332
Views
17
CrossRef citations to date
0
Altmetric
Progesterone Antagonist

Progesterone antagonist, RU486, represses LHCGR expression and LH/hCG signaling in cultured luteinized human mural granulosa cells

, , , , , & show all
Pages 42-47 | Received 11 Apr 2013, Accepted 13 Sep 2013, Published online: 22 Oct 2013

References

  • Stocco C, Telleria C, Gibori G. The molecular control of corpus luteum formation, function, and regression. Endocr Rev 2007;28:117–49
  • Stouffer RL. Progesterone as a mediator of gonadotrophin action in the corpus luteum: beyond steroidogenesis. Hum Reprod Update 2003;9:99–117
  • Chaffkin LM, Luciano AA, Peluso JJ. The role of progesterone in regulating human granulosa cell proliferation and differentiation in vitro. J Clin Endocrinol Metab 1993;76:696–700
  • Lei ZM, Mishra S, Zou W, et al. Targeted disruption of luteinizing hormone/human chorionic gonadotropin receptor gene. Mol Endocrinol 2001;15:184–200
  • Zhang FP, Poutanen M, Wilbertz J, Huhtaniemi I. Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice. Mol Endocrinol 2001;15:172–83
  • Peng X-R, Hsueh AJW, Lapolt PS, et al. Localization of luteinizing hormone receptor messenger ribonucleic acid expression in ovarian cell types during follicle development and ovulation. Endocrinology 1991;129:3200–7
  • Segaloff DL, Wang HY, Richards JS. Hormonal regulation of luteinizing hormone/chorionic gonadotropin receptor mRNA in rat ovarian cells during follicular development and luteinization. Mol Endocrinol 1990;4:1856–65
  • Eppig JJ, Wigglesworth K, Pendola F, Hirao Y. Murine oocytes suppress expression of luteinizing hormone receptor messenger ribonucleic acid by granulosa cells. Biol Reprod 1997;56:976–84
  • Maman E, Yung Y, Kedem A, et al. High expression of luteinizing hormone receptors messenger RNA by human cumulus granulosa cells is in correlation with decreased fertilization. Fertil Steril 2012;97:592–8
  • Nair AK, Kash JC, Peegel H, Menon KM. Post-transcriptional regulation of luteinizing hormone receptor mRNA in the ovary by a novel mRNA-binding protein. J Biol Chem 2002;277:21468–73
  • Richards JS, Ireland JJ, Rao MC, et al. Ovarian follicular development in the rat: hormone receptor regulation by estradiol, follicle stimulating hormone and luteinizing hormone. Endocrinology 1976;99:1562–70
  • Zhang M, Shi H, Segaloff DL, Van Voorhis BJ. Expression and localization of luteinizing hormone receptor in the female mouse reproductive tract. Biol Reprod 2001;640:179–87
  • Smith GW, Gentry PC, Roberts RM, Smith MF. Ontogeny and regulation of luteinizing hormone receptor messenger ribonucleic acid within the ovine corpus luteum. Biol Reprod 1996;54:76–83
  • Liao M, Zhang Y, Kang JH, Dufau ML. Coactivator function of positive cofactor 4 (PC4) in Sp1-directed luteinizing hormone receptor (LHR) gene transcription. J Biol Chem 2011;286:7681–91
  • Iwai T, Nanbu Y, Iwai M, et al. Immunohistochemical localization of oestrogen receptors and progesterone receptors in the human ovary throughout the menstrual cycle. Virchows Arch A Pathol Anat Histopathol 1990;417:369–75
  • Hild-Petito S, Stouffer RL, Brenner RM. Immunocytochemical localization of estradiol and progesterone receptors in the monkey ovary throughout the menstrual cycle. Endocrinology 1988;123:2896–905
  • Revelli A, Pacchioni D, Cassoni P, et al. In situ hybridization study of messenger RNA for estrogen receptor and immunohistochemical detection of estrogen and progesterone receptors in the human ovary. Gynecol Endocrinol 1996;10:177–86
  • Suzuki T, Sasano H, Kimura N, et al. Immunohistochemical distribution of progesterone, androgen and oestrogen receptors in the human ovary during the menstrual cycle: relationship to expression of steroidogenic enzymes. Hum Reprod 1994;9:1589–95
  • Conneely OM, Mulac-Jericevic B, Lydon JP. Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms. Steroids 2003;68:771–8
