Nerve growth factor and autophagy: effect of nasal anti-NGF-antibodies administration on Ambra1 and Beclin-1 expression in rat brain

References

• Aloe L, Calzà L. 2004. NGF and related molecules in health and disease. Progr Brain Res. Vol. 146. Amsterdam, the Netherland: Elsevier
   Google Scholar
• Aloe L, Rocco ML, Bianchi P, Manni L. 2012. Nerve growth factor: From the early discoveries to the potential clinical use. J Transl Med 10:239
   PubMed Web of Science ®Google Scholar
• Aloe L, Mugnaini E, Levi-Montalcini R. 1975. Light and electron microscopic studies on the excessive growth of sympathetic ganglia in rats injected daily from birth with 6-OHDA and NGF. Arch Ital Biol 113:326–353
   PubMed Web of Science ®Google Scholar
• Aloe L, Bianchi P, De Bellis A, Soligo M, Rocco ML. 2014. Intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury. Neural Regen Res 9:1025–1030
   PubMed Web of Science ®Google Scholar
• Berry A, Aloe L, Rossi S, Bonsignore LT, Capone F, Alleva E, Cirulli F. 2010. Conjunctivally administered NGF antibody reduces pain sensitivity and anxiety-like behavioral responses in aged female mice. Behav Brain Res 210:284–287
   PubMed Web of Science ®Google Scholar
• Bocchini V, Angeletti PU. 1969. The nerve growth factor: Purification as a 30,000-molecular-weight protein. Proc Natl Acad Sci USA 64:787–794
   PubMed Web of Science ®Google Scholar
• Boland B, Nixon RA. 2006. Neuronal macroautophagy: From development to degeneration. Mol Aspects Med 27:503–519
   PubMedGoogle Scholar
• Cavallucci V, Bisicchia E, Cencioni MT, Ferri A, Latini L, Nobili A, Biamonte F, et al. 2014. Acute focal brain damage alters mitochondrial dynamics and autophagy in axotomized neurons. Cell Death Dis 5:e1545
   PubMed Web of Science ®Google Scholar
• Chao MV, Hempstead BL. 1995. p75 and Trk: A two-receptor system. Trends Neurosci 18:321–326
   PubMed Web of Science ®Google Scholar
• Chen XQ, Fawcett JR, Rahman YE, Ala TA, Frey IW. 1998. Delivery of nerve growth factor to the brain via the olfactory pathway. J Alzheimers Dis 1:35–44
   PubMedGoogle Scholar
• Choi AM, Ryter SW, Levine B. 2013. Autophagy in human health and disease. N Engl J Med 368:651–662
   PubMed Web of Science ®Google Scholar
• Colafrancesco V, Cirulli F, Rossi S, Berry A, Aloe L. 2009. Anti-NGF-antibody administration as collyrium reduces the presence of NGF and enhances the expression of VEGF in the retina, lacrimal gland and hippocampus. Neurosci Lett 463:203–206
   PubMed Web of Science ®Google Scholar
• Connor B, Dragunow M. 1998. The role of neuronal growth factors in neurodegenerative disorders of the human brain. Brain Res Brain Res Rev 27:1–39
   PubMed Web of Science ®Google Scholar
• Fimia GM, Stoykova A, Romagnoli A, Giunta L, Di Bartolomeo S, Nardacci R, Corazzari M, et al. 2007. Ambra1 regulates autophagy and development of the nervous system. Nature 447:1121–1125
   PubMed Web of Science ®Google Scholar
• Fimia GM, Corazzari M, Antonioli M, Piacentini M. 2013. Ambra1 at the crossroad between autophagy and cell death. Oncogene 32:3311–3318
   PubMed Web of Science ®Google Scholar
• Fischer W, Wictorin K, Bjorklund A, Williams LR, Varon S, Gage FH. 1987. Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature 329:65–68
   PubMed Web of Science ®Google Scholar
