335
Views
8
CrossRef citations to date
0
Altmetric
Original Article

The value of flow cytometry in the measurement of platelet activation and aggregation in human immunodeficiency virus infection

, &
Pages 250-257 | Received 22 Nov 2013, Accepted 23 Mar 2014, Published online: 15 May 2014

References

  • Lundgren JD, Babiker A, El-Sadr W, Emery S, Grund B, Neaton JD, Neuhaus J, Phillips AN. Inferior clinical outcome of the CD4 + cell count-guided antiretroviral treatment interruption strategy in the SMART study: Role of CD4 + cell counts and HIV RNA levels during follow-up. J Infect Dis 2008;197:1145–1155
  • Friis-Møller N, Thiébaut R, Reiss P, Weber R, Monforte AD, De Wit S, El-Sadr W, Fontas E, Worm S, Kirk O, et al. Predicting the risk of cardiovascular disease in HIV infected patients: The data collection on adverse effects of anti-HIV drugs study. Eur J Cardiovasc Prev Rehabil 2010;17:491–501
  • Triant VA. HIV infection and coronary Heart disease: An intersection of Epidemics. J Infect Dis 2012;205:S355–S361
  • Petoumenos K, Worm SW. HIV infection, aging and cardiovascular disease: Epidemiology and prevention. Sex Health 2011;8:465–473
  • Boccara F, Lang S, Meuleman C, Ederhy S, Mary-Krause M, Costagliola D, Capeau J, Cohen A. HIV and coronary heart disease time for a better understanding. J Am Coll Cardiol 2013;61:511–523
  • Baker J, Quick H, Hullsiek KH, Tracy R, Duprez D, Henry K, Neaton JD. Interleukin-6 and d-dimer levels are associated with vascular dysfunction in patients with untreated HIV infection. HIV Med 2010;11:608–609
  • El-Sadr WM, Lundgren JD, Neaton JD, Gordin F, Abrams D, Arduino RC, Babiker A, Burman W, Clumeck N, Cohen CJ, et al. CD4 + count-guided interruption of antiretroviral treatment. New Engl J Med 2006;355:2283–2296
  • Feeney ER, McAuley N, O'Halloran JA, Rock C, Low J, Satchell CS, Lambert JS, Sheehan GJ, Mallon PW. The expression of cholesterol metabolism genes in monocytes from HIV-infected subjects suggests intracellular cholesterol accumulation. J Infect Dis 2013;207:628–637
  • Appay V, Sauce D. Immune activation and inflammation in HIV-1 infection: Causes and consequences. J Pathol 2008;214:231–241
  • da Silva EF, Fonseca FA, Franca CN, Ferreira PR, Izar MC, Salomao R, Camargo LM, Tenore SB, Lewi DS. Imbalance between endothelial progenitors cells and microparticles in HIV-infected patients naive for antiretroviral therapy. AIDS 2011;25:1595–1601
  • Kaperonis EA, Liapis CD, Kakisis JD, Dimitroulis D, Papavassilou VG. Inflammation and atherosclerosis. Eur J Vasc Endovasc Surg 2006;31:386–393
  • O'Brien M, Montenont E, Hu L, Nardi MA, Valdes V, Merolla M, Gettenberg G, Cavanagh K, Aberg JA, Bhardwaj N, Berger JS. Aspirin attenuates platelet activation and immune activation in HIV-1-infected subjects on antiretroviral therapy: A pilot study. J Acquir Immune Defic Syndr 2013;63:280–288
  • Duprez DA, Neuhas J, Kuller LH, Tracy R, Belloso W, De Wit S, Drummond F, Lane HC, Ledergerber B, Lundgren J, et al; INSIGHT SMART Study Group. Inflammation, coagulation and cardiovascular disease in HIV-1 infected patients. PLoS One 2012;7:e44454
  • Vorchheimer DA, Becker R. Platelets in atherothrombosis. Mayo Clin Proc 2006;81:59–68
  • Rorberts W, Magwenzi S, Aburima A, Naseem KM. Thrombospondin 1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signalling cascade. Blood 2010;116:4297–4306
  • Mayne E, Funderburg NT, Sieg SF, Asaad R, Kalinowska M, Rodriguez B, Schmaier AH, Stevens W, Lederman MM. Increased platelet and microparticle activation in HIV infection: upregulation of P-selectin and tissue factor expression. J Acquir Immune Defic Syndr 2012;59:340–346
  • Febbraio M, Hajjar DP, Silverstein RL. CD36: A class B scavenger receptor involved in angiogenesis, artherosclerosis, inflammation and lipid metabolism. J Clin Invest 2001;108:785–791
