Obesity and eating behaviour in children and adolescents: Contribution of common gene polymorphisms

References

• Agurs-Collins, T. & Fuemmeler, B.F. (2011). Dopamine polymorphisms and depressive symptoms predict foods intake. Results from a nationally representative sample. Appetite, 57, 339–348.
   PubMed Web of Science ®Google Scholar
• Andreasen, C.H., Stender-Petersen, K.L., Mogensen, M.S., Torekov, S.S., Wegner, L., Andersen, G., … Hansen, T (2008). Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes, 57, 95–101.
   PubMed Web of Science ®Google Scholar
• Angeli, C.B., Kimura, L., Auricchio, M.T., Vicente, J.P., Mattevi, V.S., Zembrzuski, V.M., … Mingroni-Netto, R.C. (2011). Multilocus analyses of seven candidate genes suggest interacting pathways for obesity-related traits in Brazilian Populations. Obesity, 19, 1244–1251.
   PubMed Web of Science ®Google Scholar
• Aoyama, M., Shidoji, Y., Saimei, M., Tsunawake, N. & Ichinose, M (2003). Phenotypic linkage between single-nucleotide polymorphisms of beta3-adrenergic receptor gene and NADH dehydrogenase subunit-2 gene, with special reference to eating behavior. Biochem Biophys Res Commun, 309, 261–265.
   PubMed Web of Science ®Google Scholar
• Arashiro, R., Katsuren, K., Fukuyama, S. & Ohta, T (2003). Effect of Trp64Arg mutation of the beta3-adrenergic receptor gene and C161T substitution of the peroxisome proliferator activated receptor gamma gene on obesity in Japanese children. Pediatrics International, 45, 135–141.
   PubMed Web of Science ®Google Scholar
• Auwerx, J (1999). PPARgamma, the ultimate thrifty gene. Diabetologia, 42, 1033–1049.
   PubMed Web of Science ®Google Scholar
• Balthasar, N., Dalgaard, L.T., Lee, C.E., Yu, J., Funahashi, H., Williams, T., … Lowell, B.B. (2005). Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell, 123, 493–505.
   PubMed Web of Science ®Google Scholar
• Beamer, B.A., Yen, C.J., Andersen, R.E., Muller, D., Elahi, D., Cheskin, L.J., … Shuldiner, A.R. (1998). Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations. Diabetes, 47, 1806–1808.
   PubMed Web of Science ®Google Scholar
• Berthoud, H.R. (2004). Neural control of appetite: Cross-talk between homeostatic and non-homeostatic systems. Appetite, 43, 315–317.
   PubMed Web of Science ®Google Scholar
• Blum, K., Braverman, E.R., Wood, R.C., Gill, J., Li, C., Chen, T.J., … Cull, J.G. (1996). Increased prevalence of the Taq I A1 allele of the dopamine receptor gene (DRD2) in obesity with comorbid substance use disorder: A preliminary report. Pharmacogenetics, 6, 297–305.
   PubMedGoogle Scholar
• Blundell JE, de Graaf K, Finlayson G, Halford J, Hetherington MM, King N, Stubbs R. (2009). Measuring Food Intake, Hunger, Satiety and Satiation in the Laboratory. In Allison DB & Baskin ML (Ed.), Handbook of Assessment Methods for Eating Behaviors and weight related problems: Measures, Theory and Research. Newbury Park: Sage Publications.
   Google Scholar
• Bouchard-Mercier, A., Godin, G., Lamarche, B., Perusse, L. & Vohl, M.-C. (2011). Effects of peroxisome proliferator-activated receptors, dietary fat intakes and gene-diet interactions on peak particle diameters of low-density lipoproteins. Journal of Nutrigenetics and Nutrigenomics, 4, 36–48.
   PubMedGoogle Scholar
• Bouchard, C (2007). The biological predisposition to obesity: Beyond the thrifty genotype scenario. International Journal of Obesity, 31, 1337–1339.
   PubMed Web of Science ®Google Scholar
• Breen, F.M., Plomin, R. & Wardle, J (2006). Heritability of food preferences in young children. Physiology & Behavior, 88, 443–447.
   PubMed Web of Science ®Google Scholar
• Buzzetti, R., Petrone, A., Caiazzo, A.M., Alemanno, I., Zavarella, S., Capizzi, M., … di Mario, U (2005). PPAR-gamma2 Pro12Ala variant is associated with greater insulin sensitivity in childhood obesity. Pediatric Research, 57, 138–140.
   PubMed Web of Science ®Google Scholar
• Cai, G., Cole, S.A., Butte, N., Bacino, C., Diego, V., Tan, K., … Comuzzie, A.G. (2006). A quantitative trait locus on chromosome 18q for physical activity and dietary intake in Hispanic children. Obesity, 14, 1596–1604.
