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Inhalation Toxicology
International Forum for Respiratory Research
Volume 26, 2014 - Issue 13
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Review Articles

Screening tests: a review with examples

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Pages 811-828 | Received 08 Jul 2014, Accepted 13 Aug 2014, Published online: 29 Sep 2014

References

  • Abbott RD, Petrovich H, Rodriguez BL, et al. (2000). Ankle/brachial blood pressure in men >70 years of age and the risk of coronary heart disease. Am J Cardiol 86:280–4
  • Achkar JM, Lawn SD, Moosa M-YS, et al. (2011). Adjunctive tests for diagnosis of tuberculosis: Serology, ELISPOT for site-specific lymphocytes, urinary lipoarabinomannan, string test, and fine needle aspiration. J Infec Dis 204:S1130–41
  • Álamo-Junquera D, Murat-Nascimento C, Maciá F, et al. (2011). Effect of false-positive results on reattendance at breast cancer screening programmes in Spain. Eur J Public Health 22:404–8
  • Alberg AJ, Park JW, Hager BW, et al. (2004). The use of “overall accuracy” to evaluate the validity of screening or diagnostic tests. JGIM 19:460–5
  • Allison JE, Tekawa IS, Ranson LJ, Adrain AL. (1996). A comparison of fecal occult-blood tests for colorectal-cancer screening. N Engl J Med 334:155–9
  • Altman DG, Bland JM. (1994a). Diagnostic tests 1: sensitivity and specificity. Br Med J 308:1552
  • Altman DG, Bland JM. (1994b). Diagnostic tests 2: predictive values. Br Med J 309:102
  • Altman DG, Bland JM. (1994c). Diagnostic tests 3: receiver operating characteristic plots. Br Med J 309:188
  • American Academy of Family Physicians. (2013). Evidence Lacking to Support or Oppose Low-dose CT Screening for Lung Cancer, Says AAFP. Available at http://www.aafp.org/news/health-of-the-public/20140113aafplungcarec.html [last accessed 30 June 2014]
  • American Lung Association (ALA). (2012). Providing guidance on lung cancer screening to patients and physicians. April 23, 2012. Available online at: http://www.lung.org/lung-disease/lung-cancer/lung-cancer-screening-guidelines/lung-cancer-screening.pdf [last accessed 26 June 2014]. Washington, DC: American Lung Association, 35 pp
  • Arbyn M, Sankaranarayanan R, Muwonge R, et al. (2008). Pooled analysis of the accuracy of five cervical cancer screening tests assessed in eleven studies in Africa and India. Int J Cancer 123:153–60
  • Baade PD, Fritschi L, Eakin EG. (2006). Non-cancer mortaility among people diagnosed with cancer (Australia). Cancer Causes Control 17:287–97
  • Bach PB, Jett JR, Pastorino U, et al. (2007). Computed tomography screening and lung cancer outcomes. JAMA 297:953–61
  • Bach PB, Mirkin JN, Oliver TK, et al. (2012). Benefits and harms of CT screening for lung cancer: a systematic review. JAMA 307:2418–29
  • Bauman A. (1990). The epidemiology of clinical tests. Aust Prescr 13:62–4
  • Black WC. (2000). Overdiagnosis: an under recognized cause of confusion and harm in cancer screening. J Nat Cancer Inst 92:1280–2
  • Boppana SB, Ross SA, Shimamura M, et al. (2011). Saliva polymerase-chain-reaction assay for cytomegalovirus screening in newborns. New Engl J Med 364:2111–18
  • Brenner DJ. (2004). Radiation risks potentially associated with low-dose CT screening of adult smokers for lung cancer. RSNA 231:440–5
  • Casscells W, Schoenberger A, Graboys TB. (1978). Interpretation by physicians of clinical laboratory results. N Engl J Med 299:999–1001
  • Catalona WJ, Smith DD, Ratliff TL, et al. (1991). Measurement of prostate-specific antigen in serum as a screening test for prostate cancer. N Engl J Med 324:1156–61
