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Original Article

Plasma albumin and platelet function: relevance to atherogenesis and thrombosis

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Pages 125-137 | Published online: 07 Jul 2009

References

  • Porcellati S, Gresele P, Stasi M, et al. Albumin prevents TXB, formation from thrombin-stimulated human platelets by sequestering the liberated arachidonic acid in the extracellular space. Platelets 1995; 6: 381–7
  • Al-Mugeirin M M, Gader A M A, Al-Rasheed S A, Bahakim H M, Al-Momen A K, Al-Salloum A. Platelet aggregometry – dose related responses to arachidonic acid in childhood nephrotic syndrome. Platelets 1995; 6: 71–4
  • Phillips A N, Shaper A G, Whincup P H. Association between serum albumin and mortality from cardiovascular disease, cancer and other causes. Lancer 1989; ii: 1434–6
  • Kuller L H, Eichner J E, Orchard T J, Grandits G A, McCallum L, Tracy R P. The relation between serum albumin levels and risk of coronary heart disease in the Multiple Risk Factor Intervention Trial. Am J Epidemiol 1991; 134: 1266–77
  • Purdon A D, Rao A K. Interaction of albumin, arachidonic acid and prostanoids in platelets. Prostagl Leukotr Essntl Fatty Acids: Revs 1989; 35: 213–8
  • Rao A K, Koike K, Day H J, Smith J B, Holmsen H. Bleeding disorder associated with albumin-dependent partial deficiency in platelet thromboxane production. Am J Clin Pathol 1985; 83: 687–96
  • Hornberger W, Patscheke H. Transient concentrations and agonist potency of PGH, in platelet activation by endogenous arachidonate. Eicosanoids 1989; 2: 241–8
  • Gresele P, Deckmyn H, Huybrechts E, Vermylen J. Serum albumin enhances the impairment of platelet aggregation with thromboxane synthase inhibition by increasing the formation of prostaglandin D. Biochem Pharmacol 1984; 33: 2083–8
  • Guichardant M, Petit F, Lagarde M. Metabolism of endogenous arachidonic acid in weakly activated platelets. Absence of leukocyte cooperative products in whole blood. Eicosanoids 1989; 2: 117–21
  • Peplow P V, Mikhailidis D P. Platelet activating factor (PAF) and its relation to prostaglandins, leukotrienes and other aspects of arachidonate metabolism. Prostagl Leukotr Essntl Fatty Acids 1990; 41: 71–82
  • Tokomura A, Yoshida J, Maruyama T, Fukuzawa K, Tsukatani H. Platelet aggregation induced by ether-linked phospholipids. I. Inhibitory actions of bovine serum albumin and structural analogues of platelet activating factor. Thromb Res 1987; 46: 51–63
  • Colli S, Maderna P, Caruso D, Stragliotto E, Galli G, Tremoli E. Albumin interferes with arachidonate metabolism in platelets and neutrophils. Eicosanoids 1989; 2: 51–7
  • Fitzgerald G A, Brash A R, Oaks J A, Pedersen A K. Endogenous prostacyclin biosynthesis and platelet function during selective inhibition of thromboxane synthase in man. J Clin Invest 1983; 72: 1336–43
  • Doweiko J P, Bistrian B R. The effect of glycosylated albumin on platelet aggregation. J Parenteral Enteral Nutrn 1994; 18: 516–20
  • Surya I I, Gorter G, Akkerman J W. Arachidonate transfer between platelets and lipoproteins. Thromb Haemostas 1992; 68: 719–26
  • Mikhailidis D P, Mikhailidis A M, Dandona P. Effect of human plasma proteins on stabilisation of platelet anti-aggregatory activity of prostacyclin. Ann Clin Biochem 1982; 19: 241–4
  • Mikhailidis D P, Mikhailidis A M, Bmadas M A, Dandona P. Effect of non-esterified fatty acids on the stability of prostacyclin activity. Metabolism 1983; 32: 717–21
  • Goodnight S H, Inkeles S B, Kovach N L, Connor W E. Reduced prostacyclin survival after fasting-induced elevation of plasma fatty acids. Thromb Haemostas 1985; 54: 418–21
  • Bakker W W, Poelstra K, Barradas M A, Mikhailidis D P. Platelets and ectonucleotidases. Platelets 1994; 5: 121–9
