The effect of menopause on the skin and other connective tissues

References

• Castelo-Branco C. Skin collagen changes related to age, menopause and hormone replacement therapy. In: Brincat, MP. editor, Hormone Replacement Therapy and the Skin UK: Parthenon Publishing 2001.
   Google Scholar
• Lovell CR, Smolenski KA, Duance VC, Light ND, Young S, Dyson M. Type I and III collagen content and fibre distribution in normal human skin during ageing. Br J Dermatol 1987;117:419–428.
   PubMed Web of Science ®Google Scholar
• Uitto J. Connective tissue biochemistry of the aging dermis. Age-related alterations in collagen and elastin. Dermatol Clin 1986;4:433–446.
   PubMed Web of Science ®Google Scholar
• Bolognia JL, Braverman IM, Rousseau ME, Sarrel PM. Skin changes in menopause. Maturitas 1989;11:295–304.
   PubMedGoogle Scholar
• Brincat M, Kabalan S, Studd JW, Moniz CF, de Trafford J, Montgomery J. A study of the decrease of skin collagen content, skin thickness, and bone mass in the postmenopausal woman. Obstet Gynecol 1987;70:840–845.
   PubMed Web of Science ®Google Scholar
• Brincat M, Moniz CJ, Studd JW, Darby A, Magos A, Emburey G, Versi E. Long-term effects of the menopause and sex hormones on skin thickness. Br J Obstet Gynaecol 1985;92:256–259.
   PubMedGoogle Scholar
• Brincat M, Versi E, Moniz CF, Magos A, de Trafford J, Studd JW. Skin collagen changes in postmenopausal women receiving different regimens of estrogen therapy. Obstet Gynecol 1987;70:123–127.
   PubMed Web of Science ®Google Scholar
• Affinito P, Palomba S, Sorrentino C, Di Carlo C, Bifulco G, Arienzo MP, Nappi C. Effects of postmenopausal hypoestrogenism on skin collagen. Maturitas 1999;33:239–247.
   PubMed Web of Science ®Google Scholar
• Sauerbronn AV, Fonseca AM, Bagnoli VR, Saldiva PH, Pinotti JA. The effects of systemic hormonal replacement therapy on the skin of postmenopausal women. Int J Gynaecol Obstet 2000;68:35–41.
   PubMed Web of Science ®Google Scholar
• Castelo-Branco C, Duran M, González-Merlo J. Skin collagen changes related to age and hormone replacement therapy. Maturitas 1992;15:113–119.
   PubMed Web of Science ®Google Scholar
• Shah MG, Maibach HI. Estrogen and skin. An overview. Am J Clin Dermatol 2001;2:143–150.
   PubMedGoogle Scholar
• Brincat M, Moniz CF, Studd JW, Darby AJ, Magos A, Cooper D. Sex hormones and skin collagen content in postmenopausal women. Br Med J (Clin Res Ed) 1983;287:1337–1338.
   PubMed Web of Science ®Google Scholar
• Kalogirou D, Aroni K, Kalogirou O, Antoniou G, Botsis D, Kontoravdis A. Histological changes induced by tibolone and estrogen/glucocorticoid on aging skin. Int J Fertil Womens Med 2000;45:273–278.
   PubMed Web of Science ®Google Scholar
• Beauregard S, Gilchrest BA. A survey of skin problems and skin care regimens in the elderly. Arch Dermatol 1987;123:1638–1643.
   PubMed Web of Science ®Google Scholar
• Dunn LB, Damesyn M, Moore AA, Reuben DB, Greendale GA. Does estrogen prevent skin aging? Results from the First National Health and Nutrition Examination Survey (NHANES I). Arch Dermatol 1997;133:339–342.
   PubMed Web of Science ®Google Scholar
• Callens A, Vaillant L, Lecomte P, Berson M, Gall Y, Lorette G. Does hormonal skin aging exist? A study of the influence of different hormone therapy regimens on the skin of postmenopausal women using non-invasive measurement techniques. Dermatology (Basel) 1996;193:289–294.
   PubMed Web of Science ®Google Scholar
• Brincat MP, Baron YM, Galea R. Estrogens and the skin. Climacteric 2005;8:110–123.
   PubMed Web of Science ®Google Scholar
• Haapasaari KM, Raudaskoski T, Kallioinen M, Suvanto-Luukkonen E, Kauppila A, Läärä E, Risteli J, Oikarinen A. Systemic therapy with estrogen or estrogen with progestin has no effect on skin collagen in postmenopausal women. Maturitas 1997;27:153–162.
   PubMed Web of Science ®Google Scholar
• Oikarinen A. Systemic estrogens have no conclusive beneficial effect on human skin connective tissue. Acta Obstet Gynecol Scand 2000;79:250–254.
   PubMed Web of Science ®Google Scholar
• Brincat M, Moniz CF, Kabalan S, Versi E, O’Dowd T, Magos AL, Montgomery J, Studd JW. Decline in skin collagen content and metacarpal index after the menopause and its prevention with sex hormone replacement. Br J Obstet Gynaecol 1987;94:126–129.