  • Centers for Disease Control and Prevention (CDC). (2013). Tuberculosis (TB): Testing and diagnosis. Centers for Disease Control and Prevention, Atlanta, GA, USA, 4 pp. Available online at: http://www.cdc.gov/TB/TOPIC/testing/default.htm [last accessed 5 August 2014]
  • Coste J, Pouchot J. (2003). A grey zone for quantitative diagnostic and screening tests. Int. J. Epidemiol 32:304–13
  • Croswell JM, Baker SG, Marcus PW, et al. (2010). Cumulative incidence of false-positive test results in lung cancer screening: a randomized trial. Ann Intern Med 152:505–11
  • Croswell JM, Kramer BS, Kreimer AR, et al. (2009). Cumulative incidence of false-positive results in repeated, multimodal cancer screening. Ann Fam Med 7:212–22
  • Cuzick J, Cadman L, Mesher D, et al. (2013). Comparing the performance of six human papillomavirus tests in a screening population. Br J Cancer 108:908–13
  • Deeks JJ, Altman DG. (2004). Diagnostic tests 4: likelihood ratios. Br Med J 329:168–9
  • Deeks JJ. (2001). Systematic reviews of evaluations of diagnostic and screening tests. Br Med J 323:157–62
  • Dendukuri N. (2011). Evaluating diagnostic tests in the absence of a gold standard. Powerpoint presentation for Advanced TB Diagnostics Course, Montreal, July 2011. 54 slides. Available at: http://www.teachepi.org/documents/courses/tbdiagrx/day2/Dendukuri%20Diagnostic%20Tests%20in%20the%20Absence%20of%20a%20Gold%20Standard.pdf [last accessed 4 August 2014]
  • Diedrerich S, Wormanns D, Semik M, et al. (2002). Screening for early lung cancer with low-dose spiral CT: prevalence in 817 asymptomatic smokers. RSNA 222:773–81
  • Diedrerich S. (2008). CT screening for lung cancer. Cancer Imaging 8:S24–6
  • Donovan L, Hartling L, Muise M, et al. (2013). Screening tests for gestational diabetes: a systematic review for the U.S. Preventative Services Task Force. Ann Intern Med 159:115–22
  • Doobay A, Anand SS. (2005). Sensitivity and Specificity of the ankle-brachial index to predict future cardiovascular outcomes: a systematic review. Arterioscler Thromb Vasc Biol 25:1463–9
  • Eddy DM. (1982). Chapter 18. Probabilistic reasoning in clinical medicine: problems and opportunities. In: Kahneman D, Slovic P, Tversky A, eds. Judgment under Uncertainty: Heuristics and Biases. Cambridge: Cambridge University Press, 249–67
  • Elmore JG, Barton MB, Moceri VM, et al. (1998). Ten-year risk of false positive screening mammograms and clinical breast examinations. N Engl J Med 338:1089–96
  • Elmore JG, Miglioretti DL, Reisch LM, et al. (2002). Screening mammograms by community radiologists: variability in false-positive rates. J Natl Cancer Inst 94:1373–80
  • Ewer AK, Middleton LJ, Furmston AT, et al. (2011). Pulse oximetry screening for congenital heart defects in newborn infants (PulseOx): a test accuracy study. Lancet 378:785–94
  • Ferreira M, Davies SL, Butler M, et al. (1992). Endomysial antibody: is it the best screening test for celiac disease? Gut 33:1633–7
  • Firnhaber C, Mayisela N, Mao L, et al. (2013). Validation of cervical cancer screening methods in HIV positive women from Johannesburg, South Africa. PLoS One 8:e53494
  • Friedewald SM, Rafferty EA, Rose SL, et al. (2014). Breast cancer screening using tomosynthesis in combination with digital mammography. JAMA 311:2499–507
  • Gart JJ, Buck AA. (1966). Comparison of a screening test and a reference test in epidemiologic studies. II. A probabilistic model for the comparison of diagnostic tests. Am J Epidemiol 83:593–602