   PubMed Web of Science ®Google Scholar
• Carnell, S., Haworth, C.M.A, Plomin, R. & Wardle, J (2008). Genetic influence on appetite in children. International Journal of Obesity, 32, 1468–1473.
   PubMed Web of Science ®Google Scholar
• Cecil, J., Tavendale, R., Watt, P., Hetherington, M. & Palmer, C (2008). An obesity-associated FTO gene variant and increased energy intake in children. New England Journal of Medicine, 359, 2558–2566.
   PubMed Web of Science ®Google Scholar
• Cecil, J.E., Fischer, B., Doney, A.S., Hetherington, M., Watt, P., Wrieden, W., … Palmer, C.N. (2005). The Pro12Ala and C-681G variants of the PPARG locus are associated with opposing growth phenotypes in young schoolchildren. Diabetologia, 48, 1496–1502.
   PubMed Web of Science ®Google Scholar
• Cecil, J.E., Palmer, C.N.A, Fischer, B., Watt, P., Wallis, D.J., Murrie, I. & Hetherington, M.M. (2007). Variants of the peroxisome proliferator-activated receptor and beta-adrenergic receptor genes are associated with measures of compensatory eating behaviors in young children. American Journal of Clinical Nutrition, 86, 167–173.
   PubMed Web of Science ®Google Scholar
• Chen, T.J., Ji, C.Y., Zheng, X.Y. & Hu, Y.H. (2007). Association of beta3 adrenergic receptor and peroxisome proliferator-activated receptor gamma 2 polymorphisms with insulin sensitivity: A twin study. Biomedical & Environmental Sciences, 20, 99–105.
   PubMed Web of Science ®Google Scholar
• Clement, K., Vaisse, C., Manning, B.S., Basdevant, A., Guy-Grand, B., Ruiz, J., … Strosberg, A.D. (1995). Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. New England Journal of Medicine, 333, 352–354.
   PubMed Web of Science ®Google Scholar
• Clifton, I.J., McDonough, M.A., Ehrismann, D., Kershaw, N.J., Granatino, N. & Schofield, C.J. (2006). Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins. Journal of Inorganic Biochemistry, 100, 644–669.
   PubMed Web of Science ®Google Scholar
• Cole, S.A., Butte, N.F., Voruganti, V.S., Cai, G., Haack, K., Kent, J.W., Jr., … Gibbs, R.A. (2010). Evidence that multiple genetic variants of MC4R play a functional role in the regulation of energy expenditure and appetite in Hispanic children. American Journal of Clinical Nutrition, 91, 191–199.
   PubMed Web of Science ®Google Scholar
• Comings, D.E. & Blum, K (2000). Reward deficiency syndrome: Genetic aspects of behavioral disorders. Progress in Brain Research, 126, 325–341.
   PubMed Web of Science ®Google Scholar
• Dahlman, I. & Arner, P (2010). Genetics of adipose tissue biology. Progress in Molecular Biology and Translational Science, 94, 39–74.
   PubMed Web of Science ®Google Scholar
• Davis, C., Zai, C., Levitan, R.D., Kaplan, A.S., Carter, J.C., Reid-Westoby, C., … Kennedy, J.L. (2011). Opiates, overeating and obesity: A psychogenetic analysis. International Journal of Obesity, 35, 1347–1354.
   Web of Science ®Google Scholar
• de Castro, J.M. (1993). Genetic influences on daily intake and meal patterns of humans. Physiology & Behaviour, 53, 777–782.
   PubMed Web of Science ®Google Scholar
• de Castro, J.M. (2002). Independence of heritable influences on the food intake of free-living humans. Nutrition, 18, 11–16; discussion 91–12.
   PubMedGoogle Scholar
• de Luis, D.A., Gonzalez Sagrado, M., Aller, R., Izaola, O. & Conde, R (2009). Influence of Trp64Arg polymorphism of beta 3-adrenoreceptor gene on insulin resistance, adipocytokines and weight loss secondary to two hypocaloric diets. Annals of Nutrition & Metabolism, 54, 104–110.
   PubMed Web of Science ®Google Scholar
• de Onis, M., Blossner, M., & Borghi, E (2010). Global prevalence and trends of overweight and obesity among preschool children. Am J Clin Nutr, 92, 1257–1264.
   PubMed Web of Science ®Google Scholar
• Dedoussis, G., Vidra, N., Butler, J., Papoutsakis, C., Yannakoulia, M., Hirschhorn, J.N. & Lyon, H.N. (2009). Peroxisome proliferator-activated receptor-gamma (PPARgamma) Pro12Ala polymorphism and risk for pediatric obesity. Clinical Chemistry & Laboratory Medicine, 47, 1047–1050.
   PubMed Web of Science ®Google Scholar
• Dedoussis, G.V., Manios, Y., Kourlaba, G., Kanoni, S., Lagou, V., Butler, J., … Lyon, H.N. (2011). An age-dependent diet-modified effect of the PPARgamma Pro12Ala polymorphism in children. Metabolism: Clinical & Experimental, 60, 467–473.
