N-acetylcysteine attenuates cigaret smoke-induced pulmonary exacerbation in a mouse model of emphysema

References

• Antunes MA, Rocco PR. (2011). Elastase-induced pulmonary emphysema: insights from experimental models. An Acad Bras Cienc 83:1385–96
   PubMed Web of Science ®Google Scholar
• Bengalli R, Molteni E, Longhin E, et al. (2013). Release of IL-1 β triggered by Milan summer PM10: molecular pathways involved in the cytokine release. Biomed Res Int 2013:158093
   PubMed Web of Science ®Google Scholar
• Coultas DB, Samet JM, McCarthy JF, Spengler JD. (1990). Variability of measures of exposure to environmental tobacco smoke in the home. Am Rev Respir Dis 142:602–6
   PubMed Web of Science ®Google Scholar
• Criner GJ, Bourbeau J, Diekemper RL, et al. (2014). Prevention of acute exacerbations of COPD: American College of Chest Physicians and Canadian Thoracic Society Guideline. Chest 147:894–942
   Web of Science ®Google Scholar
• Dekhuijzen PN, van Beurden WJ. (2006). The role for N-acetylcysteine in the management of COPD. Int J Chron Obstruct Pulmon Dis 1:99–106
   PubMedGoogle Scholar
• Deng X, Zhang F, Rui W, et al. (2013). PM2.5-induced oxidative stress triggers autophagy in human lung epithelial A549 cells. Toxicol In Vitro 27:1762–70
   PubMed Web of Science ®Google Scholar
• Deng X, Zhang F, Wang L, et al. (2014). Airborne fine particulate matter induces multiple cell death pathways in human lung epithelial cells. Apoptosis 19:1099–112
   PubMed Web of Science ®Google Scholar
• Dunnill MS. (1962). Quantitative methods in the study of pulmonary pathology. Thorax 17:320–8
   PubMedGoogle Scholar
• Hansel NN, McCormack MC, Belli AJ, et al. (2013). In-home air pollution is linked to respiratory morbidity in former smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 187:1085–90
   PubMed Web of Science ®Google Scholar
• Kaji DA, Belli AJ, McCormack MC, et al. (2014). Indoor pollutant exposure is associated with heightened respiratory symptoms in atopic compared to non-atopic individuals with COPD. BMC Pulm Med 14:147
   PubMed Web of Science ®Google Scholar
• Khanna AK, Xu J, Mehra MR. (2012). Antioxidant N-acetyl cysteine reverses cigarette smoke-induced myocardial infarction by inhibiting inflammation and oxidative stress in a rat model. Lab Investig 92:224–35
   PubMed Web of Science ®Google Scholar
• Kimmel EC, Winsett DW, Diamond L. (1985). Augmentation of elastase-induced emphysema by cigarette smoke. Description of a model and a review of possible mechanisms. Am Rev Respir Dis 132:885–93
   PubMed Web of Science ®Google Scholar
• Kobayashi S, Fujinawa R, Ota F, et al. (2013). A single dose of lipopolysaccharide into mice with emphysema mimics human chronic obstructive pulmonary disease exacerbation as assessed by micro-computed tomography. Am J Respir Cell Mol Biol 49:971–7
   PubMed Web of Science ®Google Scholar
• Kumar N, Liang D, Comellas A, et al. (2013). Satellite-based PM concentrations and their application to COPD in Cleveland, OH. J Expo Sci Environ Epidemiol 23:637–46
   PubMed Web of Science ®Google Scholar
• Ling SH, van Eeden SF. (2009). Particulate matter air pollution exposure: role in the development and exacerbation of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 4:233–43
   PubMedGoogle Scholar
• Michael S, Montag M, Dott W. (2013). Pro-inflammatory effects and oxidative stress in lung macrophages and epithelial cells induced by ambient particulate matter. Environ Pollut 183:19–29
   PubMed Web of Science ®Google Scholar
• Mueller D, Uibel S, Braun M, et al. (2011). Tobacco smoke particles and indoor air quality (ToPIQ) – the protocol of a new study. J Occup Med Toxicol 6:35. doi: 10.1186/1745-6673-6-35
   PubMed Web of Science ®Google Scholar
