Medical Application of Synthetic Phospholipids as Liposomes and Drugs

References

• Eibl H. Phospholipids as functional constituents of biomembranes. Angew. Chem. Int. Ed. Engl. 1984; 23: 257
   Web of Science ®Google Scholar
• Bangham A. D., Standish M. M., Watkins J. C. Diffusion of univalent ions across the lamellae of swollen phospholipids. J. Mol. Biol. 1965; 13: 238
   PubMed Web of Science ®Google Scholar
• Andreesen R., Giese V. Differential effcts of ether lipids on he activity and secretion of interleukin-1 and interleukin-2. Lipids 1987; 22: 836
   PubMed Web of Science ®Google Scholar
• Shoji M., Raynor R. L., Fleer E. A.M., Eibl H., Vogler W. R., Kuo J. F. Effects of hexadecylphosphocholine on proteinkinase C and TPA-indced differentiation of HL60 cells. Lipids 1991; 26: 145
   PubMed Web of Science ®Google Scholar
• Munder P. G., Weltzien H. U., Modolell M. Lysolecithin analogs: a new class of immunopotentiators. VII Int. Symp. Immunopathology, P. A. Miescher. Schwabe, Basel 1976; 411
   Google Scholar
• Eibl H., Unger C. Hexadecylphosphocholine: a new and selective antitumor drug. Cancer Treat. Rev. 1990; 17: 233
   PubMed Web of Science ®Google Scholar
• Eibl H., Woolley P. Synthesis of enantiomerically pure glyceryl esters and ethers. I. Methods employing the precursor 1,2-isopropylidene-sn-glycerol. Chem. Phys. Lipids 1986; 41: 53
   Web of Science ®Google Scholar
• Eibl H., Woolley P. Synthesis of enantiomerically pure glyceryl esters and ethers. II. Methods employing the precursor 3,4-isopropylidene-D-mannitol. Chem. Phys. Lipids 1988; 47: 47
   Google Scholar
• Kranich A., Kaufmann-Kolle P., Unger C., Eibl H. Doxorubicin liposomes: the influence of lipid composition on biodistribution in mice. Lipids 1994, accepted for publication
   Google Scholar
• Jain M. K., Rogers J., Marecek J. F., Ramirez F., Eibl H. Effect of the structure of phospholipid on the kinetics of intravesicle scooting of phospholipase A2. Biochim. Biophys. Acta 1986; 860: 462
   PubMed Web of Science ®Google Scholar
• Ries U., Fleer E. A.M., Unger C., Eibl H. Synthetic phospholipids as aubstrates for phospholipase C from Bacillus cereus. Biochim. Biophys. Acta 1992; 1125: 166
   PubMedGoogle Scholar
• Eibl H., Engel J. Synthesis of hexadecylphosphocholine. Alkylphosphocholines: New drugs in cancer therapy, H. Eibl, P. Hilgard, C. Unger. Prog. Exp. Tumor Res., S. Karger, Basel 1992; 34: 1
   Google Scholar
• Kaufmann-Kolle P. Liposomen aus synthetischen Phospholipiden: Struktur, Stabilität und biologisches Verhalten. Ph. D. Thesis, Technische Universität Braunschweig, FRG 1986
   Google Scholar
• Kaufmann-Kolle P., Unger C., Eibl H. Hexadecylphosphocholine in liposomal dispersion. Alkylphosphocholines: New drugs in cancer therapy, H. Eibl, P. Hilgard, C. Unger. Prog. Exp. Tumor Res., S. Karger, Basel 1992; 34: 12
   Google Scholar
• Profitt R. T., Satorius A., Chiang S. M., Sullivan L., Adler-Moore J. P. Pharmacology and toxicology of a liposomal formulation of amphotericin B (AMBISOME™). J. Antimicrob. Chemother. 1991; 28(Suppl.)49
   Google Scholar
• Woolley P., Eibl H. Synthesis of enantiomerically pure phospholipids including phosphatidylserine and phosphatidylglycerol. Chem. Phys. Lipids 1988; 47: 55
   Google Scholar
• Eibl H., Woolley P. A general synthetic method for enantiomerically pure ester and ether lyso-phospholipids. Chem. Phys. Lipids 1988; 47: 63
   Google Scholar
• Unger C., Eibl H. Phospholipide als Antitumormittel, zytotoxische Prinzipien als Ergebnis von Strukturvariationen. Mammacarcinome — neue Perspektiven experimenteller und klinischer Therapieforschung, G. A. Nagel. Springer, Berlin 1986; 115
   Google Scholar
• Fleer E. A.M., Kim D.-J., Nagel G. A., Eibl H., Unger C. Cytotoxic activity of lysophospatidylcholine and analogues on human lymphoma Raji cells. Onkologie 1990; 13: 295
   PubMedGoogle Scholar
• Kötting J., Marschner N., Neumüller W., Unger C., Eibl H. Hexadecylphosphocholine and octadecyl-methyl-glycero-3-phosphocholine: A comparison of hemolytic activity, serum binding and tissue distribution. Alkylphosphocholines: New drugs in cancer therapy, H. Eibl, P. Hilgard, C. Unger. Prog. Exp. Tumor Res., Karger, Basel 1992; 34: 131
   Google Scholar
• Berger M. R., Schmähl D., Eibl H., Unger C. Structure activity relationship of alkylphosphocholines in methylnitrosourea (MNU)-induced rat mammary carcinoma. J. Cancer Res. Clin. Oncol. 1988; 114(Suppl.)S73
   Google Scholar
• Unger C., Eibl H., Nagel G. A., Heyden H. W., Breiser A., Engel J., Stekar J., Peukert P., Hilgart P., Berger M. R. Hexadecylphosphocholine in the topical treatment of skin metastases, a phase I trial. Contributions to oncology. New drugs in oncology, W. Queißer, H. H. Fiebig. S. Karger, Basel 1989; 219
   Google Scholar
• Kaufmann-Kolle P., Fleer E. A.M., Kötting J., Behnert C., Unger C., Eibl H. Liposomal hexadecylphosphocholine: Characterization and effects on adherent tumor cells. J. Liposome Res. 1994, in press
   Google Scholar
• Kaufmann-Kolle P., Kötting J., Drevs J., Berger M. R., Unger C., Eibl H. Intravenous application of alkylphosphocholines: comparison of different homologues in lamellar structures. J. Cancer Res. Clin. Oncol. 1992; 120(Suppl.)R14
   Google Scholar
• Kaufmann-Kolle P., Drevs J., Berger M. R., Kötting J., Marschner N., Unger C., Eibl H. Pharmacokinetic behaviour and antineoplastic activity of liposomal hexadecylphosphocholine. Cancer Chemother. Pharmacol. 1994; 34: 393
   PubMed Web of Science ®Google Scholar
• Berger M. R., Habs M., Schmähl D. Non-carcinogenic chemotheapy with a combination of vincristine, methotrexate and fluorouracil (VMF) in rats. Int. J. Cancer 1983; 32: 231
   Google Scholar
• Kötting J., Marschner N., Unger C., Eibl H. Determination of alkylphosphocholines in biological fluids and tissues. Alkylphosphocholines: New drugs in cancer therapy, H. Eibl, P. Hilgard, C. Unger. Prog. Exp. Tumor Res., S. Karger, Basel 1992; 34: 6
   Google Scholar