584
Views
31
CrossRef citations to date
0
Altmetric
Research Article

Development and characterization of liposomal formulations for rapamycin delivery and investigation of their antiproliferative effect on MCF7 cells

, , &
Pages 322-331 | Received 27 Feb 2009, Accepted 12 Apr 2009, Published online: 28 Oct 2009

References

  • Alemdar AY, Sadi D, McAlister VC, Mendez I. (2004). Liposomal formulations of tacrolimus and rapamycin increase graft survival and fiber outgrowth of dopaminergic grafts. Cell Transpl 13:263–271.
  • Allen TM, Hansen C. (1991). Pharmacokinetics of stealth versus conventional liposomes: effect of dose. Biochim Biophys Acta 1068:133–141.
  • Allen TM, Romans AY, Kercret H., Segrest JP. (1980). Detergent removal during membrane reconstitution. Biochim Biophys Acta 601:328.
  • Arceci RJ, Stieglitz K, Bierer BE. (1992). Immunosuppressants FK506 and rapamycin function as reversal agents of the multidrug resistance phenotype. Blood 80:1528–1536.
  • Baker H, Sidorowicz A, Sehgal SN. (1978). Rapamycin (AY-22,989), a new antifungal antibiotic. III. In vitro and in vivo evaluation. J Antibiot (Tokyo) 31:539–545.
  • Batzri S, Korn ED. (1973). Single-bilayer liposome without sonication. Biochim Biophys Acta 298:1015.
  • Barenholz Y, Crommelin DCA. (1994). Liposomes as pharmaceutical dosage forms. In Swarbrick J, Boylan JC (Ed.), Encyclopedia for Pharmaceutical Technology, Volume 9 (p 27). New York: Informa Healthcare.
  • Douros J, Suffness M. (1981). New antitumor substances of natural origin. Cancer Treat Rev 8:63–87.
  • Eng CP, Sehgal SN, Vezina C. (1984). Activity of rapamycin (AY-22, 989) against transplanted tumors. J Antibiot (Tokyo) 37:1231–1237.
  • Ferron GM, Conway WD, Jusko WJ. (1997). Lipophilic benzamide and anilide derivatives as high-performance liquid chromatography internal standards: application to sirolimus(rapamycin) determination. J Chromatogr B 703:243–251.
  • Gabizon AA. (1992). Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long circulating liposomes. Cancer Res 52:891–896.
  • Gabizon A, Papahadjopoulos D. (1988). Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors. Proc Natl Acad Sci U S A 85:6949–6953.
  • Guba M, von Breitenbuch P, Steinbauer M. (2002). Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med 8:128–135.
  • Holt DW, Lee T, Johnston A. (2000). Measurement of Sirolimus in whole blood using high-performance liquid chromatography with ultraviolet detection. Clin Ther 22:B38–B48.
  • Hong RL, Huang CJ, Tseng YL, Pang VF, Chen ST, Liu JJ, et al. (1999). Direct comparison of liposomal doxorubicin with or without polyethylene glycol coating in C-26 tumor-bearing mice: is surface coating with polyethylene glycol beneficial? Clin Cancer Res 5:3645–3652.
  • Houchens DP, Ovejera AA, Riblet SM, Slagel DE. (1983). Human brain tumor xenografts in nude mice as a chemotherapy model. Eur J Cancer Clin Oncol 19:799–805.
  • Martel RR, Klicius J, Galet S. (1977). Inhibition of the immune response by rapamycin, a new antifungal antibiotic. Can J Physiol Pharmacol 55:48–51.
  • Marx SO, Marks AR. (2001). Bench to bedside: the development of rapamycin and its application to stent restenosis. Circulation 104:852–855.
  • McAlpine JB, Swanson SJ, Jackson M. (1991). Revised NMR assignments for rapamycin. J Antiobiot (Tokyo) 44:688.
  • Montaguti P, Melloni E, Cavalletti E. (1994). Acute intravenous toxicity of dimethyl sulfoxide, polyethylene glycol 400, dimethylformamide, absolute ethanol, and benzyl alcohol in inbred mouse strains, Arzneim Forsch Drug Res 44:566–570.
  • Mosmann T. (1983). Rapid calorimetric assay for cellular growth and survival: application of proliferation and cytotoxicity assay. J Immunol Meth 65:55–63.
  • Pagano RE, Takeichi M. (1977). Adhesion of phospholipid vesicles to Chinese hamster fibroblasts. Role of cell surface proteins. J Cell Biol 4:531–546.
  • Papahadjopoulos D, Allen TM, Gabizon A, Mayhew E, Matthay K, Huang SK, et al. (1991). Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy. Proc Natl Acad Sci U S A 88:11460–11464.
  • Parr MJ, Masin D, Cullis PR, Bally MB. (1997). Accumulation of liposomal lipid and encapsulated doxorubicin in murine Lewis lung carcinoma: the lack of beneficial effects by coating liposomes with poly(ethylene glycol). J Pharmacol Exp Ther 280:1319–1327.
  • Rao LS. (1984). Preparation of liposomes on the industrial scale: problems and perspectives. In: Gregoridis G (Ed.), Liposome Technology: Volume I, Preparation of Liposome (p 252). Boca Raton, Florida, USA: CRC Press.
  • Rapamune®. (2009). Product literature. Philadelphia, Pennsylvania, USA: Wyeth Pharmaceuticals Inc. Online at: www.fda.gov/cder/foi/label/2005/21083s019,21110s024lbl.pdf. Accessed March 24, 2009.
  • Raymond E, Alexandre J, Faivre S, Vera K, Materman E, Boni J, et al. (2004). Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. J Clin Oncol 22:2336–2347.
  • Simamora P. (2001). Solubilization of rapamycin. Int J Pharmaceut 213:25–29.
  • Stewart JCM. (1980). Colorimetric determination of phospholipids with ammonium ferrothiocyanates. Anal Biochem 104:10–14.
  • Straubinger RM, Hong K, Friend DS, Papahadjopoulos D. (1983). Endocytosis of liposomes and intracellular fate of encapsulated molecules: encounter with a low pH compartment after internalization in coated vesicles. Cell 32:1069–1079.
  • Vinals F, Chambard JC, Pouyssegur J. (1999). p70 S6 kinase-mediated protein synthesis is a critical step for vascular endothelial cell proliferation. J Biol Chem 274:26776–26782.
  • Yatscoff R. (1996). Pharmacokinetics of rapamycin. Transplant Proc 28:970–973.
  • Yatscoff RD, LeGatt D, Keenan R, Chackowski P. (1993). Blood distribution of rapamycin. Transplantation 56:1202–1206.
  • Yu Y, Sato JD. (1999). MAP kinases, phosphatidylinositol 3-kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor. J Cell Physiol 78:235–246.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.