  • Nergiz-Unal R, Lamers MM, Van Kruchten R, Luiken JJ, Cosemans JM, Glatz JF, Kuijpers MJ, Heemskerk JW. Signaling role of CD36 in platelet activation and thrombus formation on immobilized thrombospondin or oxidized low-density lipoprotein. J Thromb Haemost 2011;9:1835–1846
  • Berger G, Caen JP, Berndt MC, Cramer EM. Ultrastractural demonstration of CD36 in the alpha-granule membrane of human platelets and megakaryocytes. Blood 1993;82:3034–3044
  • Miao WM, Vasile E, Lane WS, Lawler J. CD36 associates with CD9 and integrins on human blood platelets. Blood 2001;97:1689–1696
  • Diaz-Ricart M, Tandon NN, Carretero M, Ordinas A, Bastida E, Jamieson GA. Platelets lacking CD36 (glycoprotein IV) show reduced adhesion in flowing whole blood. Blood 1993;91:491–499
  • Sun M, Finnemann SC, Febbraio M, Shan L, Annangudi SP, Podrez EA, Hoppe G, Darrow R, Organisciak DT, Salomon RG, et al. Light-induced oxidation of photoreceptor outer segment phospholipids generates ligands for CD36-mediated phagocytosis by retinal pigment epithelium: A potential mechanism for modulating outer segment phagocytosis under oxidant stress condition. J Biol Chem 2006;281:4222–4230
  • Collot-Teixeira S, Martin J, McDermott-Roe C, Poston R, Mcgregor JL. CD36 and macrophages in atherosclerosis. Cardiovasc Res 2007;75:468–477
  • Ren Y, Silverstein RL, Allen J, Savill J. CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis. J Exp Med 1995;181:1857–1862
  • Ghosh A, Li W, Febbraio M, Espinola RG, McCrae KR, Cockrell E, Silverstein RL. Platelet CD36 mediates interactions with endothelial cell–derived microparticles and contributes to thrombosis in mice. J Clin Invest 2008;118:1934–1943
  • Liani R, Halvorsen B, Sestili S, Handberg A, Santilli F, Vazzana N, Formoso G, Aukrust P, Davi G. Plasma levels of soluble CD36, platelet activation, inflammation, and oxidative stress are increased in type 2 diabetic patients. Free Radic Biol Med 2012;52:1318–1324
  • Silverstein RL. Type 2 scavenger receptor CD36 in platelet activation: The role of hyperlipemia and oxidative stress. Clin Lipidol 2009;4:767
  • Meroni L, Riva A, Morelli P, Galazzi M, Mologni D, Adorni F, Galli M. Increased CD36 expression on circulating monocytes during HIV infection. J Acquir Immune Defic Syndr 2005;38:310–313
  • Coupland LA, Chong BH, Parish CR. Platelets and p-selectin control tumor cell metastasis in an organ-specific manner and independently of NK cells. Cancer Res 2012;72:4662–4671
  • Zarbock A, Müller H, Kuwano Y, Ley K. PSGL-1-dependent myeloid leukocyte activation. J Leukoc Biol 2009;86:1119–1124
  • Holme PA, Müller F, Solum NO, Brosstad F, Frøland SS, Aukrust P. Enhanced activation of platelets with abnormal release of RANTES in human immunodeficiency virus type 1 infection. FASEB J 1998;12:79–90
  • Calza L, Pocaterra D, Pavoni M, Colangeli V, Manfredi R, Verucchi G, Chiodo F, Cantu M, Pariali M. Plasma levels of VCAM-1, ICAM-1, E-Selectin, and P-Selectin in 99 HIV-positive patients versus 51 HIV-negative healthy controls. J Acquir Immune Defic Syndr 2009;50:430–432
  • Satchell CS, Cotter AG, O'Connor EF, Peace AJ, Tedesco AF, Clare A, Lambert JS, Sheehan GJ, Kenny D, Mallon PW. Platelet function and HIV: A case-control study. AIDS 2010;24:649–657
  • Harrison P, Mackie I, Mumford A, Briggs C, Liesner R, Winter M, Machin S; British Committee for Standards in Haematology. Guidelines for the laboratory investigation of heritable disorders of platelet function. Br J Haematol 2011;155:30–44
  • Harrison P. Platelet function analysis. Blood Rev 2005;19:111–123
  • Schmitz G, Rothe G, Ruf A, Barlage S, Tschöpe D, Clemetson KJ, Goodall AH, Michelson AD, Nurden AT, Shankey TV. European Working Group on Clinical Cell Analysis: Consensus protocol for the flow cytometric characterisation of platelet function. Thromb Haemost 1998;79:885–896
  • van Velzen JF, Laros-van Gorkom BA, Pop GA, van Heerde WL. Multicolor flow cytometry for evaluation of platelet surface antigens and activation markers. Thromb Res 2012;130:92–98