  • Barradas M A, Mikhailidis D P, Dandona P. The effect of non-esterified fatty acids on vascular ADP-degrading enzyme activity. Diabetes Res Clin Pract 1987; 3: 9–19
  • Mikhailidis D P, Barradas M A, Maris A, Jeremy J Y, Dandona P. Fibrinogen mediated activation of platelet aggregation and thromboxane A release: implications in vascular disease. J Clin Pathol 1985; 38: 1166–71
  • Goubran F, Maklady F. In vivo platelet activity and serum albumin concentration in nephrotic syndrome. Blut 1988; 57: 15–17
  • Bennett A, Cameron J S. Platelet hyperaggregability in the nephrotic syndrome which is not dependent on arachidonic acid metabolism or on plasma albumin concentration. Clin Nephrol 1987; 27: 182–8
  • Jackson C A, Greaves M, Patterson A D, Brown C B, Preston F E. Relationship between platelet aggregation, thromboxane synthesis and albumin concentration in nephrotic syndrome. Br J Haematol 1982; 52: 69–77
  • Vaziri N D, Gonzales E C, Shayestehfar B, Barton C H. Plasma levels and urinary excretion of fibrinolytic and protease inhibitory proteins in nephrotic syndrome. J Lab Clin Med 1994; 124: 118–24
  • Schieppati A, Dodesini P, Benigni A, et al. The metabolism of arachidonic acid by platelets in nephrotic syndrome. Kidney Intnl 1984; 25: 671–6
  • Kuhlmann U, Steurer J, Rhyner K, von Felten A, Briner J, Siegenthaler W. Platelet aggregation and beta-thromboglobulin levels in nephrotic patients with and without thrombosis. Clin Nephrol 1981; 15: 229–35
  • Remuzzi G, Mecca G, Marchesi D, et al. Platelet hyperaggregability and the nephrotic syndrome. Thromb Res 1979; 16: 345–54
  • Stuart M, Spitzer R E, Nelson D A, Sills R H. Nephrotic Syndrome: increased platelet prostaglandin formation, hyperaggregability, and reduced platelet life span. Pediatr Res 1980; 14: 1078–81
  • Machleidt C, Mettang T, Starz E, Weber J, Risler T, Kuhlmann U. Multifactorial genesis of enhanced platelet aggregability in patients with nephrotic syndrome. Kidney Intnl 1989; 36: 1119–24
  • Ernst E, Resch K L. Therapeutic interventions to lower plasma fibrinogen concentration. Eur Heart J 1995; 16(Suppl. A)47–53
  • Koenig W. Recent progress in the clinical aspects of fibrinogen. Eur Heart J 1995; 16(Suppl. A)54–9
  • Thaulow E, Erikssen J, Sandvik L, Storkmoren H, et al. Blood platelet count and function are related to total and cardiovascular death in apparently healthy men. Circulation 1991; 84: 613–7
  • Russi G, Weigand K. Analbuminemia. Klin Woschenschrift 1983; 61: 541–5
  • Baldo G, Fellin R, Manzato E, et al. Characterization of hyperlipidemia in two patients with analbuminemia. Clin Chim Acta 1983; 128: 307–19
  • Frohlich J, Pudek M R, Cormode E J, Sellers E M, Abel J G. Further studies on plasma proteins, lipids, and dye-and-drug-binding in a child with analbuminemia. Clin Chem 1981; 27: 1213–6
  • Stewart M W, Laker M F, Alberti K G. The contribution of lipids to coronary heart disease in diabetes mellitus. J Intern Med (Suppl) 1994; 736: 41–6
  • Reinila A. Long-term effects of untreated diabetes on the arterial wall in rat. Diabetologia 1981; 20: 205–12
  • Thompson C S, Strong P, Mikhailidis D P. Improvement of ketoacidosis in the diabetic rat after the administration of the oral antilipolytic agent GR 79236. Clin Sci 1994; 86: 593–8
  • Tietz N W, Finley P R. Clinical Guide to Laboratory Tests. WB Saunders, Philadelphia 1983; 17
  • Gruden G, Cavallo-Perin P, Romagnoli R, Ruiu G, Pagano G. Plasma beta-thromboglobulin and platelet factor 4 are not increased in insulin-dependent diabetic patients with micro-albuminuria. Acta Diabetol 1994; 31: 130–2
  • Baba T, Kodama T, Yasuda T K, Ishizaki T. Comparison of platelet aggregability in Japanese type 2 diabetic patients with and without microalbuminuria. Diabetic Med 1993; 10: 643–6
