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Gynecological Endocrinology Volume 10, 1996 - Issue sup2
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Original Article

In low-dose oral contraceptives containing 20 µg or 30 µg ethinylestradiol, gestodene is associated with a lower increase in coagulant factor VII than is desogestrel

K. W. M. Bloemenkamp Department of Obstetrics, Gynecology and Reproductive Medicine, University Hospital Leiden; Gaubius Laboratory, TNO-PG, Leiden
,
J. A. Gevers Leuven Gaubius Laboratory, TNO-PG, Leiden
,
F. M. Helmerhorst Department of Obstetrics, Gynecology and Reproductive Medicine, University Hospital Leiden
,
M. C. Dersjant-Roorda Department of Obstetrics, Gynecology and Reproductive Medicine, University Hospital Leiden
,
R. de Boer Department of Obstetrics and Gynecology, Groot Gasthuis, Den Bosch, The Netherlands
,
P. Meyer Gaubius Laboratory, TNO-PG, Leiden
,
D. Spielnrann Wyeth-Ayerst Research, Pans, France
&
C. Kluft Department of Obstetrics, Gynecology and Reproductive Medicine, University Hospital Leiden
 show all
Pages 145-148 | Published online: 07 Jul 2009

References

  • Clinical studies with a new low-dose oral contraceptive combination, containing 0.150 mg desogestrel and 0.020 mg ethinylestradiol. Acta Obstet. Gynecol. Sand. 1987; 144: 1–44
  • Bonnar J. Changes in coagulation and fibrinolysis with low dose oral contraceptives. Adv. Contracept. 1991; 7(Suppl. 3)285–91
  • Meade T. W. Risks and mechanism of cardiovascular events in users of oral contraceptives. Am. J. Obstet. Gynecol. 1988; 158: 1646
  • Inman W. H. W., Vessey M. P., Westerholm B., Engelund A. Thromboembolic disease and the steroidal content of oral contraceptives: a report to the committee on safety of drugs. Br. Med. J. 1970; 2: 203–9
  • Vessey M. P. Female hormones and vascular disease — an epidemiological overview. Br. J. Fam. Plann. 1980; 6: 1–12
  • Meade T. W., Greenburg G., Thompson S. G. Progestogens and cardiovascular reactions associated with oral contraceptives and a comparison of the safety of 50- and 30- μg estrogen preparations. Br. Med. J. 1980; 280: 1157
  • Kay C. R. Progestogens and arterial disease - evidence from the Royal College of General Practioners' study. Am. J. Obstet. Gynecol. 1982; 142: 762–5
  • Meade T. W., Mellows S., Brozovic M., Miller G. J., Chakrabarti R. R., North W. R. S., Haines A. P., Stirling Y., Imeson J. D., Thompson S. G. Haemostatic function and ischaemic heart disease; principal results of the Northwick Park Heart Study. Lancet 1986; 2: 533–7
  • Gevers Leuven J. A., Kluft C., Dersjant-Roorda M. C., Harthoom-Lasthuizen E. J., Peters F. P.A.M.N., Bernsen M. J., Helmerhorst F. M. Changes in coagulation and fibrinolysis variables during use of two oral contraceptives containing the same dose of ethinyl estradiol and either gestodene or desogestrel. Adv. Contracept. 1990; 6: 69–73
  • Oswaldsson U., Wilson S., Rosén S. A simple chromogenic assay for the determination of factor VII in microtiter plates. Thromb. Haemostas. 1985; 54: 26
  • Daly L., Bonnar J. Comparative studies of 30 μg EE2 combined with gestodene and desogestrel on blood coagulation, fibrinolysis and platelets. Am. J. Obstet. Gynecol. 1990; 163: 430–7
  • Daume E. Influence of modem low-dose oral contraceptives on hemostasis. Adv. Contracept. 1990; 6: 51–68
  • Consensus Development Meeting. Aspects of oral contraceptives of relevance for cardiovascular diseases. Am. J. Obstet. Gynecol. 1990; 162: 1335–7

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