273
Views
25
CrossRef citations to date
0
Altmetric
Research Paper

Hepatocyte growth factor-modified adipose tissue-derived stem cells improve erectile function in streptozotocin-induced diabetic rats

, , , , &
Pages 282-289 | Received 11 May 2015, Accepted 27 Jul 2015, Published online: 28 Aug 2015

References

  • Abidu-Figueiredo M, Ribeiro IC, Chagas MA, Cardoso LE, Costa WS, Sampaio FJ. 2011. The penis in diabetes: Structural analysis of connective tissue and smooth muscle alterations in a rabbit model. BJU Int 108:400–404
  • Albersen M, Fandel TM, Lin G, Wang G, Banie L, Lin CS, Lue TF. 2010. Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury. J Sex Med 7:3331–3340
  • Cameron NE, Cotter MA. 2007. Erectile dysfunction and diabetes mellitus: Mechanistic considerations from studies in experimental models. Curr Diabetes Rev 3:149–158
  • Carson CC, Lue TF. 2005. Phosphodiesterase type 5 inhibitors for erectile dysfunction. BJU Int 96:257–280
  • Francis SH, Corbin JD. 2011. PDE5 inhibitors: Targeting erectile dysfunction in diabetics. Curr Opin Pharmacol 11:683–688
  • Fandel TM, Albersen M, Lin G, Qiu X, Ning H, Banie L, Lue TF, et al. 2012. Recruitment of intracavernously injected adipose-derived stem cells to the major pelvic ganglion improves erectile function in a rat model of cavernous nerve injury. Eur Urol 61:201–210
  • Ferrini MG, Kovanecz I, Sanchez S, Umeh C, Rajfer J, Gonzalez-Cadavid NF. 2009. Fibrosis and loss of smooth muscle in the corpora cavernosa precede corporal venoocclusive dysfunction (CVOD) induced by experimental cavernosal nerve damage in the rat. J Sex Med 6:415–428
  • Fulda S. 2013. Modulation of mitochondrial apoptosis by PI3K inhibitors. Mitochondrion 13:195–198
  • Garcia MM, Fandel TM, Lin G, Shindel AW, Banie L, Lin CS, Lue TF. 2010. Treatment of erectile dysfunction in the obese type 2 diabetic ZDF rat with adipose tissue-derived stem cells. J Sex Med 7:89–98
  • Gokce A, Abd Elmageed ZY, Lasker GF, Bouljihad M, Kim H, Trost LW, Kadowitz PJ, et al. 2014. Adipose tissue-derived stem cell therapy for prevention and treatment of erectile dysfunction in a rat model of Peyronie's disease. Andrology 2:244–251
  • Hu ZX, Geng JM, Liang DM, Luo M, Li ML. 2010. Hepatocyte growth factor protects human embryonic stem cell derived-neural progenitors from hydrogen peroxide-induced apoptosis. Eur J Pharmacol 645:23–31
  • Le Bras M, Rouy I, Brenner C. 2006. The modulation of inter-organelle cross-talk to control apoptosis. Med Chem 2:1–12
  • Li L, He D, Yang J, Wang X. 2011. Cordycepin inhibits renal interstitial myofibroblast activation probably by inducing hepatocyte growth factor expression. J Pharmacol Sci 117:286–294
  • Li WJ, Wang H, Zhou J, Li B, Zhang J, Lu M, Wang Z. 2013. P144, A TGFβ1 antagonist peptide, synergizes with sildenafil and enhances erectile response via amelioration of cavernosal fibrosis in diabetic rats. J Sex Med 10:2942–2951
  • Maiorino MI, Bellastella G, Esposito K. 2014. Diabetes and sexual dysfunction: Current perspectives. Diabetes Metab Syndr Obes 7:95–105
  • Nakamura T, Sakai K, Nakamura T, Matsumoto K. 2011. Hepatocyte growth factor twenty years on: Much more than a growth factor. J Gastroenterol Hepatol 26:188–202
  • Ning H, Liu G, Lin G, Garcia M, Li LC, Lue TF, Lin CS. 2009. Identification of an aberrant cell line among human adipose tissue-derived stem cell isolates. Differentiation 77:172–180
  • Qin M, Luo Y, Meng XB, Wang M, Wang HW, Song SY, Ye JX, et al. 2015. Myricitrin attenuates endothelial cell apoptosis to prevent atherosclerosis: An insight into PI3K/Akt activation and STAT3 signaling pathways. Vascul Pharmacol 70:23–34
  • Qiu X, Sun C, Yu W, Lin H, Sun Z, Chen Y, Wang R, Dai Y. 2012. Combined strategy of mesenchymal stem cell injection with vascular endothelial growth factor gene therapy for the treatment of diabetes-associated erectile dysfunction. J Androl 33:37–44
  • Ryu JK, Song SU, Choi HK, Seong DH, Yoon SM, Kim SJ, Suh JK. 2004. Plasma transforming growth factor-beta1 levels in patients with erectile dysfunction. Asian J Androl 6:349–353
  • Song KM, Chung JS, Choi MJ, Jin HR, Yin GN, Kwon MH, Park JM, et al. 2014. Effectiveness of intracavernous delivery of adenovirus encoding Smad7 gene on erectile function in a mouse model of cavernous nerve injury. J Sex Med 11:51–63
  • Shamloul R, Ghanem H. 2013. Erectile dysfunction. Lancet 381:153–165
  • Shen B, Liu X, Fan Y, Qiu J. 2014. Macrophages regulate renal fibrosis through modulating TGFβ superfamily signaling. Inflammation 37:2076–2084
  • Redrow GP, Thompson CM, Wang R. 2014. Treatment strategies for diabetic patients suffering from erectile dysfunction: An update. Expert Opin Pharmacother 15:1827–1836
  • Wen X, Li Y, Hu K, Dai C, Liu Y. 2005. Hepatocyte growth factor receptor signaling mediates the anti-fibrotic action of 9-cis-retinoic acid in glomerular mesangial cells. Am J Pathol 167:947–957
  • Xu F, Yu H, Liu J, Cheng L. 2013. αB-crystallin regulates oxidative stress-induced apoptosis in cardiac H9c2 cells via the PI3K/AKT pathway. Mol Biol Rep 40:2517–2526
  • Yi X, Li X, Zhou Y, Ren S, Wan W, Feng G, Jiang X. 2014. Hepatocyte growth factor regulates the TGF-β1-induced proliferation, differentiation and secretory function of cardiac fibroblasts. Int J Mol Med 34:381–390
  • Zhang LW, Piao S, Choi MJ, Shin HY, Jin HR, Kim WJ, Song SU, et al. 2008. Role of increased penile expression of transforming growth factor-beta1 and activation of the Smad signaling pathway in erectile dysfunction in streptozotocin-induced diabetic rats. J Sex Med 5:2318–2329
  • Zhao W, Chen SS, Chen Y, Ahokas RA, Sun Y. 2008. Kidney fibrosis in hypertensive rats: Role of oxidative stress. Am J Nephrol 28:548–554
  • Zhou F, Li GY, Gao ZZ, Liu J, Liu T, Li WR, Cui WS, et al. 2012. The TGF-β1/Smad/CTGF pathway and corpus cavernosum fibrous-muscular alterations in rats with streptozotocin-induced diabetes. J Androl 33:651–659
  • Zhou YJ, Yang HW, Wang XG, Zhang H. 2009. Hepatocyte growth factor prevents advanced glycation end products-induced injury and oxidative stress through a PI3K/Akt-dependent pathway in human endothelial cells. Life Sci 85:670–677

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.