  • Gastwirth JL. (1987). The statistical precision of medical screening procedures: application to polygraph and AIDS antibodies test data. Stat Sci 2:213–38
  • Goetzinger KR. Odibo AO. (2011). Statistical analysis and interpretation of prenatal diagnostic imaging studies, Part 1: evaluating the efficiency of screening and diagnostic tests. J Ultrasound Med 30:1121–7
  • Gohagan J, Marcus P, Fagerstrom R, et al. (2004). Baseline findings of a randomized feasibility trial of lung cancer screening with spiral CT scan vs chest radiograph; The lung screening study of the national cancer institute. Chest 126:114–21
  • Gotzak-Uzan L, Jiminez W, Nofech-Mozes S, et al. (2010). Sentinel lymph node biopsy vs. pelvic lymphadenectomy in early stage cervical cancer: is it time to change the gold standard? Gynecol Oncol 116:28–32
  • Greenhalgh T. (1997). Papers that report diagnostic or screening tests. BMJ 315:540–3
  • Grim CE, Luft FC, Weinberger MH, Grim CM. (1979). Sensitivity and specificity of screening tests for renal vascular hypertension. Ann Intern Med 91:617–22
  • Grimes DA, Schulz KF. (2002). Uses and abuses of screening tests. Lancet 359:881–4
  • Harper R, Henson D, Reeves BC. (2000). Appraising evaluations of screening/diagnostic tests: the importance of the study populations. Br J Opthalmol 84:1198–202
  • Hawkins DM, Garrett JA, Stephenson B. (2001). Some issues in resolution of diagnostic tests using and imperfect gold standard. Technical Report 628, School of Statistics, University of Minnesota. Stat Med 20:1987–2001
  • Heffner JE, Silvestri G. (2002). CR screening for lung cancer: is smaller better? Am J Respir Crit Care Med 165:433–7
  • Henschke CI, Yankelevitz DF, Mirtcheva R, et al. (2002). CT screening for lung cancer: frequency and significance of part-solid and nonsolid nodules. AJR 178:1053–7
  • Henschke CI, Yip R, Yankelevitz DF, Smith JP. (2013). Definition of a positive test result in computed tomography screening for lung cancer. Ann Int Med 158:246–52
  • Herman C. (2006). What makes a screening exam “good”? Ethics J Am Med Assoc 8:34–7
  • Humphrey LL, Deffebach M, Pappas M, et al. (2013). Screening for lung cancer with low-dose computed tomography: a systematic review to update the U.S. Preventative Services Task Force recommendation. Ann Int Med 159:411–20
  • Jafari Y, Peeling RW, Shivkumar S, et al. (2013). Are Treponema pallidum specific rapid and point-of-care tests for Syphilis accurate enough for screening in resource limited settings? Evidence from a meta-analysis. PLoS One 8:e54695
  • Johnson WO, Gastwirth JL, Pearson LM. (2001). Screening without a “gold standard”: the Hui-Walter paradigm revisited. Am J Epidemiol 153:921–4
  • Joseph L, Gyorkos TW, Coupal L. (1995). Bayesian estimation of disease prevalence and the parameters of diagnostic tests in the absence of a gold standard. Am J Epidemiol 141:263–72
  • Karaağaoğlu E. (1999). Estimation of the prevalence of a disease from screening tests. Trends J Med Sci 29:429–30
  • Kaufman PA, Bloo KJ, Burris H, et al. (2014). Assessing the discordance rate between local and central HER2 testing in women with locally determined HER2-negative breast cancer. Cancer 120:2657–64
  • Kerlikowske K, Grady D, Barclay J, et al. (1993). Positive predictive value of screening mammography by age and family history of breast cancer. JAMA 270:2444–50
  • Kloten V, Becker B, Winner K, et al. (2013). Promoter hypermethylation of the tumor-suppressor genes ITIH5, DKK3, and RASSF1A as novel biomarkers for blood-based breast cancer screening. Breast Cancer Res 15:1–11
