170
Views
1
CrossRef citations to date
0
Altmetric
2-Methoxyestradiol effect on Vascular Endothelial Cells

2-Methoxyestradiol prevents monocyte adhesion to vascular endothelial cells via downregulation of VCAM-1 expression

, , , &
Pages 571-576 | Received 14 Dec 2015, Accepted 10 Jan 2016, Published online: 16 Feb 2016

References

  • Giordano S, Hage FG, Xing D, et al Estrogen and cardiovascular disease: is timing everything? Am J Med Sci 2015;350:27–35
  • Dubey RK, Jackson EK. Potential vascular actions of 2-methoxyestradiol. Trends Endocrinol Metab 2009;20:374–9
  • Mueck AO, Seeger H. 2-Methoxyestradiol-biology and mechanism of action. Steroids 2010;75:625–31
  • Bonacasa B, Sanchez ML, Rodriguez F, et al 2-Methoxyestradiol attenuates hypertension and coronary vascular remodeling in spontaneously hypertensive rats. Maturitas 2008;61:310–16
  • Bourghardt J, Bergstrom G, Krettek A, et al The endogenous estradiol metabolite 2-methoxyestradiol reduces atherosclerotic lesion formation in female apolipoprotein E-deficient mice. Endocrinology 2007;148:4128–32
  • Barchiesi F, Jackson EK, Fingerle J, et al 2-Methoxyestradiol, an estradiol metabolite, inhibits neointima formation and smooth muscle cell growth via double blockade of the cell cycle. Circ Res 2006;99:266–74
  • Xu J, Zou MH. Molecular insights and therapeutic targets for diabetic endothelial dysfunction. Circulation 2009;120:1266–86
  • Vanhoutte PM. Endothelial dysfunction: the first step toward coronary arteriosclerosis. Circ J 2009;73:595–601
  • Chen W, Cui Y, Zheng S, et al 2-Methoxyestradiol induces vasodilation by stimulating NO release via PPARγ/PI3K/Akt pathway. PLoS One 2015;10:e0118902
  • Kurokawa A, Azuma K, Mita T, et al 2-Methoxyestradiol reduces monocyte adhesion to aortic endothelial cells in ovariectomized rats. Endocr J 2007;54:1027–31
  • Schnoor M, Alcaide P, Voisin MB, van Buul JD. Crossing the vascular wall: common and unique mechanisms exploited by different leukocyte subsets during extravasation. Mediators Inflamm 2015;2015:946509
  • Liao W, Huang W, Guo Y, et al Testosterone promotes vascular endothelial cell migration via upregulation of ROCK-2/moesin cascade. Mol Biol Rep 2013;40:6729–35
  • Lemaire M, Negro Silva LF, Lemarie CA, et al Arsenic exposure increases monocyte adhesion to the vascular endothelium, a pro-atherogenic mechanism. PLoS One 2015;10:e0136592
  • Desplats P, Dumaop W, Cronin P, et al Epigenetic alterations in the brain associated with HIV-1 infection and methamphetamine dependence. PLoS One 2014;9:e102555
  • Genazzani AR, Simoncini T. Pharmacotherapy: benefits of menopausal hormone therapy-timing is key. Nat Rev Endocrinol 2013;9:5–6
  • Barchiesi F, Lucchinetti E, Zaugg M, et al Candidate genes and mechanisms for 2-methoxyestradiol-mediated vasoprotection. Hypertension 2010;56:964–72
  • Cook-Mills JM, Marchese ME, Abdala-Valencia H. Vascular cell adhesion molecule-1 expression and signaling during disease: regulation by reactive oxygen species and antioxidants. Antioxid Redox Signal 2011;15:1607–38
  • Iiyama K, Hajra L, Iiyama M, et al Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation. Circ Res 1999;85:199–207
  • Huo Y, Hafezi-Moghadam A, Ley K. Role of vascular cell adhesion molecule-1 and fibronectin connecting segment-1 in monocyte rolling and adhesion on early atherosclerotic lesions. Circ Res 2000;87:153–9
  • Simoncini T, Maffei S, Basta G, et al Estrogens and glucocorticoids inhibit endothelial vascular cell adhesion molecule-1 expression by different transcriptional mechanisms. Circ Res 2000;87:19–25
  • Simoncini T, Mannella P, Fornari L, et al Differential signal transduction of progesterone and medroxyprogesterone acetate in human endothelial cells. Endocrinology 2004;145:5745–56
  • Duncan GS, Brenner D, Tusche MW, et al 2-Methoxyestradiol inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation. Proc Natl Acad Sci USA 2014;109:21034–9
  • Rath PC, Mukhopadhyay T. p53 gene expression and 2-methoxyestradiol treatment differentially induce nuclear factor kappa B activation in human lung cancer cells with different p53 phenotypes. DNA Cell Biol 2009;28:615–23
  • Ou HC, Lee WJ, Lee SD, et al Ellagic acid protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway. Toxicol Appl Pharmacol 2010;248:134–43
  • Bonavida B, Baritaki S. Dual role of NO donors in the reversal of tumor cell resistance and EMT: Downregulation of the NF-κB/Snail/YY1/RKIP circuitry. Nitric Oxide 2011;24:1–7
  • Zhang Y, Zhan RX, Chen JQ, et al Pharmacological activation of PPAR gamma ameliorates vascular endothelial insulin resistance via a non-canonical PPAR gamma-dependent nuclear factor-kappa B trans-repression pathway. Eur J Pharmacol 2015;754:41–51

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.