Does the Microbiome Cause B27-related Acute Anterior Uveitis?

REFERENCES

• Brewerton DA, Caffrey M, Nicholls A, et al. Acute anterior uveitis and HL-A 27. Lancet. 1973;302:994–996.
   PubMed Web of Science ®Google Scholar
• Reveille JD, Sims AM, Danoy P, et al. Australo-Anglo-American Spondyloarthritis Consortium (TASC). Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. Nat Genet. 2010;42:123–127.
   PubMed Web of Science ®Google Scholar
• Robinson PC, Claushuis TA, Cortes A, et al. Genetic dissection of acute anterior uveitis reveals similarities and differences in associations observed with ankylosing spondylitis. Arthritis Rheumatol. 2015;67:140–151.
   PubMed Web of Science ®Google Scholar
• Martin TM, Zhang G, Luo J, et al. A locus on chromosome 9p predisposes to a specific disease manifestation, acute anterior uveitis, in ankylosing spondylitis, a genetically complex, multisystem, inflammatory disease. Arthritis Rheum. 2005;52:269–274.
   PubMed Web of Science ®Google Scholar
• Agnani S, Choi D, Martin TM, et al. Gender and laterality affect recurrences of acute anterior uveitis. Br J Ophthalmol. 2010; 94:1643–1647.
   Google Scholar
• Levinson RD, Greenhill LH. The monthly variation in acute anterior uveitis in a community-based ophthalmology practice. Ocul Immunol Inflamm. 2002;10:133–139.
   PubMed Web of Science ®Google Scholar
• Rosenbaum JT. Characterization of uveitis associated with spondyloarthritis. J Rheumatol. 1989;16:792–796.
   PubMed Web of Science ®Google Scholar
• Paiva ES, Macaluso DC, Edwards A, et al. Characterisation of uveitis in patients with psoriatic arthritis. Ann Rheum Dis. 2000;59:67–70.
   PubMed Web of Science ®Google Scholar
• Lyons JL, Rosenbaum JT. Uveitis associated with inflammatory bowel disease compared with uveitis associated with spondyloarthropathy. Arch Ophthalmol. 1997;115:61–64.
   PubMedGoogle Scholar
• Khan MA. Polymorphism of HLA-B27: 105 subtypes currently known. Curr Rheumatol Rep. 2013;15:362.
   PubMed Web of Science ®Google Scholar
• Taurog JD. The role of HLA-B27 in spondyloarthritis. J Rheumatol. 2010;37:2606–2616.
   PubMedGoogle Scholar
• Colbert RA, Delay ML, Layh-Schmitt G, et al. HLA-B27 misfolding and spondyloarthropathies. Adv Exp Med Biol. 2009;649:217–234.
   PubMed Web of Science ®Google Scholar
• Granfors K, Jalkanen S, Lindberg AA, et al. Salmonella lipopolysaccharide in synovial cells from patients with reactive arthritis. Lancet. 1990;335:685–688.
   PubMed Web of Science ®Google Scholar
• Stieglitz H, Lipsky P. Association between reactive arthritis and antecedent infection with Shigella flexneri carrying a 2-Md plasmid and encoding an HLA-B27 mimetic epitope. Arthritis Rheum. 1993;36:1387–1391.
   PubMed Web of Science ®Google Scholar
• Keat A, Nkwazi GC, Pegrum GD, et al. Role of chlamydia trachomatis and HLA-B27 in sexually acquired reactive arthritis. Br Med J. 1978;1:605–607.
   PubMed Web of Science ®Google Scholar
• Taurog JD. The role of HLA-B27 in spondyloarthritis. J Rheumatol. 2010;37:2606–2616.
   PubMedGoogle Scholar
• Lederberg J, McCray AT. ‘Ome Sweet’ Omics: a genealogical treasury of words. The Scientist. 2001;15:8.
   Web of Science ®Google Scholar
• Hill DA, Artis D. Intestinal bacteria and the regulation of immune cell homeostasis. Annu Rev Immunol. 2010;28:623–667.
