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Inhalation Toxicology
International Forum for Respiratory Research
Volume 7, 1995 - Issue 3
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Research Article

Pulmonary Toxicity Assessments Of Inhaled Ethylene Oxide/Propylene Oxide Copolymer Lubricants In Rats

D. B. Warheit DuPont Haskell Laboratory, Newark, Delaware, USA
,
H. Fogle AlliedSignal Corp., Hopewell, Virginia, USA
,
W. C. Thomas Hoechst-Celanese Corp., Somerville, New Jersey, USA
,
S. R. Murphy BASF Corp., Wyandotte, Michigan, USA
,
T. R. Tyler Union Carbide, Export, Pennsylvania, USA
,
R. W. Reinhold AlliedSignal Inc., Morristown, New Jersey, USA
&
G. L. Kennedy DuPont Haskell Laboratory, Newark, Delaware, USA
 show all
Pages 377-392 | Received 17 May 1994, Accepted 16 Aug 1994, Published online: 27 Sep 2008

References

  • Fowler E. H., Losco P. E., Neptun D. A., Myers R. C, Tyler T. R. The pathogenesis of pulmonary toxicity from IV administration of UCON Lubricant 50-HB-5100. Toxicologist 1993; 13: 153
  • Hoffman G. M., Newton P. E., Thomas W. C, Birnbaum H. A., Kennedy G. L., Jr. Acute inhalation toxicity studies in several animal species of an ethylene oxide/propylene oxide copolymer (UCON 50-HB-51O0). Drug. Chem. Toxicol. 1991; 14: 243–256
  • Kier L. D., Wagner L. M., Wilson T. V., Li A. P., Kennedy G. L., Jr. Cytotoxicity of ethylene oxide/propylene oxide copolymers in cultured mammalian cells. 1994, Submitted for publication
  • Klonne D. R., Nachreiner D. J., Losco P. E., Tyler T. R. Acute and 2-week inhalation toxicity studies on aerosols of selected ethylene oxide/propylene oxide polymers in rats. Fundam. Appl. Toxicol. 1987; 9: 773–784
  • Ulrich C. E., Geil R. C, Tyler T. R., Kennedy C. L., Jr. Two-week aerosol inhalation study in rats of ethylene oxide/propylene oxide copolymers. Drug Chem. Toxicol. 1992; 15: 13–31
  • Warheit D. B., Carakostas M. C, Hartsky M. A., Hansen J. F. Development of a short-term inhalation bioassay to assess pulmonary toxicity of inhaled particles: Comparisons of pulmonary responses to carbonyl iron and silica. Toxicol. Appl. Pharmacol. 1991; 107: 350–368
  • Warheit D. B., Kellor K. A., Hartsky M. A. Pulmonary cellular effects in rats following aerosol exposure to ultrafine Kevlar aramid fibrils: Evidence for biodegradability of inhaled fibrils. Toxicol. Appl. Pharmacol. 1992; 116: 225–239
  • Warheit D. B., Hill L. H., Brody A. R. Pulmonary macrophage phagocytosis: Quantification by secondary and backscattered electron imaging. Scanning Electron Microsc. 1983; 14: 431–437
  • Warheit D. B., Hill L. H., Brody A. R. Surface morphology and correlated phagocytic capacity of pulmonary macrophages lavaged from the lungs of rats. Exp. Lung Res. 1984; 6: 71–82

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