   PubMed Web of Science ®Google Scholar
• Dedoussis, G.V., Theodoraki, E.V., Manios, Y., Yiannakouris, N., Panagiotakos, D., Papoutsakis, C., … Zampelas, A (2007). The Pro12Ala polymorphism in PPARgamma2 gene affects lipid parameters in Greek primary school children: A case of gene-to-gender interaction. American Journal of the Medical Sciences, 333, 10–15.
   PubMed Web of Science ®Google Scholar
• Deeb, S.S., Fajas, L., Nemoto, M., Pihlajamaki, J., Mykkanen, L., Kuusisto, J., … Auwerx, J (1998). A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nature Genetics, 20, 284–287.
   PubMed Web of Science ®Google Scholar
• den Hoed, M., Ekelund, U., Brage, S., Grontved, A., Zhao, J.H., Sharp, S.J., … Loos, R.J.F. (2010). Genetic susceptibility to obesity and related traits in childhood and adolescence: Influence of loci identified by genome-wide association studies. Diabetes, 59, 2980–2988.
   PubMed Web of Science ®Google Scholar
• Dina, C., Meyre, D., Gallina, S., Durand, E., Korner, A., Jacobson, P., … Froguel, P (2007). Variation in FTO contributes to childhood obesity and severe adult obesity. Nature Genetics, 39, 724–726.
   PubMed Web of Science ®Google Scholar
• Doney, A., Fischer, B., Frew, D., Cumming, A., Flavell, D.M., World, M., … Palmer, C.N. (2002). Haplotype analysis of the PPARgamma Pro12Ala and C1431T variants reveals opposing associations with body weight. BMC Genetics, 3, 21.
   PubMed Web of Science ®Google Scholar
• Doney, A.S., Dannfald, J., Kimber, C.H., Donnelly, L.A., Pearson, E., Morris, A.D. & Palmer, C.N. (2009). The FTO gene is associated with an atherogenic lipid profile and myocardial infarction in patients with type 2 diabetes: a Genetics of Diabetes Audit and Research Study in Tayside Scotland (Go-DARTS) study. Circulation, Cardiovascular Genetics, 2, 255–259.
   PubMed Web of Science ®Google Scholar
• Doney, A.S., Fischer, B., Cecil, J.E., Boylan, K., McGuigan, F.E., Ralston, S.H., … Palmer, C.N. (2004). Association of the Pro12Ala and C1431T variants of PPARG and their haplotypes with susceptibility to Type 2 diabetes. Diabetologia, 47, 555–558.
   PubMed Web of Science ®Google Scholar
• Dubois, L., Ohm Kyvik, K., Girard, M., Tatone-Tokuda, F., Perusse, D., Hjelmborg, J., … Martin, N.G. (2012). Genetic and environmental contributions to weight, height, and BMI from birth to 19 years of age: An international study of over 12,000 twin pairs. PLoS One, 7, e30153.
   PubMed Web of Science ®Google Scholar
• Ellsworth, D.L., Coady, S.A., Chen, W., Srinivasan, S.R., Elkasabany, A., Gustat, J., … Berenson, G.S. (2002). Influence of the beta2-adrenergic receptor Arg16Gly polymorphism on longitudinal changes in obesity from childhood through young adulthood in a biracial cohort: the Bogalusa Heart Study. International Journal of Obesity and Related Metabolic Disorders, 26, 928–937.
   PubMed Web of Science ®Google Scholar
• Emorine, L., Blin, N. & Strosberg, A.D. (1994). The human beta 3-adrenoceptor: the search for a physiological function. Trends in Pharmacological Science, 15, 3–7.
   PubMed Web of Science ®Google Scholar
• Endo, K., Yanagi, H., Hirano, C., Hamaguchi, H., Tsuchiya, S. & Tomura, S (2000). Association of Trp64Arg polymorphism of the beta3-adrenergic receptor gene and no association of Gln223Arg polymorphism of the leptin receptor gene in Japanese schoolchildren with obesity. International Journal of Obesity & Related Metabolic Disorders, 24, 443–449.
   PubMed Web of Science ®Google Scholar
• Epstein, L.H., Dearing, K.K. & Erbe, R.W. (2010). Parent–child concordance of Taq1 A1 allele predicts similarity of parent–child weight loss in behavioral family-based treatment programs. Appetite, 55, 363–366.
   PubMed Web of Science ®Google Scholar
• Erhardt, E., Czako, M., Csernus, K., Molnar, D. & Kosztolanyi, G (2005). The frequency of Trp64Arg polymorphism of the beta 3-adrenergic receptor gene in healthy and obese Hungarian children and its association with cardiovascular risk factors. European Journal of Clinical Nutrition, 59, 955–959.