   PubMedGoogle Scholar
• Punnonen R, Vaajalahti P, Teisala K. Local oestriol treatment improves the structure of elastic fibers in the skin of postmenopausal women. Ann Chir Gynaecol Suppl 1987;202:39–41.
   PubMedGoogle Scholar
• Rebora A. Pathogenesis of androgenetic alopecia. J Am Acad Dermatol 2004;50:777–779.
   PubMedGoogle Scholar
• Hoffmann R, Niiyama S, Huth A, Kissling S, Happle R. 17alpha-estradiol induces aromatase activity in intact human anagen hair follicles ex vivo. Exp Dermatol 2002;11:376–380.
   PubMed Web of Science ®Google Scholar
• Wallace ML, Smoller BR. Estrogen and progesterone receptors in androgenic alopecia versus alopecia areata. Am J Dermatopathol 1998;20:160–163.
   PubMed Web of Science ®Google Scholar
• Kossard S, Lee MS, Wilkinson B. Postmenopausal frontal fibrosing alopecia: a frontal variant of lichen planopilaris. J Am Acad Dermatol 1997;36:59–66.
   PubMed Web of Science ®Google Scholar
• Anttinen H, Orava S, Ryhänen L, Kivirikko KI. Assay of protocollagen lysyl hydroxylase activity in the skin of human subjects and changes in the activity with age. Clin Chim Acta 1973;47:289–294.
   Google Scholar
• Henry F, Piérard-Franchimont C, Cauwenbergh G, Piérard GE. Age-related changes in facial skin contours and rheology. J Am Geriatr Soc 1997;45:220–222.
   PubMed Web of Science ®Google Scholar
• Piérard GE, Letawe C, Dowlati A, Piérard-Franchimont C. Effect of hormone replacement therapy for menopause on the mechanical properties of skin. J Am Geriatr Soc 1995;43:662–665.
   PubMed Web of Science ®Google Scholar
• Kafantari H, Kounadi E, Fatouros M, Milonakis M, Tzaphlidou M. Structural alterations in rat skin and bone collagen fibrils induced by ovariectomy. Bone 2000;26:349–353.
   PubMed Web of Science ®Google Scholar
• Ashcroft GS, Greenwell-Wild T, Horan MA, Wahl SM, Ferguson MW. Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response. Am J Pathol 1999;155:1137–1146.
   PubMed Web of Science ®Google Scholar
• Calvin M. Oestrogens and wound healing. Maturitas 2000;34:195–210.
   PubMed Web of Science ®Google Scholar
• Schmidt JB, Binder M, Demschik G, Bieglmayer C, Reiner A. Treatment of skin aging with topical estrogens. Int J Dermatol 1996;35:669–674.
   PubMed Web of Science ®Google Scholar
• Graziottin A. Libido: the biologic scenario. Maturitas 2000;34 Suppl 1:S9–16.
   PubMed Web of Science ®Google Scholar
• Sumino H, Ichikawa S, Abe M, Endo Y, Ishikawa O, Kurabayashi M. Effects of aging, menopause, and hormone replacement therapy on forearm skin elasticity in women. J Am Geriatr Soc 2004;52:945–949.
   PubMed Web of Science ®Google Scholar
• Black MM, Shuster S, Bottoms E. Osteoporosis, skin collagen, and androgen. Br Med J 1970;4:773–774.
   PubMedGoogle Scholar
• Takahashi M, Kushida K, Hoshino H, Ohishi T, Inoue T. Biochemical markers of bone turnover do not decline after menopause in healthy women. Br J Obstet Gynaecol 1999;106:427–431.
   Google Scholar
• Brincat MP, Baron YM, Galea R. Skin and connective tissues. In: Studd J, Lauritzen C, editors. Current Management of the Menopause.London: Taylor & Francis; 2001.
   Google Scholar
• Haenggi W, Linder HR, Birkhaeuser MH, Schneider H. Microscopic findings of the nail-fold capillaries–dependence on menopausal status and hormone replacement therapy. Maturitas 1995;22:37–46.
   PubMed Web of Science ®Google Scholar
• Arora S, Veves A, Caballaro AE, Smakowski P, LoGerfo FW. Estrogen improves endothelial function. J Vasc Surg 1998;27:1141–6; discussion 1147.
   Google Scholar
• Moskowitz D. A comprehensive review of the safety and efficacy of bioidentical hormones for the management of menopause and related health risks. Altern Med Rev 2006;11:208–223.
   PubMed Web of Science ®Google Scholar
• Schmidt IU, Wakley GK, Turner RT. Effects of estrogen and progesterone on tibia histomorphometry in growing rats. Calcif Tissue Int 2000;67:47–52.
   PubMed Web of Science ®Google Scholar
• Jacobsen E, Billings JK, Frantz RA, Kinney CK, Stewart ME, Downing DT. Age-related changes in sebaceous wax ester secretion rates in men and women. J Invest Dermatol 1985;85:483–485.