   PubMed Web of Science ®Google Scholar
• Haag LM, Siegmund B. Intestinal microbiota and the innate immune system – A crosstalk in Crohn’s disease pathogenesis. Front Immunol. 2015;6:489.
   PubMed Web of Science ®Google Scholar
• Moayyedi P, Surette MG, Kim PT, et al. Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial. Gastroenterology. 2015;149:102–109 e6.
   PubMed Web of Science ®Google Scholar
• Scher JU, Ubeda C, Artacho A, et al. Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease. Arthritis Rheumatol. 2015;67:128–139.
   PubMed Web of Science ®Google Scholar
• Costello ME, Ciccia F, Willner D, et al. Intestinal dysbiosis in ankylosing spondylitis. Arthritis Rheumatol. 2014.
   Google Scholar
• Lin P, Bach M, Asquith M, et al. HLA-B27 and Human beta2-microglobulin affect the gut microbiota of transgenic rats. PLoS One. 2014;9:e105684.
   PubMed Web of Science ®Google Scholar
• Gomez A, Luckey D, Yeoman CJ, et al. Loss of sex and age driven differences in the gut microbiome characterize arthritis-susceptible 0401 mice but not arthritis-resistant 0402 mice. PLoS One. 2012;7:e36095.
   PubMed Web of Science ®Google Scholar
• Olivares M, Neef A, Castillejo G, et al. The HLA-DQ2 genotype selects for early intestinal microbiota composition in infants at high risk of developing coeliac disease. Gut. 2015;64:406–417.
   PubMed Web of Science ®Google Scholar
• Stoll ML, Kumar R, Morrow CD, et al. Altered microbiota associated with abnormal humoral immune responses to commensal organisms in enthesitis-related arthritis. Arthritis Res Ther. 2014;16:486.
   PubMed Web of Science ®Google Scholar
• Martinez-Gonzalez O, Cantero-Hinojosa J, Paule-Sastre P, et al. Intestinal permeability in patients with ankylosing spondylitis and their healthy relatives. Br J Rheumatol. 1994;33:644–647.
   PubMedGoogle Scholar
• Smith MD, Gibson RA, Brooks PM. Abnormal bowel permeability in ankylosing spondylitis and rheumatoid arthritis. J Rheumatol. 1985;12:299–305.
   PubMed Web of Science ®Google Scholar
• Mielants H, Veys EM, De Vos M, et al. Increased intestinal permeability in ankylosing spondylitis. Gut. 1992;33:1150.
   PubMed Web of Science ®Google Scholar
• Merilahti-Palo R, Soderstrom KO, Lahesmaa-Rantala R, et al. Bacterial antigens in synovial biopsy specimens in Yersinia triggered reactive arthritis. Ann Rheum Dis. 1991;50:87–90.
   PubMed Web of Science ®Google Scholar
• Nikkari S, Rantakokko K, Ekman P, et al. Salmonella-triggered reactive arthritis: use of polymerase chain reaction, immunocytochemical staining, and gas chromatography-mass spectrometry in the detection of bacterial components from synovial fluid. Arthritis Rheum. 1999;42:84–89.
   PubMed Web of Science ®Google Scholar
• Rubin RM, Noland J, Rosenbaum JT. Reduction of endotoxin-induced vascular permeability by monoclonal antibodies against lipopolysaccharide determinants. Circ Shock. 1992;36:217–223.
   PubMedGoogle Scholar
• Cousins SW, Guss RB, Howes Jr. EL, Rosenbaum JT. Endotoxin-induced uveitis in the rat: observations on altered vascular permeability, clinical findings, and histology. Exp Eye Res. 1984;39:665–676.
   PubMed Web of Science ®Google Scholar
• Rosenbaum JT, Cousins S. Uveitis and arthritis: experimental models and clinical correlates. Semin Arthritis Rheum. 1982;11:383–389.
