PubMed Web of Science ®Google Scholar
• Vittorio O, Raffa V, Cuschieri A. (2009). Influence of purity and surface oxidation on cytotoxicity of multiwalled carbon nanotubes with human neuroblastoma cells. Nanomedicine 5:424–31
   PubMed Web of Science ®Google Scholar
• Ye S, Wang Y, Jiao F, et al. (2011). The role of NADPH oxidase in multi-walled carbon nanotubes-induced oxidative stress and cytotoxicity in human macrophages. J Nanosci Nanotechnol 11:3773–81
   PubMed Web of Science ®Google Scholar
• Ye SF, Wu YH, Hou ZQ, Zhang QQ. (2009). ROS and NF-kappa B are involved in upregulation of IL-8 in A549 cells exposed to multi-walled carbon nanotubes. Biochem Biophys Res Commun 379:643–8
   PubMed Web of Science ®Google Scholar
• Zegura B, Filipic M. (2004). Application of in vitro comet assay for genotoxicity testing. In: Yan Z, Caldwell G. (eds.) Optimization in drug discovery: in vitro methods (methods in pharmacology and toxicology). Totowa, NJ: Human Press, 301–13
   Google Scholar