Reexamination of Respiratory Tract Responses in Rats, Mice, and Rhesus Monkeys Chronically Exposed to Inhaled Chlorine

References

• Akpavie S. O., Pirie H. M. The globule leucocyte: Morphology, origin, function and fate, a review. Anat. Histol. Embryol. 1989; 18: 87–95
   PubMed Web of Science ®Google Scholar
• Amoore J. E. Effects of chemical exposure on olfaction in humans, C. S. Barrow. Hemisphere, Washington, DC 1986
   Google Scholar
• Bardana E. J. J. Occupational asthma and related respiratory disorders. Dis. Man 1995; 41: 143–199
   PubMed Web of Science ®Google Scholar
• Benninger M. S. Nasal mucociliary transport after exposure to swimming pool water. Am. J. Rhinol. 1994; 8: 207–209
   Google Scholar
• Bolon B., Bonnefoi M. S., Roberts K. C., Marshall M. W., Morgan K. T. Toxic interactions in the rat nose: Pollutants from soiled bedding and methyl bromide. Toxicol. Pathol. 1991; 19: 571–579
   PubMed Web of Science ®Google Scholar
• Boysen M., Reith A. The surface structure of the human nasal mucosa. II. Metaplasia, dysplasia and carcinoma in nickel workers. A correlated study by scanning/transmission electron and light microscopy. Virchows Arch. [Cell Pathol.] 1982; 40: 295–309
   Google Scholar
• Buckley L. A., Jiang X. Z., James R. A., Morgan K. T., Barrow C. S. Respiratory tract lesions induced by sensory irritants at the RD50 concentration. Toxicol. Appl. Pharmacol. 1984; 74: 417–429
   PubMed Web of Science ®Google Scholar
• Buckley L. A., Morgan K. T., Swenberg J. A., James R. A., Hamm T. E. J., Barrow C. S. The toxicity of dimethylamine in F-344 rats and B6C3F1 mice following a 1 year inhalation exposure. Fundam. Appl. Toxicol. 1985; 5: 341–352
   PubMedGoogle Scholar
• Calderon-Garcidueñas L., Rodriguez-Alcaraz A., Garcia R., Sanchez G., Barragan G., Camacho R., Ramirez L. Human nasal mucosal changes after exposure to urban pollution. Environ. Health Perspect. 1994; 102: 1074–1080
   PubMed Web of Science ®Google Scholar
• Chemical Industry Institute of Toxicology. Chronic Inhalation Study of Chlorine Gas Toxicity in Female and Male B6C3F1 Mice and F344 Rats. CIIT. 1993
   Google Scholar
• Coulston F. Editorial. Qual. Ass. Good Pract. Law 1993; 2: 211–212
   PubMedGoogle Scholar
• DeSesso J. M. The relevance to humans of animal models for inhalation studies of cancer in the nose and upper airways. Qual. Ass. Good Pract. Law 1993; 2: 213–231
   PubMedGoogle Scholar
• Ferris B. C., Puleo S., Chen H. Y. Mortality and morbidity in a pulp and a paper mill in the United States: A ten-year follow-up. Br. J. Ind. Med. 1979; 36: 127–134
   PubMedGoogle Scholar
• Frederick C. B., Morris J. B., Kimbell J. S., Morgan K. T., Hanna L. M., Scherer P. W. Comparison of four biologically-based dosimetry models for the rodent nasal cavity to describe the deposition and distribution of rapidly metabolized vapors. Inhal. Toxicol. 1994; 6: 135–157
   Web of Science ®Google Scholar
• Getchell T. V., Doty R. L., Bartoshuk L. M., Snow J. B. J. Smell and taste in health and disease. Raven Press, New York 1991
   Google Scholar
• Gibson W. D. Chlorine: Reaction central. Chemical Business 1994; 13, January
   Google Scholar
• Gleich C. J., Adolphson C. R., Leiferman K. M. Eosinophils. Inflammation: Basic principles and clinical correlates, 2nd ed., M. I Goldstein, J. I. Gallin, R. Snyderman. Raven Press, New York 1992; 663–692