   PubMed Web of Science ®Google Scholar
• Evans, R.M., Barish, G.D. & Wang, Y.X. (2004). PPARs and the complex journey to obesity. Nature Medicine, 10, 355–361.
   PubMed Web of Science ®Google Scholar
• Faith, M.S., Keller, K.L., Johnson, S.L., Pietrobelli, A., Matz, P.E., Must, S., … Allison, D.B. (2004). Familial aggregation of energy intake in children. American Journal of Clinical Nutrition, 79, 844–850.
   PubMed Web of Science ®Google Scholar
• Faith, M.S., Pietrobelli, A., Nunez, C., Heo, M., Heymsfield, S.B. & Allison, D.B. (1999). Evidence for independent genetic influences on fat mass and body mass index in a pediatric twin sample. Pediatrics, 104, 61–67.
   PubMed Web of Science ®Google Scholar
• Falciglia, G.A. & Norton, P.A. (1994). Evidence for a genetic influence on preference for some foods. Journal of the American Dietetic Association, 94, 154–158.
   PubMedGoogle Scholar
• Fang, H., Li, Y., Du, S., Hu, X., Zhang, Q., Liu, A. & Ma, G (2010). Variant rs9939609 in the FTO gene is associated with body mass index among Chinese children. BMC Medical Genetics, 11, 136.
   PubMed Web of Science ®Google Scholar
• Farooqi, I.S., Keogh, J.M., Yeo, G.S.H, Lank, E.J., Cheetham, T. & O’Rahilly, S (2003). Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. New England Journal of Medicine, 348, 1085–1095.
   PubMed Web of Science ®Google Scholar
• Farooqi, I.S. & O’Rahilly, S (2005). Monogenic obesity in humans. Annual Review of Medicine, 56, 443–458.
   PubMed Web of Science ®Google Scholar
• Ferreira, A.P., Oliveira, C.E. & Franca, N.M. (2007). Metabolic syndrome and risk factors for cardiovascular disease in obese children: The relationship with insulin resistance (HOMA-IR). Jornal de Pediatria, 83, 21–26.
   PubMed Web of Science ®Google Scholar
• Finlayson, G., King, N. & Blundell, J.E. (2007). Liking vs wanting food: Importance for human appetite control and weight regulation. Neuroscience & Biobehavioral Reviews, 31, 987–1002.
   PubMed Web of Science ®Google Scholar
• Fischer, J., Koch, L., Emmerling, C., Vierkotten, J., Peters, T., Bruning, J.C. & Ruther, U (2009). Inactivation of the FTO gene protects from obesity. Nature, 458, 894–898.
   PubMed Web of Science ®Google Scholar
• Fisher, J.O., Cai, G., Jaramillo, S.J., Cole, S.A., Comuzzie, A.G. & Butte, N.F. (2007). Heritability of hyperphagic eating behavior and appetite-related hormones among hispanic children. Obesity, 15, 1484–1495.
   PubMed Web of Science ®Google Scholar
• Frayling, T.M., Timpson, N.J., Weedon, M.N., Zeggini, E., Freathy, R.M., Lindgren, C.M., … McCarthy, M.I. (2007). A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science, 316, 889–894.
   PubMed Web of Science ®Google Scholar
• Fredriksson, R., Hagglund, M., Olszewski, P.K., Stephansson, O., Jacobsson, J.A., Olszewska, A.M., … Schioth, H.B. (2008). The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. Endocrinology, 149, 2062–2071.
   PubMed Web of Science ®Google Scholar
• Galvao, A.C., Kruger, R.C., Campagnolo, P.D., Mattevi, V.S., Vitolo, M.R. & Almeida, S (2012). Association of MAOA and COMT gene polymorphisms with palatable food intake in children. Journal of Nutritional Biochemistry, 23, 272–277.
   PubMed Web of Science ®Google Scholar
• Gearing, K.L., Gottlicher, M., Widmark, E., Banner, C.D., Tollet, P., Stromstedt, M., … Gustafsson, J.A. (1994). Fatty acid activation of the peroxisome proliferator activated receptor, a member of the nuclear receptor gene superfamily. Journal of Nutrition, 124, S1284–S1288.
   PubMed Web of Science ®Google Scholar
• Gerken, T., Girard, C.A., Tung, Y.C., Webby, C.J., Saudek, V., Hewitson, K.S., … Schofield, C.J. (2007). The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science, 318, 1469–1472.
   PubMed Web of Science ®Google Scholar
• Grant, S.F., Li, M., Bradfield, J.P., Kim, C.E., Annaiah, K., Santa, E., … Hakonarson, H (2008). Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP. PLoS One, 3, e1746.
