Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 8, 1996 - Issue 6
7
Views
2
CrossRef citations to date
0
Altmetric
Research Article

Effects of Repeated Exposure to Nitric Acid Vapor and Ozone on Respiratory Tract Clearance in the Rat

, , , &
Pages 595-605 | Received 30 Oct 1995, Accepted 17 Jan 1996, Published online: 27 Sep 2008

References

  • Amdur M. O. Sulfuric acid: The animals tried to tell us. Appl. Ind. Hyg. 1989; 4: 189–197
  • Aris R., Christian D., Sheppard D., Balmes J. R. Acid fog-induced bronchoconstriction. The role of hydroxymethanesulfonic acid. Am. Rev. Respir. Dis. 1990; 141: 546–551
  • Aris R., Christian D., Sheppard D., Balmes J. R. Lack of bronchoconstrictor response to sulfuric acid aerosols and fogs. Am. Rev. Respir. Dis. 1991; 143: 744–758
  • Aris R., Christian D., Tager I., Ngo L., Finkbeiner W. E., Balmes J. R. Effects of nitric acid gas alone or in combination with ozone on healthy volunteers. Am. Rev. Respir. Dis. 1993; 148: 965–973
  • Frager N. B., Phalen R. F., Kenoyer J. L. Adaptation to ozone in reference to mucociliary clearance. Arch. Environ. Health 1979; 34: 51–57
  • Hinrichs R. J., Kenoyer J. L., Phalen R. F., Crocker T. T. Labeling of monodisperse polystyrene microspheres with tightly bound 51Cr. Am. Ind. Hyg. Assoc. J. 1978; 39: 570–575
  • Horvath S. M., Folinsbee L. J., Bedi J. F. Combined effect of ozone and sulfuric acid on pulmonary function in man. Am. Ind. Hyg. Assoc. J. 1987; 48: 94–98
  • Kenoyer J. L., Phalen R. F., Davis J. R. Particle clearance from the respiratory tract as a test of toxicity: Effect of ozone on short and long term clearance. Exp. Lung Res. 1981; 2: 111–120
  • Kleinman M. T., Bailey R. M., Chang Y., Clark K. W., Jones M. P., Linn W. S., Hackney J. D. Exposures of human volunteers to a controlled atmospheric mixture of ozone, sulfur dioxide and sulfuric acid. Am. Ind. Hyg. J. 1981; 42: 61–69
  • Kulle T. J., Kerr H. D., Farrell B. P., Sauder L. R., Bermel M. S. Pulmonary function and bronchial reactivity in human subjects with exposure to ozone and respirable sulfuric acid aerosol. Am. Rev. Respir. Dis. 1982; 126: 996–1000
  • Last J. A., Hyde D. M., Guth D. J., Warren D. L. Synergistic interaction of ozone and respirable aerosols on rat lungs. I. Importance of aerosol acidity. Toxicology 1986; 39: 247–257
  • Lippmann M. Health effects of ozone, a critical review. J. Air Pollut. Control Assoc. 1989; 39: 672–695
  • Mannix R. C., Phalen R. F., Kenoyer J. L., Crocker T. T. Effect of sulfur dioxide sulfate exposure on rat respiratory tract clearance. Am. Ind. Hyg. Assoc. I. 1982; 43: 679–685
  • Mannix R. C., Phalen R. F., Walters R. B., Kurosaki T. T. Effects of sulfur dioxide and formaldehyde on particle clearance in the rat. J. Toxicol. Environ. Health 1983; 12: 429–440
  • Mannix R. C., Phalen R. F., Nguyen T. N. Effects of sulfuric acid on ferret respiratory tract clearance. Inhal. Toxicol. 1991; 3: 277–291
  • Mercer T. T., Tillery M. I., Newton G. J. A multistage low flow rate cascade impactor. J. Aerosol. Sci. 1970; 1: 9–15
  • Nadziejko C. E., Nansen L., Mannix R. C., Kleinman M. T., Phalen R. F. Effect of nitric acid vapor on the response to inhaled ozone. Inhal. Toxicol. 1992; 4: 343–358
  • Patrick G. The retention of uranium dioxide particles in the trachea of the rat. Int. J. Radial Biol. 1979; 35: 571–576
  • Patrick G, Stirling C. The retention of particles in large airways of the respiratory tract. Proc. R. Soc. Lond., Ser. B 1977; 198: 455–462