  • Kovalchik SA, Tammemagi M, Berg CD, et al. (2013). Targeting of low-dose CT screening according to the risk of lung-cancer death. N Engl J Med 369:245–54
  • Kulasingam SL, Hughes JP, Kiviat NB, et al. (2002). Evaluation of human papillomavirus testing in primary screening for cervical abnormalities: comparison of sensitivity, specificity, and frequency of referral. JAMA 288:1749–57
  • Lalkhen AG, McCluskey A. (2008). Clinical tests: sensitivity and specificity. Cont Ed Anesth Crit Care Pain 9:221–3
  • Lam S, McWilliams A, Mayo J, Tammemagi M. (2013). Computed tomography screening for lung cancer: what is a positive screen? Ann Int Med 158:289–90
  • Legro RS, Finegood D, Dunaif A. (1998). A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome. J Clin Endocrinol Metabol 83:2694–8
  • LeMasters GK, Lockey JE, Yiin JH, et al. (2003). Mortality of workers occupationally exposed to refractory ceramic fibers. J Occup Environ Med 45:440–50
  • Levy PS, Kass EH. (1970). A three-population model for sequential screening for bacteriuria. Am J Epidemiol 91:148–54
  • Lewis FI, Torgerson PR. (2012). A tutorial in estimating the prevalence of disease in humans and animals in the absence of a gold standard diagnostic. Emerg Themes Epidemiol 9:1–8
  • Li F, Sone S, Abe H, et al. (2004). Malignant versus benign nodules at CT screening for lung cancer: comparison of thin-section CT findings. Radiology 233:793–8
  • Lu D, Fall K, Sparen P, et al. (2013). Suicide and suicide attempt after a cancer diagnosis among young individuals. Ann Oncol 24:3112–17
  • MacRedmond R, McVey G, Lee M, et al. (2006). Screening for lung cancer using low dose CT scanning: results of 2 year follow up. Thorax 61:54–6
  • Mahadevia PJ, Fleisher LA, Frick KD, et al. (2003). Lung cancer screening with helical computed tomography in older adult smokers: a decision and cost-effectiveness analysis. JAMA 289:313–22
  • Maisel AS, Koon J, Krishnaswamy P, et al. (2001). Utility of B-natriuretic peptide as a rapid, point-of-care test for screening patients undergoing echocardiography to determine left ventricular dysfunction. Am Heart J 141:367–74
  • Manos D. (2013). CT screening for lung cancer: controversy and misconceptions. Oncology Exch 12:10–12
  • Manrai AK, Bhatia G, Strymish J, et al. (2014). Medicine’s uncomfortable relationship with math: calculating positive predictive value. JAMA Intern Med 174:991–3
  • Marshall HM, Bowman RC, Yang IA, et al. (2013). Screening for lung cancer with low-dose computed tomography: a review of current status. J Thor Dis 5:S524–39
  • Mayrand M-H, Duarte-Franco E, Rodriques I, et al. (2007). Human Papillomavirus DNA versus Papanicolaou screening tests for cervical cancer. N Engl Med J 357:1579–88
  • McQueen MJ. (2002). Some ethical and design challenges of screening programs and screening tests. Clin Chim Acta 315:41–8
  • McWilliams A, Mayo J, MacDonald S, et al. (2003). Lung cancer screening: a different paradigm. Am J Respir Crit Care Med 168:1167–73
  • Menon U, Gentry-Maharaj A, Hallett R, et al. (2009). Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). Lancet 10:327–40
  • Mertens L, Friedberg MK. (2009). The gold standard for noninvasive imaging in congenital heart disease: echocardiography. Curr Opin Cardiol 24:119–24
  • National Lung Screening Trial Research Team. (2011). Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 365:395–409
  • Nawa T, Nakagawa T, Kusano S, et al. (2002). Lung cancer screening using low-dose spiral CT: results of baseline and 1-Year follow-up studies. Chest 122:15–20