  • Feskens E J M, Kromhout D. Hyperinsulinaemia, risk factors, and coronary heart disease. The Zutphen elderly study. Arterioscler Thromb 1994; 14: 1641–7
  • Jeremy J Y, Mikhailidis D P, Dandona P. Simulating the diabetic environment modifies in vitro prostacyclin synthesis. Diabetes 1983; 32: 217–21
  • Glassman A B. Platelet abnormalities in diabetes mellitus. Ann Clin Lab Sci 1993; 23: 47–50
  • The diabetes control and complications trial research group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329: 977–86
  • Jeremy J Y, Mikhailidis D P, Pittilo R M. Cigarette smoking and cardiovascular disease. J Royal Soc Health 1995; 115: 289–95
  • Mikhailidis D P, Barradas M A, Jeremy J Y, Dandona P. Cigarette smoking inhibits prostacyclin formation. Lancet 1983; ii: 627–8
  • Margetts B, Jackson A. Interactions between people's diet and their smoking habits: the dietary and nutritional survey of British adults. Br Med J 1993; 307: 1381–4
  • Midgette A S, Baron J A, Rohan T E. Do cigarette smokers have diets that increase the risk of coronary heart disease and cancer?. Am J Epidemiol 1993; 137: 521–9
  • Musabayane C T, Ndhlovu C E, Bwititi P, Msamati B C. Serum albumin concentrations in rural Zimbabweans. Centr African J Med 1995; 41: 204–8
  • Myers L A, Boyce J T, Robison R L. The tolerability and pharmacology of interleukin-6 administered in combination with GM-CSF or G-CSF in the rhesus monkey. Toxicology 1995; 101: 157–66
  • Yanagawa H, Sone S, Takahashi Y, et al. Serum levels of interleukin 6 in patients with lung cancer. Br J Cancer 1995; 71: 1095–8
  • Burstein S A, Downs T, Friese P, et al. Thrombocytopoiesis in normal and sublethally irradiated dogs: response to human interleukin-6. Blood 1992; 80: 420–8
  • Mackiewicz A, Speroff T, Ganapathi M K, Kushner I. Effects of cytokine combinations on acute phase protein production in two human hepatoma cell lines. J Immunol 1991; 146: 3032–7
  • Hoak J C. Stearic acid, clotting, and thrombosis. Am J Clin Nutr 1994; 60(Suppl. 6)1050S–3S
  • Mikhailidis D P, Winder A F. A place for fibrinogen-lowering drugs in cardiovascular disease?. J Drug Develop Clin Pract 1995; 7: 3–5
  • Ueda N. Effect of corticosteroids on some hemostatic parameters in children with minimal change nephrotic syndrome. Nephron 1990; 56: 374–8
  • Hoyer P F, Gonda S, Barthels M, Krohn H P, Brodehl J. Thromboembolic complications in children with nephrotic syndrome. Risk and incidence. Acta Paediatr Scand 1986; 75: 804–10
  • Iioka Y, Kikuchi K, Tada H, Isogai S, Urayama T. Plasma soluble fibrin monomer complexes in nephrotic syndrome – with reference to hypoalbuminemia. Tohuku J Exper Med 1984; 143: 53–7
  • Barradas M A, Mikhailidis D P, Phillips A N, Shaper A G. Albumin, haemostasis and cardiovascular disease. Fibrinolysis 1991; 5: 131
  • Delvos U, Preissner K T, Muller-Berghaus G. Binding of fibrinogen to cultured bovine endothelial cells. Thromb Haemostas 1985; 53: 26–31
  • George J N. Platelet IgG: measurement, interpretation, and clinical significance. Progr Haemostas Thromb 1991; 10: 97–126
  • Coller B S, Seligsohn U, West S M, Scudder L E, Norton K J. Platelet fibrinogen and vitronectin in Glanzmann thrombasthenia. Blood 1991; 78: 2603–10
  • Hotchkiss A J, Leissinger C A, Smith M E, Jordan J V, Kautz C A, Shulman N R. Evaluation by quantitative acid elution and radioimmunoassay of multiple classes of immunoglobulins and serum albumin associated with platelets in idiopathic thrombocytopenic purpura. Blood 1986; 67: 1126–3I
  • Thorne S A, Abbot S E, Winyard P G, Blake D R, Mills P G. Extent of oxidative modification of low density lipoprotein determines the degree of cytotoxicity to human coronary artery cells. Heart 1996; 75: 11–16, (Abstr.).
