18
Views
8
CrossRef citations to date
0
Altmetric
Original Article

Pharmacokinetic Analysis of Pegylated Megakaryocyte Growth and Development Factor in Humans

, , , , , , & show all
Pages 215-226 | Received 01 Jul 1999, Accepted 01 Jul 2000, Published online: 11 Jul 2009

References

  • Alexander W. S., Roberts A. W., Nicola N. A., Li R., Metcalf D. Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoesis in mice lacking the thrombopoietin receptor c-mpl. Blood 1996; 87: 2162–2170
  • Bartley T. D., Bogenberger J., Hunt P., Li Y.-S., Lu H. S., Martin F., Chang M.-S., Samal B., Nichol J. L., Swift S., Johnson M. J., Hsu R.-Y., Parker V. P., Suggs S., Skrine J. D., Merewether L. A., Clogston C., Hsu E., Hokom M. M., Hornkohl A., Choi E., Pangelinan M., Sun Y., Mar V., McNinch J., Simonet L., Jacobsen F., Xie C., Shutter J., Chute H., Basu R., Selander L., Trollinger D., Sieu L., Padilla D., Trail G., Elliott G., Izumi R., Covey T., Crouse J., Garcia A., Xu W., Del Castillo J., Biron J., Cole S., Hu M. C. -T., Pacifici R., Ponting I., Saris C., Wen D., Yung Y. P., Lin H., Bosselman R. A. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 1994; 77: 1117–1124
  • Bartocci A., Mastrogiannis D. S., Migliorti G., Stockert R. J., Wolkoff A. W., Stanley E. R. Macrophages specifically regulate the concentration of their own growth factor in the circulation. Proceedings of the National Academy of Sciences of the United States of America. 1987; 84: 6179–6183
  • Basser R. L., Clarke K., Rasko J. E.J., Cebon J., Green M. D., Grigg A. P., Zalcberg J., Cohen B., O'Byrne J., Menchaca D., Sheridan W. P., Fox R. M., Begley C. G. Randomised, blinded, placebo-controlled phase 1 trial of pegylatedrecombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) with filgrastim after dose-intensive chemotherapy in patients with advanced cancer. Blood 1997; 89: 3118–3128
  • Basser R. L., Rasko J. E.J., Clarke K., Cebon J., Green M. D., Hussein S., Alt C., Menchaca D., Tomita D., Marty J., Fox R. M., Begley C. G. Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer. Lancet 1996; 348: 1279–1281
  • Bloedow D., Vadhan-Raj S., Paton V., Johnston T., Yang T., Yang T., Yang T., Senn T., Ashby M., Sims P. Pharmacokinetics of recombinant human thrombopoietin (rhTPO) after intravenous administration in cancer patients (Abstract). Blood 1996; 88: 351a
  • Broudy V. C., Lin N. L., Kaushansky K. Thromobopoietin (c-Mpl-ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increase megakaryocyte ploidy, in vitro. Blood 1995; 85: 1719–1726
  • Chang M. S., McNinch J., Basu R., Shutter J., Hsu R., Perkins C., Mar V., Suggs S., Welcher A., Li L., Lu H., BartleyHunt T., Hunt P., Martin F., Samal B., Bogenberger J. Cloning and characterization of the human megakaryocyte growth and development factor (MGDF) gene. Journal of Biological Chemistry 1995; 270: 511–514
  • Choi E. S., Nichol J. L., Hokom M. M., Hornkohl A. C., Hunt P. Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional. Blood 1995; 85: 402–413
  • de Sauvage F. J., Hass P. E., Spencer S. D., Malloy B. E., Gurney A. L., Spencer S. A., Darbonne W. C., Henzel W. J., Wong S. C., Kuang W.-J., Oles K. J., Hultgren B., Jr., Colberg L. A., Goeddel D. V., Eaton D. L. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl-ligand. Nature 1994; 369: 553–538
  • Fielder P. J., Gurney A. L., Stefanich E., Marian M., Moore M. W., Carver-Moore K., de Sauvage F. J. Regulation of thrombopoietin levels by c-Mpl-mediated binding to platelets. Blood 1996; 87: 2154–2161
  • Gurney A. L., Kuang W.-J., Xie M.-H., Malloy B. E., Eaton D. L., de Sauvage F. J. Genomic structure, chromosomal localisation, and conserved alternative splice forms of thrombopoietin. Blood 1995; 85: 981–988
  • Harker L. A., Hunt P., Marzec U. M., Kelly A. B., Tomer A., Hanson S. R., Stead R. B. Regulation of platelet production and function by megakaryocyte growth and development factor in non-human primates. Blood 1996; 87: 1833–1844
  • Hokom M. M., Lacey D., Kinder O. B., Choi E., Kaufman S., Faust J., Rowan C., Dwyer E., Nichol J. L., Grasel T., Wilson J., Steinbrink R., Hecht R., Winters D., Boone T., Hunt P. Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice. Blood 1995; 86: 4486–4492
  • Ishikawa M., Okada Y., Satake-Ishikawa R., Kakitana M., Kawagishi M., Matsuki S., Kusada M., Asano K. Pharmacological effects of recombinant human granulocyte colony-stimulating factor modified by poly ethylene glycol on anticancer drug-induced neutropenia in mice. General Pharmacology 1994; 25: 533–537
