18
Views
1
CrossRef citations to date
0
Altmetric
Original Article

A new variant of Glanzmann's thrombasthenia with defective activation-dependent fibrinogen binding and altered expression of epitopes for several monoclonal antibodies against GP IIb-IIIa

, , , , , & show all
Pages 215-224 | Published online: 07 Jul 2009

References

  • Caen J P. Glanzmann's thrombasthenia. Clin Haematol 1972; 1: 383–92
  • Nurden A T, Caen J P. An abnormal platelet glycoprotein pattern in three cases of Glanzmann's thrombasthenia. Br J Haematol 1974; 28: 253–60
  • Phillips D R, Agin P P. Platelet membrane defects in Glanzmann's thrombasthenia. Evidence for decreased amounts of two major glycoproteins. J Clin Invest 1977; 60: 535–45
  • Bennett J I, Hoxie J A, Leitman S F, Vilaire G, Cines D B. Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody. Proc Natl Acad Sci USA 1983; 80: 2417–21
  • Coller B S, Peerschke E I, Scudder L E, Sullivan C A. A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenia-like state in normal platelets and binds to glycoprotein-IIb and/or glycoprotein-IIIa. J Clin Invest 1983; 72: 325–38
  • Ruggeri Z M, DeMarco L, Gatti L, Bader R, Montgomery R R. Platelets have more than one binding site for von Willebrand factor. J Clin Invest 1983; 72: 1–12
  • Ginsberg M H, Loftus J C, Plow E F. Cytoadhesins, integrins, and platelets. Thromb Haemost 1988; 59: 1–6
  • Hagen I, Nurden A T, Bjerrum O J, Solum N O, Caen J P. Immunochemical differences between type I and type II thrombasthenic platelets. Proteids of Biological Fluids. 27th Colloquium, H. Peeters. Pergamon Press Oxford, New York 1979; 875–78
  • Caen J P, Rosa J P, Soria C, Boizard B. Variant de thrombasthenie Paris-I Lariboisiere, anomalie moléculaire du complexe glycoprotéinique plaquettaire IIb-IIIa. C R Acad Sc Paris 1983; 296: 479–81
  • Nurden A T, Rosa J P, Fournier D, Legrand C, Didry D, Parquet A, Pidard D. A variant of Glanzmann's thrombasthenia with abnormal glycoprotein IIb-IIIa complexes in the platelet membrane. J Clin Invest 1987; 79: 962–69
  • Fournier D J, Kabral A, Castaldi P A, Berndt M C. A variant of Glanzmann's thrombasthenia characterized by abnormal glycoprotein IIb/IIIa complex formation. Thromb Haemost 1989; 62: 977–83
  • Lanza F, Stierlé A, Fournier D, Morales M, André G, Nurden A T, Cazenave J P. A new variant of Glanzmann's thrombasthenia (Strasbourg I). Platelets with functionally defective glycoprotein IIb-IIIa complexes and a glycoprotein IIIa 214Arg → 214Trp mutation. J Clin Invest 1992; 89: 1995–2004
  • Escolar G, Diaz-Ricart M, Garrido M, Reverter C, Villamor N, Sanz C, Maragall S, Castillo R, Ordinas A, Nurden A T. A variant of Glanzmann's thrombasthenia which fails to express a GP IIb-IIIa related epitope that is recognized by a specific monoclonal antibody (C17). Brit J Haematol 1992; 81: 545–51
  • Ginsberg M H, Lightsey A, Kunicki T J, Kaufmann A, Marguerie G, Plow E F. Divalent cation regulation of the surface orientation of platelet membrane glycoprotein IIb. Correlation with fibrinogen binding function and definition of a novel variant of Glanzmann's thrombasthenia. J Clin Invest 1986; 78: 1103–11
  • Chen Y P, Djaffar I, Pidard D, Steiner B, Cieutat A M, Caen J P, Rosa J P. Ser-72 → Pro mutation in the cytoplasmic domain of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann's thrombasthenia. Proc Natl Acad Sci USA 1992; 89: 10169–73
  • Bajt M L, Ginsberg M H, Frelinger A L, Berndt M C, Loftus J C. A spontaneous mutation of integrin α11bβ3 (platelet glycoprotein IIb-IIIa) helps define a ligand binding site. J Biol Chem 1992; 267: 3789–94