  • Nelson R. (2009). ASCO 2009: low-dose CT screening for lung cancer produces high rate of false positives. Available at: http://www.medscape.com/viewarticle/703909 [last accessed 9 June 2014]
  • Newcombe RG. (1998). Two-sided confidence intervals for the single proportion: comparison of seven methods. Stat Med 17:857–72
  • Newman AB, Shemanski L, Manolio TA, et al. (1999). Ankle-arm index as a predictor of cardiovascular disease and mortality in the Cardiovascular Health Study. Arterioscler Thromb Vasc Biol 19:538–45
  • Ng AK, Garber JE, Diller LR, et al. (2013). Prospective study of the efficacy of breast magnetic resonance imaging and mammographic screening in survivors of Hodgkin Lymphoma. J Clin Oncol 31:2282–8
  • Novello S, Fava C, Borasio P, et al. (2005). Three-year findings of an early lung cancer detection feasibility study with low-dose spiral computed tomography in heavy smokers. Ann Oncol 16:1662–6
  • Oken MM, Hocking WC, Kvale PA, et al. (2011). Screening by chest radiograph and lung cancer mortality: the prostate, lung, colorectal, and ovarian (PLCO) randomized trial. JAMA 306:1865–73
  • Pastorino U, Bellomi M, Landoni C, et al. (2003). Early lung-cancer detection with spiral CT and positron emission tomography in heavy smokers: 2-year results. Lancet 362:593–7
  • Pastorino U, Rossi M, Rosato V, et al. (2012). Annual or biennial CT screening versus observation in heavy smokers: 5-year results of the MILD trial. Eur J Cancer Prev 21:308–15
  • Patz EF, Pinsky P, Gatsonis C, et al. (2014). Overdiagnosis in low-dose computed tomography screening for lung cancer. JAMA Intern Med 174:269–74
  • Patz EF, Swenson SJ, Herndon JE, II. (2004). Estimate of lung cancer mortality from low-dose spiral computed tomography screening trials: implications for current mass screening recommendations. J Clin Oncol 22:2202–6
  • Pedersen JH, Ashraf H, Dirksen A, et al. (2009). The Danish randomized lung cancer CT screening trial – overall design and results of the prevalence round. J Thorac Oncol 4:609–14
  • Pepe MS. (2003). The statistical evaluation of medical tests for classification and prediction. Oxford: Oxford University Press
  • Perkins BA, Olaleye D, Zinman B, Bril V. (2001). Simple screening tests for peripheral neuropathy in the diabetes clinic. Diabetes Care 24:250–6
  • Petticrew MP, Sowden AJ, Lister-Sharp D, Wright K. (2000). False-negative results in screening programmes: systematic review of impact and implications. Health Technol Assess 4:1–20
  • Petticrew MP, Sowden AJ, Lister-Sharp D, Wright K. (2001). False-negative results in screening programmes: medical, psychological, and other implications. Int J Tech Technol Assess Health Care 17:164–70
  • Phend C. (2014). Medicare advisers say no to lung cancer screening. Available at: http://www.medpagetoday.com/Pulmonology/LungCancer/45512 [last accessed 9 June 2014]
  • Pickering TG, Hall JE, Appel LJ, et al. (2005). Recommendations for blood pressure measurements in humans and experimental animals: Part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Hypertension 45:142–61
  • Rafferty EA, Park JM, Philpotts LE, et al. (2013). Assessing radiologist performance using combined digital mammography and breast tomosynthesis compared with digital mammography alone: results of a multicenter multireader trial. Radiology 266:104–13
  • Rogan WJ, Gladen B. (1978). Estimating prevalence from the results of a screening test. Am J Epidemiol 107:71–6
  • Ruano-Ravina A, Ríos MP, Fernández-Villar A. (2013). Cribado de cáncer de pulmón con tomografía computarizada de baja dosis después del National Lung Screening Trial. El debate continúa abierto. Arch Bronconeumol 49:158–65
