Proliferation of murine c-kit^pos cardiac stem cells stimulated with IGF-1 is associated with Akt-1 mediated phosphorylation and nuclear export of FoxO3a and its effect on downstream cell cycle regulators

References

• Accili D, Arden KC. 2004. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117:421–426
   PubMed Web of Science ®Google Scholar
• Aghila Rani KG, Kartha CC. 2010. Effects of epidermal growth factor on proliferation and migration of cardiosphere-derived cells expanded from adult human heart. Growth Factors 28:157–165
   PubMed Web of Science ®Google Scholar
• Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, et al. 1999. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96:857–868
   PubMed Web of Science ®Google Scholar
• Brunet A, Park J, Tran H, Hu LS, Hemmings BA, Greenberg ME. 2001. Protein kinase SGK mediates survival signals by phosphorylating the Forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol 21:952–965
   PubMed Web of Science ®Google Scholar
• Calnan DR, Brunet A. 2008. The FoxO code. Oncogene 27:2276–2288
   PubMed Web of Science ®Google Scholar
• Cheung TH, Rando TA. 2013. Molecular regulation of stem cell quiescence. Nat Rev Mol Cell Biol 14:329–340
   PubMed Web of Science ®Google Scholar
• Del Re DP, Sadoshima J. 2009. Optimizing cell-based therapy for cardiac regeneration. Circulation 120:831–834
   Google Scholar
• Dixon IM. 2001. Help from within: Cardioprotective properties of hepatocyte growth factor. Cardiovasc Res 51:4–6
   Google Scholar
• Engelmann GL, Boehm KD, Haskell JF, Khairallah PA, Ilan J. 1989. Insulin-like growth factors and neonatal cardiomyocyte development: Ventricular gene expression and membrane receptor variations in normotensive and hypertensive rats. Mol Cell Endocrinol 63:1–14
   PubMed Web of Science ®Google Scholar
• Evans-Anderson HJ, Alfieri CM, Yutzey KE. 2008. Regulation of cardiomyocyte proliferation and myocardial growth during development by FoxO transcription factors. Circ Res 102:686–694
   PubMed Web of Science ®Google Scholar
• Fischer KM, Din S, Gude N, Konstandin MH, Wu W, Quijada P, Sussman MA. 2011. Cardiac progenitor cell commitment is inhibited by nuclear Akt expression. Circ Res 108:960–970
   PubMed Web of Science ®Google Scholar
• Gao D, Inuzuka H, Tseng A, Wei W. 2009. Akt finds its new path to regulate cell cycle through modulating Skp2 activity and its destruction by APC/Cdh1. Cell Div 4:11 . doi:10.1186/1747-1028-4-11
   PubMed Web of Science ®Google Scholar
• Haq S, Choukroun G, Lim H, Tymitz KM, del Monte F, Gwathmey J, Grazette L, et al. 2001. Differential activation of signal transduction pathways in human hearts with hypertrophy versus advanced heart failure. Circulation 103:670–677
   PubMed Web of Science ®Google Scholar
• Huang H, Tindall DJ. 2007. Dynamic FoxO transcription factors. J Cell Sci 120:2479–2487
   PubMed Web of Science ®Google Scholar
• Janssens S. 2010. Stem cells in the treatment of heart disease. Annu Rev Med 61:287–300
   PubMed Web of Science ®Google Scholar
• Kaestner KH, Knochel W, Martinez DE. 2000. Unified nomenclature for the winged helix/forkhead transcription factors. Genes Dev 14:142–146
   PubMed Web of Science ®Google Scholar
• Khan AS, Sane DC, Wannenburg T, Sonntag WE. 2002. Growth hormone, insulin-like growth factor-1 and the aging cardiovascular system. Cardiovasc Res 54:25–35
   PubMed Web of Science ®Google Scholar
• Kofidis T, de Bruin JL, Yamane T, Balsam LB, Lebl DR, Swijnenburg RJ, Tanaka M, et al. 2004. Insulin-like growth factor promotes engraftment, differentiation, and functional improvement after transfer of embryonic stem cells for myocardial restoration. Stem Cells 22:1239–1245
   PubMed Web of Science ®Google Scholar
• Kops GJ, de Ruiter ND, De Vries-Smits AM, Powell DR, Bos JL, Burgering BM. 1999. Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature 398:630–634
