Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 27, 2015 - Issue 14
153
Views
31
CrossRef citations to date
0
Altmetric
Research Article

Characterization of a nose-only inhaled phosgene acute lung injury mouse model

, , , &
Pages 832-840 | Received 06 Aug 2015, Accepted 03 Nov 2015, Published online: 16 Dec 2015

References

  • Blakey DH, Lafontaine M, Lavigne J, et al. (2013). A screening tool to prioritize public health risk associated with accidental or deliberate release of chemicals into the atmosphere. BMC Public Health 13:253
  • Cannon WC, Blanton EF, McDonald KE. (1983). The flow-past chamber: an improved nose-only exposure system for rodents. Am Ind Hyg Assoc J 44:923–8
  • Cordier D, Cordier G. (1953). [Toxicity of weak concentrations of phosgene in repeated inhalations]. J Physiol (Paris) 45:421–8
  • Cox JA, Roszell LE, Whitmire M. (2010). Chemical terrorism risk assessment: a biennial assessment of risk to the nation. Chemical Security Analysis Center, United States Department of Homeland Security
  • Currie WD, Hatch GE, Frosolono MF. (1987). Changes in lung ATP concentration in the rat after low-level phosgene exposure. J Biochem Toxicol 2:105–14
  • Diller WF. (1978). Medical phosgene problems and their possible solution. J Occup Med 20:189–93
  • Diller WF, Bruch J, Dehnen W. (1985). Pulmonary changes in the rat following low phosgene exposure. Arch Toxicol 57:184–90
  • Diller WF, Zante R. (1982). [Dose-response relations in the phosgene effect on humans and animals (literature study)]. Zentralbl Arbeitsmed Arbeitsschutz Prophyl Ergonomie 32:360–8
  • Duniho SM, Martin J, Forster JS, et al. (2002). Acute changes in lung histopathology and bronchoalveolar lavage parameters in mice exposed to the choking agent gas phosgene. Toxicol Pathol 30:339–49
  • Good K, Winkel D, VonNiederhausern M, et al. (2013). Medical mitigation model: quantifying the benefits of the public health response to a chemical terrorism attack. J Med Toxicol 9:125–32
  • Gordon CJ, Spencer PJ, Hotchkiss J, et al. (2008). Thermoregulation and its influence on toxicity assessment. Toxicology 244:87–97
  • Gross P, Rinehart WE, Hatch T. (1965). Chronic pneumonitis caused by phosgene. An experimental study. Arch Environ Health 10:768–75
  • International Program on Chemical Safety. (1997). Environmental health criteria 193: phosgene. Geneva, Switzerland: International Program on Chemical Safety
  • Ji L, Liu R, Zhang XD, et al. (2010). Nacetylcysteine attenuates phosgene-induced acute lung injury via up-regulation of Nrf2 expression. Inhal Toxicol 22:535–42
  • Leikauf G, Concel V, Bein K, et al. (2013). Functional genomic assessment of phosgene-induced acute lung injury in mice. Am J Resp Cell Molec Biol 49:368–83
  • Li W, Liu F, Wang C, et al. (2013). Novel insights into phosgene-induced acute lung injury in rats: role of dysregulated cardiopulmonary reflexes and nitric oxide in lung edema pathogenesis. Toxicol Sci 131:612–28
  • Li WL, Hai CX, Liang X, et al. (2006). Apoptosis of ATII cells in mice induced by phosgene. Inhal Toxicol 18:71–7
  • Li WL, Hai CX, Pauluhn J. (2011). Inhaled nitric oxide aggravates phosgene model of acute lung injury. Inhal Toxicol 23:842–52
  • Li WL, Hai CX, Yang C, et al. (2005). Apoptosis of pulmonary epithelial cells and endothelial cells in mice exposed to phosgene. Di Yi Jun Yi Da Xue Xue Bao 25:983–5, 990
  • Long JE, Hatch TF. (1961). A method for assessing the physiological impairment produced by low-level exposure to pulmonary irritants. Am Ind Hyg Assoc J 22:6–13
  • NIOSH. (1993). Criteria for a recommended standard: occupational exposure to phosgene. Washington, DC: CDC Publication
  • Pauluhn J. (2006a). Acute nose-only exposure of rats to phosgene. Part I. Concentration x time dependence of LC50s, nonlethal-threshold concentrations, and analysis of breathing patterns. Inhal Toxicol 18:423–35
  • Pauluhn J. (2006b). Acute nose-only exposure of rats to phosgene. Part II. Concentration x time dependence of changes in bronchoalveolar lavage during a follow-up period of 3 months. Inhal Toxicol 18:595–607
  • Pauluhn J. (2006c). Acute head-only exposure of dogs to phosgene. Part III. Comparison of indicators of lung injury in dogs and rats. Inhal Toxicol 18:609–21
  • Pauluhn J, Carson A, Costa DL, et al. (2007). Workshop summary: phosgene-induced pulmonary toxicity revisited: appraisal of early and late markers of pulmonary injury from animal models with emphasis on human significance. Inhal Toxicol 19:789–810
  • Sciuto AM, Cascio MB, Moran TS, Forster JS. (2003). The fate of antioxidant enzymes in bronchoalveolar lavage fluid over 7 days in mice with acute lung injury. Inhal Toxicol 15:675–85
  • Sciuto AM, Hurt HH. (2004). Therapeutic treatments of phosgene-induced lung injury. Inhal Toxicol 16:565–80
  • Sciuto AM, Strickland PT, Kennedy TP, Gurtner GH. (1995). Protective effects of N-acetylcysteine treatment after phosgene exposure in rabbits. Am J Respir Crit Care Med 151:768–72
  • Sciuto AM, Strickland PT, Kennedy TP, et al. (1996). Intratracheal administration of DBcAMP attenuates edema formation in phosgene-induced acute lung injury. J Appl Physiol 80:149–57
  • Wang P, Ye XL, Liu R, et al. (2013). Mechanism of acute lung injury due to phosgene exposition and its protection by cafeic acid phenethyl ester in the rat. Exp Toxicol Pathol 65:311–18

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.