  • Miller Y J, Felikman Y, Shaklai N. The involvement of low-density lipoprotein in hemia transport potentiates peroxidative damage. Biochim Biophys Acta 1995; 1272: 119–27
  • McDowell I F, McEnemy J, Trimble E R. A rapid method for measurement of the susceptibility to oxidation of low-density lipoprotein. Ann Clin Biochem 1995; 32: 167–74
  • Luoma P V, Nayha S, Sikkila K, Hassi J. High serum alpha-tocopherol, albumin, selenium and cholesterol, and low mortality from coronary heart disease in northern Finland. J Intern Med 1995; 237: 49–54
  • Asayama K, Uchida N, Nakane T, et al. Antioxidants in the serum of children with insulin-dependent diabetes mellitus. Free Radical Biol Med 1993; 15: 597–602
  • Hu M L, Louie S, Cross C E, Motchnik P, Halliwell B. Anti-oxidant protection against hypochlorous acid in human plasma. J Lab Clin Med 1993; 121: 257–62
  • Strubelt O, Younes M, Li Y. Protection by albumin against ischaemia- and hypoxia-induced hepatic injury. Pharmacol Toxicol 1994; 75: 280–4
  • Silverman L M, Christenson R H, Grant G H. Textbook of Clinical Chemistry, N W Tietz. WB Saunders, Philadelphia 1986; 587–9
  • Schwertner H A, Jackson W C, Tolan G. Association of low serum concentration of bilirubin with increased risk of coronary artery disease. Clin Chem 1994; 40: 18–23
  • Breimer L H, Spyropoulos K A, Winder A F, Mikhailidis D P, Hamilton G. Is bilirubin protective against coronary artery disease?. Clin Chem 1994; 40: 1987–8
  • Breimer L H, Wannamethee G, Ebrahim S, Shaper A G. Serum bilirubin and risk of ischemic heart disease in middle-aged British men. Clin Chem 1995; 41: 1504–8
  • McPherson R A. Clinical Diagnosis and Management by Laboratory Methods, J B Henry. WB Saunders., Philadelphia 1991; 215: 28
  • Stocker R, Glazer A N, Ames B N. Antioxidant activity of albumin-bound bilirubin. PNAS 1987; 84: 5918–22
  • Neuzil J, Stocker R. Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation. J Biol Chem 1994; 269: 16712–9
  • Wu T W, Wu J, Li R K, Mickle D, Carey D. Albumin-bound bilürubins protect human ventricular myocytes against oxyradical damage. Biochem Cell Biol 1991; 69: 683–8
  • Neuzil J, Stocker R. Bilirubin attenuates radical-mediated damage to serum albumin. FEBBS Lett 1993; 331: 281–4
  • Kaapa P. Immunoreactive thromboxane 82 and 6-keto-prostaglandin F1 alpha in neonatal hyperbilirubinemia. Prostagl Leukotr Med 1985; 17: 97–105
  • Dahlen G H. Lp(a) lipoprotein in cardiovascular disease. Atherosclerosis 1994; 108: 111–26
  • Hong S Y, Yang D H. Lipoprotein (a) levels and fibrinolytic activity in patients with nephrotic syndrome. Nephron 1995; 69: 125–30, (Abstr.).