   PubMed Web of Science ®Google Scholar
• Mourkioti F, Rosenthal N. 2005. IGF-1, inflammation and stem cells: Interactions during muscle regeneration. Trends Immunol 26:535–542
   PubMed Web of Science ®Google Scholar
• Paik JH, Ding Z, Narurkar R, Ramkissoon S, Muller F, Kamoun WS, Chae SS, et al. 2009. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5:540–553
   Google Scholar
• Porrello ER, Olson EN. 2010. Building a new heart from old parts. Cir Res 107:1292–1294
   Google Scholar
• Rathbone CR, Booth FW, Lees SJ. 2008. FoxO3a preferentially induces p27Kip1 expression while impairing muscle precursor cell-cycle progression. Muscle Nerve 37:84–89
   Google Scholar
• Ronnebaum SM, Patterson C. 2010. The FoxO family in cardiac function and dysfunction. Annu Rev Physiol 72:81–94
   PubMed Web of Science ®Google Scholar
• Saetrum Opgaard O, Wang PH. 2005. IGF-I is a matter of heart. Growth Horm IGF Res 15:89–94
   PubMedGoogle Scholar
• Salih DA, Brunet A. 2008. FoxO transcription factors in the maintenance of cellular homeostasis during aging. Curr Opin Cell Biol 20:126–136
   PubMed Web of Science ®Google Scholar
• Shin I, Bakin AV, Rodeck U, Brunet A, Arteaga CL. 2001. Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1. Mol Biol Cell 12:3328–3339
   PubMedGoogle Scholar
• Shioi T, McMullen JR, Kang PM, Douglas PS, Obata T, Franke TF, Cantley LC, et al. 2002. Akt/protein kinase B promotes organ growth in transgenic mice. Mol Cell Biol 22:2799–2809
   PubMed Web of Science ®Google Scholar
• Shiojima I, Yefremashvili M, Luo Z, Kureishi Y, Takahashi A, Tao J, Rosenzweig A, et al. 2002. Akt signaling mediates postnatal heart growth in response to insulin and nutritional status. J Biol Chem 277:37670–37677
   PubMedGoogle Scholar
• Siddle K. 2011. Signalling by insulin and IGF receptors: Supporting acts and new players. J Mol Endocrinol 47:R1–R10
   PubMed Web of Science ®Google Scholar
• Skurk C, Izumiya Y, Maatz H, Razeghi P, Shiojima I, Sandri M, Sato K, et al. 2005. The FoxO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling. J Biol Chem 280:20814–20823
   PubMed Web of Science ®Google Scholar
• Song G, Ouyang G, Bao S. 2005. The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med 9:59–71
   PubMed Web of Science ®Google Scholar
• Torella D, Rota M, Nurzynska D, Musso E, Monsen A, Shiraishi I, Zias E, et al. 2004. Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression. Circ Res 94:514–524
   PubMed Web of Science ®Google Scholar
• van der Vos KE, Coffer PJ. 2011. The extending network of FoxO transcriptional target genes. Antioxid Redox Signal 14:579–592
   PubMed Web of Science ®Google Scholar
• Walsh K. 2006. Akt signaling and growth of the heart. Circulation 113:2032–2034
   PubMed Web of Science ®Google Scholar
• Webb AE, Pollina AE, Vierbuchen T, Urbán N, Ucar D, Leeman DS, Martynoga B, et al. 2013. FOXO3 shares common targets with ASCL1 genome-wide and inhibits ASCL1-dependent neurogenesis. Cell Rep 4:477–491
   Google Scholar
• Wen Q, Duan X, Liao R, Little P, Gao G, Jiang H, Lalit S, et al. 2011. Characterization of intracellular translocation of Forkhead transcription factor O (FoxO) members induced by NGF in PC12 cells. Neurosci Lett 498:31–36
   Google Scholar
• Wu Y, Peng H, Cui M, Whitney NP, Huang Y, Zheng JC. 2009. CXCL12 increases human neural progenitor cell proliferation through Akt-1/FOXO3a signaling pathway. J Neurochem 109:1157–1167
   PubMed Web of Science ®Google Scholar
• Zhang X, Tang N, Hadden TJ, Rishi AK. 2011. Akt, FoxO and regulation of apoptosis. Biochim Biophys Acta 1813:1978–1986
   PubMed Web of Science ®Google Scholar
• Zhao Y, Wang Y, Zhu WG. 2011. Applications of post-translational modifications of FoxO family proteins in biological functions. J Mol Cell Biol 3:276–282
   Google Scholar