18
Views
20
CrossRef citations to date
0
Altmetric
Original Article

Involvement of Loop 2 of Platelet-Derived Growth Faetor-AA and-BB in Receptor Binding

, , , , &
Pages 159-164 | Received 12 Apr 1995, Accepted 03 May 1995, Published online: 11 Jul 2009

References

  • Andersson M., Östman A., Bäckström G., Hellman U., George-Nascimento C., Westermark B., Heldin C.-H. Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomelic PDGF. J. Biol. Chem. 1992; 267: 11260–11266
  • Betsholtz C., Johnsson A., Heldin C.-H., Westermark B., Lind P., Urdea M. S., Eddy R., Shows T. B., Philpott K., Mellor A. L., Knott T. J., Scott J. cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines. Nature 1986; 320: 695–699
  • Blobel G., Dobberstein B. Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components. J. Cell. Biol. 1975; 67: 835–851
  • Clements J. M., Bawden L. J., Bloxidge R. E., Catlin G., Cook A. L., Craig S., Drummond A. H., Edwards R. M., Fallon A. D., Green R., Hellewell P. G., Kirwin P. M., Nayee P. D., Richardson S. J., Brown D., Chahwala S. B., Snarey M., Winslow D. Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation. EMBO J. 1991; 10: 4113–4120
  • Eriksson A., Siegbahn A., Westermark B., Heldin C.-H., Claesson-Welsh L. PDGF α-and β-receptors activate unique and common signal transduction pathways. EMBO J. 1992; 11: 543–550
  • Fenstermaker R. A., Poptic E., Bonfield T. L., Knauss T. C., Corsillo L., Piskurich J. F., Kaetzel C. S., Jentoft J. E., Gelfand C., DiCorleto P. E., Kaetzel J., David M. A cationic region of the platelet-derived growth factor (PDGF) A-chain (Arg159-Lys161) is required for receptor binding and mitogenic activity of the PDGF-AA homodimer. J. Biol. Chem. 1993; 268: 10482–10489
  • Heldin C.-H., Westermark B. Platelet-derived growth factor: mechanism of action and possible in vivo function. Cell Regul. 1990; 1: 555–566
  • Herren B., Rooney B., Weyer K. A., Iberg N., Schmid G., Pech M. Dimerization of extracellular domains of platelet-derived growth factor receptors. J. Biol. Chem. 1993; 268: 15088–15095
  • Jaumann M., Hoppe V., Tatje D., Eichner W., Hoppe J. On the structure of platelet-derived growth factor AA: C-terminal processing, epitopes, and characterization of cysteine residues. Biochemistry 1991; 30: 3303–3309
  • Kenney W. C., Haniu M., Herman A. C., Arakawa T., Costigan V. J., Lary J., Yphantis D. A., Thomason A. R. Formation of mitogenically active PDGF-B dimer does not require interchain disulfide bonds. J. Biol. Chem. 1994; 260: 12351–12359
  • Kunkel T. A., Roberts J. D., Zakour R. A. Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol. 1987; 154: 367–382
  • LaRochelle W. J., Pierce J. H., May-Siroff M., Giese N., Aaronson S. A. Five PDGF B amino acid substitutions convert PDGF A to a PDGF B-like transforming molecule. J. Biol. Chem. 1992; 267: 17074–17077
  • Maher D. W., Strawn L. M., Donoghue D. J. Alanine mutagenesis of conserved residues in the platelet-derived growth factor family: identification of residues necessary for dimerization and transformation. Oncogene 1993; 8: 533–541
  • Oefner C., D'Arcy A., Winkler F. K., Eggimann B., Hosang M. Crystal structure of human platelet-derived growth factor BB. EMBO J. 1992; 11: 3921–3926
  • Östman A., Andersson M., Betsholtz C., Westermark B., Heldin C.-H. Identification of a cell retention signal in the B-chain of platelet-derived growth factor and in the long splice version of the A-chain. Cell Regul. 1991a; 2: 503–512
  • Östman A., Andersson M., Hellman U., Heldin C.-H. Identification of three amino acids in the platelet-derived growth factor (PDGF) B-chain that are important for binding to the PDGF β-receptor. J. Biol. Chem. 1991b; 266: 10073–10077
  • Östman A., Bäckström G., Fong N., Betsholtz C., Wernstedt C., Hellman U., Westermark B., Valenzuela P., Heldin C.-H. Expression of three recombinant homodimeric isoforms of PDGF in Saccharomyces cerevisiae: Evidence for difference in receptor binding and functional activities. Growth Factors 1989; 1: 271–281
  • Raines E. W., Bowen-Pope D. F., Ross R. Platelet-derived growth factor. Handbook of Experimental Pharmacology. Peptide growth factors and their receptors, M. B. Sporn, A. B. Roberts. Springer-Verlag, Heidelberg 1990; Vol. 95: 173–262, Part I
  • Thyberg J., Östman A., Bäckström G., Westermark B., Heldin C.-H. Localization of platelet-derived growth factor (PDGF) in CHO cells transfected with PDGF A-or B-chain cDNA: retention of PDGF-BB in the endoplasmic reticulum and Golgi complex. J. Cell Sci. 1990; 97: 219–229
  • Vassbotn F. S., Andersson M., Westermark B., Heldin C.-H., Östman A. Reversion of autocrine transformation by a dominant negative platelet-derived growth factor mutant. Mol. Cell. Biol. 1993; 13: 4066–4076

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.