  • Gansevoort R T, Heeg J E, Dikkeschei F D, de Zeeuw D, de Jong P E, Dullaart R P. Symptomatic antiproteinuric treatment decreases serum lipoprotein (a) concentration in patients with glomerular proteinuria. Nephrol Dial Transplant 1994; 9: 244–50
  • Kanno H, Saito E, Fujioka T, Yasugi T. Lipoprotein (a) levels in the nephrotic syndrome. Intern Med 1992; 31: 1004–8
  • Malle E, Ibovnik A, Stienmetz A, Kostner G M, Sattler W. Identification of glycoprotein IIb as the lipoprotein (a)-binding protein on platelets. Arteriosclerosis 1994; 14: 345–52
  • Ezratty A, Simon D I, Loscalzo J. Lipoprotein (a) binds to human platelets and attenuates plasminogen binding and activation. Biochemistry 1993; 32: 4628–33
  • Malle E, Sattler W, Prenner E, Leis H J, Hermetter A, Cries A, Kostner G M. Effects of dietary fish oil supplementation on platelet aggregability and platelet membrane fluidity in normolipemic subjects with and without high plasma lipoprotein (a) concentrations. Atherosclerosis 1991; 88: 193–201, (Abstr.).
  • Mikhailidis D P, Spyropoulos K A, Jagroop I A, Byrne D J, Vallance D T, Winder A F. Lipoprotein (a) and fibrinogen: relationships in a cardiovascular risk management clinic. Atherosclerosis 1995; 115(Suppl.)S91
  • Folsom A R, Wu K K, Davis C E, Conlan M G, Sorlie P D, Szklo M. Population correlates of plasma fibrinogen and factor VII, putative cardiovascular risk factors. Atherosclerosis 1991; 91: 191–205
  • Mikhailidis D P, Fonseca V A, Barradas M A, Jeremy J Y, Dandona P. Platelet activation following intravenous injection of a conventional heparin: absence of effect with a low molecular weight heparnoid (Org 10172). Br J Clin Pharmacol 1987; 24: 415–24, (Abstr.).
  • Jagroop I A, Barradas M A, Mikhailidis D P. A low molecular weight heparin, nadroparin (Fraxiparine), inhibits thrombin-induced platelet shape change and does not enhance spontaneous platelet aggregation. Br J Clin Pharmacol 1996; 41: 163–5
  • Mikhailidis D P, Hutton R A, Jeremy J Y, Dandona P. Hypothermia and pancreatitis. J Clin Pathol 1983; 36: 483–4
  • Jensen J S. Renal and systemic transvascular albumin leakage in severe atherosclerosis. Arterioscler Thromb Vasc Biol 1995; 15: 1324–9
  • McCandless B K, Powers M R, Cooper J A, Malik A B. Effect of albumin on hydraulic conductivity of pulmonary artery endothelial monolayers. Am J Physiol 1991; 260: L571–6
  • Salive M E, Cornoni-Huntley J, Phillips C L, et al. Serum albumin in older persons: relationship with age and health status. J Clin Epidemiol 1992; 45: 213–21
  • Klonoff-Cohen H, Barrett-Connor E L, Edelstein S L. Albumin levels as a predictor of mortality in the healthy elderly. J Clin Epidemiol 1992; 45: 207–12
  • Hu H, Sparrow D, Weiss S. Association of serum albumin with blood pressure in the normative aging study. Am J Epidemiol 1992; 136: 1465–73
  • Cederblad G, Korsan-Bengsten K. Effect of clofibrate on plasma proteins including components of the hemostatic mechanism. Clin Chim Acta 1976; 66: 9–17
  • Caimi G, Francavilla G, Romano A, Catania C, Santonocito G, Sarno A. Blood rheology changes during bezafibrate treatment. Br J Clin Pract 1988; 42: 456–8
  • Mathur S, Barradas M A, Mikhailidis D P, et al. The effects of a slow release formulation of bezafibrate on lipids, glucose homeostasis, platelets and fibrinogen in type II diabetics: a pilot study. Diabetes Res 1990; 14: 133–8
  • Mulvihill J N, Faradji A, Oberling F, Cazenave J P. Surface passivation by human albumin of plasmapheresis circuits reduces platelet accumulation and thrombus formation. Experimental and clinical studies. J Biomed Materials Res 1990; 24: 155–63
