Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 8, 1996 - Issue 6
25
Views
12
CrossRef citations to date
0
Altmetric
Research Article

An Empirical Dosimetry Model of Aerodynamic Particle Deposition in the Rat Respiratory Tract

, &
Pages 539-578 | Received 10 Oct 1995, Accepted 06 Jan 1996, Published online: 27 Sep 2008

References

  • American Conference of Governmental Industrial Hygienists. 1992–1993 Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices Cincinnati, OH. [Also published in ACCIH Trans. (1984). Ann. Am. Conf. Ind. Hyg. 1992; 11: 23–100
  • Asgharian B., Wood R., Schlesinger R. B. Empirical modeling of particle deposition in the alveolar region of the lungs: A basis for interspecies extrapolation. Fundam. Appl. Toxicol. 1995; 27: 232–238
  • Berteau P. B., Biermann A. H. Respiratory deposition and early distribution of inhaled vegetable oil aerosols in mice and rats. Toxicol. Appl. Pharmacol. 1977; 39: 177–183
  • Breysse P. N., Swift D. L. Inhalability of large particles into the human nasal passage: In vivo studies in still air. Aerosol Sci. Technol. 1990; 13: 459–464
  • Chan T. L., Lippmann M. Experimental measurements and empirical modelling of the regional deposition of inhaled particles in humans. Am. Ind. Hyg. Assoc. 1980; 41: 399–409
  • Chan T. L., Yu C. P. Charge effects on particle deposition in the human tracheobronchial tree. Ann. Occup. Hyg. 1982; 11: 65–75
  • Costa D. L., Tepper J. S. Approaches to lung function assessment in small mammals. Toxicology of the lung, D. E. Gardner, J. D. Crapo, E. J. Massaro. Raven Press, New York 1988; 147–174
  • Dahlbäck M, Eirefelt S. Total deposition of fluorescent monodisperse particles in rats. Ann. Occup. Hyg. 1994; 38: 127–134
  • Dahlbäck M., Eirefelt S., Karlberg I.-B., Nerbrink O. Total deposition of Evans blue in aerosol exposed rats and guinea pigs. J. Aerosol Sci. 1989; 20(8)1325–1327
  • Foster W. M. Is 24 hour lung retention an index of alveolar deposition?. J. Aerosol Med. 1988; 1(1)1–9
  • Gonda I. Study of the effects of polydispersity of aerosols on regional deposition in the respiratory tract. J Pharm. Pharmacol. 1981; 33(s)52P
  • Guyton A. C. Measurement of the respiratory volumes of laboratory animals. Am. J Physiol. 1947; 150: 70–77
  • Heyder J., Rudolf G. Deposition of aerosol particles in the human nose. Inhaled particles IV, W. H. Walton. Pergamon Press, Oxford 1977; 107–126
  • Hofmann W., Steinhäusler F., Pohl E. Dose calculations for the respiratory tract from inhaled natural radioactive nuclides as a function of age. I. Compartmental deposition, retention and resulting dose. Health Phys. 1979; 37: 517–532
  • Holford N., Sheiner L. Kinetics of pharmacologic response. Pharmacol. Ther. 1982; 16: 143–166
  • Johnson R. F., Jr., Ziemer P. L. The deposition and retention of inhaled '52–54europium oxide in the rat. Health Phys. 1971; 20: 187–193
  • Kimbell J. S., Gross E. A., Joyner D. R., Godo M. N., Morgan K. T. Application of computational fluid dynamics to regional dosimetry of inhaled chemicals in the upper respiratory tract of the rat. Toxicol. Appl. Pharmacol. 1993; 121: 253–263
  • Köbrich R., Rudolf G., Stahlhofen W. A mathematical model of mass deposition in man. Ann. Occup. Hyg. 1994; 38(S1)15–23
  • Köhler D., Oberdörster G. Definition of different therapeutic, diagnostic, and environmental aerosols. Expert meeting III: Summary statement of co-chairs. J Aerosol Med. 1991; 4(3)269–272
  • Lippmann M., Albert R. E. The effect of particle size on the regional deposition of inhaled aerosols in the human respiratory tract. Am. Ind. Hyg. Assoc. J. 1969; 30: 257–275
  • Martonen T. B., Zhang Z., Yang Y. Extrapolation modeling of aerosol deposition in human and laboratory rat lungs. Inhal. Toxicol. 1992; 4: 303–324
  • Mauderly J. L. Respiration of F344 rats in nose-only inhalation exposure tubes. J Appl. Toxicol. 1986; 6(1)25–30
  • Mauderly J. L., Tesarek J. E., Sifford L. J., Sifford L. J. Respiratory measurements of unsedated small laboratory mammals using nonrebreathing valves. Lab. Anim. Sci. 1979; 29(3)323–329
  • McMahon T. A., Brain J. D., Lemott S. Species differences in aerosol deposition. Inhaled particles IV, W. H. Walton. Pergamon Press, New York 1977; 23–33