   Web of Science ®Google Scholar
• Hakanen, M., Raitakari, O.T., Lehtimaki, T., Peltonen, N., Pahkala, K., Sillanmaki, L., … Ronnemaa, T (2009). FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity. Journal of Clinical Endocrinology and Metabolism, 94, 1281–1287.
   PubMed Web of Science ®Google Scholar
• Hamann, A., Munzberg, H., Buttron, P., Busing, B., Hinney, A., Mayer, H., … Greten, H (1999). Missense variants in the human peroxisome proliferator-activated receptor-gamma2 gene in lean and obese subjects. European Journal of Endocrinology, 141, 90–92.
   PubMed Web of Science ®Google Scholar
• Hardy, R., Wills, A.K., Wong, A., Elks, C.E., Wareham, N.J., Loos, R.J., … Ong, K.K. (2010). Life course variations in the associations between FTO and MC4R gene variants and body size. Human Molecular Genetics, 19, 545–552.
   PubMed Web of Science ®Google Scholar
• Haupt, A., Thamer, C., Staiger, H., Tschritter, O., Kirchhoff, K., Machicao, F., … Fritsche, A (2009). Variation in the FTO gene influences food intake but not energy expenditure. Experimental & Clinical Endocrinology & Diabetes, 117, 194–197.
   PubMed Web of Science ®Google Scholar
• Haworth, C.M., Butcher, L.M., Docherty, S.J., Wardle, J. & Plomin, R. (2008a). No evidence for association between BMI and 10 candidate genes at ages 4, 7 and 10 in a large UK sample of twins. BMC Medical Genetics, 9, 12.
   PubMed Web of Science ®Google Scholar
• Haworth, C.M.A, Carnell, S., Meaburn, E.L., Davis, O.S.P, Plomin, R. & Wardle, J. (2008b). Increasing heritability of BMI and stronger associations with the FTO gene over childhood. Obesity, 16, 2663–2668.
   PubMed Web of Science ®Google Scholar
• Heard-Costa, N.L., Zillikens, M.C., Monda, K.L., Johansson, A., Harris, T.B., Fu, M., … North, K.E. (2009). NRXN3 is a novel locus for waist circumference: A genome-wide association study from the CHARGE consortium. PLoS Genetics, 5, e1000539.
   PubMed Web of Science ®Google Scholar
• Hinney, A., Lentes, K.U., Rosenkranz, K., Barth, N., Roth, H., Ziegler, A., … Hebebrand, J (1997). Beta 3-adrenergic-receptor allele distributions in children, adolescents and young adults with obesity, underweight or anorexia nervosa. International Journal of Obesity & Related Metabolic Disorders, 21, 224–230.
   PubMed Web of Science ®Google Scholar
• Hsiao, G., Chapman, J., Ofrecio, J.M., Wilkes, J., Resnik, J.L., Thapar, D., … Sears, D.D. (2011). Multi-tissue, selective PPARgamma modulation of insulin sensitivity and metabolic pathways in obese rats. American Journal of Physiology: Endocrinology & Metabolism, 300, E164–174.
   PubMed Web of Science ®Google Scholar
• Hsueh, W.C., Cole, S.A., Shuldiner, A.R., Beamer, B.A., Blangero, J., Hixson, J.E., … Mitchell, B.D. (2001). Interactions between variants in the beta3-adrenergic receptor and peroxisome proliferator-activated receptor-gamma2 genes and obesity. Diabetes Care, 24, 672–677.
   PubMed Web of Science ®Google Scholar
• Keskitalo, K., Tuorila, H., Spector, T.D., Cherkas, L.F., Knaapila, A., Kaprio, J., … Perola, M (2008). The Three-Factor Eating Questionnaire, body mass index, and responses to sweet and salty fatty foods: A twin study of genetic and environmental associations. American Journal of Clinical Nutrition, 88, 263–271.
   PubMed Web of Science ®Google Scholar
• Kilpelainen, T.O., Qi, L., Brage, S., Sharp, S.J., Sonestedt, E., Demerath, E., … Loos, R.J. (2011). Physical activity attenuates the influence of FTO variants on obesity risk: A meta-analysis of 218,166 adults and 19,268 children. PLoS Medicine, 8, e1001116.
   PubMed Web of Science ®Google Scholar
• Krief, S., Lonnqvist, F., Raimbault, S., Baude, B., van Spronsen, A., Arner, P., … Emorine, L.J. (1993). Tissue distribution of beta 3-adrenergic receptor mRNA in man. Journal of Clinical Investigation, 91, 344–349.
   PubMed Web of Science ®Google Scholar
• Kurokawa, N., Nakai, K., Kameo, S., Liu, Z.-M. & Satoh, H (2003). Relationship between the beta3-adrenoceptor gene variant and body fat in Japanese children. Tohoku Journal of Experimental Medicine, 201, 271–276.
