17
Views
6
CrossRef citations to date
0
Altmetric
Original Article

Identification of an Alternatively Spliced mRNA Transcript of Human Betacellulin Lacking the C-Loop of the EGF Motif and the Transmembrane Domain

&
Pages 169-175 | Received 27 Mar 2000, Accepted 01 Jun 2000, Published online: 11 Jul 2009

References

  • Alimandi M., Wang L.-M., Bottaro D., Lee C.-C., Kuo A., Frankel M., Fedi P., Tang C., Lippman M., Pierce J. H. Epidermal growth factor and betacellulin mediate signal transduction through co-expressed ErbB2 and ErbB3 receptors. EMBO J 1997; 16: 5608–5617
  • Alroy I., Yarden Y. The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial tigand-receptor interactions. FEBS Letters 1997; 410: 83–86
  • Beerli R. R., Hynes N. E. Epidermal growth factor-related peptides activate distinct subsets of erbB receptors and differ in their biological activities. J. Biol. Chem 1996; 271: 6071–6076
  • Boyd C. D., Pierce R. A., Schwarzbauer J. E., Doege K., Sandell L. J. Alternate exon usage is a commonly used mechanism for increasing coding diversity within genes coding for extracellular matrix proteins. Matrix 1993; 13: 457–469
  • Carpenter G., Walsh M. I. The epidermal growth factor family. peptide Growth Factors and their Receptors, M. D. Sporn, A. B. Roberts. Springer, New York 1990; 69–171
  • Carraway K. L., III, Weber J. L., Unger M. J., Ledesma J., Yu N., Gassmann M., Lai C. Neuregulin-2, a new ligand of ErbB3/erbB4-receptor tyrosine kinases. Nature 1997; 387: 512–516
  • Chang H., Riese D. J., II, Gilbert W., Stem D. F., McMahan U. J. Ligands for ErbB-family receptors encoded by a neuregulin-like gene. Nature 1997; 387: 509–512
  • Harari D., Tzahar E., Romano J., Shelly M., Pierce J. H., Andrews G. C., Yarden Y. Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase. Oncogene 1999; 18: 2681–2689
  • Higashiyama S., Abraham J. A., Miller J., Fiddes J. C., Klagsbrun M. A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science 1991; 251: 936–939
  • Huotari M.-A., Palgi J., Otonkoski T. Growth factor-mediated proliferation and differentiation of insulin-producing INS-I and RINm5F cells: identification of betacellulin as a novel β-cell mitogen. Endocrinology 1998; 139: 1494–1499
  • Ishiyama N., Kanzaki M., Seno M., Yamada H., Kobayashi I., Kojima I. Studies on the betacellulin receptor in pancreatic AR42J cells. Diabetologia 1998; 41: 623–628
  • Jones J. T., Akita R. W., Sliwkowski M. X. Binding specificities and affinities of EGF domains for ErbB receptors. FEBS Letters 1999; 447: 227–231
  • Loukianov E., Loukinanov T., Wiedlocha A., Olsnes S. Expression of mRNA for a short form of heparin-binding EGF-like growth factor. Gene 1997; 195: 81–86
  • Marchionni M. A., Goodearl A. D., Chen M. S., Bermingham-McDonogh O., Kirk C., Hendricks M., Danehy F., Msumi D., Sudhalter J., Kobayashi K. Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system. Nature 1993; 362: 312–318
  • Marquardt H., Hunkapiller M. W., Hood L. E., Todaro G. J. Rat transforming growth factor type-1: structure and relation to epidermal growth factor. Science 1984; 223: 1079–1082
  • Mashima H., Ohnishi H., Wakabayashi K., Mine T., Miyagawa J., Hanafusa T., Seno M., Yamada H., Kojima I. Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells. J. Clin. Invest 1996; 97: 1647–1654
  • Mashima H., Yamada S., Tajima T., Seno M., Yamada H., Takeda J., Kojima I. Genes expressed during the differentiation of pancreatic AR42J cells into insulin-secreting cells. Diabetes 1999; 48: 304–309
  • Massague J., Pandiella A. Membrane-anchored growth factors. Annu. Rev. Biochem 1993; 62: 515–541
  • Pinkas-Kramarski R., Lenferink A. E.G., Bacus S. S., Lyass L., van de Poll M. L.M., Kkdpper L. N., Tzahar E., Sela M., van Zoelen E. J.J., Yarden Y. The oncogenic ErbB-2/ErbB-3 heterodimer is a surrogate receptor of the epidermal growth factor and betacellulin. Oncogene 1998; 16: 1249–1258
  • Riese D. J., II, Bermingham Y., van Raaj T. M., Buckley S., Plowman G. D., Stern D. F. Betacellulin activates the epidermal growth factor receptor and erbB-4 and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta. Oncogene 1996a; 12: 345–353
  • Riese D. J., II, Kim E. D., Elenius K., Buckley S., Klagsbrun M., Plowman G. D., Stern D. The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4. J. Biol. Chew 1996b; 271: 20047–20052
  • Sasada R., Ono Y., Taniyama Y., Shing Y., Folkman J., Igarashi K. Cloning and expression of CDNA encoding human betacellulin, a new member of the EGF family. Biochem. Biophys. Res. Commum 1993; 190: 1173–1179
  • Savage C. R., Inagami T., Cohen S. The primary structure of epidermal growth factor. J. Biol. Chem 1972; 247: 7612–7621
  • Shing Y., Christafori G., Hanahan D., Ono Y., Sasada R., Igarashi K., Folkman J. Betacellulin: A mitogen from pancreatic beta cell tumors. Science 1993; 259: 1604–1607
  • Shoyah M., Plowman G. D., McDonald V. L., Bradley J. G., Todaro G. J. Structure and function of human amphiregulin: a member of the epidermal growth factor family. Science 1989; 24: 1074–1076
  • Toyoda H., Komurasaki T., Uchida D., Takayama Y., Isobe T., Okuyama T., Hanada K. Epiregulin. A novel epidermal growth factor with mitogenic activity for rat primary hepatocytes. J. Biol. Chem 1995; 270: 7495–7500
  • Van der Geer P., Hunter T., Lindberg R. A. Receptor protein-tyrosine kinases and their signaling pathways. Ann Rev. Cell Biol 1994; 10: 251–337
  • Wang L.-M., Kuo A., Alimandi M., Veri M. C., Lee C.-C., Kapoor V., Ellmore N., Chen X.-H., Pierce J. H. ErbB2 expression increases the spectrum and potency of ligand-mediated signal transduction through ErbB4. Proc. Natl. Acad. Sci. USA 1998; 95: 6809–6814
  • Watada H., Kajimoto Y., Myagawa J., Hanafusa T., Hamaguchi K., Matsuoka T. A., Yamamoto K., Matsuzawa Y., Kawamori R., Yamasaki Y. Pdx-1 induces insulin and glucokinase expressions in α-TC 1 clone 6 cells in the presence of betacellulin. Diubefes 1996; 45: 1826–1831
  • Watanabe T., Shintani A., Nakata M., Shing Y., Folkman J., Igarashi K., Sasada R. Recombinant human betacellulin. Molecular structure, biological activities, and receptor interaction. J. Biol. Chem 1994; 269: 9966–9973
  • Zhang D., Sliwkowski M. X., Mark M., Frantz G., Akita R., Sun Y., Hillan K., Crowley C., Brush J., Godowski P. J. Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates erbB4. Proc. Natl. Acad. Sci. USA 1997; 94: 9562–9567

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.