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Combined Oral Contraception

Effects of a combined oral contraceptive containing 20 mcg of ethinylestradiol and 3 mg of drospirenone on the blood pressure, renin-angiotensin-aldosterone system, insulin resistance, and androgenic profile of healthy young women

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Pages 912-915 | Received 17 Feb 2015, Accepted 12 Jun 2015, Published online: 14 Jul 2015

References

  • Mishell Jr DR. State of the art in hormonal contraception: an overview. Am J Obstet Gynecol 2004;190:S1–4
  • Sitruk-Ware R, Nath A. Metabolic effects of contraceptive steroids. Rev Endocr Metab Disord 2011;12:63–75
  • Sitruk-Ware R. New progestagens for contraceptive use. Hum Reprod Update 2006;12:169–78
  • Nath A, Sitruk-Ware R. Different cardiovascular effects of progestins according to structure and activity. Climacteric 2009;12:96–101
  • Godsland IF, Walton C, Felton C, et al. Insulin resistance, secretion, and metabolism in users of oral contraceptives. J Clin Endocrinol Metab 1992;74:64–70
  • Kojima T, Lindheim SR, Duffy DM, et al. Insulin sensitivity is decreased in normal women by doses of ethinyl estradiol used in oral contraceptives. Am J Obstet Gynecol 1993;169:1540–4
  • Weir RJ. When the pill causes a rise in blood pressure. Drugs 1978;16:522–7
  • Crane MG, Harris JJ. Estrogens and hypertension: effect of discontinuing estrogens on blood pressure, exchangeable sodium and the renin-aldosterone system. Am J Med Sci 1978;276:33–55
  • The WHO multicentre trial of the vasopressor effects of combined oral contraceptives: 1. Comparisons with IUDs. Contraception 1989;40:129–45. 33
  • The WHO multicentre trial of the vasopressor effects of combined oral contraceptives: 2. Lack of effect of estrogen. Contraception 1989;40:147–56. 34
  • Chasan-Taber L, Walter CW, JoAnn EM, et al. Prospective study of oral contraceptives and hypertension among women in the United States. Circulation 1996;94:483–9
  • Oelkers W, Schoneshofer M, Blumel A. Effects of progesterone and four synthetic progestogens on sodium balance and the renin-aldosterone system in man. J Clin Endocrinol Metab 1974;39:882–90
  • Oelkers WK. Effects of estrogens and progestogens on the renin-aldosterone system and blood pressure. Steroids 1996;61:166–71
  • Oelkers W. Antimineralocorticoid activity of a novel oral contraceptive containing drospirenone, a unique progestogen resembling natural progesterone. Eur J Contracept Reprod Health Care 2002;7:19–26
  • Oelkers W, Berger V, Bolik A, et al. Dihydrospirorenone, a new progestogen with antimineralocorticoid activity: effects on ovulation, electrolyte excretion, and the renin-aldosterone system in normal women. J Clin Endocrinol Metab 1991;73:837–42
  • Oelkers W, Helmerhorst FM, Wuttke W, Heithecker R. Effect of an oral contraceptive containing drospirenone on the renin-angiotensin-aldosterone system in healthy female volunteers. Gynecol Endocrinol 2000;14:476–8
  • Oelkers W, Foidart JM, Dombrovicz N, et al. Effects of a new oral contraceptive containing an antimineralocorticoid progestogen, drospirenone, on the renin aldosterone system, body weight, blood pressure, glucose tolerance, and lipid metabolism. J Clin Endocrinol Metab 1995;80:1816–21
  • World Health Organization. Medical eligibility criteria for contraceptive use. 4th ed. Amsterdam: Elsevier; 2010
  • Pickering TG, Hall JE, Appel LJ, et al. AHA Scientific Statement. Recommendations for blood pressure measurement in humans and experimental animals. Part 1: blood pressure measurement in humans: a statement for professionals from the subcommittee of professional and public education of the American heart association council on high blood pressure research. Hypertension 2005;45:142–61
  • Sealey JE. Plasma renin activity and plasma prorenin assays. Clin Chem 1991;37:1811–19
  • Giribela CR, Melo NR, Silva RC, et al. A combined oral contraceptive containing drospirenone changes neither endothelial function nor hemodynamic parameters in healthy young women: a prospective clinical trial. Contraception 2012;86:35–41
  • Nisenbaum MG, de Melo NR, Giribela CR, et al. Effects of a contraceptive containing drospirenone and ethinyl estradiol on blood pressure and autonomic tone: a prospective controlled clinical trial. Eur J Obstet Gynecol Reprod Biol 2014;175:62–6
  • Klipping C, Marr J. Effects of two combined oral contraceptives containing ethinyl estradiol 20 microg combined with either drospirenone or desogestrel on lipids, hemostatic parameters and carbohydrate metabolism. Contraception 2005;71:409–16
  • Taneepanichskul S, Phupong V. Influence of a new oral contraceptive with drospirenone on lipid metabolism. Gynecol Endocrinol 2007;23:347–50
  • Gaspard U, Endrikat J, Desager JP, et al. A randomized study on the influence of oral contraceptives containing ethinylestradiol combined with drospirenone or desogestrel on lipid and lipoprotein metabolism over a period of 13 cycles. Contraception 2004;69:271–8
  • Cagnacci A, Piacenti I, Zanin R, et al. Influence of an oral contraceptive containing drospirenone on insulin sensitivity of healthy women. Eur J Obstet Gynecol Reprod Biol 2014;178:48–50
  • Oelkers W, Foidart JM, Dombrovicz N, et al. Effects of a new oral contraceptive containing an antimineralocorticoid progestogen, drospirenone, on the renin-aldosterone system, body weight, blood pressure, glucose tolerance, and lipid metabolism. J Clin Endocrinol Metab 1995;80:18:16–21
  • Cagnacci A, Ferrari S, Tirelli A, et al. Insulin sensitivity and lipid metabolism with oral contraceptives containing chlormadinone acetate or desogestrel: a randomized trial. Contraception 2009;79:111–16
  • Knopp RH, Broyles FE, Cheung M, et al. Comparison of the lipoprotein, carbohydrate, and hemostatic effects of phasic oral contraceptives containing desogestrel or levonorgestrel. Contraception 2001;63:1–11
  • Song S, Chen JK, Yang PJ, et al. A cross-over study of three oral contraceptives containing ethinyloestradiol and either desogestrel or levonorgestrel. Contraception 1992;45:523–32

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