  • Kato T., Iwamatsu A., Shimada Y., Horie K., Kokubo A., Maeda E., Ogami K., Sohma Y., Akahori H., Sudo Y., Kubomura N., Matsumoto A., Tahara T., Ohashi H., Tsumura H., Inoue H., Kawamura K., Miyazaki H. Purification and characterisation of thrombopoietin derived from thromboctyopenic rat plasma. Journal of Biochemistry 1995; 119: 229–236
  • Kuter D. J., Beeler D. L., Rosenberg R. D. The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production. Proceedings of the National Academy of Sciences of the United States of America. 1994; 91: 11104–11108
  • Kuter D. J., Rosenberg R. D. The reciprocal relationship of thrombopoietin (c-Mpl-ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood 1995; 85: 2720–2730
  • Layton J. E., Hockman H., Sheridan W., Morstyn G. Evidence for a novel in vivo control mechanism of granulopoiesis: Mature cell-regulated control of a regulatory growth factor. Blood 1989; 74: 1303–1307
  • Lok S., Kaushansky K., Holly R. D., Kuijper J. L., Lofton-Day C. E., Oort P. J., Grant F. J., Helpel M. D., Burkhead S. K., Kramer J. M., Bell L. A., Sprecher C. A., Blumberg H., Johnson R., Prunkard D., Ching A. F.T., Evans S. J., Sheppard P. O., Presnell S. R., O'Hara P. H., Hagen F. S., Roth G. J., Foster D. C. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl-ligand thrombopoietin. Nature 1994; 369: 568–571
  • McCarthy J. M., Sprugel K. H., Fox N. E., Sabath D. E., Kaushansky K. Murine thrombopoietin mRNA levels are modulated by platelet count. Blood 1995; 86: 3668–3675
  • Methia N., Louache F., Vainchenker W., Wendling F. Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood 1993; 82: 1395–1401
  • Meyers F. J., Paradise C., Scudder S. A., Goodman G., Konrad M. A phase 1 study including pharmacokinetics of polyethylene glycol conjugated interleukin-2. Clinical Pharmacology and Therapeutics 1991; 49: 307–313
  • Nichol J. L., Hokom M. M., Hornkohl A., Sheridan W. P., Ohashi H., Kato T., Li Y. S., Bartley T., Choi E., Bogenberger J., Skrine J. D., Knudten A., Chen J., Trail G., Sleeman L., Cole S., Grampp G., Hunt P. Megakaryocyte growth and development factor: analyses of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy-induced thrombocytopenia. Journal of Clinical Investigation 1995; 95: 2973–2978
  • O'Malley C. J., Rasko J. E.J., Basser R. L., McGrath K. M., Cebon J., Grigg A. P., Hopkins W., Cohen B., O'Byrne J., Green M. D., Fox R. M., Berndt M. C., Begley C. G. Administration of pegylated recombinant human megakaryocyte growth and development factor to humans stimulates the production of functional platelets that show no evidence of in vivo activation. Blood 1996; 88: 3288–3298
  • Rasko J. E.J., Basser R. L., Boyd J., Mansfield R., O'Malley C. J., Hussein S., Berndt M. C., Clarke K., O'Byrne J., Sheridan W. P., Grigg A. P., Begley C. G. Multilineage mobilization of peripheral blood progenitor cells in humans following administration of PEG-rHuMGDF. British Journal of Haematology 1997; 97: 871–880
  • Rasko J. E.J., O'Flaherty E., Begley C. G. Mpl-ligand (MGDF) alone and in combination with Stem Cell Factor (SCF) promotes proliferation and survival of human megakaryocyte, erythroid and granulocyte/macro-phage progenitors. Stem Cells 1997; 15: 33–42
  • Roskos L., Stead R., Harker L., Cebon J., Basser R., Begley G., Farese A., McVittie T., Tomita D., Paine T., Cheung E. A cytokinetic model of platelet (PLT) production and destruction following administration of PEG-rHuMGDF (Abstract). Blood 1997; 90: 171a
  • Stoffel R., Wiestner A., Skoda R. C. Thrombopoietin in thrombocytopenic mice: Evidence against regulation at the mRNA level and for a direct regulatory role of platelets. Blood 1996; 87: 567–513
  • Ulich T. R., del Castillo J., Yin S., Swift S., Padilla D., Senaldi G., Bennett L., Shutter J., Bogenberger J., Sun D., Samal B., Shimamoto G., Lee R., Steinbrink R., Boone T., Sheridan W. T., Hunt P. Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice. Blood 1995; 86: 971–976
  • Yamasaki M., Asano M., Okabe M., Morimoto M., Yokoo Y. Modification of recombinant granulocyte colony-stimulating factor (rhFILGRASTIM) and its derivative ND 28 with polyethylene glycol. Journal of Biochemistry 1994; 115: 814–819
  • Zeigler F. C., de Sauvage G., Widmer H. R., Keller G. A., Donahue C., Schreiber R. D., Malloy B., Hass P., Eaton D., Matthews W. In vitro megakaryo-cytopoietic and thrombopoietic activity of c-Mpl-ligand (TPO) on purified murine hematopoietic stem cells. Blood 1994; 84: 4045–4052

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.