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Articles

Limited but heterogeneous osteogenic response of human bone marrow mesenchymal stem cells to bone morphogenetic protein-2 and serum

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Pages 34-43 | Received 06 Feb 2009, Accepted 11 Sep 2009, Published online: 19 Oct 2009

References

  • Agata H, Asahina I, Yamazaki Y, Uchida M, Shinohara Y, Honda M, Kagami H, Ueda M. 2007. Effective bone engineering using periosteum-derived cells. J Dent Res. 86:79–83.
  • Canalis E, Economides AN, Gazzerro E. 2003. Bone morphogenetic proteins, their antagonists, and the skeleton. Endocr Rev. 24:218–235.
  • Chen D, Zhao M, Mundy GR. 2004. Bone morphogenetic proteins. Growth Factors. 22:233–241.
  • Diefenderfer DL, Osyczka AM, Reilly GC, Leboy PS. 2003. BMP responsiveness in human mesenchymal stem cells. Connect Tissue Res. 44:305–311.
  • Friedman MS, Long MW, Hankenson KD. 2006. Osteogenic differentiation of human mesenchymal stem cells is regulated by bone morphogenic protein-6. J Biol Chem. 98:538–554.
  • Jamali M, Karamboulas C, Rogerson PJ, Skerjanc IS. 2001. BMP signaling regulates Nkx2-5 activity during cardiomyogenesis. FEBS Lett. 509:126–130.
  • Kwong FN, Harris MB. 2008. Recent developments in the biology of fracture repair. J Am Acad Orthop Surg. 16:619–625.
  • Kwong FNK, Richardson SM, Evans CH. 2008. Chordin knockdown enhances the osteogenic differentiation of human mesenchymal stem cells. Arthritis Res Ther. 10:R65.
  • Osyczka AM, Diefenderfer DL, Bhargave G, Leboy PS. 2004. Different effects of BMP-2 on marrow stromal cells from human and rat bone. Cell Tissues Organs. 176:109–119.
  • Osyczka AM, Leboy PS. 2005. Bone morphogenetic protein regulation of early osteoblast genes in human marrow stromal cells is mediated by extracellular signal-regulated kinase and phospha tidylinositol 3-kinase signaling. Endocrinology. 146:3428–3437.
  • Reilly GC, Radin S, Chen AT, Ducheyne P. 2007. Differential alkaline phosphatase responses of rat and human bone marrow derived mesenchymal cells to 45S5 bioactive glass. Biomaterials. 28:4091–4097.
  • Rifas L. 2007. The role of noggin in human mesenchymal stem cell differentiation. J Cell Biochem. 100:824–838.
  • Singhatanadgit W, Mordan N, Salih V, Olsen I. 2008. Changes in bone morphogenic protein receptor-IB localization regulate osteogenic responses of human bone cells to bone morphogenic protein-2. Int J Biochem Cell Biol. 40:2854–2864.
  • ten Dijke P. 2006. Bone morphogenetic protein signal transduction in bone. Curr Med Res Opin. 22 1: S7–11Sul.
  • Tsutsumi S, Shimazu A, Miyazaki K, Pan H, Koike C, Yoshida E, Takagishi K, Kato Y. 2001. Retention of multilineage differentiation potential of mesenchymal cells during proliferation in response to FGF. Biochem Biophys Res Commun. 288:413–419.
  • Urist MR. 1965. Bone: Formation by autoinduction. Science. 150:893–899.
  • Valenzuela DM, Economides AN, Rojas E, Lamb TM, Nunez L, Jones P, Lp NY, Espinosa RIII, Brannan CI, Gilbert DJ, Copeland NG, Jenkins NA, Lebeau MM, Harland RM, Yancopoulos GD. 1995. Identification of mammalian noggin and its expression in the adult nervous system. J Neurosci. 15:6077–6084.
  • Wan DC, Pomerantz JH, Brunet LJ, Kim J-B, Chou F-Y, Wu BM, Harland R, Blau HM, Longaker MT. 2007. Noggin suppression enhances in vitro osteogenesis and accelerates in vivo bone formation. J Biol Chem. 282:26450–26459.
  • Warren SM, Brunet LJ, Harland RM, Economides AN, Longaker MT. 2003. The BMP antagonist noggin regulates cranial suture fusion. Nature. 422:625–629.

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