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Inhalation Toxicology
International Forum for Respiratory Research
Volume 5, 1993 - Issue 1
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Research Article

Characteristics of Bronchoalveolar Leukocytes from the Lungs of Rats Inhaling 0.2–0.8 ppm OF Ozone

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Pages 149-164 | Published online: 27 Sep 2008

References

  • Amaruso M. A., Witz G., Goldstein B. D. Decreased superoxide anion radical production by rat alveolar macrophages following inhalation of ozone or nitrogen dioxide. Life Sci. 1981; 28: 2215–2221
  • Aranyi C., Vana S. L., Thomas P. T., Bradof J. N., Fenters J. D., Graham J. A., Miller F. J. Effects of subchronic exposure to a mixture of O3, SO2 and (NH4)SO4 on host defenses of mice. J. Toxicol. Environ. Health 1983; 12: 55–71
  • Barry B. E., Mercer R. R., Miller F. J., Crapo J. D. Effects of inhalation of 0.25 ppm ozone on the terminal bronchioles of juvenile and adult rats. Exp. Lung Res. 1988; 14: 225–245
  • Barry B. E., Miller F. J., Crapo J. D. Effects of inhalation of 0.12 and 0.25 parts per million ozone on the proximal alveolar region of juvenile and adult rats. Lab. Invest. 1985; 53: 692–704
  • Boorman G. A., Schwartz L. W., Dungworth D. L. Pulmonary effects of prolonged ozone insult in rats. Lab. Invest. 1980; 43: 108–115
  • Bresnitz E. A., Rest K. M. Epidemiologic studies of effects of oxidant exposure on human populations. Air Pollution, the Automobile and Public Health, A. Y. Watson, R. R. Bates, D. Kennedy. Academy Press, Washington, D.C. 1988
  • Brown G. M., Donaldson K. The degradation of connective tissue components by lung-derived leukocytes in vitro: The role of proteases and oxidants. Thorax 1988; 43: 132–139
  • Brown G. M., Irvine J., Donaldson K. Characterisation of the fibronectin degrading activity of inflammatory bronchoalveolar macrophages and neutrophils. Thorax 1989; 44: 331
  • Campbell E. J., White R. R., Senior P. M., Rodriguez R. J., Kohn L. Receptor-mediated binding and internalization of leukocyte elastase by alveolar macrophages in vitro. J. Clin. Invest. 1979; 64: 824–833
  • Donaldson K., Bolton R. E., Brown G. M., Douglas A. An improved macrophage spreading assay–A simple and effective measure of activation. Immunol. Commun. 1984; 13: 229–244
  • Donaldson K., Slight J., Brown G. M., Bolton R. E. The ability of inflammatory bron-choalveolar leukocyte populations elicited with microbes or mineral dusts to injure alveolar epithelial cells and degrade extracellular matrix in vitro. Br. J. Exp. Pathol. 1988; 69: 327–338
  • Driscoll K. E., Schlesinger R. B. Alveolar macrophage-stimulated neutrophil and monocyte migration: Effect of in vitro ozone exposure. Toxicol. Appl. Pharmacol. 1988; 93: 312–318
  • Esterline R. L., Bassett D. J. P., Trush M. A. Characterization of the oxidant generation by inflammatory cells lavaged from rats following acute exposure to ozone. Toxicol. Appl. Pharmacol. 1989; 99: 229–239
  • Hassett C., Mustafa M. G., Coulson W. F., Elashoff R. M. Murine lung carcinogenesis following exposure to ambient ozone concentrations. JNCI 1985; 75: 771–777
  • Holtzman M. J., Fabri L. M., O'Byrne P. M., Gold B. D., Aizawa H., Walters E. H., Alpert S. E., Wadel J. A. Importance of airway inflammation for hyper-responsiveness induced by ozone. Am. Rev. Respir. Dis. 1983; 127: 686–690
  • Hotchkiss J. A., Harkema J. R., Sun J. D., Henderson R. F. Comparison of acute ozone-induced nasal and pulmonary inflammatory responses in rats. Toxicol. Appl. Pharmacol. 1989a; 98: 289–302
  • Hotchkiss J. A., Harkema J. R., Kirkpatrick D. T., Henderson R. F. Response of rat alveolar macrophages to ozone: Quantitative assessment of population size, morphology and proliferation following acute exposure. Exp. Lung Res. 1989b; 15: 1–16
  • Hu P. C., Miller F. J., Daniels M. J., Hatch G. E., Graham J. A., Gardner D. E., Selgrade M. K. Protein accumulation in lung lavage fluid following ozone exposure. Environ. Res. 1982; 29: 377–388
  • Johnston R. B. Secretion of superoxide anion. Methods for Studying Mononuclear Phagocytes, D. O. Adams, P. J. Edelson, H. Koren. Publisher, City 1981; 489–497
  • Koren H., Devlin R. B., Graham D. E., Mann R., et al. Ozone-induced inflammation in the lower airways of human subjects. Am. Rev. Respir. Dis. 1989; 139: 407–415
  • Lannan S., McLean A., Drost E., Gilhooly M., Donaldson K., Lamb D., MacNee W. Changes in neutrophil morphology and morphometry following exposure to cigarette smoke. Int. J. Exp. Pathol. 1992; 73: 183–191
  • Last J. A., Gerriets J. E., Hyde D. M. Synergistic effects on rat lungs of mixtures of oxidant air pollutants (ozone in nitrogen dioxide) and respirable aerosols. Am. Rev. Respir. Dis. 1983; 128: 539–544
  • Lieber M., Smith B., Szakal A., Nelson-Rees W., Todaro G. A continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells. Int. J. Cancer 1976; 17: 62–70
  • Menzel D. B. Ozone: An overview of its toxicity in man and animals. J. Toxicol. Environ. Health 1984; 13: 183–204
  • Mustafa M. G., Hassett C. M., Newell G. W., Schravzer G. N. Pulmonary carcinogenic effects of ozone. Ann. NY Acad. Sci. 1988; 534: 714–723
  • Reiser K. M., Tyler W. S., Hennessy S. M., Dominguez J. J., Wast J. A. Long-term consequences of exposure to ozone II. Structural alteration in lung collagen of monkeys. Toxicol. Appl. Pharmacol. 1987; 89: 314–322
  • Ryerpowder J. E., Amaruso M. A., Czerniecki B., Witz G., Goldstein B. D. Inhalation of ozone produces a decrease in superoxide anion radical production in mouse alveolar macrophages. Am. Rev. Respir. Dis. 1986; 138: 1129–1133
  • Tepper J. S., Cusza D. L., Lehmann J. R., Weber M. F., Hatch G. E. Unattenuated structural and biochemical alteration in the rat lung during functional adaptation to ozone. Am. Rev. Respir. Dis. 1989; 140: 493–501
  • Wright E. S., Kehrer J. P., White D. M., Smiler K. L. Effects of chronic exposure to ozone on collagen in rat lung. Toxicol. Appl. Pharmacol. 1988; 92: 445–452
  • Wright E. S., White D. M., Brady A. N., Li L. C., D'Arcy J. B., Smiler K. L. DNA synthesis in pulmonary alveolar macrophages and type II cells: Effects of ozone exposure and treatment with alpha-difluoromethylornithine. J. Toxicol. Environ. Health 1987; 21: 15–26

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