Episodic ozone exposure in adult and senescent Brown Norway rats: acute and delayed effect on heart rate, core temperature and motor activity

References

• Adar SD. (2012). Childhood exposures to ozone: the fast track to cardiovascular disease? Circulation 126:1570–2
   PubMed Web of Science ®Google Scholar
• Alfaro-Rodriguez A, Gonzalez-Pina R. (2005). Ozone-induced paradoxical sleep decrease is related to diminished acetylcholine levels in the medial preoptic area in rats. Chem Biol Interact 151:151–8
   PubMed Web of Science ®Google Scholar
• Arito H, Uchiyama I, Yokoyama E. (1992). Acute effecs of ozone on EEG activity, sleep–wakefulness and heart rate in rats. Indus Health 30:23–34
   PubMed Web of Science ®Google Scholar
• Balasubramanian P, Sirivelu MP, Weiss KA, et al. (2012). Differential effects of inhalation exposure to PM2.5 on hypothalamic monamines and corticotrophin releasing hormone in lean and obese rats. NeuroToxicology 36:106–11
   PubMed Web of Science ®Google Scholar
• Bass V, Gordon CJ, Jarema KA, et al. (2013). Ozone induces glucose intolerance and systemic metabolic effects in young and aged Brown Norway rats. Toxicol Sci 273:551–60
   Google Scholar
• Devlin RB, Duncan KE, Jardim M, et al. (2012). Controlled exposure of health young volunteers to ozone causes cardiovascular effects. Circulation 126:104–11
   PubMed Web of Science ®Google Scholar
• Dong CC, Yin XJ, Ma JY, et al. (2005). Effect of diesel exhaust particles on allergic reactions and airway responsiveness in ovalbumin-sensitized brown Norway rats. Toxicol Sci 88:202–12
   PubMed Web of Science ®Google Scholar
• Gonzalez-Pina R, Alfaro-Rodriguez A. (2003). Ozone exposure alters 5-hydroxy-indole-acetic acid contents in dialysates from dorsal raphe and medial preoptic area in freely moving rats. Relationships with simultaneous sleep disturbances. Chem Biol Interact 146:147–56
   PubMed Web of Science ®Google Scholar
• Gordon CJ. (1993). Temperature regulation in laboratory rodents. New York, NY: Cambridge University Press
   Google Scholar
• Gordon CJ. (2005). Temperature and toxicity: an integrative, comparative, and environmental approach. Boca Raton, FL: CRC Press
   Google Scholar
• Gordon CJ. (2008). Cardiac and thermal homeostasis in the aging Brown Norway rat. J Gerontol A Biol Sci Med Sci 63:1307–13
   PubMed Web of Science ®Google Scholar
• Gordon CJ, Yang Y. (1997). Contribution of spontaneous motor activity to the 24 hour control of body temperature in male and female rats. J Therm Biol 22:59–68
   Web of Science ®Google Scholar
• Gordon CJ, Gottipolu RR, Kenyon EM, et al. (2010). Aging and susceptibility to toluene in rats: a pharmacokinetic, biomarker, and physiological approach. J Toxicol Environ Health 73:301–18
   PubMed Web of Science ®Google Scholar
• Gordon CJ, Jarema KA, Lehmann JR, et al. (2013). Susceptibility of adult and senescent Brown Norway rats to repeated ozone exposure: an assessment of behavior, serum biochemistry and cardiopulmonary function. Inhal Toxicol 25:141–59
   PubMed Web of Science ®Google Scholar
• Groves AM, Gow AJ, Massa CB, et al. (2013). Age-related increases in ozone-induced injury and altered pulmonary mechanics in mice with progressive lung inflammation. Am J Physiol Lung Cell Mol Physiol 305:L555–68
   PubMed Web of Science ®Google Scholar
• Mautz WJ, Bufalino C. (1989). Breathing pattern and metabolic rate responses of rats exposed to ozone. Respir Physiol 76:69–78
   PubMedGoogle Scholar
• Nadon NL. (2006). Gerontology and age-associated lesions. In: Sucknow MA, Weisbroth SH, Franklin CL. (eds.) The laboratory rat. 2nd ed. New York, NY: Academic Press, 761–72
   Google Scholar
• National Academies of Science (NAC). (2011). Guide for the care and use of laboratory animals. 8th ed. Washington, DC: The National Academies Press
   Google Scholar
• National Research Council (NRC). (2009). Science and decisions: advancing risk assessment. Washington, DC: The National Academy Press
   Google Scholar
• Postlethwait EM, Langford SD, Bidani A. (1994). Determinants of inhaled ozone absorption in isolated rat lungs. Toxicol Appl Pharmacol 125:77–89
   PubMed Web of Science ®Google Scholar
• Sacks JD, Stanek LW, Luben TJ, et al. (2011). Particulate matter-induced health effects: who is susceptible? Environ Health Perspect 119:446–54
   PubMed Web of Science ®Google Scholar
• Servais S, Boussouar A, Molnar A, et al. (2005). Age-related sensitivity to lung oxidative stress during ozone exposure. Free Radic Res 39:305–16
   PubMed Web of Science ®Google Scholar
• Slade R, Watkinson WP, Hatch GE. (1997). Mouse strain differences in ozone dosimetry and body temperature changes. Am J Physiol 272:L73–7
   PubMed Web of Science ®Google Scholar
• Srebot V, Gianicolo EA, Rainaldi G, et al. (2009). Ozone and cardiovascular injury. Cardiovasc Ultrasound 7:30 . doi: 10.1186/1476-7120-7-30
   PubMed Web of Science ®Google Scholar
• Tesfaigzi Y, McDonald JD, Reed MD, et al. (2005). Low-level subchronic exposure to wood smoke exacerbates inflammatory responses in allergic rats. Toxicol Sci 88:505–13
   PubMed Web of Science ®Google Scholar
• Toco-Bradley R, Singer R, Kluger MJ, Kauffman CA. (1985). Effect of age on the febrile response of rats to endogenous pyrogen. Gerontology 31:349–54
   PubMed Web of Science ®Google Scholar
• Turturro A, Witt WW, Lewis S, et al. (1999). Growth curves and survival characteristics of the animals used in the biomarkers of aging program. J Gerontol A Biol Sci Med Sci 54:B492–501
   PubMed Web of Science ®Google Scholar
• Watkinson WP, Aileru AA, Dowd SM, et al. (1993). Acute effects of ozone on heart rate and body temperature in the unanesthetized, unrestrained rat maintained at different ambient temperatures. Inhal Toxicol 5:129–47
   Web of Science ®Google Scholar
• Watkinson WP, Campen MJ, Lyon JY, et al. (1997). Impact of the hypothermic response in inhalation toxicology studies. Ann NY Acad Sci 813:849–63
   PubMed Web of Science ®Google Scholar
• Watkinson WP, Highfill JW, Slade R, Hatch GE. (1996). Ozone toxicity in the mouse: comparison and modeling of responses in susceptible and resistant strains. J Appl Physiol 80:2134–42
   PubMed Web of Science ®Google Scholar