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Gynecological Endocrinology Volume 13, 1999 - Issue 5
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Original Article

Barbiturates inhibit progesterone synthesis in cultured Leydig tumor cells and human granulosa cells

P. M. Gocze Department of Obstetrics and Gynecology, Medical University of Pecs, Hungary; Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA; Department of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA; Department of Veterans, Affairs Medical Center, Oklahoma City, Oklahoma, USA
,
I. Szabo Department of Obstetrics and Gynecology, Medical University of Pecs, Hungary
,
Z. Porpaczy Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA; Department of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA; Department of Veterans, Affairs Medical Center, Oklahoma City, Oklahoma, USA
&
D. A. Freeman Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA; Department of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA; Department of Veterans, Affairs Medical Center, Oklahoma City, Oklahoma, USAView further author information
Pages 305-310 | Published online: 05 Aug 2009

References

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  • Ascoli M. Characterization of several clonal lines of cultured Leydig tumor cells: gonadotropin receptors and steroidogenic responses. Endocrinology 1981; 108: 88–95
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  • Freeman D A. Constitutive steroidogenesis in the R2C Leydig tumor cell line is maintained by the adenosine 3′,5′-cyclic monophosphate-independent production of a cycloheximide-sensitive factor that enhances mitochondrial pregnenolone biosynthesis. Endocrinology 1987; 120: 124–32
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