• Florez-McClure ML, Linseman DA, Chu CT, Barker PA, Bouchard RJ, Le SS, Laessig TA, Heidenreich KA. 2004. The p75 neurotrophin receptor can induce autophagy and death of cerebellar Purkinje neurons. J Neurosci 24:4498–4509
   PubMed Web of Science ®Google Scholar
• Flugel A, Matsumuro K, Neumann H, Klinkert WE, Birnbacher R, Lassmann H, Otten U, Wekerle H. 2001. Anti-inflammatory activity of nerve growth factor in experimental autoimmune encephalomyelitis: Inhibition of monocyte transendothelial migration. Eur J Immunol 31:11–22
   PubMed Web of Science ®Google Scholar
• Friden PM, Walus LR, Watson P, Doctrow SR, Kozarich JW, Backman C, Bergman H, et al. 1993. Blood–brain barrier penetration and in vivo activity of an NGF conjugate. Science 259:373–377
   PubMed Web of Science ®Google Scholar
• Greene LA, Tischler AS. 1976. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 73:2424–2428
   PubMed Web of Science ®Google Scholar
• Hansen K, Wagner B, Hamel W, Schweizer M, Haag F, Westphal M, Lamszus K. 2007. Autophagic cell death induced by TrkA receptor activation in human glioblastoma cells. J Neurochem 103:259–275
   PubMed Web of Science ®Google Scholar
• Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Yokoyama M, et al. 2006. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441:885–889
   PubMed Web of Science ®Google Scholar
• He C, Levine B. 2010. The Beclin 1 interactome. Curr Opin Cell Biol 22:140–149
   PubMed Web of Science ®Google Scholar
• Jaeger PA, Wyss-Coray T. 2009. All-you-can-eat: Autophagy in neurodegeneration and neuroprotection. Mol Neurodegener 4:16
   PubMed Web of Science ®Google Scholar
• Johnson CW, Melia TJ, Yamamoto A. 2012. Modulating macroautophagy: A neuronal perspective. Future Med Chem 4:1715–1731
   PubMed Web of Science ®Google Scholar
• Kuo YC, Chou PR. 2014. Neuroprotection against degeneration of sk-N-mc cells using neuron growth factor-encapsulated liposomes with surface cereport and transferrin. J Pharm Sci 103:2484–2497
   PubMed Web of Science ®Google Scholar
• Levi-Montalcini R, Angeletti PU. 1968. Nerve growth factor. Physiol Rev 48:534–569
   PubMed Web of Science ®Google Scholar
• Levi-Montalcini R, Skaper SD, Dal Toso R, Petrelli L, Leon A. 1996. Nerve growth factor: From neurotrophin to neurokine. Trends Neurosci 19:514–520
   PubMed Web of Science ®Google Scholar
• Levi-Montalcini R. 1987. The nerve growth factor 35 years later. Science 237:1154–1162
   PubMed Web of Science ®Google Scholar
• Liao GS, Li XB, Zhang CY, Shu YY, Tang SX. 2001. Pharmacological actions of nerve growth factor-transferrin conjugate on the central nervous system. J Nat Toxins 10:291–297
   PubMedGoogle Scholar
• McCray BA, Taylor JP. 2008. The role of autophagy in age-related neurodegeneration. Neurosignals 16:75–84
   PubMedGoogle Scholar
• McMahon SB, Priestley JV. 1995. Peripheral neuropathies and neurotrophic factors: Animal models and clinical perspectives. Curr Opin Neurobiol 5:616–624
   PubMed Web of Science ®Google Scholar
• Meakin SO, Shooter EM. 1992. The nerve growth factor family of receptors. Trends Neurosci 15:323–331
   PubMed Web of Science ®Google Scholar
• Mnich K, Carleton LA, Kavanagh ET, Doyle KM, Samali A, Gorman AM. 2014. Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner. Cell Death Dis 5:e1202
   PubMed Web of Science ®Google Scholar
• Nixon RA. 2007. Autophagy, amyloidogenesis and Alzheimer disease. J Cell Sci 120:4081–4091