  • Rutjes AWS, Reitsma JB, Coomarasamy A, et al. (2007). Evaluation of diagnostic tests when there is no gold standard. A review of methods. Health Technol Assess 11:1–72
  • Sabroe RA, Grattan CE, Francis DM, et al. (1999). The autologous serum skin test: a screening test for autoantibodies in chronic idiopathic utricaria. Br J Dermatol 140:446–52
  • Saghir Z, Dirksen A, Ashraf H, et al. (2012). CT screening for lung cancer brings forward early disease. The randomized Danish Lung Cancer Screening Trial: status after five annual screening rounds with low-dose CT. Thorax 67:296–301
  • Salami SS, Schmidt F, Laxman B, et al. (2013). Combining urinary detection of TMPRSS2:ERG and PCA3 with serum PSA to predict diagnosis of prostate cancer. Urol Oncol 31:566–71
  • Samet JM, Avila-Tang E, Boffetta P, et al. (2009). Lung cancer in never smokers: clinical epidemiology and environmental risk factors. Clin Cancer Res 15:5626–45
  • Schiffman M, Herrero R, Hildesheim A, et al. (2000). HPV DNA testing in cervical cancer screening: results from women in a high-risk province of Costa Rica. JAMA 283:87–93
  • Schroeder S, Enderle MD, Ossen R, et al. (1999). Noninvasive determination of endothelium-mediated vasodilation as a screening test for coronary artery disease: pilot study to assess the predictive value in comparison with angina pectoris, exercise electrocardiography, and myocardial perfusion imaging. Am Heart J 138:731–9
  • Shumway-Cook A, Brauer S, Woollacott M. (2000). Predicting the probability for falls in community-dwelling older adults using the timed up & go test. Phys Ther 80:896–903
  • Silvestri GA. (2011). Screening for lung cancer: it works, but does it really work? Ann Intern Med 155:537–9
  • Sone S, Li F, Yang Z-G, et al. (2001). Results of three-year mass screening programme for lung cancer using mobile low-dose spiral computed tomography scanner. Br J Cancer 84:25–32
  • Stoll C, Kapfhammer HP, Rothenhauser HB, et al. (1999). Sensitivity and specificity of a screening test to document traumatic experiences and to diagnose post-traumatic stress disorder in ARDS patients after intensive care treatment. Intensive Care Med 25:697–704
  • Stramer SL. (2007). Current risks of transfusion-transmitted agents: a review. Arch Pathol Lab Med 131:702–7
  • Swensen SJ, Jett JR, Hartman TE, et al. (2003). Lung cancer screening with CT: Mayo Clinic experience. RSNA 226:756–61
  • Swensen SJ, Jett JR, Hartman TE, et al. (2005). CT screening for lung cancer: five-year prospective experience. RSNA 235:259–65
  • Swensen SJ, Jett JR, Sloan JA, et al. (2002). Screening for lung cancer with low-dose spiral computed tomography. Am J Respir Crit Care Med 165:508–13
  • Teertstra HJ, Loo CE, van den Bosch MAAJ, et al. (2009). Breast tomosynthesis in clinical practice: initial results. Eur Radiol 20:16–24
  • Thejls H, Gnarpe J, Gnarpe H, et al. (1994). Expanded gold standard in the diagnosis of Chlamydia trachomatis in a low prevalence population: diagnostic efficacy of tissue culture, direct immunofluorescence, enzyme immunoassay, PCR and serology. Genitourin Med 70:300–3
  • Thompson IA, Ankerst DP, Chi C, et al. (2005). Operating characteristics of prostate-specific antigen in men with an initial PSA level of 3.0 ng/mL or lower. JAMA 294:66–70
  • Tiitola M, Kivisaari L, Huuskonen MS, et al. (2002). Computed tomography screening for lung cancer in asbestos-exposed workers. Lung Cancer 35:17–22
  • Toyoda Y, Nakayama T, Kusunoki Y, et al. (2008). Sensitivity and specificity of lung cancer screening using chest low-dose computed tomography. Br J Cancer 98:1602–7