  • Lydon JP, DeMayo FJ, Funk CR, et al. Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev 1995;9:2266–78
  • Robker RL, Akison LK, Russell DL. Control of oocyte release by progesterone receptor-regulated gene expression. Nucl Recept Signal 2009;7:e012
  • Makrigiannakis A, Coukos G, Christofidou-Solomidou M, et al. Progesterone is an autocrine/paracrine regulator of human granulosa cell survival in vitro. Ann N Y Acad Sci 2000;900:16–25
  • Rung E, Friberg PA, Shao R, et al. Progesterone-receptor antagonists and statins decrease de novo cholesterol synthesis and increase apoptosis in rat and human periovulatory granulosa cells in vitro. Biol Reprod 2005;72:538–45
  • Rothchild I. The regulation of the mammalian corpus luteum. Recent Prog Horm Res 1981;37:183–298
  • Lindeberg M, Carlstrom K, Ritvos O, Hovatta O. Gonadotrophin stimulation of non-luteinized granulosa cells increases steroid production and the expression of enzymes involved in estrogen and progesterone synthesis. Hum Reprod 2007;22:401–6
  • Negishi H, Ikeda C, Nagai Y, et al. Regulation of amphiregulin, EGFR-like factor expression by hCG in cultured human granulosa cells. Acta Obstet Gynecol Scand 2007;86:706–10
  • Tieszen CR, Goyeneche AA, Brandhagen BN, et al. Antiprogestin mifepristone inhibits the growth of cancer cells of reproductive and non-reproductive origin regardless of progesterone receptor expression. BMC Cancer 2011;11:207
  • Zhang J, Jiang Z, Mu X, et al. Effect of triptolide on progesterone production from cultured rat granulosa cells. Arzneimittelforschung 2012;62:301--6
  • Jones LS, Ottobre JS, Pate JL. Progesterone regulation of luteinizing hormone receptors on cultured bovine luteal cells. Mol Cell Endocrinol 1992;85:33–9
  • Montano E, Olivera M, Ruiz-Cortes ZT. Association between leptin, LH and its receptor and luteinization and progesterone accumulation (P4) in bovine granulosa cell in vitro. Reprod Domest Anim 2009;44:699–704
  • Ben-Ami I, Armon L, Freimann S, et al. EGF-like growth factors as LH mediators in the human corpus luteum. Hum Reprod 2009;24:176–84
  • Park JY, Su YQ, Ariga M, et al. EGF-like growth factors as mediators of LH action in the ovulatory follicle. Science 2004;303:682–4
  • Sriraman V, Sinha M, Richards JS. Progesterone receptor-induced gene expression in primary mouse granulosa cell cultures. Biol Reprod 2009;82:402–12
  • Shimada M, Hernandez-Gonzalez I, Gonzalez-Robayna I, Richards JS. Paracrine and autocrine regulation of epidermal growth factor-like factors in cumulus oocyte complexes and granulosa cells: key roles for prostaglandin synthase 2 and progesterone receptor. Mol Endocrinol 2006;20:1352–65
  • Das SK, Chakraborty I, Paria BC, et al. Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus. Mol Endocrinol 1995;9:691–705
  • Dimattina M, Albertson B, Seyler DE, et al. Effect of the antiprogestin RU486 on progesterone production by cultured human granulosa cells: inhibition of the ovarian 3B-hydroxysteroid dehydrogenase. Contraception 1986;34:199–206
  • Sugino N, Telleria CM, Gibori G. Progesterone inhibits 20alpha-hydroxysteroid dehydrogenase expression in the rat corpus luteum through the glucocorticoid receptor. Endocrinology 1997;138:4497–500
  • Stocco CO, Deis RP. Participation of intraluteal progesterone and prostaglandin F2 alpha in LH-induced luteolysis in pregnant rat. J Endocrinol 1998;156:253–9
  • Pharriss BB, Wyngarden LJ. The effect of prostaglandin F 2alpha on the progestogen content of ovaries from pseudopregnant rats. Proc Soc Exp Biol Med 1969;130:92–4
  • Faivre EJ, Lange CA. Progesterone receptors upregulate Wnt-1 to induce epidermal growth factor receptor transactivation and c-Src-dependent sustained activation of Erk1/2 mitogen-activated protein kinase in breast cancer cells. Mol Cell Biol 2007;27:466–80

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.