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Gonadotropins

Circulating kisspeptin and pituitary adenylate cyclase-activating polypeptide (PACAP) do not correlate with gonadotropin serum levels

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Pages 583-587 | Received 10 Jul 2012, Accepted 25 Feb 2013, Published online: 09 May 2013

References

  • Gharib SD, Wierman ME, Shupnik MA, et al. Molecular biology of the pituitary gonadotropins. Endocr Rev 1990;11:177–99
  • Ohtaki T, Shintani Y, Honda S, et al. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature 2001;411:613–7
  • de Roux N, Genin E, Carel JC, et al. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci U S A 2003;100:10972–6
  • Seminara SB, Messager S, Chatzidaki EE, et al. The GPR54 gene as a regulator of puberty. N Engl J Med 2003;349:1614–27
  • Silveira LG, Noel SD, Silveira-Neto AP, et al. Mutations of the KISS1 gene in disorders of puberty. J Clin Endocrinol Metab 2011;95:2276–80
  • Teles MG, Bianco SD, Brito VN, et al. A GPR54-activating mutation in a patient with central precocious puberty. N Engl J Med 2008;358:709–15
  • Li D, Mitchell D, Luo J, et al. Estrogen regulates KiSS1 gene expression through estrogen receptor alpha and SP protein complexes. Endocrinology 2007;148:4821–8
  • Rometo AM, Krajewski SJ, Voytko ML, et al. Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeys. J Clin Endocrinol Metab 2007;92:2744–50
  • Hrabovszky E, Ciofi P, Vida B, et al. The kisspeptin system of the human hypothalamus: sexual dimorphism and relationship with gonadotropin-releasing hormone and neurokinin B neurons. Eur J Neurosci 2010;31:1984–98
  • Meczekalski B, Podfigurna-Stopa A, Genazzani AR. Why kisspeptin is such important for reproduction? Gynecol Endocrinol 2011;27:8–13
  • Lehman MN, Ladha Z, Coolen LM, et al. Neuronal plasticity and seasonal reproduction in sheep. Eur J Neurosci 2010;32:2152–64
  • Pineda R, Aguilar E, Pinilla L, et al. Physiological roles of the kisspeptin/GPR54 system in the neuroendocrine control of reproduction. Prog Brain Res 2010;181:55–77
  • Miyata A, Arimura A, Dahl RR, et al. Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells. Biochem Biophys Res Commun 1989;164:567–74
  • Vaudry D, Falluel-Morel A, Bourgault S, et al. Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery. Pharmacol Rev 2009;61:283–357
  • Culler MD, Paschall CS. Pituitary adenylate cyclase-activating polypeptide (PACAP) potentiates the gonadotropin-releasing activity of luteinizing hormone-releasing hormone. Endocrinology 1991;129:2260–2
  • Counis R, Laverriere JN, Garrel-Lazayres G, et al. What is the role of PACAP in gonadotrope function? Peptides 2007;28:1797–04
  • Koves K, Kantor O, Molnar J, et al. The role of PACAP in gonadotropic hormone secretion at hypothalamic and pituitary levels. J Mol Neurosci 2003;20:141–52
  • Harada T, Kanasaki H, Mutiara S, et al. Cyclic adenosine 3′,5′monophosphate/protein kinase A and mitogen-activated protein kinase 3/1 pathways are involved in adenylate cyclase-activating polypeptide 1-induced common alpha-glycoprotein subunit gene (Cga) expression in mouse pituitary gonadotroph LbetaT2 cells. Biol Reprod 2007;77:707–16
  • Kanasaki H, Mutiara S, Oride A, et al. Pulse frequency-dependent gonadotropin gene expression by adenylate cyclase-activating polypeptide 1 in perifused mouse pituitary gonadotroph LbetaT2 cells. Biol Reprod 2009;81:465–72