  • Troy LM, Michels KB, Hunter DJ, et al. (1996). Self-reported birthweight and history of having been breastfed among younger women: an assessment of validity. Int J Epidemiol 25:122–7
  • Tsai AW, Folsom AR, Rosamon W, Jones DW. (2001). Ankle-brachial index and 7-year ischemic stroke incidence. The ARIC Study. Stroke 32:1721–4
  • US Preventive Services Task Force. (2013). Screening for Lung Cancer; U.S. Preventive Services Task Force Recommendation Statement. Available at http://www.uspreventiveservicestaskforce.org/uspstf13/lungcan/lungcanfinalrs.htm [last accessed 30 June 2014]
  • Utell MJ, Maxim LD. (2010). Refractory ceramic fiber (RCF) toxicity and epidemiology: a review. Inhal Toxicol 22:500–21
  • van Klavern RJ, Oudkerk M, Prokop M, et al.(2009). Management of lung nodules detected by volume CT scanning. N Engl J Med 361:2221–9
  • van Nagell JR, DePriest PD, Ueland FR, et al. (2007). Ovarian cancer screening with annual transvaginal sonography: findings of 25,000 women screened. Cancer 109:1887–96
  • van Smeden M, Naaktegeboren CA, Reitsma JB, et al. (2014). Latent class models in diagnostic studies when there is no reference standard – a systematic review. Am J Epidemiol 179:423–31
  • Vansteenkiste J, Dooms C, Mascaux C, Nackaerts K. (2012). Screening and early detection of lung cancer. Ann Oncol 23:320–7
  • Versi E. (1992). “Gold standard” is an appropriate term. BMJ 305:187
  • Vogelsang H, Wyatt GD, Lochs WJ, et al. (1995). Screening for celiac disease: a prospective study on the value of noninvasive tests. Am J Gastroenterol 90:394–8
  • Walter SD, Irwig LM. (1988). Estimation of test error rates, disease prevalence and relative risk from misclassified data: a review. J Clin Epidemiol 43:923–37
  • Watson EJ, Templeton A, Russell I, et al. (2002). The accuracy and efficacy of screening tests for chlamydia trachmatis: a systematic review. J Med Microbiol 51:1021–31
  • Wegwarth O, Schwartz LM, Woloshin S, et al. (2012). Do physicians understand cancer screening statistics? A national survey of primary care physicians in the United States. Ann Intern Med 156:340–9
  • Weiss SH, Goedert JJ, Samgadharanm MG, et al. (1985). Screening test for HTLV-III (AIDS Agent) Antibodies, specificity, sensitivity, and applications. JAMA 253:221–5
  • Whiting P, Rutjes AWS, Reitsma JB, et al. (2004). Chapter 2. A systematic review of sources of variation and bias in studies of diagnostic accuracy. Ann Int Med 140:189–202
  • Whitlock EP, Lin JS, Liles E, et al. (2008). Screening for colorectal cancer: a targeted, updated systematic review for the U.S. Preventative Services Task Force. Ann Int Med 149:638–58
  • Wiener RS, Schwartz LM, Woloshin S, Welch HG. (2011). Population-based risk for complications after transthoracic needle lung biopsy of a pulmonary nodule: an analysis of discharge records. Ann Intern Med 155:137–44
  • Wilson JMG, Jungner G. (1968). Principles and practice of screening for disease. Geneva: WHO. Available at: http://whqlibdoc.who.int/php/WHO_PHP_34.pdf [last accessed 5 August 2014]
  • World Health Organization (WHO). (2003). Review of ethical issues in medical genetics. Prepared for WHO by Wertz DC, Fletcher JC, and Berg K. WHO/HGN/ETH/00.4. 48 pp. Available online at: http://www.who.int/genomics/publications/en/ethical_issuesin_medgenetics%20report.pdf [last accessed 5 August 2014]
  • Zou KH, O’Malley J, Mauri L. (2007). Receiver-operating characteristic analysis for evaluating diagnostic tests and predictive models. Circulation 115:654–7