• Ouyang W, Rutz S, Crellin NK, et al. (2011). Regulation and functions of the IL-10 family of cytokines in inflammation and disease. Annu Rev Immunol 29:71–109
   PubMed Web of Science ®Google Scholar
• Peacock JL, Anderson HR, Bremner SA, et al. (2011). Outdoor air pollution and respiratory health in patients with COPD. Thorax 66:591–6
   PubMed Web of Science ®Google Scholar
• Ristovski ZD, Miljevic B, Surawski NC, et al. (2012). Respiratory health effects of diesel particulate matter. Respirology 17:201–12
   PubMed Web of Science ®Google Scholar
• Rubio M, Sanchez-Cifuentes M, Ortega M, et al. (2000). N-acetylcysteine prevents cigarette smoke induced small airways alterations in rats. Eur Respir J 15:505–11
   PubMed Web of Science ®Google Scholar
• Santus P, Russo A, Madonini E, et al. (2012). How air pollution influences clinical management of respiratory diseases. A case-crossover study in Milan. Respir Res 13:95. doi: 10.1186/1465-9921-13-95
   PubMed Web of Science ®Google Scholar
• Semple S, Latif N. (2014). How long does secondhand smoke remain in household air: analysis of PM2.5 data from smokers' homes. Nicotine Tob Res 16:1365–70
   PubMed Web of Science ®Google Scholar
• Shapiro SD. (2000). Animal models for COPD. Chest 117:223S–7
   PubMed Web of Science ®Google Scholar
• Sint T, Donohue JF, Ghio AJ. (2008). Ambient air pollution particles and the acute exacerbation of chronic obstructive pulmonary disease. Inhal Toxicol 20:25–9
   PubMed Web of Science ®Google Scholar
• Suzuki M, Betsuyaku T, Ito Y, et al. (2009). Curcumin attenuates elastase- and cigarette smoke-induced pulmonary emphysema in mice. Am J Physiol Lung Cell Mol Physiol 296:L614–23
   PubMed Web of Science ®Google Scholar
• Thatcher TH, Hsiao HM, Pinner E, et al. (2013). Neu-164 and Neu-107, two novel antioxidant and anti-myeloperoxidase compounds, inhibit acute cigarette smoke-induced lung inflammation. Am J Physiol Lung Cell Mol Physiol 305:L165–74
   PubMed Web of Science ®Google Scholar
• Tsai SS, Chang CC, Yang CY. (2013). Fine particulate air pollution and hospital admissions for chronic obstructive pulmonary disease: a case-crossover study in Taipei. Int J Environ Res Public Health 10:6015–26
   PubMed Web of Science ®Google Scholar
• Valavanidis A, Vlachogianni T, Fiotakis K, Loridas S. (2013). Pulmonary oxidative stress, inflammation and cancer: respirable particulate matter, fibrous dusts and ozone as major causes of lung carcinogenesis through reactive oxygen species mechanisms. Int J Environ Res Public Health 10:3886–907
   PubMed Web of Science ®Google Scholar
• Valença SS, Rueff-Barroso CR, Pimenta WA, et al. (2011). l-NAME and l-arginine differentially ameliorate cigarette smoke-induced emphysema in mice. Pulmon Pharmacol Therapeut 24:587–94
   PubMed Web of Science ®Google Scholar
• Vestbo J, Hurd SS, Agusti AG, et al. (2013). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 187:347–65
   PubMed Web of Science ®Google Scholar
• Wang D, Wang Y, Liu YN. (2010). Experimental pulmonary infection and colonization of Haemophilus influenzae in emphysematous hamsters. Pulm Pharmacol Ther 23:292–9
   PubMed Web of Science ®Google Scholar
• Wright JL, Cosio M, Churg A. (2008). Animal models of chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol 295:L1–15
   PubMed Web of Science ®Google Scholar
• Yageta Y, Ishii Y, Morishima Y, et al. (2014). Carbocisteine reduces virus-induced pulmonary inflammation in mice exposed to cigarette smoke. Am J Respir Cell Mol Biol 50:963–73
   PubMed Web of Science ®Google Scholar
• Zheng JP, Wen FQ, Bai CX, et al. (2014). Twice daily N-acetylcysteine 600 mg for exacerbations of chronic obstructive pulmonary disease (PANTHEON): a randomised, double-blind placebo-controlled trial. Lancet Respir Med 2:187–94
   PubMed Web of Science ®Google Scholar