   Google Scholar
• Gross E. A., Patterson D. L., Morgan K. T. Effects of acute and chronic dimethyl-amine exposure on the nasal mucociliary apparatus of F-344 rats. Toxicol. Appl. Pharmacol. 1987; 90: 359–376
   PubMed Web of Science ®Google Scholar
• Harkema J. R. Comparative aspects of nasal airway anatomy: Relevance to inhalation toxicology. Toxicol. Pathol. 1991; 19: 321–336
   PubMed Web of Science ®Google Scholar
• Harkema J. R., Plopper C. G., Hyde D. M., StGeorge J. A., Dungworth D. L. Effects of an ambient level of ozone on primate nasal epithelial mucosubstances: Quantitative histochemistry. Am. J. Pathol. 1987; 127: 90–96
   PubMed Web of Science ®Google Scholar
• Harkema J. R., Hotchkiss J. A., Henderson R. F. Effects of 0.12 and 0.80 ppm ozone on rat nasal and nasopharyngeal epithelial mucosubstances: Quantitative histochemistry. Toxicol. Pathol. 1989; 17: 525–535
   PubMed Web of Science ®Google Scholar
• Harkema J. R., Morgan K. T., Gross E. A., Catalano P. J., Griffith W. C. Consequences of Prolonged Inhalation of Ozone on F344/N Rats: Collaborative Studies: Part VII: Effects on the mucociliary apparatus. Health Effects Institute, Cambridge, MA 1994, Report number 65
   Google Scholar
• Henneberger P. K., Lax M. B., Ferris B. G. J. Decrements in spirometry values associated with chlorine gassing events and pulp mill work. Am. J. Respir. Crit. Care Med. 1996; 153: 225–231
   PubMed Web of Science ®Google Scholar
• Hileman B., Long J. R., Kirschner E. M. Chlorine industry running flat out despite persistent health fears. Chem. Eng. News 1994; 12–26, November
   Web of Science ®Google Scholar
• Hotchkiss J. A., Harkema J. R., Henderson R. F. Effect of cumulative ozone exposure on ozone-induced nasal epithelial hyperplasia and secretory metaplasia in rats. Exp. Lun. 1990; 15: 589–600
   Google Scholar
• Jones R. N., Hughes J. M., Glindmeyer H., Weill H. Lung function after acute chlorine exposure. Am. Rev. Respir. Dis. 1986; 134: 1190–1195
   PubMed Web of Science ®Google Scholar
• Kennedy S. M., Enarson D. A., Janssen R. G., Chan-Yeung M. Lung health consequences of reported accidental chlorine gas exposures among pulpmill workers. Am. Rev. Respir. Dis. 1991; 143: 74–79
   PubMed Web of Science ®Google Scholar
• Kepler G. M., Joyner D. R., Fleishman A., Richardson R., Gross E. A., Morgan K. T., Kimbell J. S. Method for obtaining accurate geometrical coordinates of nasal airways for computer dosimetry modeling and lesion mapping. Inhal. Toxicol. 1995; 7: 1207–1224
   Web of Science ®Google Scholar
• Keyhani K., Scherer P. W., Mozell M. M. Numerical simulation of airflow in the human nasal cavity. J. Biomech. Eng. 1995; 117: 429–441
   PubMed Web of Science ®Google Scholar
• Kimbell J. S., Gross E. A., Joyner D. R., Godo M. N., Morgan K. T. Application of computational fluid dynamics to regional dosimetry of inhaled chemicals in the upper respiratory tract of the rat. Toxicol. Appl. Pharmacol. 1993; 121: 253–263
   PubMed Web of Science ®Google Scholar
• Kimbell J. S., Kepler G. M., Morgan K. T. Three-dimensional, steady-state inspiratory airflow simulations in rhesus monkey nasal passages. J. Aerosol Med. 1995; 8: 64, (abstr.)
