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Pregnancy

The role of interferons in early pregnancy

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Pages 1-6 | Received 13 Jun 2012, Accepted 15 Oct 2012, Published online: 04 Nov 2013

References

  • Isaacs A, Lindenmann J. Virus interference. I. The interferon. Proc R Soc Lond B 1957;147:258–67
  • Gresser I. Biologic effects of interferons. J Invest Dermatol 1990;95:66S–71S
  • Sen GC, Lengyel P. The interferon system – a bird's eye view of its biochemistry. J Biol Chem 1992;267:5017–20
  • Kotenko SV, Gallagher G, Baurin VV, et al. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol 2003;4:69–77
  • Wheelock EF. Virus replication and high-titered interferon production in human leukocyte cultures inoculated with Newcastle disease virus. J Bacteriol 1966;92:1415–21
  • Donnelly RP, Kotenko SV. Interferon-lambda: a new addition to an old family. J Interferon Cytokine Res 2010;30:555–64
  • Prejean C, Colamonici OR. Role of the cytoplasmic domains of the type I interferon receptor subunits in signaling. Semin Cancer Biol 2000;10:83–92
  • Aguet M, Dembic Z, Merlin G. Molecular cloning and expression of the human interferon-γ receptor. Cell 1988;55:273–80
  • Gray PW, Leong S, Fennie EH, et al. Cloning and expression of the cDNA for the murine interferon gamma receptor. Proc Natl Acad Sci USA 1989;86:8497–501
  • Cleary CM, Donnelly RJ, Soh J, et al. Knockout and reconstitution of a functional human type I interferon receptor complex. J Biol Chem 1994;269:18747–9
  • Hemmi S, Böhni R, Stark G, et al. A novel member of the interferon receptor family complements functionality of the murine interferon-γ receptor in human cells. Cell 1994;76:803–10
  • Farrar MA, Schreiber RD. The molecular cell biology of interferon-gamma and its receptor. Annu Rev Immunol 1993;11:571–611
  • Bach EA, Aguet M, Schreiber RD. The IFN gamma receptor: a paradigm for cytokine receptor signaling. Annu Rev Immunol 1997;15:563–91
  • Zhou Z, Hamming JO, Ank N, et al. Type III interferon (IFN) induces a Type I IFN-like response in a restricted subset of cells through signaling pathways involving both the Jak-STAT pathway and the mitogen-activated protein kinases. J Virol 2007;81:7749–58
  • Sprang SR, Bazan JF. Cytokine structural taxonomy and mechanisms of receptor engagement. Curr Opin Struct Biol 1993;3:815–27
  • Klaus W, Gsell B, Labhardt AM, et al. The three-dimensional high resolution structure of human interferon alpha-2a determined by heteronuclear NMR spectroscopy in solution. J Mol Biol 1997;274:661–75
  • David G. RCSB portein data bank, interferons – August 2010 molecule of the month. 2010. Available from: http://www.rcsb.org/pdb/101/motm.do?momID=128 [last accessed 20 Sep 2011]
  • Ealick SE, Cook WJ, Vijay-Kumar S, et al. Three-dimensional structure of recombinant human interferon-gamma. Science 1991;252:698–702
  • Pestka S, Krause CD, Walter MR. Interferons, interferon-like cytokines, and their receptors. Immunol Rev 2004;202:8–32
  • Lieberman M, Marks AD, Smith CM. (2008). Marks' basic medical biochemistry: a clinical approach. Philadelphia: Lippincott Williams & Wilkins
  • Fish NE, Uddin S, Korkmaz M, et al. Activation of a CrkL-Stat5 signaling complex by Type I interferons. J Biol Chem 1999;274:571–3
  • Li Y, Sassano A, Majchrzak B, et al. Role of p38α Map kinase in Type I interferon signaling. J Biol Chem 2003;279:970–9
  • Platanias LC. Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol 2005;5:375–86
  • Hardy MP, Owczarek CM, Jermiin LS, et al. Characterization of the type I interferon locus and identification of novel genes. Genomics 2004;84:331–45
  • Henco K, Brosius FJ, Fujisawa A, et al. Structural relationship of human interferon alpha genes and pseudogenes. J Mol Biol 1985;185:227–60
  • Hauptmann R, Swetly P. A novel class of human type 1 interferons. Nucleic Acids Res 1985;13:4739–49
  • Nardelli B, Zaritskaya L, Semenuk M, et al. Regulatory effect of IFN-κ, A novel Type I IFN, on cytokine production by cells of the innate immune system. J Immunol 2002;169:4822–30
  • van Boxel-Dezaire AH, Stark GR. Cell type-specific signaling in response to interferon-gamma. Curr Top Microbiol Immunol 2007;316:119–54
  • Su X, Yee LJ, Im K, et al. Association of single nucleotide polymorphisms in interferon signaling pathway genes and interferon-stimulated genes with the response to interferon therapy for chronic hepatitis C. J Hepatol 2008;49:184–91