  • Pearson L, Thom J, Adams M, Oostryck R, Krueger R, Yong G, Baker R. A rapid flow cytometric technique for the detection of platelet-monocyte complexes, activated platelets and platelet-derived microparticles. Int J Lab Hematol 2009;31:430–439
  • De Cuyper IM, Meinders M, van de Vijver E, de Korte D, Porcelijn L, de Haas M, Eble JA, Seeger K, Rutella S, Pagliara D, et al. A novel flow cytometry-based platelet aggregation assay. Blood 2013;121:e70–e80
  • Levin E, Serrano K, Devine DV. Standardization of CD62P measurement: Results of an international comparative study. Vox Sang 2013;105:38–46
  • Singh MV, Davidson DC, Kiebala M, Maggirwar SB. Detection of circulating platelet-monocyte complexes in persons infected with human immunodeficiency virus type-1. J Virol Methods 2012;181:170–176
  • Metcalf Pate KA, Lyons CE, Dorsey JL, Shirk EN, Queen SE, Adams RJ, Gama L, Morrell CN, Mankowski JL. Platelet activation and platelet-monocyte aggregate formation contribute to decreased platelet count during acute simian immunodeficiency virus infection in pig-tailed macaques. J Infect Dis 2013;208:874–883
  • Vaughan J, Wiggill T, Munster M. Immature platelet fraction levels in a variety of bone marrow pathologies in South African HIV-positive patients with thrombocytopenia. Hematology 2013. [Epub ahead of print]
  • Flaujac C, Boukour S, Cramer-Bordé E. Platelets and viruses: An ambivalent relationship. Cell Mol Life Sci 2010;67:545–556
  • Tsegaye TS, Gnirß K, Rahe-Meyer N, Kiene M, Krämer-Kühl A, Behrens G, Pöhlmann S. Platelet activation suppresses HIV-1 infection of T cells. Retrovirology 2013;10:48
  • Podrez EA, Byzova TV, Febbraio M, Salomon RG, Ma Y, Valiyaveettil M, Poliakov E, Sun M, Finton PJ, Curtis BR, et al. Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. Nat Med 2007;13:1086–1095
  • Gruarin P, Thorne RF, Dorahy DJ, Burns GF, Sitia R, Alessio M. CD36 is a ditopic glycoprotein with the N-terminal domain implicated in intracellular transport. Biochem Biophys Res Commun 2000;275:446–454
  • Grinspoon S, Carr A. Cardiovascular risk and body-fat abnormalities in HIV-infected adults. N Engl J Med 2005;352:48–62
  • Temelkova-Kurktschiev T, Hanefeld M. The lipid triad in type 2 diabetes-prevalence and relevance of hypertriglyceridaemia/low high-density lipoprotein syndrome in type 2 diabetes. Exp Clin Endocrinol Diabetes 2004;112:75–79
  • Gresele P, Falcinelli E, Sebastiano M, Baldelli F. Endothelial and platelet function alterations in HIV-infected patients. Thromb Res 2012;129:301–308
  • Boulware DR, Hullsiek KH, Puronen CE, Rupert A, Baker JV, French MA, Bohjanen PR, Novak RM, Neaton JD, Sereti IS. Higher levels of CRP, D-dimer, IL-6, and hyaluronic acid before initiation of antiretroviral therapy (ART) are associated with increased risk of AIDS or death. J Infec Dis 2011;203:1637–1646
  • Karim R, Mack WJ, Stiller T, Operskalski E, Frederick T, Landay A, Young MA, Tien PC, Augenbraun M, Strickler HD, Kovacs A. Association of HIV clinical disease progression with profiles of early immune activation: results from a cluster analysis approach. AIDS 2013;27:1473–1481
  • Kovacs A, Karim R, Mack WJ, Xu J, Chen Z, Operskalski E, Frederick T, Landay A, Voris J, Spencer LS, et al. Activation of CD8 T cells predicts progression of HIV infection in women coinfected with hepatitis C virus. J Infect Dis 2010;201:823–834
  • Jennings LK. Role of platelets in atherothrombosis. Am J Cardiol 2009;103:4A–10A
  • Cunningham MR, Nisar SP, Mundell SJ. Molecular mechanisms of platelet P2Y12 receptor regulation. Biochem Soc Trans 2012;41:225–230
  • Hillman-Wiseman C. 2010. Laboratory testing in coagulation. In: Mckenzie SB, Williams JL, editors. Clinical Laboratory Hematology. New York: Pearson. pp 890–922

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.