   Google Scholar
• Kimbell J. S., Godo M. N., Gross E. A., Joyner D. R., Richardson R. B., Morgan K. T. Simulation of respiratory airflow in the olfactory region of the F344 rat nasal passages. Toxicologist 1996; 30: 99
   Google Scholar
• Klementsson H. Eosinophils and the pathophysiology of allergic rhinitis. Clin. Exp. Allergy 1992; 22: 1058–1064
   PubMed Web of Science ®Google Scholar
• Klonne D. R., Ulrich C. E., Riley M. C., Hamm T. E. J., Morgan K. T., Barrow C. S. One-year inhalation toxicity study of chlorine in rhesus monkeys (Macaca mulatta). Fundam. Appl. Toxicol. 1987; 9: 557–572
   PubMedGoogle Scholar
• Leopold D. A. Nasal toxicity: End points of concern in humans. Inhal. Toxicol. 1994; 6: 23–39
   Web of Science ®Google Scholar
• Manual of histological staining methods of the Armed Forces Institute of Pathology, 3rd., L. C. Luna. McGraw-Hill, New York 1968
   Google Scholar
• Lund V. J. Toxicity of nasal respiratory mucosa in humans. Inhal. Toxicol. 1994; 6: 277–287
   Web of Science ®Google Scholar
• McClellan R. O. Research strategy for assessing human risk from inhaled nasal toxicants. Inhal. Toxicol. 1994; 6: 11–21
   Web of Science ®Google Scholar
• Meggs W. J. RADS and RUDS—The toxic induction of asthma and rhinitis. Clin. Toxicol. 1994; 32: 487–501
   Web of Science ®Google Scholar
• Mery S., Gross E. A., Joyner D. R., Godo M., Morgan K. T. Nasal diagrams: A tool for recording the distribution of nasal lesions in rats and mice. Toxicol. Pathol. 1994; 22: 353–372
   PubMed Web of Science ®Google Scholar
• Moneret-Vautrin D. A., Jankowski R., Bene M. C., Kanny G., Hsieh V., Faure G., Wayoff M. NARES: A model of inflammation caused by activated eosinophils?. Rhinology 1992; 30: 161–168
   PubMedGoogle Scholar
• Morgan K. T., Gross E. A., Patterson D. L. Distribution, progression, and recovery of acute formaldehyde-induced inhibition of nasal mucociliary function in F-344 rats. Toxicol. Appl. Pharmacol. 1986; 86: 448–456
   PubMed Web of Science ®Google Scholar
• Morgan K. T., Kimbell J. S., Monticello T. M., Patra A. L., Fleishman A. Studies of inspiratory airflow patterns in the nasal passages of the F344 rat and rhesus monkey using nasal molds: Relevance to formaldehyde toxicity. Toxicol. Appl. Pharmacol. 1991; 110: 223–240
   PubMed Web of Science ®Google Scholar
• Morgan K. T., Gross E. A., Joyner D., Mery S. Mapping of lesions in the nose provides insight into mechanism of action of nasal toxicants. CIIT Activities 1995; 15: 1–10
   Google Scholar
• Philip G., Togias A. G. Nonallergic rhinitis. Eur. Arch. Otorhinolaryngol. 1995; 252((suppl. 1))S27–S32
   Google Scholar
• Plopper C. G., Chu F. P., Haselton C. J., Peake J., Wu J., Pinkerton K. E. Dose-dependent tolerance to ozone. I. Tracheobronchial epithelial reorganization in rats after 20 months' exposure. Am. J. Pathol. 1994; 144: 404–421
   PubMed Web of Science ®Google Scholar
• Rotman H. H., Fliegelman M. J., Moore T. Effects of low concentrations of chlorine on pulmonary function in humans. J. Appl. Physiol. 1983; 54: 1120–1124
   PubMed Web of Science ®Google Scholar
• Wolf D. C., Morgan K. T., Gross E. A., Barrow C., Moss O. R., James R. A., Popp J. A. Two-year inhalation exposure of B6C3F1 mice and F344 rats to chlorine induces nasal lesions confined to the nose. Fundam. Appl. Toxicol. 1995; 24: 111–131
   PubMedGoogle Scholar