A Model for the Interaction of the GM-CSF, IL-3 and IL-5 Receptors with their Ligands

References

• Bazan J. F. Structural design and molecular evolution of a cytokine receptor superfamily. Proc. Natl. Acad. Sci. USA 1990a; 87: 6934–6938
   PubMed Web of Science ®Google Scholar
• Bazan J. F. Haemopoietic receptors and helical cytokines. Immunol. Today 1990b; 11: 350–354
   PubMedGoogle Scholar
• Clark S. C., Kamen R. The human hematopoietic colony-stimulating factors. Science 1987; 236: 1229–1237
   PubMed Web of Science ®Google Scholar
• Cosman D., Lyman S. D., Idzerda R. L., Beckmann M. P., Park L. S., Goodwin R. G., March C. J. A new cytokine receptor superfamily. Trends. Biochem. Sci. 1990; 17: 265–270
   Google Scholar
• Cunningham G. C., Ultsch M., de Vos A. M., Mulkerrin M. G., Clauser K. R., Wells J. A. Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule. Science 1991; 254: 821–825
   PubMed Web of Science ®Google Scholar
• Devereux J., Haeberli P., Smithies O. A comprehensive set of sequence analysis programs for the VAX. Nucl. Acids. Res 1984; 12: 387–395
   PubMed Web of Science ®Google Scholar
• de Vos A. M., Ultsch M., Kossiakoff A. A. Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 1992; 255: 306–312
   PubMed Web of Science ®Google Scholar
• Diederichs K., Boone T., Karplus P. A. Novel fold and putative receptor binding site of granulocyte-macrophage colony-stimulating factor. Science 1991; 254: 1779–1782
   PubMed Web of Science ®Google Scholar
• Elliott M. J., Vadas M. A., Eglinton J. M., Park L. S., To L. B., Cleland L. G., Clark S. C., Lopez A. F. Recombinant human interleukin-3 and granulocyte-macrophage colony-stimulating factor show common biological effects and binding characteristics on human monocytes. Blood 1989; 74: 2349–2359
   PubMed Web of Science ®Google Scholar
• Fukunaga R., Ishizaka-Ikeda E., Pan C., Seto Y., Nagata S. Functional domains of the granulocyte colony-stimulating factor receptor. EMBO J 1991; 10: 2855–2865
   PubMed Web of Science ®Google Scholar
• Garnier J., Robson B. Prediction of Protein Structure and the Principles of Protein Conformation, G. D. Fasman. Plenum, New York 1989; 417–465
   Google Scholar
• Garrett D. S., Powers R., March C. J., Frieden E. A., Clore G. M., Gronenborn A. M. Determination of the Secondary Structure and Folding Topology of Human Interleukin-4 Using Three-Dimensional Heteronuclear Magnetic Resonance Spectroscopy. Biochemistry 1992; 31: 4347–4353
   PubMed Web of Science ®Google Scholar
• Gasson J. C., Weisbart R. H., Kaufman S. E., Clark C., Hewick R. M., Wong G. G., Golde D. W. Purified human granulocyte-macrophage colony-stimulating factor: Direct action on neutrophils. Science 1984; 226: 1339–1342
   PubMed Web of Science ®Google Scholar
• Gearing D. P., King J. A., Gough N. M., Nicola N. A. Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor. EMBO J 1989; 8: 3667–3676
   PubMed Web of Science ®Google Scholar
• Gearing D. P., Thut C. J., VandenBos T., Gimpel S. D., Delaney P. B., King J., Price V., Cosman D., Beckmann M. P. Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J 1991; 10: 2839–2848
   PubMed Web of Science ®Google Scholar
• Gearing D. P., Comeau M. R., Friend D. J., Gimpei S. D., Thut C. J., McGourty J., Brasher K. K., King J. A., Gillis S., Mosley B., Ziegler S. F., Cosman D. The IL-6 signal transducer, gp130: An oncostatin M receptor and affinity converter for the LIF receptor. Science 1992; 255: 1434–1437
   PubMed Web of Science ®Google Scholar
• Gesner T. G., Mufson R. A., Norton C. R., Turner K. J., Yang Y.-C., Clark S. C. Specific binding, internalization, and degradation of human recombinant interleukin-3 by cells of the acute myelogenous leukemia line, KG-1. J. Cell Physiol 1988; 136: 493–499
   PubMed Web of Science ®Google Scholar
• Haak-Frendscho M., Arai N., Arai K.-I., Baeza M. L., Finn A., Kaplan A. P. Human recombinant granulocyte-macrophage colony-stimulating factor and interleukin 3 cause basophil histamine release. J. Clin. Invest 1988; 82: 17–20
