38
Views
7
CrossRef citations to date
0
Altmetric
Original Article

Extracellular FGF-1 Inhibits Cytoskeletal Organization and Promotes Fibroblast Motility

, , , , , & show all
Pages 93-107 | Received 12 Nov 1999, Accepted 14 Dec 1999, Published online: 11 Jul 2009

References

  • Boudreau N. J., Jones P. L. Extracellular matrix and integrin signalling: the shape of things to come. Biochem. J 1999; 339: 481–488
  • Brooks P. C., Klemke R. L., Schon S., Lewis J. M., Schwartz M. A., Cheresh D. A. Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination, in vivo. J. Clin. Invest 1997; 99: 1390–1398
  • Burgess W. H., Maciag T. The heparin-binding (fibroblast) growth factor family of proteins. Annu. Rev. Biochem 1989; 58: 575–606
  • Cary L. A., Han D. C., Polte T. R., Hanks S. K., Guan J.-L. Identification of p 130Cas as a mediator of focal adhesion kinase-promoted cell migration. J. Cell Biol 1998; 140: 211–221
  • Clark E. A., Brugge J. S. Integrins and signal transduction pathways: the road taken. Science 1995; 268: 233–239
  • Fincham V. J., Chudleigh A., Frame M. C. Regulation of p190 Rho-GAP by v-Src is linked to cytoskeletal disruption during transformation. J. Cell Sci 1999; 112: 947–956
  • Folkman J., Klagsbrun M. Angiogenic factors. Science 1987; 235: 442–447
  • Forough R., Engleka K., Thompson J. A., Jackson A., Imamura T., Maciag T. Differential expression in Escherichia coli of the alpha and beta forms of heparin-binding acidic fibroblast growth factor-I: potential role of RNA secondary structure. Biochim. Biophys. Acta 1991; 1090: 293–298
  • Forough R., Xi Z., MacPhee M., Friedman S., Engleka K. A., Sayers T., Wiltrout R. H., Maciag T. Differential transforming abilities of non-secreted and secreted forms of human fibroblast growth factor-1. J. Biol. Chem 1993; 268: 2960–2968
  • Friesel R. E., Maciag T. Molecular mechanisms of angiogenesis: fibroblast growth factor signal transduction. FASEBJ 1995; 9: 919–925
  • Gladson C. L., Wilcox J. N., Sanders L., Gillespie G. Y., Cheresh D. A. Cerebral microenvironment influences expression of the vitronectin gene in astrocytic tumors. J. Cell Sci 1995; 108: 947–956
  • Guidry C., Hook M. Endothelins produced by endothelial cells promote collagen gel contraction by fibroblasts. J. Cell Biol 1991; 115: 873–880
  • Hildebrand J. D., Taylor J. M., Parsons J. T. An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase. Molec. Cell. Bid 1996; 16: 3169–3178
  • Huang C., Ni Y., Wang T., Gao Y., Haudenschild C. C., Zhan X. Down-regulation of the filamentous actin cross-linking activity of cortactin by Src-mediated tyrosine phosphorylation. J. Biol. Chem 1997; 272: 13911–13915
  • Hynes R. O. Integrins: a family of cell surface receptors. Cell 1987; 48: 549–554
  • Jaye M., Schlessinger J., Dionne C. A. Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction. Biochim. Biophys. Acta 1992; 1135: 185–199
  • Klemke R. L., Yebra M., Bayna E. M., Cheresh D. A. Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin. J. Cell Biol 1994; 127: 859–866
  • Klemke R. L., Leng J., Molander R., Brooks P. C., Vuori K., Cheresh D. A. CAS/Crk coupling serves as a “molecular switch” for induction of cell migration. J. Cell Bid 1998; 140: 961–972
  • LaVallee T. M., Prudovsky L. A., McMahon G. A., Hu X., Maciag T. Activation of the MAP kinase pathway by FGF-1 correlates with cell proliferation induction while activation of the Src pathway correlates with migration. J. Cell Biol 1998; 141: 1647–1658
  • Leavesley D. I., Ferguson G. D., Wayner E. A., Cheresh D. I. Requirement of the integrin beta 3 subunit for carcinoma cell spreading or migration on vitronectin and fibrinogen. J. Cell Biol 1992; 117: 1101–1107
  • Maciag T., Friesel R. E. Molecular mechanisms of fibroblast growth factor-1 trafficking, signaling and release. Thrombosis and Haemostasis 1995; 74: 411–414
  • McManus M. J., Lingle W. L., Salisbury J. L., Maihle N. J. A transformation-associated complex involving tyrosine kinase signal adapter proteins and caldesmon links v-erbB signaling to actin stress fiber disassembly. Proc. Natl. Acad. Sci 1997; 94: 11351–11356