  • Kottke-Marchant K, Anderson J M, Umemura Y, Marchant R E. Effect of albumin coating on the in vitro blood compatibility of Dacron arterial prosthesis. Biomaterials 1989; 10: 147–55
  • Chandy T, Sharma C P. The antithrombotic effect of prostaglandin El immobilized on albuminated polymer matrix. J Biomed Materials Res 1984; 18: 1115–24
  • Bellavite P, Andrioli G, Guzzo P, et al. A colorimetric method for the measurement of platelet adhesion in microtiter plates. Analyt Biochem 1994; 216: 444–50
  • Freedman J E, Frei B, Welch G N, Loscalzo J. Glutathione peroxidase potentiates the inhibition of platelet function by S-nitrosothiols. J Clin Invest 1995; 96: 394–400
  • Amano M, Takahasbi M, Kosaka T, Kinoshita M. Differential inhibition of platelet aggregation and calcium mobilization by nitroglycerin and stabilized nitric oxide. J Cardiovasc Pharmacol 1994; 24: 860–6
  • Simon D I, Stamler J S, Jaraki O, et al. Antiplatelet properties of protein S-nitrosothiols derived from nitric oxide and endothelium-derived relaxing factor. Arterioscler Thromb 1993; 13: 791–9
  • Gurdol F, Nwose O M, Mikhailidis D P. Gamma-glutamyl transferase activity in human platelets: quantification of activity, isoenzyme characterization and potential clinical relevance. Platelets 1995; 6: 200–3
  • Szekanecz Z, Shah M R, Pearce W H, Koch A E. Human atherosclerotic abdominal aortic aneurysms produce interleukin (IL)-6 and interferon-gamma but not IL-2 and IL-4: the possible role for IL-6 and interferon-gamma in vascular inflammation. Agents Actions 1994; 42: 159–62
  • Lopes-Virella M F, Virella G. Immune mechanisms of atherosclerosis in diabetes mellitus. Diabetes 1992; 41(Suppl. 2)86–91
  • Moyer C F, Sajuthi D, Tulli H, Williams J K. Synthesis of IL-1 alpha and IL-1 beta by arterial cells in atherosclerosis. Am J Pathol 1991; 138: 951–60
  • Heinrich J, Schulte H, Schonfeld R, Kohler E, Assmann G. Association of variables of coagulation, fibrinolysis and acute-phase with atherosclerosis in coronary and peripheral arteries and those arteries supplying the brain. Thromb Haemostas 1995; 73: 374–9
  • Mori T, Sasaki J, Kawaguchi H, et al. Serum glycoproteins and severity of coronary atherosclerosis. Am Heart J 1995; 129: 234–8
  • Niewiarowski S. Secreted platelet proteins. Haemostasis and Thrombosis, 3rd edn., A L Bloom, C D Forbes, D P Thomas, E G D Tuddenham. Churchill Livingstone, Edinburgh 1994; 167–81
  • Robson S C, Shephard E G, Kirsch R E. Fibrin degradation product D-dimer induces the synthesis and release of biologically active IL-1 beta, II-6 and plasminogen activator inhibitors from monocytes in vitro. Br J Haematol 1994; 86: 322–6
  • Hamaguchi M, Morishita Y, Takahashi I, Ogura M, Takamatsu J, Saito H. FDP D-dimer induces the secretion of interleukin-I, urokinase-type plasminogen activator, and plasminogen activator inhibitor-2 in a human promonocytic leukemia line. Blood 1991; 71: 94–100
  • Soria C, Soria J, Collet J P, . Thrombotic disorder with decreased fibrinolysis related to fibrinogen abnormality. Fibrinogen a “New” Cardiovascular Risk Factor, E Ernst, W Koenig, G D O Lowe, T W. Made, et al. Blackwell-MZV, Vienna 1992; 315–20
  • Slunga L, Asplund K, Johnson O, Dahlen G H. Lipoprotein (a) in a randomly selected 25–64 year old population: the Northern Sweden MONICA Study. J Clin Epidemiol 1993; 46: 617–24
  • Heinrich J, Sandkarnp M, Kokott R, Schulte H, Assmann G. Relationship of lipoprotein (a) to variables of coagulation and fibrinolysis in a healthy population. Clin Chem 1991; 37: 1950–4
