Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 8, 1996 - Issue 9
17
Views
23
CrossRef citations to date
0
Altmetric
Research Article

Incorporation of Nasal-Lining Mass-Transfer Resistance into Acfd Model for Prediction of Ozone Dosimetry in the Upper Respiratory Tract

, &
Pages 831-857 | Accepted 11 May 1996, Published online: 27 Sep 2008

References

  • Aharonson E. F., Menkes H., Gurtner C., Swift D. L., Proctor D. F. Effects of respiratory airflow rate on removal of soluble vapors by the nose. J. Appl. Physiol. 1974; 37: 654–657
  • Calderon-Carciduenas L., Osnoro-Velazquez A., Bravo-Alvarez H., Delgado-Chavez R., Barrios-Marquez R. Histopathological changes of nasal mucosa in southwest metropolitan Mexico City inhabitants. Am. J. Pathol. 1992; 140: 225–232
  • Cohen Hubal E. A., Fedkiw P. S., Kimbell J. S. Mass-transport models to predict toxicity of inhaled gases in the upper respiratory tract. J. Appl. Physiol. 1996; 80(4)1415–1427
  • Cussler E. L. Diffusion: Mass transfer in fluid systems. Cambridge University Press, Cambridge 1984
  • Hanna L. M., Frank R., Scherer P. Absorption of soluble gases and vapors in the respiratory system. Respiratory physiology: An analytical approach, H. K. Chang, M. Parna. Marcel Dekker, New York 1989; 277–316
  • Harkema J. R. Comparative aspects of nasal airway anatomy: Relevence to inhalation toxicology. Toxicol. Pathol. 1991; 19: 321–336
  • Harkema J. R., Hotchkiss J. A. Ozone-induced proliferative and metaplastic lesions in nasal transitional and respiratory epithelium: Comparative pathology. Inhal. Toxicol. 1994; 6((suppl.))187–204
  • Harkema J. R., Hotchkiss J. A., Henderson R. F. Effects of 0.1 2 and 0.88 ozone on rat nasal and nasopharyngeal epithelial mucosubstances: Quantitative histochemistry. Toxicol. Pathol. 1989; 17: 525–535
  • Hatch C. E., Wiester M. J., Overton J. H., Aissa M. Respiratory tract dosimetry of 18O-labeled ozone in rats: Implications for a rat-human extrapolation of dose. Atmospheric ozone research and its policy implications, T. Schneider, S. D. Lee, G. T. R. Walters, L. D. Grant. Elsevier, Amsterdam 1989; 553–565
  • Hatch G. E., Harkema J. R., Plopper C. G., Harris L. Ozone dosimetry studies in the nose and eye using oxygen-18. Inhal. Toxicol. 1994; 6((suppl.))125–134
  • Hildebrand F. B. Advanced calculus for applications. Prentice Hall, Englewood Cliffs, NJ 1976
  • Hotchkiss J. A., Herrera L. K., Harkema J. R., Kimbell J. S., Morgan K. T., Hatch G. E. Regional differences in ozone-induced nasal epithelial cell proliferation in F344 rats: Comparison with computational mass flux predictions of ozone dosimetry. Inhal. Toxicol. 1994; 6((suppl.))390–392
  • Kimbell J. S., Gross E. A., Joyner D. R., Godo M. N., Morgan K. T. Application of computational fluid dynamics to regional dosimetry of inhaled chemicals in the upper respiratory tract of the rat. Toxicol. Appl. Pharmacol. 1993; 121: 253–263
  • Kimbell J. S., Gross E. A., Harkema J. R., Godo M. N., Richardson R. A., Joyner D. R., Morgan K. T. Spatial distribution and surface area of the major epithelial types in F344 rat anterior nasal passages. Am. J. Respir. Crit. Care Med. 1994; 149: A994
  • Lippmann M. Health effects of ozone: A critical review. J. Air Pollut. Control Assoc. 1989; 39: 672–695
  • Miller F. J. A Mathematical Model of Transport and Removal of Ozone in the Mammalian Lungs. North Carolina State University, Raleigh, NC 1977
  • Miller F. J. Uptake and fate of ozone in the respiratory tract. Toxicol. Lett. 1995; 82/83: 277–285
  • Miller F. J., Menzel D. B., Coffin D. L. Similarity between man and laboratory animals in regional pulmonary deposition of ozone. Environ. Res. 1978; 17: 84–101
  • Miller F. J., Overton J. H., Jaskot R. H., Menzel D. B. A model of the regional uptake of gaseous pollutants in the lung: I. The sensitivity of the uptake of ozone in the human lung to lower respiratory tract secretions and exercise. Toxicol. Appl. Pharmacol. 1985; 79: 11–27
  • Morgan K. T., Jiang X. Z., Patterson D. L., Gross E. A. The nasal mucociliary apparatus: Correlation of structure and function in the rat. Am. Rev. Respir. Dis. 1984; 130: 275–281
  • Pryor W. A. How far does ozone penetrate into the pulmonary air/tissue boundary before it reacts?. Free Radical Biol. Med. 1992; 12: 83–88
  • Raub J. A. Air Quality Criteria for Ozone and Related Photochemical Oxidants. National Center for Environmental Assessment, U.S. Environmental Protection Agency, Washington, DC 1995
  • Scherer P. W., Keyhani K., Mozell M. M. Nasal dosimetry modelling for humans. Inhal. Toxicol. 1994; 6: 85–97
  • Ultman J. S. Transport and uptake of inhaled gases. Air pollution, the automobile, and public health, A. Y. Watson, R. R. Baker, D. Kemway. National Academy Press, Washington, DC 1988; 323–366

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.