  • Nobes C. D., Hall A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 1995; 81: 53–62
  • Opalenik S. R., Shin J. T., Wehby J. N., Mahesh V. K., Thompson J. A. The HIV-I TAT protein induces the expression and extracellular appearance of acidic fibroblast growth factor. J. Bid. Chem 1995; 270: 17457–17467
  • Pijuan-Thompson V., Gladson C. L. Ligation of integrin alpha-5-beta-1 is required for internalization of vitronectin by integrin alpha-v-beta-3. J. Biol. Chem 1997; 272: 2736–2743
  • Polte T. R., Hanks S. K. Complexes of focal adhesion kinase (FAK) and Crk-associated substrate (p130(Cas)) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation. Requirements for Src kinase activity and FAK proline-rich motifs. J. Biol. Chem 1997; 272: 5501–5509
  • Richardson A., Parsons J. T. Signal transduction through integrins: a central role for focal adhesion kinase?. Bioassays 1995; 17: 229–236
  • Robinson M. L., Overbeek P. A., Verran D. J., Grizzle W. E., Stockard C. R., Friesel R., Maciag T., Thompson J. A. Extracellular FGF-I acts as a lens differentiation factor in transgenic mice. Development 1995; 121: 505–514
  • Rogelj S., Weinberg R. A., Fanning P., Klagsbrun M. Basic fibroblast growth factor fused to a signal peptide transforms cells. Nature 1988; 331: 173–175
  • Rosales C., O'Brien V., Kornberg L., Juliano R. Signal transduction by cell adhesion receptors. Biochim. Biophys. Acta 1995; 1242: 77–98
  • Rozzo C., Ratti P., Ponzoni M., Cornaglia-Ferraris P. Modulation of alpha-l beta-I, alpha-2 beta-1 and alpha-3 beta-I integrin heterodimers during human neuro-blastoma cell differentiation. FEBS Letters 1993; 332: 263–267
  • Ruoslahti E. Integrins as signaling molecules and targets for tumor therapy. Kid. Int 1997; 51: 1413–1417
  • Schaller M. D., Hildebrand J. D., Shannon J. D., Fox J. W., Vines R. R., Parsons J. T. Autophosphorlyation of the focal adhesion kinase, ppl25FAK, directs SH2-dependent binding of pp60src. Molec. Cell. Bid 1994; 14: 1680–1688
  • Schlaepfer D. D., Broome M. A., Hunter T. Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb 2, p130cas, and Nck adaptor proteins. Molec. Cell. Biol 1997; 17: 1702–1713
  • Schwartz M. A., Schaller M. D., Ginsberg M. H. Integrins: emerging paradigms of signal transduction. Annu. Rev. Cell Dev. Biol 1995; 11: 549–599
  • Shin J. T., Opalenik S. R., Wehby J. N., Mahesh V. K., Jackson A., Tarantini F., Maciag T., Thompson J. A. Serum-starvation induces the extracellular appearance of FGF-1. Biochim. Biophys. Acta 1996; 1312: 27–38
  • Tachibana K., Urano T., Fujita H., Ohashi Y., Kamiguchi K., Iwata S., Hirai H., Morimoto C. Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates. J. Biol. Chem 1997; 272: 29083–29090
  • Taylor J. M., Macklem M. M., Parsons J. T. Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho. J. Cell Sci 1999; 112: 231–242
  • Thompson J. A., Anderson K. D., DiPietro J. M., Zwiebel J. A., Zametta M., Anderson W. F., Maciag T. Site-directed neovessel formation, in vivo. Science 1988; 241: 1349–1352
  • Thompson J. A., Haudenschild C. C., Anderson K. D., DiPietro J. M., Anderson W. F., Maciag T. Heparin-binding growth factor 1 induces the formation of organoid neovascular structures, in vivo. Proc. Natl. Acad. Sci 1989; 86: 7928–7932
  • Valles A. M., Boyer B., Tarone G., Thiery J. P. Alpha-2-beta-1 integrin is required for the collagen and FGF-1 induced cell dispersion in a rat bladder carcinoma cell line. Cell Adhes. Commun 1996; 4: 187–199
  • Vuori K., Hirai H., Aizawa S., Ruoslahti E. Induction of p130 cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases. Molec. Molec. Cell. Biol 1996; 16: 2606–2613
  • Wojciak-Stothard B., Williams L., Ridley A. J. Monocyte adhesion and spreading on human endothelial cells is dependent on Rho-regulated receptor clustering. J. Cell. Biol 1999; 145: 1293–1307
  • Zhan X., Plourde C., Hu X., Friesel R., Maciag T. Association of fibroblast growth factor receptor-1 with c-Src correlates with association between c-Src and cortactin. J. Biol. Chem 1994; 269: 20221–20224

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.