Advanced search
Publication Cover
Growth Factors Volume 29, 2011 - Issue 6
Submit an article Journal homepage
246
Views
12
CrossRef citations to date
0
Altmetric
Articles

A novel vaccine delivery system: Biodegradable nanoparticles in thermosensitive hydrogel

Qin Jie WuState Key Laboratory of Biotherapy, West China Hospital, West China Medical School, and School of Life Sciences, Sichuan University, Chengdu 610041, People's Republic of China
,
Xue Chen ZhuState Key Laboratory of Biotherapy, West China Hospital, West China Medical School, and School of Life Sciences, Sichuan University, Chengdu 610041, People's Republic of China
,
Xiong XiaoState Key Laboratory of Biotherapy, West China Hospital, West China Medical School, and School of Life Sciences, Sichuan University, Chengdu 610041, People's Republic of China
,
Pan WangState Key Laboratory of Biotherapy, West China Hospital, West China Medical School, and School of Life Sciences, Sichuan University, Chengdu 610041, People's Republic of China
,
Da ke XiongState Key Laboratory of Biotherapy, West China Hospital, West China Medical School, and School of Life Sciences, Sichuan University, Chengdu 610041, People's Republic of China
,
Chang Yang GongState Key Laboratory of Biotherapy, West China Hospital, West China Medical School, and School of Life Sciences, Sichuan University, Chengdu 610041, People's Republic of ChinaCorrespondence[email protected]
,
Yong Sheng WangState Key Laboratory of Biotherapy, West China Hospital, West China Medical School, and School of Life Sciences, Sichuan University, Chengdu 610041, People's Republic of China
,
Li YangState Key Laboratory of Biotherapy, West China Hospital, West China Medical School, and School of Life Sciences, Sichuan University, Chengdu 610041, People's Republic of China
&
Yu Quan WeiState Key Laboratory of Biotherapy, West China Hospital, West China Medical School, and School of Life Sciences, Sichuan University, Chengdu 610041, People's Republic of China
 show all
Pages 290-297 | Received 21 Jul 2011, Accepted 14 Sep 2011, Published online: 10 Oct 2011