  • Ménache M. G., Miller F. J., Raabe O. G. Particle inhalability curves for humans and small laboratory animals. Ann. Occup. Hyg. 1995; 39(3)317–328
  • Miller F. J., Martonen T. B., Ménache M. G., Graham R. C., Spektor D. M., Lippmann M. Influence of breathing mode and activity level on the regional deposition of inhaled particles and implications for regulatory standards. Ann. Occup. Hyg. 1988; 32(S1)3–10
  • Miller F. J., Anjilvel S., Ménache M. C., Asgharian B., Cerrity T. R. Dosimetric issues relating to particulate toxicity. Inhal. Toxicol. 1995; 7: 615–632
  • Newton P. E., Pfledderer C. Measurement of the deposition and clearance of inhaled radiolabeled particles from rat lungs. J Appl. Toxicol. 1986; 6(2)113–119
  • Patra A. L., Ménache M. C., Shaka N. B., Cooya A. A morphometric study of nasal-pharyngeal growth for particle deposition in the rat. Am. Ind. Hyg. Assoc. J 1987; 48(6)556–562
  • Raabe O. G., Yeh H. C., Newton G. J., Phalen R. F., Velasquez D. J. Deposition of inhaled monodisperse aerosols in small rodents. Inhaled particles IV, W. H. Walton. Pergamon Press, Oxford 1977; 3–21
  • Raabe O. G., Al-Bayati M. A., Teague S. V., Rasolt A. Regional deposition of inhaled monodisperse coarse and fine aerosol particles in small laboratory animals. Ann. Occup. Hyg. 1988; 32(S1)53–63
  • Rudolf G. A mathematical model for the deposition of aerosol particles in the human respiratory tract. J Aerosol Sci. 1984; 15: 195–199
  • Rudolf G., Gebhart J., Heyder J., Scheuch G., Stahlhofen W. Modelling the deposition of aerosol particles in the human respiratory tract. J. Aerosol Sci. 1983; 14: 188–192
  • Rudolf G., Gebhart J., Heyder J., Scheuch G., Stahlhofen W. Mass deposition from inspired polydisperse aerosols. Ann. Occup. Hyg. 1988; 32(S1)919–938
  • Rudolf G., Köbrich Stahlhofen W., James A. C. Regional aerosol deposition in man–-A statistical and algebraic model. Ann. Occup. Hyg. 1994; 38(S1)1–14
  • SAS Institute, Inc. SAS/STAT User's Guide, Version, 4th ed. SAS Institute, Inc., Cary, NC 1989; vols. 1–2: 6
  • Schlesinger R. B. Comparative deposition of inhaled aerosols in experimental animals and humans: A review. J. Toxicol. Environ. Health 1985; 15: 197–214
  • Shiotsuka R. N., Costa D. L., Osheroff M. R., Drew R. T. Method of measuring deposition of unlabeled monodisperse microspheres in rat lungs. J Toxicol. Environ. Health 1987; 21: 1–13
  • Stahlhofen W., Gebhart J., Heyder J. Experimental determination of the regional deposition of aerosol particles in the human respiratory tract. Am. Ind. Hyg. Assoc. J. 1980; 41: 385–398
  • Stahlhofen W., Rudolf G., James A. C. Intercomparison of experimental regional aerosol deposition data. J. Aerosol Med. 1989; 2(3)285–308
  • U.S. Environmental Protection Agency. Recommendations for and Documentation of Biological Values for Use in Risk Assessment. Office of Health and Environmental Assessment, Cincinnati, OH 1988, Environmental Criteria and Assessment Office. EPA report no. EPA-600/6–87–008. Available from NTIS, Springfield, VA, PB88–179874
  • Weibel E. R. Morphometry of the human lung. Academic Press, New York 1963
  • Yeh H. C., Schum G. M. Models of human lung airways and their application to inhaled particle deposition. Bull. Math. Biol. 1980; 42: 461–480
  • Yeh H. C., Schum G. M., Duggan M. T. Anatomic models of the tracheobronchial and pulmonary regions of the rat. Anat. Rec. 1979; 195: 483–492
  • Yeh H. C., Snipes M. B., Eidson A. F., Hobbs C. H. Comparative evaluation of nose-only versus whole-body inhalation exposures for rats–-Aerosol characteristics and lung deposition. Inhal. Toxicol. 1990; 2: 205–221
  • Yu C. P., Xu G. B. Predictive models for deposition of diesel exhaust particulates in human and rat lungs. Aerosol Sci. Technol. 1986; 5: 337–347
  • Yu C. P., Diu C. K. Total and regional deposition of inhaled aerosols in humans. J. Aerosol Sci. 1983; 14(5)699–609
  • Yu C. P., Diu C. K., Soong T. T. Statistical analysis of aerosol deposition in nose and mouth. Am. Ind. Hyg. Assoc. J 1981; 42: 726–733
  • Zhang L., Yu C. P. Empirical equations for nasal deposition of inhaled particles in small laboratory animals and humans. Aerosol Sci. Technol. 1993; 19: 51–56

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.