   PubMed Web of Science ®Google Scholar
• Lagou, V., Liu, G., Zhu, H., Stallmann-Jorgensen, I.S., Gutin, B., Dong, Y. & Snieder, H (2011). Lifestyle and socioeconomic-status modify the effects of ADRB2 and NOS3 on adiposity in European-American and African-American adolescents. Obesity, 19, 595–603.
   PubMed Web of Science ®Google Scholar
• Lagou, V., Scott, R.A., Manios, Y., Chen, T.L.J, Wang, G., Grammatikaki, E., … Pitsiladis, Y.P. (2008). Impact of peroxisome proliferator-activated receptors and on adiposity in toddlers and preschoolers in the GENESIS study. Obesity, 16, 913–918.
   PubMed Web of Science ®Google Scholar
• Lajunen, H.R., Kaprio, J., Keski-Rahkonen, A., Rose, R.J., Pulkkinen, L., Rissanen, A. & Silventoinen, K (2009). Genetic and environmental effects on body mass index during adolescence: A prospective study among Finnish twins. International Journal of Obesity, 33, 559–567.
   Web of Science ®Google Scholar
• Lee, H.J., Kim, I.K., Kang, J.H., Ahn, Y., Han, B.G., Lee, J.Y. & Song, J (2010). Effects of common FTO gene variants associated with BMI on dietary intake and physical activity in Koreans. Clinica Chimica Acta, 411, 1716–1722.
   PubMed Web of Science ®Google Scholar
• Lillycrop, K.A. & Burdge, G.C. (2011). Epigenetic changes in early life and future risk of obesity. International Journal of Obesity, 35, 72–83.
   PubMed Web of Science ®Google Scholar
• Lima, J.J., Feng, H., Duckworth, L., Wang, J., Sylvester, J.E., Kissoon, N. & Garg, H (2007). Association analyses of adrenergic receptor polymorphisms with obesity and metabolic alterations. Metabolism, 56, 757–765.
   PubMed Web of Science ®Google Scholar
• Llewellyn, C.H., van Jaarsveld, C.H.M, Boniface, D., Carnell, S. & Wardle, J (2008). Eating rate is a heritable phenotype related to weight in children. American Journal of Clinical Nutrition, 88, 1560–1566.
   PubMed Web of Science ®Google Scholar
• Loos, R.J. & Bouchard, C (2008). FTO: The first gene contributing to common forms of human obesity. Obesity Reviews, 9, 246–250.
   PubMed Web of Science ®Google Scholar
• Loos, R.J., Lindgren, C.M., Li, S., Wheeler, E., Zhao, J.H., Prokopenko, I., … Mohlke, K.L. (2008). Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature Genetics, 40, 768–775.
   PubMed Web of Science ®Google Scholar
• Luan, J., Browne, P.O., Harding, A.H., Halsall, D.J., O’Rahilly, S., Chatterjee, V.K. & Wareham, N.J. (2001). Evidence for gene-nutrient interaction at the PPARgamma locus. Diabetes, 50, 686–689.
   PubMed Web of Science ®Google Scholar
• Lutter, M. & Nestler, E.J. (2009). Homeostatic and hedonic signals interact in the regulation of food intake. Journal of Nutrition, 139, 629–632.
   PubMed Web of Science ®Google Scholar
• Maes, H.H., Neale, M.C. & Eaves, L.J. (1997). Genetic and environmental factors in relative body weight and human adiposity. Behavior Genetics, 27, 325–351.
   PubMed Web of Science ®Google Scholar
• Marti, A., Corbalan, M.S., Martinez-Gonzalez, M.A., Forga, L. & Martinez, J.A. (2002). CHO intake alters obesity risk associated with Pro12Ala polymorphism of PPARgamma gene. Journal of Physiology & Biochemistry, 58, 219–220.
   PubMed Web of Science ®Google Scholar
• Marti, A., Corbalan, M.S., Martinez-Gonzalez, M.A. & Martinez, J.A. (2002). TRP64ARG polymorphism of the beta 3-adrenergic receptor gene and obesity risk: effect modification by a sedentary lifestyle. Diabetes, Obesity & Metabolism, 4, 428–430.
   PubMed Web of Science ®Google Scholar
• Meirhaeghe, A., Fajas, L., Gouilleux, F., Cottel, D., Helbecque, N., Auwerx, J. & Amouyel, P (2003). A functional polymorphism in a STAT5B site of the human PPAR gamma 3 gene promoter affects height and lipid metabolism in a French population. Arteriosclerosis, Thrombosis & Vascular Biology, 23, 289–294.
   PubMed Web of Science ®Google Scholar
• Meirhaeghe, A., Fajas, L., Helbecque, N., Cottel, D., Lebel, P., Dallongeville, J., … Amouyel, P (1998). A genetic polymorphism of the peroxisome proliferator-activated receptor gamma gene influences plasma leptin levels in obese humans. Human Molecular Genetics, 7, 435–440.