   PubMed Web of Science ®Google Scholar
• Mayashida K., Kitamura T., Gorman D. M., Arai K.-I., Yokota T., Miyajima A. Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): Reconstitution of a high-affinity GM-CSF receptor. Proc. Natl. Acad. Sci. USA 1990; 87: 9655–9659
   PubMed Web of Science ®Google Scholar
• Hibi M., Murakami M., Saito M., Hirano T., Taga T., Kishimoto T. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 1990; 63: 1149–1157
   PubMed Web of Science ®Google Scholar
• Hirai K., Mrita Y., Misaki Y., Oha K., Takashi T., Suzuki S., Motoyoshi K., Miyamoto T. Modulation of human basophil histamine release by hemopoietic growth factors. J. Immunol 1988; 141: 3958–3964
   PubMed Web of Science ®Google Scholar
• Ip N. Y., Nye S. H., Boulton T. G., Davis S., Taga T., Li Y., Birren S. J., Yasukawa K., Kishimoto T., Anderson D. J., Stahl N., Yancopoulos G. D. CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130. Cell 1992; 69: 1121–1132
   PubMed Web of Science ®Google Scholar
• Kanehisa M. Los Alamos sequence analysis package for nucleic acids and proteins. Nucl. Acids. Res 1982; 10: 183–196
   PubMed Web of Science ®Google Scholar
• Kitamura T., Sato N., Arai K. I., Miyajima A. Expression cloning of the human IL-3 receptor cDNA reveals a shared β subunit for the human IL-3 and GM-CSF receptors. Cell 1991a; 66: 1165–1174
   PubMed Web of Science ®Google Scholar
• Kitamura T., Hayashida K., Sakamaki K., Yokota T., Arai K.-I., Miyajima A. Reconstitution of functional receptors for human granulocyte/macrophage colony-stimulating factor (GM-CSF): Evidence that the protein encoded by the AIC2B cDNA is a subunit of the murine GM-CSF receptor. Proc. Natl. Acad. Sci. USA 1991b; 88: 5082–5086
   PubMed Web of Science ®Google Scholar
• Lokker N., Zenke G., Strittmatter U., Fagg B., Movva N. Structure-activity relationship study of human interleukin-3: role of the C terminal region for biological activity. EMBO J 1991; 10: 2125–2131
   PubMed Web of Science ®Google Scholar
• Lopez A. F., Nicola N. A., Burgess A. B., Metcalf D., Battye F. L., Sewell W. A., Vadas M. A. Activation of granulocyte cytotoxic function by purified mouse colony-stimulating factors. J. Immunol 1983; 131: 2983–2988
   PubMed Web of Science ®Google Scholar
• Lopez A. F., Williamson D. J., Gamble J. R., Begley C. G., Harlan J. M., Klebanoff S. J., Waltersdorph A., Wong G., Clark S. C., Vadas M. A. Recombinant human granulocyte-macrophage colony-stimulating factor (rH GM-CSF) stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression and survival. J. Clin. Invest 1986a; 78: 1220–1228
   PubMed Web of Science ®Google Scholar
• Lopez A. F., Begley C. G., Williamson D. J., Warren D. J., Vadas M. A., Sanderson C. J. Murine eosinophil differentiation factor with activity for human cells. J. Exp. Med 1986b; 163: 1085–1099
   PubMed Web of Science ®Google Scholar
• Lopez A. F., To L. B., Yang Y-C., Gamble J. R., Shannon M. F., Burns G. F., Dyson P. G., Juttner C. A., Clark S., Vadas M. A. Stimulation of proliferation, differentiation and function of human cells by primate interleukin-3. Proc. Natl. Acad. Sci. USA 1987; 84: 2761–2765
   PubMed Web of Science ®Google Scholar
• Lopez A. F., Eglinton J. M., Gillis D., Park L. S., Clark S., Vadas M. A. Reciprocal inhibition of binding between interleukin 3 and granulocyte-macrophage colony-stimulating factor to human eosinophils. Proc. Natl. Acad. Sci 1989; 86: 7022–7026
   PubMed Web of Science ®Google Scholar
• Lopez A. F., Eglinton J. M., Lyons A. B., Tapley P. M., To L. B., Park L. S., Clark S. C., Vadas M. A. Human interleukin-3 inhibits the binding of granulocyte-macrophage colony-stimulating factor and interleukin-5 to basophils and strongly enhances their functional activity. J. Cell. Physiol 1990; 145: 69–77
   PubMed Web of Science ®Google Scholar