  • Ginsberg M H, Frelinger A L, Lam S CT, Forsyth J, McMillan R, Plow E F, Shattil S J. Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIa with conformation-specific monoclonal antibodies. Blood 1990; 76: 2017–23
  • Loftus J C, O'Toole T E, Plow E F, Glass A, Frelinger A L, III, Ginsberg M H. A beta3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation. Science 1990; 249: 915–18
  • Djaffar I, Rosa J P. A second case of variant of Glanzmann's thrombasthenia due to substitution of platelet GP IIIa (integrin P3) Arg 214 by Trp. Hum Mol Genet 1993; 2: 2179–80
  • D'Souza S E, Ginsberg M H, Burke T A, Lam S CT, Plow E F. Localization of an Arg-Gly-Asp recognition site within an integrin adhesion receptor. Science 1988; 242: 91–3
  • Charo I F, Nannizzi L, Phillips D R, Hsu M A, Scarborough R M. Inhibition of fibrinogen binding to GP IIb-IIIa by a GP IIIa peptide. J Biol Chem 1991; 266: 1415–21
  • Bennett J S, Vilaire G. Exposure of platelet fibrinogen receptors by ADP and epinephrine. J Clin Invest 1979; 64: 1393–1401
  • Hantgan R R. Fibrin protofibril and fibrinogen binding to ADP stimulated platelets: evidence for a common mechanism. Biochim Biophys Acta 1988; 968: 24–35
  • Savage B, Ruggeri Z M. Selective recognition of adhesive sites in surface-bound fibrinogen by glycoprotein IIb-IIIa on nonactivated platelets. J Biol Chem 1991; 266: 11227–33
  • Courtois G, Ryckewaert J J, Woods V L, Ginsberg M H, Plow E F. Expression of intracellular fibrinogen on the surface of stimulated platelets. Eur J Biochem 1986; 159: 61–7
  • Harrison P, Wilbourn B, Debili N, Vainchenker W, Breton-Gorius J, Lawrie A S, Masse J M, Savidge G F, Cramer E M. Uptake of plasma fibrinogen into the alpha granules of human megakaryocytes and platelets. J Clin Invest 1989; 84: 1320–4
  • Born G VR. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 1962; 194: 927–9
  • Breddin K. Zur Messung der Thrombozytenadhäsivität. Thromb Diath Haemorrh 1964; 12: 269–81
  • Frelinger A L, III, Lam S CT, Plow E F, Smith M A, Loftus C, Ginsberg M H. Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion. J Biol Chem 1988; 263: 12397–12402
  • Frelinger A L, III, Cohen I, Plow E F, Smith M A, Roberts J, Lam S CT, Ginsberg M H. Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers. J Biol Chem 1990; 265: 6346–52
  • Modderman P W, Huisman H G, Van Mourik J A, Von dem Borne A EGK. A monoclonal antibody to the human platelet glycoprotein IIb/IIIa complex induces platelet aggregation. Thromb Haemost 1988; 60: 68–74
  • Tomiyama Y, Tsubakio T, Piotrowicz R S, Kurata Y, Loftus J C, Kunicki T J. The arg-gly-asp (RGD) recognition site of platelet glycoprotein IIb/IIIa on nonactivated platelets is accessible to high affinity macromolecules. Blood 1992; 79: 2303–12
  • Niiya K, Hodson E, Bader R, Byers-Ward V, Koziol J A, Plow E F, Ruggeri Z M. Increased surface expression of the membrane glycoprotein IIb/IIIa complex induced by platelet activation. Relationship to the binding of fibrinogen and platelet aggregation. Blood 1987; 70: 475–83
  • Lombardo V T, Hodson E, Roberts J R, Kunicki T J, Zimmerman T S, Ruggeri Z M. Independent modulation of von Willebrand factor and fibrinogen binding to the platelet membrane glycoprotein IIb/IIIa complex as demonstrated by monoclonal antibody. J Clin Invest 1985; 76: 1950–8
  • Nomura S, Nagata H, Oda K, Kokawa T, Yasunaga K. Effects of EDTA on the membrane glycoproteins IIb-IIIa complex – analysis using flow cytometry. Thromb Res 1987; 47: 47–58
  • Coller B S. A new murine monoclonal antibody reports on activation-dependent change in the conformation and/or micro-environment on the platelet glycoprotein IIb/IIIa complex. J Clin Invest 1985; 76: 101–8
  • Tetteroo P AT, Landsdorp P M, Leeksma O C, Von dem Borne A EGKr. Monoclonal antibodies against human platelet glycoprotein IIIa. Brit J Haematol 1983; 55: 509–22