   PubMed Web of Science ®Google Scholar
• Memisoglu, A., Hu, F.B., Hankinson, S.E., Manson, J.E., de Vivo, I., Willett, W.C. & Hunter, D.J. (2003). Interaction between a peroxisome proliferator-activated receptor gamma gene polymorphism and dietary fat intake in relation to body mass. Human Molecular Genetics, 12, 2923–2929.
   PubMed Web of Science ®Google Scholar
• Nadeau, K.J., Maahs, D.M., Daniels, S.R. & Eckel, R.H. (2011). Childhood obesity and cardiovascular disease: Links and prevention strategies. Nature Reviews Cardiology, 8, 513–525.
   PubMed Web of Science ®Google Scholar
• Noble EP, Blum K, Ritchie T, Montgomery A, Sheridan PJ. (1991). Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism. Archives of General Psychiatry, 48, 648–54.
   PubMed Web of Science ®Google Scholar
• Ochoa, M.C., Marti, A., Azcona, C., Chueca, M., Oyarzabal, M., Pelach, R., … Groupo de Estudio Navarro de Obesidad, I (2004). Gene–gene interaction between PPAR gamma 2 and ADR beta 3 increases obesity risk in children and adolescents. International Journal of Obesity & Related Metabolic Disorders, 28, S37–41.
   PubMed Web of Science ®Google Scholar
• Okuda, M., Hinoda, Y., Okayama, N., Suehiro, Y., Shirabe, K., Sasaki, S., … Hobara, T (2011). Association between the FTO gene and overweight in Japanese children and adolescents. Pediatric Diabetes, 12, 494–500.
   PubMed Web of Science ®Google Scholar
• Park, H.S., Kim, Y. & Lee, C (2005). Single nucleotide variants in the beta2-adrenergic and beta3-adrenergic receptor genes explained 18.3% of adolescent obesity variation. Journal of Human Genetics, 50, 365–369.
   PubMed Web of Science ®Google Scholar
• Perusse, L., Leblanc, C. & Bouchard, C (1988). Familial resemblance in lifestyle components: results from the Canada Fitness Survey. Canadian Journal of Public Health, 79, 201–205.
   PubMed Web of Science ®Google Scholar
• Pierola, J., Barcelo, A., de la Pena, M., Barbe, F., Soriano, J.B., Sanchez Armengol, A., … Agusti, A (2007). beta3-Adrenergic receptor Trp64Arg polymorphism and increased body mass index in sleep apnoea. European Respiratory Journal, 30, 743–747.
   PubMed Web of Science ®Google Scholar
• Pihlajamaki, J., Vanhala, M., Vanhala, P. & Laakso, M (2004). The Pro12Ala polymorphism of the PPAR gamma 2 gene regulates weight from birth to adulthood. Obesity Research, 12, 187–190.
   PubMedGoogle Scholar
• Rankinen, T. & Bouchard, C (2006). Genetics of food intake and eating behavior phenotypes in humans. Annual Review of Nutrition, 26, 413–434.
   PubMed Web of Science ®Google Scholar
• Rendo, T., Moleres, A. & Marti Del Moral, A (2009). Effects of the FTO gene on lifestyle intervention studies in children. Obesity Facts, 2, 393–399.
   PubMed Web of Science ®Google Scholar
• Rosado, E.L., Bressan, J., Martinez, J.A. & Marques-Lopes, I (2010). Interactions of the PPARgamma2 polymorphism with fat intake affecting energy metabolism and nutritional outcomes in obese women. Annals of Nutrition & Metabolism, 57, 242–250.
   PubMed Web of Science ®Google Scholar
• Rosado, E.L., Bressan, J., Martins, M.F., Cecon, P.R. & Martinez, J.A. (2007). Polymorphism in the PPARgamma2 and beta2-adrenergic genes and diet lipid effects on body composition, energy expenditure and eating behavior of obese women. Appetite, 49, 635–643.
   PubMed Web of Science ®Google Scholar
• Rosen, E.D., Hsu, C.H., Wang, X., Sakai, S., Freeman, M.W., Gonzalez, F.J. & Spiegelman, B.M. (2002). C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes & Development, 16, 22–26.
   PubMed Web of Science ®Google Scholar
• Rutters, F., Nieuwenhuizen, A.G., Bouwman, F., Mariman, E. & Westerterp-Plantenga, M.S. (2011). Associations between a single nucleotide polymorphism of the FTO gene (rs9939609) and obesity-related characteristics over time during puberty in a Dutch children cohort. Journal of Clinical Endocrinology & Metabolism, 96, E939–942.
   Web of Science ®Google Scholar
• Rzehak, P., Scherag, A., Grallert, H., Sausenthaler, S., Koletzko, S., Bauer, C.P., … Group, L.S. (2010). Associations between BMI and the FTO gene are age dependent: Results from the GINI and LISA birth cohort studies up to age 6 years. Obesity Facts, 3, 173–180.
