References
- Barik S. (2005). Silence of the transcripts: RNA interference in medicine. J Mol Med 83:764–73
- Bide RW, Armour SJ, Yee E. (2000). Allometric respiration/body mass data for animals to be used for estimates of inhalation toxicity to young adult humans. J Appl Toxicol 20:273–90
- Barnes PJ. (2012). Severe asthma: advances in current management and future therapy. J Allergy Clin Immunol 129:48–59
- Bregman CL, Adler RR, Morton DG, et al. (2003). Recommended tissue list for histopathologic examination in repeat-dose toxicity and carcinogenicity studies: a proposal of the society of toxicologic pathology (STP). Toxicol Pathol 2:252–3
- Burger GT, Renne RA, Sagartz JW, et al. (1989). Histologic changes in the respiratory tract induced by inhalation of xenobiotics: physiologic adaptation or toxicity? Toxicol Appl Pharmacol 101:521–42
- Butler M, Stecker K, Bennett CF. (1997). Cellular distribution of phosphorothioate oligodeoxynucleotides in normal rodent tissues. Lab Invest 77:379–88
- Chatila TA. (2004). Interleukin-4 receptor signaling pathways in asthma pathogenesis. Trends Mol Med 10:493–9
- ClinicalTrials.gov Identifier NCT00658749, 24 June 2009. A phase 1 study of AIR645 in healthy subjects and subjects with controlled asthma (AIR645-CS1). Available from: http://clinicaltrials.gov. [Last accessed: 6 Jan 2014]
- ClinicalTrials.gov Identifier NCT00941577, 21 July 2010. Study evaluating the effects of AIR645 on allergen-induced airway responses in subjects with mild atopic asthma. Available from: http://clinicaltrials.gov. [Last accessed: 6 Jan 2014]
- Crosby JR, Guha M, Tung D, et al. (2007). Inhaled CD86 antisense oligonucleotide suppresses pulmonary inflammation and airway hyper-responsiveness in allergic mice. J Pharmacol Exp Ther 321:938–46
- Cross S. (2001). Asthma inhalation delivery systems: the patient's viewpoint. J Aerosol Med 14:S3–7
- Fanta CH. (2009). Asthma (a review). N Engl J Med 360:1002–14
- Farman CA, Kornbrust DJ. (2003). Oligodeoxynucleotide studies in primates: antisense and immune stimulatory indications. Toxicol Pathol 31:119–22
- Gauvreau GM, Boulet LP, Cockcroft DW, et al. (2008). Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responses. Am J Respir Crit Care Med 177:952–8
- Guimond A, Viau E, Aubé P, et al. (2008). Advantageous toxicity profile of inhaled antisense oligonucleotides following chronic dosing in non-human primates. Pulm Pharmacol Ther 21:845–54
- Henry SP, Giclas PC, Leeds J, et al. (1997). Activation of the alternative pathway of complement by a phosphorothioate oligonucleotide: potential mechanism of action. J Pharmacol Exp Ther 281:810–16
- Henry SP, Templin MV, Gillett N, et al. (1999). Correlation of toxicity and pharmacokinetic properties of a phosphorothioate oligonucleotide designed to inhibit ICAM-1. Toxicol Pathol 27:95–100
- Henry SP, Johnson M, Zanardi TA, et al. (2012). Renal uptake and tolerability of a 2′-O-methoxyethyl modified antisense oligonucleotide (ISIS 113715) in monkey. Toxicology 301:13–20
- Hodges MR, Castelloe E, Chen A, et al. (2009). Randomized, double-blind, placebo controlled first in human study of inhaled AIR645, an IL-4Rα oligonucleotide, in healthy volunteers. ajrccmconference 179.1_MeetingAbstracts.A3640
- Jason TL, Koropatnick J, Berg RW. (2004). Toxicology of antisense therapeutics. Toxicol Appl Pharmacol 201:66–83
- Karras JG, Crosby JR, Guha M, et al. (2007). Anti-inflammatory activity of inhaled IL-4 receptor-alpha antisense oligonucleotide in mice. Am J Respir Cell Mol Biol 36:276–85
- Levin A, Henry S, Monteith D, Templin M. (2001). Toxicity of antisense oligonucleotides. In: Crooke ST (ed.). Antisense drug technology: principles, strategies, and applications. New York: Marcel Dekker, Inc., 201–67
- Minton K. (2008). Allergy and asthma: what “drives” IL-4 versus IL-13 signalling? Nat Rev Immunol 8:166–7
- Nikula KJ, McCartney JE, McGovern T, et al. (2014). STP position paper: interpreting the significance of increased alveolar macrophages in rodents following inhalation of pharmaceutical materials. Toxicol Pathol 42:472–86
- Pakhale S, Mulpuru S, Boyd M. (2011). Optimal management of severe/refractory asthma. Clin Med Insights Circ Respir Pulm Med 5:37–47
- Rodrigo GJ, Rodrigo C, Hall JB. (2004). Acute asthma in adults: a review. Chest 125:1081–102
- Schlesinger RB. (1985). Comparative deposition of inhaled aerosols in experimental animals and humans: A review. J Toxicol Environ Health 15:197–214
- Tanaka M, Nyce Jonathan W. (2001). Respirable antisense oligonucleotides: a new drug class for respiratory disease. Respir Res 2:5–9
- Templin MV, Levin AA, Graham MJ, et al. (2000). Pharmacokinetic and toxicity profile of a phosphorothioate oligonucleotide following inhalation delivery to lung in mice. Antisense Nucleic Acid Drug Dev 10:359–68
- Tomkinson A, Tepper J, Morton M, et al. (2010). Inhaled vs subcutaneous effects of a dual IL-4/IL-13 antagonist in a monkey model of asthma. Allergy 65:69–77
- Yu RZ, Kim TW, Hong A, et al. (2007). Cross-species pharmacokinetic comparison from mouse to man of a second-generation antisense oligonucleotide, ISIS 301012, targeting human apolipoprotein B-100. Drug Metab Dispos 35:460–8