  • Olofsson B O, Dahlen G H, Nilsson T K. Evidence for increased levels of plasminogen activator inhibitor and tissue plasminogen activator in plasma of patients with angiographically verified coronary artery disease. Eur Heqart J 1989; 10: 77–82
  • Ganotakis E S, Mikhailidis D P. Bezafibrate: treating hyperlipidemias as well as other cardiovascular risk factors. Today's Therap Trends 1996; 13: 231–49
  • O'Brien R. Biological importance of low density lipoprotein subfractions. J Cardiovasc Risk 1994; 1: 207–11
  • Halle M, Berg A, Keul J, Baumstark M W. Association between serum fibrinogen concentration and HDL and LDL subfraction phenotypes in healthy men. Arterioscl Thromb Vasc Biol 1996; 16: 144–8
  • Glueck C J, Glueck H I, Tracy T, Speirs I, McCray C, Stroop D. Relationships between lipoprotein (a), lipids apolipoproteins, basal and stimulated fibrinolytic regulators, and D-dimers. Metabolism 1993; 42: 236–46
  • Mikhailidis D P, Barradas M A, Jeremy J Y, Winder A F. Platelets and lipoproteins. Platelets 1994; 5: 279
  • Heinrich J, Balleisen L, Schulte H, et al. Fibrinogen and factor VII in the prediction of coronary risk. Results from the PROCAM study in healthy men. Arterioscler Thromb 1994; 14: 54–9, Correction: Arterioscler Thromb 1994; 14: 1392.
  • Meade T W, Vickers M V, Thompson S G, Stirling Y, Haines A P, Miller G J. Epidemiological characteristics of platelet aggregability. Br Med J 1985; 290: 428–32
  • Coumar A, Gill J K, Barradas M A, O'Donoghue S, Jeremy J Y, Mikhailidis D P. The effect of treatment with simvastatin on platelet function indices in hypercholesterolaemia. J Drug Develop 1991; 4: 79–86
  • Pickart L. Increased ratio of plasma free fatty acids to albumin during normal aging and in patients with coronary heart disease. Atherosclerosis 1983; 46: 21–8
  • Pickart L. Free fatty acidaemia as an inducer of systemic hyperfibrinogenemia and fibrinolytic inhibition. Inflammation 1981; 5: 61–70
  • Pickart L, Thaler M M. Suppression of tumor-associated hyperfibrinogenemia and free fatty acidaemia with p-phenoxybenzalbutyrate (clofibrate). Cancer Res 1979; 39: 3845–8
  • Pickart L. Fat metabolism, the fibrinogen/fibrinolytic system and blood flow: new potentials for the pharmacological treatment of coronary heart disease. Pharmacology 1981; 23: 271–80
  • Ericsson C G, Hamsten A, Nilsson J, Grip L, Svane B, de Faire U. Angiographic assessment of effects of bezafibrate on progression of coronary artery disease in young male postinfarction patients. Lancet 1996; 347: 849–53
  • de Faire U, Ericsson C G, Hamsten A, Nilsson J. Design features of a five-year bezafibrate coronary atherosclerosis intervention trial (BECAIT). Drugs Expert Clin Res 1995; 21: 105–124
  • Levenson J, Giral P, Razavian M, Gariepy J, Simon A. Fibrinogen and silent atherosclerosis in subjects with cardiovascular risk factors. Arterioscler Thromb Vasc Biol 1995; 15: 1263–8
  • Tracy R P, Bovill E G, Yanez D, et al. Fibrinogen and factor VIII, but not factor VII, are associated with measures of subclinical cardiovascular disease in the elderly. Results from the Cardiovascular Health Study. Arterioscler Thromb Vasc Biol 1995; 15: 1269–79
  • Woodburn K R, Lowe G D O, Rumley A, Love J, Pollock J G. Relation of haemostatic, fibrinolytic, and rheological variables to the angiographic extent of peripheral arterial occlusive disease. Int Angiol 1995; 14: 346–52

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