Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 2, 1990 - Issue 3
40
Views
20
CrossRef citations to date
0
Altmetric
Research Article

Comparative Evaluation of Nose-Only Versus Whole-Body Inhalation Exposures for Rats—Aerosol Characteristics and Lung Deposition

, , , &
Pages 205-221 | Published online: 27 Sep 2008

References

  • American Chemical Society Committee on Environmental Improvement. Subcommittee on environmental monitoring and analysis. Anal. Chem. 1983; 55: 2210–2218
  • Beethe R. L., Wolff R. K., Griffis L. C., Hobbs C. H., McClellan R. O. Evaluation of a recently designed multi-tiered exposure chamber. Lovelace lnhalation Toxicology Research Institute, LF-67. NTIS., Springfield, Va 1979
  • Carpenter R. L., Beethe R. L. Cones, cone angles, plenums and manifolds. Proc. Workshop on Inhalation Chamber Technology, R. T. Drew, 1978; 21–30
  • Cheng Y. S., Marshall T. C., Henderson R. F., Newton G. J. Use of a jet mill for dispersing dry powder for inhalation studies. Am. Ind. Hyg. Assoc. J. 1985; 46: 449–454
  • Cheng Y. S., Barr E. B., Benson J. M., Damon E. G., Medinsky M. A., Hobbs C. H., Goehl T. J. Evaluation of a real-time aerosol monitor (RAM-S) for inhalation studies. Fundam. Appl. Toxicol. 1988; 10: 321–328
  • Ferin J., Oberdorster G. Biological effects and toxicity assessment of titanium dioxides: Anatase and rutile. Am. Ind. Hyg. Assoc. J. 1985; 46: 69–72
  • Langlrd S., Nordhagen A.-L. Small animal inhalation chambers and the significance of dust ingestion from the contaminated coat when exposing rats to zinc. Acta Pharmacol. Toxicol. 1980; 46: 43–46
  • Lee K. P., Trochimowicz H. J., Reinhardt C. F. Pulmonary response of rats exposed to titanium oxide (TiO2) by inhalation for two years. Toxicol. Appl. Pharmacol. 1985; 79: 179–192
  • MacFarland N. H. Designs and operational characteristics of inhalation exposure equipment—A review. Fundam. Appl. Toxicol. 1983; 3: 603–613
  • Mauderly J. L. Respiration of F344 rats in nose-only inhalation exposure tubes. J. Appl. Toxicol. 1986; 6: 25–30
  • Mauderly J. L., Tesarek J. E., Sifford L. J. Respiratory measurements of unsedated small laboratory mammals using nonrebreathing valves. Lab. Anim. Sci. 1979; 29: 323–329
  • Moss O. R., Decker J. R., Cannon W. C. Aerosol mixing in an animal exposure chamber having three levels of caging with excreta pans. Am. Ind. Hyg. Assoc. J. 1982; 43: 244–249
  • Phalen R. F. Inhalation Studies: Foundations and Techniques. CRC Press, Boca Raton, Fla 1984
  • Raabe O. G., Bennick J. E., Light M. E., Hobbs C. H., Thomas R. L., Tillery M. I. An improved apparatus for acute inhalation exposure of rodents to radioactive aerosols. Toxicol. Appl. Pharmacol. 1973; 26: 264–273
  • Raabe O. G., Yeh H. C., Newton G. J., Phalen R. F., Velasquez D. J. Deposition of inhaled monodisperse aerosols in small rodents. Inhaled Particles IV, W. H. Walton. Pergamon Press., New York 1977; 3–21
  • Schum M., Yeh H. C. Theoretical evaluation of aerosol deposition in anatomical models of mammalian lung airways. Bull. Math. Biol. 1980; 42: 1–15
  • Teague S. V., Yeh H. C., Newton G. J. Fabrication and use of krypton-85 aerosol discharge devices. Health Phys. 1978; 35: 391–392
  • Thomson S., Burnett D. C., Bergmann J. D., Hixson C. J. Comparative inhalation hazards of aluminum and brass powders using bronchopulmonary lavage as an indicator of lung damage. J. Appl. Toxicol. 1986; 6: 197–209
  • Wright B. M. A new dust-feed mechanism. Sci. Instr. 1950; 27: 12–15
  • Yeh H. C., Newton G. J., Barr E. B., Carpenter R. L., Hobbs C. H. Studies of the temporal and spatial distribution of aerosols in multi-tiered inhalation exposure chambers. Am. Ind. Hyg. Assoc. J. 1986; 47: 540–545

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.