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Original Article

Differences in Binding to the Solid Substratum and Extracellular Matrix may Explain Isoform-Specific Paracrine Effects of Platelet-Derived Growth Factor

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Pages 77-87 | Received 10 Oct 1993, Accepted 01 Nov 1993, Published online: 11 Jul 2009

References

  • Betsholtz C., Johnsson A., Heldin C.-H., Westermark B. Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin. Proc. Natl Acad. Sci. USA 1986; 83: 6440–6444
  • Bolton A. E., Hunter W. M. The labeling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. Nature 1973; 133: 529–539
  • Bowen-Pope D. F., Hart C. E., Seifert R. A. Sera and conditioned media contain different isoforms of platelet-derived growth factor (PDGF) which bind to different classes of PDGF receptor. J. Biol. Chem. 1989; 264: 2502–2508
  • Carpenter G., Cohen S. 125I-Labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts. J. Cell. Physiol. 1976; 71: 159–171
  • Deuel T. F., Senior R. M., Huang J. S., Griffin G. L. Chemotaxis of monocytes and neutrophils to platelet-derived growth factor. J. Clin. Invest. 1982; 69: 1046–1049
  • Fleming T. P., Matsui T., Molloy C. J., Robbins K. C., Aaronson S. A. Autocrine mechanism for v-sis transformation requires cell surface localization of internally activated growth factor receptors. Proc. Natl Acad. Sci. USA 1989; 86: 8063–8067
  • Forsberg K., Valyi-Nagy I., Heldin C.-H., Herlyn M., Westermark B. A novel role for PDGF in oncogenesis is suggested by the development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB. Proc. Nail Acad. Sci. USA 1993; 90: 393–397
  • Grotendorst G. R., Chang T., Seppä H. E. J., Kleinman H. K., Martin G. R. Platelet-derived growth factor is a chemoattractant for vascular smooth muscle cells. J. Cell. Physiol. 1982; 113: 261–266
  • Hammacher A., Mellström K., Heldin C.-H., Westermark B. Isoform-specific induction of actin reorganization by platelet-derived growth factor suggests that the functionally active receptor is a dimer. EMBO J. 1989; 8: 2489–2495
  • Heldin C-H., Bäckström G., Östman A., Hammacher A., Ronnstrand L., Rubin K., Nistér M., Westermark B. Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types. EMBO J. 1988; 7: 1387–1394
  • Heldin C.-H., Wasteson Å., Westermark B. Interaction of platelet-derived growth factor with its fibroblast receptor. Demonstration of ligand degradation and receptor modulation. J. Biol. Chem. 1982; 257: 4216–4221
  • Heldin C.-H., Westermark B. Platelet-derived growth factor: mechanism of action and possible in vivo function. Cell Regulation 1990; 1: 555–566
  • Hosang M., Rouge M., Wipf B., Eggimann B., Kaufmann F., Hunziker W. Both homodimeric isoforms of PDGF (AA and BB) have mitogenic and chemotactic activity and stimulate phosphoinositol turnover. J. Cell. Physiol. 1989; 140: 558–564
  • Hunter W. M., Greenwood F. C. Preparation of iodine 131 labeled human growth hormone of high specific activity. Nature 1962; 194: 495–496
  • Johnsson A., Betsholtz C., Heldin C.-H., Westermark B. Antibodies against platelet-derived growth factor inhibit acute transformation by simian sarcoma virus. Nature 1985; 317: 438–440
  • Keating M. T., Williams L. T. Autocrine stimulation of intracellular PDGF receptors in v-sis transformed cells. Science 1988; 239: 914–916
  • Matsui T., Pierce J. H., Fleming T. P., Greenberger J. S., La-Rochelle W. J., Ruggiero M., Aaronson S. A. Independent expression of human α or β platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways. Proc. Natl Acad. Sci. USA 1989; 86: 8314–8318
  • Oefner C., D'Arcy A. D., Winkler F. K., Eggimann B., Hosang M. Crystal structure of human platelet-derived growth factor BB. EMBO J. 1992; 11: 3921–3926
  • Östman A., Bäckstrom G., Fong N., Betsholtz C., Wernstedt C., Hellman U., Westermark B., Valenzuela P., Heldin C.-H. Expression of three recombinant homodimeric isoforms of PDGF in Saccharomyces cerevisiae: Evidence for difference in receptor binding and functional activities. Growth Factors 1989; 1: 271–281
  • Östman A., Rall L., Hammacher A., Wormstead M. A., Coit D., Valenzuela P., Betsholtz C., Westermark B., Heldin C.-H. Synthesis and assembly of a functionally active recombinant platelet-derived growth-factor AB heterodimer. J. Biol. Chem. 1988; 263: 16202–16208
  • Östman A., Thyberg J., Westermark B., Heldin C.-H. PDGF-AA and PDGF-BB biosynthesis: Proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly. J. Cell Biol. 1992; 118: 509–519
  • Raines E. W., Bowen-Pope D. F., Ross R. Platelet-derived growth factor. Handbook of Experimental Pharmacology Peptide growth factors and their receptors, M. B. Sporn, A. B. Roberts. Springer-Verlag, Heidelberg 1990; 95: 173–262, part I
  • Raines E. W., Lane T. F., Iruela-Arispe M. L., Ross R., Sage E. H. The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB inhibits the binding of PDGF to its receptors. Proc. Natl Acad. Sci. USA 1992; 89: 1281–1285
  • Raines E. W., Ross R. Compartmentalization of PDGF on extracellular binding sites dependent on exon-6-encoded sequences. J. Cell Biol. 1992; 116: 533–543
  • Robbins K. C., Antoniades H. N., Devare S. G., Hunkapiller M. W., Aaronson S. A. Structural and immunological similarities between simian sarcoma virus gene product(s) and human platet derived growth factor. Nature 1983; 305: 605–609
  • Ross R., Raines E. W., Bowen-Pope D. F. The biology of platelet-derived growth factor. Cell 1986; 46: 155–169
  • Seppä H., Grotendorst G., Seppä S., Schiffmann E., Martin G. R. Platelet-derived growth factor is chemotactic for fibroblasts. J. Cell Biol. 1982; 92: 584–588
  • Siegbahn A., Hammacher A., Westermark B., Heldin C.-H. Differential effects of the various isoforms of platelet-derived growth factor on chemotaxis of fibroblasts, monocytes and granulocytes. J. Clin. Invest. 1990; 85: 916–920
  • Smith J. C., Singh J. P., Lillquist J. S., Goon D. S., Stiles C. D. Growth factors adherent to cell substrate are mitogenically active in situ. Nature 1982; 296: 154–156
  • Sprugel K. H., McPherson J. M., Clowes A. W., Ross R. Effects of growth factors in vivo I. Cell ingrowth into porous subcutaneous chambers. Am. J. Pathol. 1987; 129: 601–613
  • Thyberg J., Östman A., Báckström G., Westermark B., Heldin C. H. Localization of platelet-derived growth factor (PDGF) in CHO cells transfected with PDGF A- or B-chain cDNA: Retention of PDGF-BB in the endoplasmic reticulum and golgi complex. J. Cell Sci. 1990; 97: 219–229
  • Westermark B., Claesson-Welsh L., Heldin C.-H. Structural and functional Aspects of the Receptors for platelet-derived growth factor. Prog. Growth Factor Res. 1989; 1: 253–266
  • Westermark B., Heldin C.-H. Platelet-derived growth factor in autocrine transformation. Cancer Res. 1991; 51: 5087–5092

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