  • Phalen R. F., Hallford J. D., Kenoyer J. L. Particle deposition and clearance as a test of toxic effect. Proc. 6th Annual Conf. Environmental Toxicology. 1975; 83–86, Available from NTIS, report ARML-TR-75–125
  • Phalen R. F., Kenoyer J. L., Crocker T. T., McClure T. R. Effects of sulfate aerosols in combination with ozone on elimination of tracer particles inhaled by rats. J. Toxicol. Environ. Health 1980; 6: 797–810
  • Prasad S. B., Rao V. S., Mannix R. C., Phalen R. F. Effects of pollutant atmospheres on surface receptors of pulmonary macrophages. J. Toxicol. Environ. Health 1988; 24: 385–402
  • Prasad S. B., Rao V. S., McClure T. R., Mannix R. C., Phalen R. F. Toxic effects of short-term exposures to acids and diesel exhaust. J. Aerosol Med. 1990; 3(2)147–163
  • Raabe O. G. Operating characteristics of two compressed air nebulizers used in inhalation experiments. 1972, Fission Product Inhalation Program Annual Report, 1971–1972, LF-45:1–6. Available from the National Technical Information Service, U.S. Department of Commerce, 5285 Port Royal Road, Springfield, VA 22161
  • Raabe O. G., Bennick J. E., Light M. E., Hobbs C. H., Thomas R. L., Tillery M. I. An improved apparatus for acute inhalation exposure of rodents to radioactive aerosols. J. Toxicol. Appl. Pharmacol. 1973; 26: 264–273
  • Raabe O. G., Yeh H. C., Newton G. J., Phalen R. F., Velasquez D. J. Deposition of inhaled monodisperse aerosols in small rodents. Inhaled particles IV, W. H. Walton. Pergamon, Oxford 1977; 1–21, part 1
  • Raabe O. G., Al-Bayati M. A., Teague S. V., Rasolt A. Regional deposition of inhaled monodisperse coarse and fine aerosol particles in small laboratory animals. Ann. Occup. Hyg. 1988; 32(suppl. 1)53–63
  • Russel A. G., McRae G. J., Cass G. R. The dynamics of nitric acid production and the fate of nitrogen oxides. Atmos. Environ. 1985; 19: 893–904
  • Schlesinger R. B., Gorczynski J. E., Dennison J., Richards L., Kinney P. L., Bosland M. C. Long-term intermittent exposure to sulfuric acid aerosol, ozone and their combination: Alterations in tracheobronchial mucociliary clearance and epithelial secretory cells. Exp. Lung Res. 1992a; 18: 505–534
  • Schlesinger R. B., Zelikoff J. T., Chen L. C., Kinney P. L. Assessment of toxicologic interactions resulting from acute inhalation exposure to sulfuric acid and ozone mixtures. Toxicol. Appl. Pharmacol. 1992b; 115: 183–190
  • Schlesinger R. B., El-Fawal H. A. N., Zelikoff J. T., Gorczynski J. E., McGovern T., Nadziejko C. E., Chen L. C. Pulmonary effects of repeated episodic exposures to nitric acid vapor alone and in combination with ozone. Inhal. Toxicol. 1994; 6: 21–41
  • Schum M., Yeh H. Theoretical evaluation of aerosol deposition in anatomical models of mammalian lung airways. Bull. Math. Bio. 1980; 42: 1–15
  • Schwartz L. W., Tyler W. S., Dungworth D. L. Pulmonary changes induced by ambient levels of ozone: A morphological study. Proc. 5th Annu. Conf. Environmental Toxicology. 1974; 367–382, Available from NTIS, report AMRL-TR-74–125
  • Stacy R. W., Seal E., Jr., House D. E., Green J., Roger L. J., Raggio L. A survey of effects of gaseous and aerosol pollutants on pulmonary function of normal males. Arch. Environ. Health 1983; 38: 104–115
  • Warheit D. B. Interspecies comparisons of lung responses to inhaled particles and gases. Crit. Rev. Toxicol. 1989; 20: 1–29

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.