  • Grafer CM, Thomas R, Lambrakos L, et al. GnRH stimulates expression of PACAP in the pituitary gonadotropes via both the PKA and PKC signaling systems. Mol Endocrinol 2009;23:1022–32
  • Burger H, Woods NF, Dennerstein L, et al. Nomenclature and endocrinology of menopause and perimenopause. Expert Rev Neurother 2007;7:S35–43
  • Beck-Peccoz P, Persani L. Premature ovarian failure. Orphanet J Rare Dis 2006;1:9
  • Seminara SB, Hayes FJ, Crowley WF Jr. Gonadotropin-releasing hormone deficiency in the human (idiopathic hypogonadotropic hypogonadism and Kallmann’s syndrome): pathophysiological and genetic considerations. Endocr Rev 1998;19:521–39
  • Oakley AE, Clifton DK, Steiner RA. Kisspeptin signaling in the brain. Endocr Rev 2009;30:713–43
  • Roa J, Vigo E, Castellano JM, et al. Follicle-stimulating hormone responses to kisspeptin in the female rat at the preovulatory period: modulation by estrogen and progesterone receptors. Endocrinology 2008;149:5783–90
  • Kinsey-Jones JS, Grachev P, Li XF, et al. The inhibitory effects of neurokinin B on GnRH pulse generator frequency in the female rat. Endocrinology 2012;153:307–15
  • Gottsch ML, Cunningham MJ, Smith JT, et al. A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology 2004;145:4073–7
  • Gottsch ML, Clifton DK, Steiner RA. Kisspepeptin-GPR54 signaling in the neuroendocrine reproductive axis. Mol Cell Endocrinol 2006;254–255:91–6
  • Dhillo WS, Savage P, Murphy KG, et al. Plasma kisspeptin is raised in patients with gestational trophoblastic neoplasia and falls during treatment. Am J Physiol Endocrinol Metab 2006;291:E878–84
  • Horikoshi Y, Matsumoto H, Takatsu Y, et al. Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans. J Clin Endocrinol Metab 2003;88:914–9
  • Kauffman AS. Gonadal and nongonadal regulation of sex differences in hypothalamic Kiss1 neurones. J Neuroendocrinol 2010;22:682–91
  • Matsui H, Takatsu Y, Kumano S, et al. Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat. Biochem Biophys Res Commun 2004;320:383–8
  • Seminara SB, Dipietro MJ, Ramaswamy S, et al. Continuous human metastin 45-54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male Rhesus monkey (Macaca mulatta): a finding with therapeutic implications. Endocrinology 2006;147:2122–6
  • Petersen B, Buchfelder M, Fahlbusch R, et al. Pituitary adenylate cyclase-activating polypeptide directly stimulates LH and FSH secretion by human pituitary gonadotrophinomas. Exp Clin Endocrinol Diabetes 1996;104:250–5
  • Koves K, Kantor O, Scammell JG, et al. PACAP colocalizes with luteinizing and follicle-stimulating hormone immunoreactivities in the anterior lobe of the pituitary gland. Peptides 1998;19:1069–72
  • Moore JP, Jr Burger LL, Dalkin AC, et al. Pituitary adenylate cyclase activating polypeptide messenger RNA in the paraventricular nucleus and anterior pituitary during the rat estrous cycle. Biol Reprod 2005;73:491–9
  • Heinzlmann A, Kirilly E, Meltzer K, et al. PACAP is transiently expressed in anterior pituitary gland of rats: in situ hybridization and cell immunoblot assay studies. Peptides 2008;29:571–7
  • Szabo E, Nemeskeri A, Arimura A, et al. Effect of PACAP on LH release studied by cell immunoblot assay depends on the gender, on the time of day and in female rats on the day of the estrous cycle. Regul Pept 2004;123:139–45
  • Jamen F, Rodriguez-Henche N, Pralong F, et al. PAC1 null females display decreased fertility. Ann N Y Acad Sci 2000;921:400–4

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