References

  • Chong CSW, Cao M, Wong WW, Fischer KP, Addison WR, Kwon GS, Tyrrell DL, Samuel J. 2005. Enhancement of T helper type 1 immune responses against hepatitis B virus core antigen by PLGA nanoparticle vaccine delivery. J Control Release. 102:85–99.
  • Coeshott CM, Smithson SL, Verderber E, Samaniego A, Blonder JM, Rosenthal GJ, Westerink MAJ. 2004. Pluronic® F127-based systemic vaccine delivery systems. Vaccine. 22:2396–2405.
  • Gander B. 2005. Trends in particulate antigen and DNA delivery systems for vaccines. Adv Drug Deliv Rev. 57:321–323.
  • Gong C-Y, Shi S, Peng X-Y, Kan B, Yang L, Huang M-J, Luo F, Zhao X, Wei Y-Q, Qian Z-Y. Biodegradable thermosensitive injectable PEG-PCL-PEG hydrogel for bFGF antigen delivery to improve humoral immunity. Growth Factors. 2009a; 27:383.
  • Gong CY, Dong PW, Shi S, Fu SZ, Yang JL, Guo G, Zhao X, Wei YQ, Qian ZY. Thermosensitive PEG-PCL-PEG hydrogel controlled drug delivery system: Sol–gel–sol transition and in vitro drug release study. J Pharm Sci. 2009b; 98:3707–3717.
  • Gong CY, Shi S, Dong PW, Kan B, Gou ML, Wang XH, Li XY, Luo F, Zhao X, Wei Y, Qian Z. Synthesis and characterization of PEG-PCL-PEG thermosensitive hydrogel. Int J Pharm. 2009c; 365:89–99.
  • Gong CY, Shi S, Wu L, Gou ML, Yin QQ, Guo QF, Dong PW, Zhang F, Luo F, Zhao X, Wei Y, Qian Z. Biodegradable in situ gel-forming controlled drug delivery system based on thermosensitive PCL-PEG-PCL hydrogel. Part 2: Sol–gel–sol transition and drug delivery behavior. Acta Biomater. 2009d; 5:3358–3370.
  • Gou M, Dai M, Gu Y, Li X, Wen Y, Yang L, Wang K, Wei Y, Qian Z. 2008. BFGF loaded biodegradable PCL-PEG-PCL copolymeric nanoparticles: Preparation, in vitro release and immunogenicity study. J Nanosci Nanotechnol. 8:1–5.
  • Gupta RK. 1998. Aluminum compounds as vaccine adjuvants. Adv Drug Deliv Rev. 32:155–172.
  • Gupta RK, Relyveld EH, Lindblad EB, Bizzini B, Ben-Efraim S, Gupta CK. 1993. Adjuvants—a balance between toxicity and adjuvanticity. Vaccine. 11:293–306.
  • Huang Y-Y, Wang C-H. 2006. Pulmonary delivery of insulin by liposomal carriers. J Control Release. 113:9–14.
  • Jilek S, Merkle HP, Walter E. 2005. DNA-loaded biodegradable microparticles as vaccine delivery systems and their interaction with dendritic cells. Adv Drug Deliv Rev. 57:377–390.
  • Julie Westerink MA, Louise Smithson S, Srivastava N, Blonder J, Coeshott C, Rosenthal GJ. 2002. ProJuvantTM (Pluronic® F127/chitosan) enhances the immune response to intranasally administered tetanus toxoid. Vaccine. 20:711–723.
  • Kang ML, Jiang H-L, Kang SG, Guo DD, Lee DY, Cho C-S, Yoo HS. 2007. Pluronic® F127 enhances the effect as an adjuvant of chitosan microspheres in the intranasal delivery of Bordetella bronchiseptica antigens containing dermonecrotoxin. Vaccine. 25:4602–4610.
  • Liu MA. 1999. Topic in review: Vaccines in the 21st century. West J Med. 171:319–322.
  • Man S, Tabi Z. 2006. Human cancer vaccines. Adv Drug Deliv Rev. 58:899–901.
  • Moll H. 2004. Antigen delivery by dendritic cells. Int J Med Microbiol. 294:337–344.
  • O'Hagan DT, Rappuoli R. Novel approaches to vaccine delivery. Pharm Res. 2004a; 21:1519–1530.
  • O'Hagan DT, Rappuoli R. The safety of vaccines. Drug Discov Today. 2004b; 9:846–854.
  • O'Hagan DT, Rappuoli R. 2006. Novel approaches to pediatric vaccine delivery. Adv Drug Deliv Rev. 58:29–51.
  • O'Hagan DT, Valiante NM. 2003. Recent advances in the discovery and delivery of vaccine adjuvants. Nat Rev Drug Discov. 2:727–735.
  • O'Hagan DT, MacKichan ML, Singh M. 2001. Recent developments in adjuvants for vaccines against infectious diseases. Biomol Eng. 18:69–85.
  • Peek LJ, Middaugh CR, Berkland C. 2008. Nanotechnology in vaccine delivery. Adv Drug Deliv Rev. 60:915–928.
  • Poland GA, Murray D, Bonilla-Guerrero R. 2002. Science, medicine, and the future: New vaccine development. Br Med J. 324:1315–1319.
  • Singh M, O'Hagan D. 1999. Advances in vaccine adjuvants. Nat Biotech. 17:1075–1081.
  • Singh M, O'Hagan DT. 2002. Recent advances in vaccine adjuvants. Pharm Res. 19:715–728.
  • Singh M, Li XM, Wang H, McGee JP, Zamb T, Koff W, Wang CY, O'Hagan DT. 1998. Controlled release microparticles as a single dose diphtheria toxoid vaccine: Immunogenicity in small animal models. Vaccine. 16:346–352.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.