  • Kekomaki R, Dawson B, McFarland J, Kunicki T J. Localization of human platelet autoantigens to the cysteine-rich region of glycoprotein IIIa. J Clin Invest 1991; 88: 847–54
  • Hermann F H, Meyer M, Gogstad G O, Solum N O. Glycoprotein IIb-IIIa complex in platelets of patients with Glanzmann's thrombasthenia. Thromb Res 1983; 32: 615–22
  • Meyer M, Schellenberg I. Platelet membrane glycoprotein Ib: Genetic polymorphism detected in the intact molecule and in proteolytic fragments. Thromb Res 1990; 58: 233–42
  • Hagen I, Bjerrum O J, Solum N O. Characterization of human platelet proteins solubilized with Triton X-100 and examined by crossed immunoelectrophoresis. Eur J Biochem 1979; 99: 9–22
  • Laemmli U K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680–5
  • O'Farrell P H. High resolution two-dimensional electrophoresis of proteins. J Biol Chem 1975; 250: 4007–21
  • Clemetson K J, Capitanio A, Luscher E F. High resolution two-dimensional gel electrophoresis of the proteins and glycoproteins of human blood platelets and platelet membranes. Biochim Biophys Acta 1979; 553: 11–24
  • Gogstad G O, Brosstad F, Krutnes M B, Hagen I, Solum N O. Fibrinogen binding properties of the human platelet glycoprotein IIb-IIIa complex: a study using crossed-immunoelectrophoresis. Blood 1982; 60: 663–71
  • Meyer M, Herrmann F H. Unusual electrophoretic behaviour of human platelet membrane glycoprotein Ib due to complex formation?. Thromb Res 1984; 35: 359–64
  • Marguerie G A, Plow E F, Edington T S. Human platelets possess an inducible and saturable receptor specific for fibrinogen. J Biol Chem 1979; 254: 5357–62
  • Jung S M, Yoshida N, Aoki N, Tanoue K, Yamazaki H, Moroi M. Thrombasthenia with an abnormal platelet membrane glycoprotein lib of different molecular weight. Blood 1988; 71: 915–22
  • Tomiyama Y, Brojer E, Ruggeri Z M, Shattil S J, Smiltneck J, Gorski J, Kumar A, Kieber-Emmons T, Kunicki T J. A molecular model of RGD ligands. Antibody D gene segments that direct specificity for the integrin alpha IIb beta 3. J Biol Chem 1992; 267: 18085–92
  • Kodandapani R, Veerapandian B, Kunicki T J, Ely K R. Crystal structure of the OPG2 Fab. J Biol Chem 1995; 270: 2268–73
  • Honda S, Tomiyama Y, Pelletier A J, Annis D, Honda Y, Orchekowski R, Ruggeri Z, Kunicki T J. Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus of the human integrin β3 subunit. J Biol Chem 1995; 270: 11947–54
  • Behnke O. Coated pits and vesicles transfer plasma components to platelet granules. Thromb Haemost 1989; 62: 718–22
  • Coller B S, Seligsohn U, West S M, Scudder L E, Norton K J. Platelet fibrinogen and fibronectin in Glanzmann thrombasthenia: Evidence consistent with specific roles for glycoprotein IIb/IIIa and αvβ3 integrins in platelet protein trafficking. Blood 1991; 78: 2603–10
  • Handagama P, Scarborough R, Shuman M A, Bainton D F. Endocytosis of fibrinogen into megakaryocytes and platelet a-granules is mediated by α11bβ3 (glycoprotein IIb-IIIa). Blood 1993; 82: 135–8
  • Suzuki M, Kawakatsu T, Nagata H, Hamamoto K, Iwata K, Ohga S, Nomura S, Kokawa T, Yasunaga K. Effects of injected antibody against the platelet glycoprotein IIb/IIIa complex on monkey platelet fibrinogen. Thromb Haemost 1992; 67: 578–81
  • Hardisty R, Pidard D, Cox A, Nokes T, Legrand C H, Bouillot C, Pannocchia A, Heilmann E, Hourdillé P, Bellucci S, Nurden A. A defect of platelet aggregation associated with an abnormal distribution of glycoprotein IIb-IIIa complexes within the platelet: The cause of a lifelong bleeding disorder. Blood 1992; 80: 696–708

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.