Advanced search
Publication Cover
Gynecological Endocrinology Volume 27, 2011 - Issue 11
Submit an article Journal homepage
66
Views
1
CrossRef citations to date
0
Altmetric
Pcos & Androgen Excess

Evidence that lack of ligand-binding domain correlates with nuclear distribution of unliganded human androgen receptor and loss of transactivation activity

Noriko SuzukiDepartment of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu, 501-1194, JapanCorrespondence[email protected]
&
Atsushi ImaiInstitute of Endocrine-Related Cancer, Matsunami General Hospital, Kasamatsu, Gifu, 501-6062, Japan
Pages 940-943 | Received 31 Aug 2010, Accepted 03 Mar 2011, Published online: 18 Apr 2011

References

  • Bennett NC, Gardiner RA, Hooper JD, Johnson DW, Gobe GC. Molecular cell biology of androgen receptor signalling. Int J Biochem Cell Biol 2010;42:813–827.
  • Li J, Al-Azzawi F. Mechanism of androgen receptor action. Maturitas 2009;63:142–148.
  • Gelmann EP. Molecular biology of the androgen receptor. J Clin Oncol 2002;20:3001–3015.
  • Prescott J, Coetzee GA. Molecular chaperones throughout the life cycle of the androgen receptor. Cancer Lett 2006;231:12–19.
  • Jenster G, Trapman J, Brinkmann AO. Nuclear import of the human androgen receptor. Biochem J 1993;293(Pt3):761–768.
  • Cutress ML, Whitaker HC, Mills IG, Stewart M, Neal DE. Structural basis for the nuclear import of the human androgen receptor. J Cell Sci 2008;121:957–968.
  • Kaku N, Matsuda K, Tsujimura A, Kawata M. Characterization of nuclear import of the domain-specific androgen receptor in association with the importin alpha/beta and Ran-guanosine 5'-triphosphate systems. Endocrinology 2008;149:3960–3969.
  • Galani A, Kitsiou-Tzeli S, Sofokleous C, Kanavakis E, Kalpini-Mavrou A. Androgen insensitivity syndrome: clinical features and molecular defects. Hormones (Athens) 2008;7: 217–229.
  • Brinkmann AO. Molecular basis of androgen insensitivity. Mol Cell Endocrinol 2001;179:105–109.
  • Gottlieb B, Beitel LK, Wu JH, Trifiro M. The androgen receptor gene mutations database (ARDB). Hum Mutat 2004;23:527–533.
  • Rong HL, Suzuki N, Imai A. A double nucleotide insertion-induced frame-shift mutation of the androgen receptor gene in a familial complete androgen insensitivity syndrome. Eur J Obstet Gynecol Reprod Biol 2010;148:53–55.
  • Zhou ZX, Sar M, Simental JA, Lane MV, Wilson EM. A ligand-dependent bipartite nuclear targeting signal in the human androgen receptor. Requirement for the DNA-binding domain and modulation by NH2-terminal and carboxyl-terminal sequences. J Biol Chem 1994;269:13115–13123.
  • Saporita AJ, Zhang Q, Navai N, Dincer Z, Hahn J, Cai X,Wang Z. Identification and characterization of a ligand-regulated nuclear export signal in androgen receptor. J Biol Chem 2003;278:41998–42005.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.