   PubMed Web of Science ®Google Scholar
• Baron YM, Brincat M, Galea R. Increased reduction in bone density and skin thickness in postmenopausal women on long-term corticosteroid therapy. A suggested role for estrogen add back therapy. Adv Exp Med Biol 1999;455:429–436.
   PubMed Web of Science ®Google Scholar
• Bland R. Steroid hormone receptor expression and action in bone. Clin Sci 2000;98:217–240.
   PubMed Web of Science ®Google Scholar
• Liang M, Liao EY, Xu X, Luo XH, Xiao XH. Effects of progesterone and 18-methyl levonorgestrel on osteoblastic cells. Endocr Res 2003;29:483–501.
   PubMed Web of Science ®Google Scholar
• Barengolts EI, Gajardo HF, Rosol TJ, D’Anza JJ, Pena M, Botsis J, Kukreja SC. Effects of progesterone on postovariectomy bone loss in aged rats. J Bone Miner Res 1990;5:1143–1147.
   PubMedGoogle Scholar
• Bowman BM, Miller SC. Elevated progesterone during pseudopregnancy may prevent bone loss associated with low estrogen. J Bone Miner Res 1996;11:15–21.
   Google Scholar
• Fujimaki T, Kurabayashi T, Yamamoto Y, Yasuda M, Tojo Y, Yahata T, Tanaka K. Effects of progesterone on the metabolism of cancellous bone in young oophorectomized rats. J Obstet Gynaecol (Tokyo 1995) 1995;21:31–36.
   Google Scholar
• Ikram Z, Dulipsingh L, Prestwood KM. Lack of effect of short-term micronized progesterone on bone turnover in postmenopausal women. J Womens Health Gend Based Med 1999;8:973–978.
   PubMedGoogle Scholar
• Burnett CC, Reddi AH. Influence of estrogen and progesterone on matrix-induced endochondral bone formation. Calcif Tissue Int 1983;35:609–614.
   PubMed Web of Science ®Google Scholar
• Yamamoto Y, Kurabayashi T, Tojo Y, Yahata T, Honda A, Tomita M, Tanaka K. Effects of progestins on the metabolism of cancellous bone in aged oophorectomized rats. Bone 1998;22:533–537.
   PubMed Web of Science ®Google Scholar
• Brincat MP, Baron YM, Galea R. Connective tissue changes in the menopause and with HRT. In: Lobo RA, editor. Treatment of the postmenopausal woman: basic and clinical aspects. 2007.
   Google Scholar
• Boos N, Weissbach S, Rohrbach H, Weiler C, Spratt KF, Nerlich AG. Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science. Spine 2002;27:2631–2644.
   PubMed Web of Science ®Google Scholar
• Baron YM, Brincat MP, Galea R, Calleja N. Intervertebral disc height in treated and untreated overweight post-menopausal women. Hum Reprod 2005;20:3566–3570.
   PubMed Web of Science ®Google Scholar
• Brincat MP, Calleja-Agius J, Baron YM. The skin, carotid and intervertebral disc: making the connection! Climacteric 2007;10 Suppl 2:83–87.
   PubMedGoogle Scholar
• Muscat Baron Y, Brincat MP, Galea R, Calleja N. Low intervertebral disc height in postmenopausal women with osteoporotic vertebral fractures compared to hormone-treated and untreated postmenopausal women and premenopausal women without fractures. Climacteric 2007;10:314–319.
   PubMed Web of Science ®Google Scholar
• Gambacciani M, Pepe A, Cappagli B, Palmieri E, Genazzani AR. The relative contributions of menopause and aging to postmenopausal reduction in intervertebral disk height. Climacteric 2007;10:298–305.
   PubMed Web of Science ®Google Scholar
• Baron YM, Galea R, Brincat M. Carotid artery wall changes in estrogen-treated and -untreated postmenopausal women. Obstet Gynecol 1998;91:982–986.
   PubMed Web of Science ®Google Scholar
• Ostberg JE, Storry C, Donald AE, Attar MJ, Halcox JP, Conway GS. A dose-response study of hormone replacement in young hypogonadal women: effects on intima media thickness and metabolism. Clin Endocrinol (Oxf) 2007;66:557–564.
   PubMed Web of Science ®Google Scholar
• Anderson GL, Limacher M, Assaf AR, Bassford T, Beresford SA, Black H, Bonds D, et al.; Women’s Health Initiative Steering Committee. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women’s Health Initiative randomized controlled trial. JAMA 2004;291:1701–1712.
   PubMed Web of Science ®Google Scholar
• Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, et al.; Writing Group for the Women’s Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. JAMA 2002;288:321–333.
   PubMed Web of Science ®Google Scholar
• Hays J, Hunt JR, Hubbell FA, Anderson GL, Limacher M, Allen C, Rossouw JE. The Women’s Health Initiative recruitment methods and results. Ann Epidemiol 2003;13:S18–S77.
   PubMed Web of Science ®Google Scholar
• MacLennan AH. HRT: a reappraisal of the risks and benefits. Med J Aust 2007;186:643–646.
   PubMed Web of Science ®Google Scholar