  • Sigurdsson S, Nordmark G, Göring HH, et al. Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. Am J Hum Genet 2005;76:528–37
  • Jahromi M, Millward A, Demaine A. A CA repeat polymorphism of the IFN-gamma gene is associated with susceptibility to type 1 diabetes. J Interferon Cytokine Res 2000;20:187–90
  • Fensterl V, Sen GC. Interferons and viral infections. Biofactors 2009;35:14–20
  • Karp CL, Biron CA, Irani DN. Interferon in multiple sclerosis: is IL-12 suppression the key? Immunol Today 2000;21:24–8
  • Durbin JE, Fernandez-Sesma A, Lee CK, et al. Type 1 IFN modulates innate and specific antiviral immunity. J Immunol 2000;164:4220–8
  • Biron CA. Role of early cytokines, including alpha and beta interferons (IFN-a/b), in innate and adaptive immune responses to viral infections. Semin Immunol 1998;10:383–90
  • Santini SM, Lapenta C, Logozzi M, et al. Type I interferon is a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice. J Exp Med 2000;191:1777–88
  • Zhang X, Sun S, Hwang I, et al. Potent and selective stimulation of memory-phenotype CD8 + T cells in vivo by IL-1. Immunity 1998;8:591–9
  • Marrack P, Kappler J, Mitchell T. Type I interferons keep activated T cells alive. J Exp Med 1999;189:521–30
  • Pitha PM. (2007) Interferon: the 50th anniversary. New York: Springer Publishing Company
  • Schroder K, Hertzog PJ, Ravasi T, Hume DA. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 2004;75:163–89
  • Finkelman FD, Katona IM, Mosmann TR, Coffman RL. IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses. J Immunol 1988;140:1022–7
  • Raghupathy R. Th1-type immunity is incompatible with successful pregnancy. Immunol Today 1997;18:478–82
  • Wegmann TG, Lin H, Guilbert L, Mosmann TR. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a Th2 phenomenon? Immunol Today 1993;14:353–6
  • Tangri S, Raghupathy R. Expression of cytokines in placenta of mice undergoing immunologically mediated foetal resorption. Biol Reprod 1993;49:840–50
  • Tangri S, Wegmann TG, Lin H, Raghupathy R. Maternal anti-placental activity in natural, immunologically mediated foetal resorption. J Immunol 1994;152:4903–10
  • Szekeres-Bartho J, Chaouat G. Lymphocyte-derived, progesterone-induced blocking factor corrects resorption in murine abortion system. Am J Reprod Immunol 1990;23:26–8
  • Chaouat G, Menu E, Mognetti B, et al. Immunopathology of early pregnancy. Infect Dis Obstet Gynecol 1997;5:73–92
  • Baines M, De Fougerolles R. Modulation of natural killer activity influences resorption rates in CBA3DBA/2 matings. J Reprod Immunol 1988;11:147–53
  • Clark DA, Chaouat G, Arck PC, et al. Cytokine-dependent abortion in CBAxDBA/2 mice is mediated by the procoagulant fg12 prothrombinase. J Immunol 1998;160:545–9
  • Laird SM, Tuckerman EM, Cork BA, et al. A review of immune cells and molecules in women with recurrent miscarriage. Hum Reprod Update 2003;9:163–74
  • Erlebacher A, Zhang D, Parlow AF, Glimcher LH. Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system. J Clin Invest 2004;114:39–48
  • Poovassery J, Sarr D, Smith G, et al. Malaria-induced murine pregnancy failure: distinct roles for IFN-γ and TNF. J Immunol 2009;183:5342–9
  • Tayade C, Black GP, Fang Y, Croy BA. Differential gene expression in endometrium, endometrial lymphocytes, and trophoblasts during successful and abortive embryo implantation. J Immunol 2006;176:48–56
  • Tayade C, Fang Y, Hilchie D, Croy BA. Lymphocyte contributions to altered endometrial angiogenesis during early and midgestation fetal loss. J Leukoc Biol 2007;82:877–86
  • Yui J, Garcia-Lloret M, Wegmann TG, Guilbert LJ. Cytotoxicity of tumor necrosis factor-α (TNF-α) and gamma-interferon (IFN-γ) against primary human placental trophoblasts. Placenta 1994;15:819–26
  • Berkowitz R, Hill JA, Kurtz CB, Anderson DJ. Effects of products of activated leukocytes (lymphokines and monokines) on the growth of malignant trophoblast cells in vitro. Am J Obstet Gynecol 1988;151:199–203
  • Polgar K, Hill JA. Identification of the white blood cell populations repsponsible for TH1 immunity to trophoblast and the timing of the response in women with recurrent pregnancy loss. Gynecol Obstet Invest 2002;53:59–64
  • Marzi M, Vigano A, Trabattoni D, et al. Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy. Clin Exp Immunol 1996;106:127–33
  • Jenkins C, Roberts J, Wilson R, et al. Evidence of a Th1 type response associated with recurrent miscarriage. Fertil Steril 2000;73:1206–8