• Lopez A. F., Vadas M. A., Woodcock J. M., Milton S. E., Lewis A., Elliott M. J., Gillis D., Ireland R., Olwell E., Park L. S. Interleukin-5, interleukin-3, and granulocyte-macrophage colony-stimulating factor cross-compete for binding to cell surface receptors on human eosinophils. J. Biol. Chem 1991; 266: 24741–24747
   PubMed Web of Science ®Google Scholar
• Lopez A. F., Shannon M. F., Hercus T., Nicola N. A., Cambareri B., Dottore M., Layton M. J., Eglinton L., Vadas M. A. Residue 21 of human granulocyte-macrophage colony-stimulating factor is critical for biological activity and for high but not low affinity binding. EMBO J 1992; 11: 909–916
   PubMed Web of Science ®Google Scholar
• Lopez A. F., Shannon M. F., Barry S., Phillips J., Cambareri B., Dottore M., Simmons P., Vadas M. A. A human interleukin-3 analog with increased biological and binding activities. Proc. Natl. Acad. Sci. USA, in press
   Web of Science ®Google Scholar
• Metcalf D. The hemopoietic colony-stimulating factors. Elsevier, Amsterdam 1984
   Google Scholar
• Murata Y., Takaki S., Migita M., Kikuchi Y., Tominaga A., Takatsu K. Molecular cloning and expression of the human interleukin-5 receptor. J. Exp. Med 1992; 175: 341–351
   PubMed Web of Science ®Google Scholar
• Nicola N. A., Begley C. G., Metcalf D. Identification of the human analogue of a regulator that induces differentiation in murine leukaemic cells. Nature 1985; 314: 625–628
   PubMed Web of Science ®Google Scholar
• Nicola N. A., Metcalf D. Subunit promiscuity among hemopoietic growth factor receptors. Cell 1991; 67: 1–4
   PubMed Web of Science ®Google Scholar
• Park L. S., Friend D., Gillis S., Urdal D. L. Characterization of the cell surface receptor for human granulocyte/macrophage colony-stimulating factor. J. Exp. Med 1986; 164: 251–262
   PubMed Web of Science ®Google Scholar
• Park L. S., Friend D., Price V., Anderson D., Singer J., Prickett K. S., Urdal D. L. Heterogeneity in human interleukin-3 receptors. A subclass that binds human granulocyte-macrophage colony-stimulating factor. J. Biol. Chem 1989; 264: 5420–5427
   PubMed Web of Science ®Google Scholar
• Parry D.A.D., Minasian E., Leach S. J. Cytokine conformations predictive studies. J. Mol. Recognition 1991; 4: 63–75
   PubMedGoogle Scholar
• Rothenberg M. E., Pomerantz J. L., Owen W. R., Jr, Abraham S., Soberman R. J., Austen K. F., Stevens R. L. Characterization of a human eosinophil proteoglycan and augmentation of its biosynthesis and size by interleukin 3, interleukin 5, and granulocyte/macrophage colony stimulating factor. J. Biol. Chem 1988; 263: 13901–13908
   PubMed Web of Science ®Google Scholar
• Shanafelt A. B., Miyajima A., Kitamura T., Kastelein R. A. The amino terminal helix of GM-CSF and 1L-5 governs high affinity binding to their receptors. EMBO J 1991; 10: 4105–4112
   PubMed Web of Science ®Google Scholar
• Shannon M. F., Gamble J. R., Vadas M. A. Nuclear proteins interacting with the promoter region of the human granulocyte/macrophage colony-stimulating factor gene. Proc. Natl. Acad. Sci. USA 1988; 85: 674–679
   PubMed Web of Science ®Google Scholar
• Tavernier J., Devos R., Cornelis S., Tuypens T., Van der Heyden J., Fiers W., Plaetinck G. A human high affinity interleukin-5 receptor (ILSR) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF. Cell 1991; 66: 1175–1184
   PubMed Web of Science ®Google Scholar
• Vadas M. A., Nicola N., Metcalf D. Activation of antibody-dependent cell-mediated cytotoxicity of human neutrophils and eosinophils by separate colony-stimulating factors. J. Immunol 1983; 130: 795–799
   PubMed Web of Science ®Google Scholar
• van Leeuwen B. H., Martinson M. E., Webb G. C., Young I. G. Molecular organisation of the cytokine gene cluster, involving the human IL-3, IL-4, IL-5, and GMCSF genes, on human chromosome 5. Blood 1989; 73: 1142–1148
   PubMed Web of Science ®Google Scholar
• Yang Y-C., Kovacic S., Kriz R., Wolf S., Clark S. C., Wellems T. E., Nienhuis A., Epstein N. The human genes for GM-CSF and IL-3 are closely linked in tandem on chromosome 5. Blood 1988; 71: 958
   PubMed Web of Science ®Google Scholar