   PubMed Web of Science ®Google Scholar
• Pagani L, Cenciarelli C, Casalbore P, Budoni M, Sposato V, Aloe L. 2008. Identification and early characterization of genetically modified NGF-producing neural stem cells grafted into the injured adult rat brain. Neurol Res 30:244–250
   PubMed Web of Science ®Google Scholar
• Rafii MS, Baumann TL, Bakay RA, Ostrove JM, Siffert J, Fleisher AS, Herzog CD, et al. 2014. A phase1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer's disease. Alzheimers Dement 10:571–581
   PubMed Web of Science ®Google Scholar
• Sarkar S, Rubinsztein DC. 2008. Huntington's disease: Degradation of mutant huntingtin by autophagy. Febs J 275:4263–4270
   PubMed Web of Science ®Google Scholar
• Sepe S, Nardacci R, Fanelli F, Rosso P, Bernardi C, Cecconi F, Mastroberardino PG, et al. 2014. Expression of Ambra1 in mouse brain during physiological and Alzheimer type aging. Neurobiol Aging 35:96–108
   PubMed Web of Science ®Google Scholar
• Sofroniew MV, Howe CL, Mobley WC. 2001. Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci 24:1217–1281
   PubMed Web of Science ®Google Scholar
• Son JH, Shim JH, Kim KH, Ha JY, Han JY. 2012. Neuronal autophagy and neurodegenerative diseases. Exp Mol Med 44:89–98
   PubMed Web of Science ®Google Scholar
• Stoeckel K, Gagnon C, Guroff G, Thoenen H. 1976. Purification of nerve growth factor antibodies by affinity chromatography. J Neurochem 26:1207–1211
   PubMed Web of Science ®Google Scholar
• Strappazzon F, Vietri-Rudan M, Campello S, Nazio F, Florenzano F, Fimia GM, Piacentini M, et al. 2011. Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy. Embo J 30:1195–1208
   PubMed Web of Science ®Google Scholar
• Thorne RG, Frey WH. 2nd 2001. Delivery of neurotrophic factors to the central nervous system: Pharmacokinetic considerations. Clin Pharmacokinet 40:907–946
   PubMed Web of Science ®Google Scholar
• Tolkovsky AM, Xue L, Fletcher GC, Borutaite V. 2002. Mitochondrial disappearance from cells: A clue to the role of autophagy in programmed cell death and disease? Biochimie 84:233–240
   PubMed Web of Science ®Google Scholar
• Tuszynski MH, Thal L, Pay M, Salmon DP, Sang UH, Bakay R, Patel P, et al. 2005. A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nat Med 11:551
   PubMed Web of Science ®Google Scholar
• Uchiyama Y, Koike M, Shibata M. 2008. Autophagic neuron death in neonatal brain ischemia/hypoxia. Autophagy 4:404–408
   PubMed Web of Science ®Google Scholar
• Vaka SR, Sammeta SM, Day LB, Murthy SN. 2009. Delivery of nerve growth factor to brain via intranasal administration and enhancement of brain uptake. J Pharm Sci 98:3640–3646
   PubMed Web of Science ®Google Scholar
• Viscomi MT, D'Amelio M, Cavallucci V, Latini L, Bisicchia E, Nazio F, Fanelli F, et al. 2012. Stimulation of autophagy by rapamycin protects neurons from remote degeneration after acute focal brain damage. Autophagy 8:222–235
   PubMed Web of Science ®Google Scholar
• Xue L, Fletcher GC, Tolkovsky AM. 1999. Autophagy is activated by apoptotic signalling in sympathetic neurons: An alternative mechanism of death execution. Mol Cell Neurosci 14:180–198
   PubMed Web of Science ®Google Scholar
• Yang Y, Xu K, Koike T, Zheng X. 2008. Transport of autophagosomes in neurites of PC12 cells during serum deprivation. Autophagy 4:243–245
   PubMed Web of Science ®Google Scholar