  • Jikihara H, Poisner AM, Handwerger S. Interferon-gamma inhibits the synthesis and release of renin from human decidual cells. Biol Reprod 1996;54:1311–6
  • Motherisk (The Hospital for Sick Children). Motherisk news: researchers find use of multiple sclerosis drug during pregnancy connected to miscarriage and low birth weight. 2005. Available from: http://www.motherisk.org/women/commonDetail.jsp?content_id=733 [last accessed 28 Jul 2011]
  • Boskovic R, Wide R, Wolpin J, et al. The reproductive effects of beta interferon therapy in pregnancy: a longitudinal cohort. Neurology 2005;65:807–11
  • Waubant E, Sadovnick AD. Interferon beta babies. Neurology 2005;65:788–9
  • Patrick LA, Smith GN. Proinflammatory cytokines: a link between chorioamnionitis and fetal brain injury. J Obstet Gynaecol 2002;24:705–9
  • Hansen-Pupp I, Harling S, Berg AC, et al. Circulating interferon-gamma and white matter brain damage in preterm infants. Pediatr Res 2005;58:946–52
  • Sargent IL, Borzychowski AM, Redman CWG. NK cells and human pregnancy – an inflammatory view. Trends Immunol 2006;27:399–404
  • Truchet S, Wietzerbin J, Debey P. Mouse oocytes and preimplantation embryos bear the two sub-units of interferon-gamma receptor. Mol Reprod Dev 2001;60:319–30
  • Chen H, Kamath LR, Pace JL, et al. Expression of the interferon-gamma receptor gene in mouse placentas is related to stage of gestation and is restricted to specific subpopulations of trophoblast cells. Placenta 1994;15:109–21
  • Croy BA, van den Heuvel MJ, Borzychowski AM, Tayade C. Uterine natural killer cells: a specialized differentiation regulated by ovarian hormones. Immunol Rev 2006;214:161–85
  • Peel S. Granulated metrial gland cells. Adv Anat Embryol Cell Biol 1989;15:1–112
  • Murphy SP, Tayade C, Ashkar AA, et al. Interferon gamma in successful pregnancies. Biol Reprod 2009;80:48–859
  • Ashkar AA, Di Santo JP, Croy BA. Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy. J Exp Med 2000;192:259–70
  • Roberts RM. Interferon-tau, a type 1 interferon involved in maternal recognition of pregnancy. Cytokine Growth Factor Rev 2007;18:403–8
  • Spencer TE, Johnson GA, Bazer FW, Burghardt RC. Fetal-maternal interactions during the establishment of pregnancy in ruminants. Soc Reprod Fertil Suppl 2007;64:379–96
  • D’Andrea S, La Bonnardiere C. Cloning of the porcine interferon-gamma receptor and its foeto-endometrial expression in early pregnancy. Mol Reprod Dev 1998;51:225–34
  • Koopman LA, Kopcow HD, Rybalov B, et al. Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential. J Exp Med 2003;198:1201–12
  • Croy BA, van den Heuvel MJ, Borzychowski AM, Tayade C. Uterine natural killer cells: a specialized differentiation regulated by ovarian hormones. Immunol Rev 2006;214:161–85
  • Hoshida MS, Gorjao R, Lima C, et al. Regulation of gene expression in mouse trophoblast cells by interferongamma. Placenta 2007;28:1059–72
  • Banerjee S, Smallwood A, Moorhead J, et al. Placental expression of interferon-gamma (IFN-gamma) and its receptor IFN-gamma R2 fail to switch from early hypoxic to late normotensive development in preeclampsia. J Clin Endocrinol Metab 2005;90:944–52
  • Saito S, Nishikawa K, Morii T, et al. Cytokine production by CD16-CD56 bright natural killer cells in the human early pregnancy decidua. Int Immunol 1993;5:559–63
  • Tabibzadeh S. Evidence of T-cell activation and potential cytokine action in human endometrium. J Clin Endocrinol Metab 1990;71:645–59
  • Tabibzadeh S. Regulatory roles of IFN-y in human endometrium. (1994). Ann NY Acad Sci 734:1–6
  • Hunt JS. Stranger in a strange land. Immunol Rev 2006;21:36–47
  • Petrozza JC. Recurrent early pregnancy loss. 2005. Available from: http://emedicine.medscape.com/article/260495-overview [last accessed 31 Oct 2011]
  • Karmakar S, Dhar R, Das C. Inhibition of cytotrophoblastic (JEG-3) cell invasion by interleukin 12 involves an interferon gamma-mediated pathway. J Biol Chem 2004;279:55297–307
  • Hu Y, Dutz JP, MacClaman CD, et al. Decidual NK cells alter in vitro first trimester extravillous cytotrophoblast migration: a role for IFN-gamma. J Immunol 2006;177:8522–30
  • Lash GE, Otun HA, Innes BA, et al. Interferon-gamma inhibits extravillous trophoblast cell invasion by a mechanism that involves both changes in apoptosis and protease levels. FASEB J 2006;20:2512–8

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