   PubMed Web of Science ®Google Scholar
• Munoz-Fernandez S, Hidalgo V, Fernandez-Melon J, et al. Sulfasalazine reduces the number of flares of acute anterior uveitis over a one-year period. J Rheumatol. 2003;30:1277–1279.
   PubMed Web of Science ®Google Scholar
• Dougados M, Berenbaum F, Maetzel A, et al. Prevention of acute anterior uveitis associated with spondyloarthropathy induced by salazosulfapyridine. Revue du Rhumatisme. 1993;60:81–83.
   PubMedGoogle Scholar
• Visser J, Rozing J, Sapone A, et al. Tight junctions, intestinal permeability, and autoimmunity: celiac disease and type 1 diabetes paradigms. Ann N Y Acad Sci. 2009;1165:195–205.
   PubMed Web of Science ®Google Scholar
• van der Heijden IM, Wilbrink B, Tchetverikov I, et al. Presence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritides. Arth Rheum. 2000;43:593–598.
   PubMed Web of Science ®Google Scholar
• Cunningham MW. Streptococcus and rheumatic fever. Curr Opin Rheumatol. 2012;24:408–416.
   PubMed Web of Science ®Google Scholar
• Yuki N. Infectious origins of, and molecular mimicry in, Guillain-Barre and Fisher syndromes. Lancet Infect Dis. 2001;1:29–37.
   PubMedGoogle Scholar
• Horai R, Zarate-Blades CR, Dillenburg-Pilla P, et al. Microbiota-dependent activation of an autoreactive T cell receptor provokes autoimmunity in an immunologically privileged site. Immunity. 2015;43:343–353.
   PubMed Web of Science ®Google Scholar
• Scofield RH, Kurien B, Gross T, et al. HLA-B27 binding of peptide from its own sequence and similar peptides from bacteria: implications for spondyloarthropathies. Lancet. 1995;345:1542–1544.
   PubMed Web of Science ®Google Scholar
• Scofield RH, Warren WL, Koelsch G, et al. A hypothesis for the HLA-B27 immune dysregulation in spondyloarthropathy: contributions from enteric organisms, B27 structure, peptides bound by B27, and convergent evolution. Proc Natl Acad Sci USA. 1993;90:9330–9334.
   PubMed Web of Science ®Google Scholar
• Wu HJ, Ivanov II, Darce J, et al. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity. 2010;32:815–827.
   PubMed Web of Science ®Google Scholar
• Arnold IC, Dehzad N, Reuter S, et al. Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells. J Clin Invest. 2011;121:3088–3093.
   PubMed Web of Science ®Google Scholar
• Sefik E, Geva-Zatorsky N, Oh S, et al. MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of RORγ+ regulatory T cells. Science. 2015;349:993–997.
   PubMed Web of Science ®Google Scholar
• Round JL, Mazmanian SK. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci USA. 2010;107:12204–12209.
   PubMed Web of Science ®Google Scholar
• Nakamura Y, Metea C, Gruner H, et al. Altering the gut microbiota ameliorates experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2014;55:2497.
   Web of Science ®Google Scholar
• Yano JM, Yu K, Donaldson GP, et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell. 2015;161:264–276.
   PubMed Web of Science ®Google Scholar
• Taurog JD, Richardson JA, Croft JT, et al. The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J Exp Med. 1994;180:2359–2364.
   PubMed Web of Science ®Google Scholar
• Rehaume LM, Mondot S, Aguirre de Carcer D, et al. ZAP-70 genotype disrupts the relationship between microbiota and host, leading to spondyloarthritis and ileitis in SKG mice. Arthritis Rheumatol. 2014;66:2780–2792.
   PubMed Web of Science ®Google Scholar
• Monteleone G, Neurath MF, Ardizzone S, et al. Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn’s disease. N Engl J Med. 2015;372:1104–1113.
   PubMed Web of Science ®Google Scholar
• Taggart A, Gardiner P, McEvoy F, et al. Which is the active moiety of sulfasalazine in ankylosing spondylitis? Arthritis Rheum. 1996;39:1400–1405.
   PubMed Web of Science ®Google Scholar