   PubMed Web of Science ®Google Scholar
• Salsberry, P.J. & Reagan, P.B. (2010). Effects of heritability, shared environment, and nonshared intrauterine conditions on child and adolescent BMI. Obesity, 18(9), 1775–1780.
   PubMed Web of Science ®Google Scholar
• Scaglioni, S., Verduci, E., Salvioni, M., Biondi, M.L., Radaelli, G., Agostoni, C. & Giovannini, M (2006). PPAR-gamma2 Pro12Ala variant, insulin resistance and plasma long-chain polyunsaturated fatty acids in childhood obesity. Pediatric Research, 60, 485–489.
   PubMed Web of Science ®Google Scholar
• Scott, R.A., Bailey, M.E.S, Moran, C.N., Wilson, R.H., Fuku, N., Tanaka, M., … Pitsiladis, Y.P. (2010). FTO genotype and adiposity in children: Physical activity levels influence the effect of the risk genotype in adolescent males. European Journal of Human Genetics, 18, 1339–1343.
   PubMed Web of Science ®Google Scholar
• Scuteri, A., Sanna, S., Chen, W.M., Uda, M., Albai, G., Strait, J., … Abecasis, G.R. (2007). Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genetics, 3, e115.
   PubMed Web of Science ®Google Scholar
• Small, D.M., Jones-Gotman, M. & Dagher, A (2003). Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers. Neuroimage, 19, 1709–1715.
   PubMed Web of Science ®Google Scholar
• Sovio, U., Mook-Kanamori, D.O., Warrington, N.M., Lawrence, R., Briollais, L., Palmer, C.N., … Early Growth Genetics Consortium (2011). Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development. PLoS Genetics, 7, e1001307.
   PubMed Web of Science ®Google Scholar
• Speakman, J.R. (2010). FTO effect on energy demand versus food intake. Nature, 464, E1; discussion E2.
   Web of Science ®Google Scholar
• Speakman, J.R., Rance, K.A. & Johnstone, A.M. (2008). Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity, 16, 1961–1965.
   PubMed Web of Science ®Google Scholar
• Speliotes, E.K., Willer, C.J., Berndt, S.I., Monda, K.L., Thorleifsson, G., Jackson, A.U., … Loos, R.J. (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nature Genetics, 42, 937–948.
   PubMed Web of Science ®Google Scholar
• Spiegelman, B.M. (1998). PPAR-gamma: Adipogenic regulator and thiazolidinedione receptor. Diabetes, 47, 507–514.
   PubMed Web of Science ®Google Scholar
• Stice, E., Spoor, S., Bohon, C. & Small, D.M. (2008). Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele. Science, 322, 449–452.
   PubMed Web of Science ®Google Scholar
• Stice, E., Yokum, S., Bohon, C., Marti, N. & Smolen, A (2010). Reward circuitry responsivity to food predicts future increases in body mass: Moderating effects of DRD2 and DRD4. Neuroimage, 50, 1618–1625.
   PubMed Web of Science ®Google Scholar
• Stratigopoulos, G., Padilla, S.L., LeDuc, C.A., Watson, E., Hattersley, A.T., McCarthy, M.I., … Leibel, R.L. (2008). Regulation of FTO/FTM gene expression in mice and humans. American Journal of Physiology: Regulatory Integrative & Comparative Physiology, 294, R1185–1196.
   PubMed Web of Science ®Google Scholar
• Stutzmann, F., Cauchi, S., Durand, E., Calvacanti-Proenca, C., Pigeyre, M., Hartikainen, A.L., … Froguel, P (2009). Common genetic variation near MC4R is associated with eating behaviour patterns in European populations. International Journal of Obesity, 33, 373–378.
   PubMed Web of Science ®Google Scholar
• Su, A.I., Wiltshire, T., Batalov, S., Lapp, H., Ching, K.A., Block, D., … Hogenesch, J.B. (2004). A gene atlas of the mouse and human protein-encoding transcriptomes. Proceedings of the National Academy of Sciences of the United States of America, 101, 6062–6067.
   PubMed Web of Science ®Google Scholar
• Sung, J., Lee, K., Song, Y.M., Lee, M.K. & Lee, D.H. (2010). Heritability of eating behavior assessed using the DEBQ (Dutch Eating Behavior Questionnaire) and weight-related traits: the Healthy Twin Study. Obesity, 18, 1000–1005.
   PubMed Web of Science ®Google Scholar
• Tafel, J., Branscheid, I., Skwarna, B., Schlimme, M., Morcos, M., Algenstaedt, P., … Hamann, A (2004). Variants in the human beta1-, beta2- and beta3-adrenergic receptor genes are not associated with morbid obesity in children and adolescents. Diabetes, Obesity and Metabolism, 6, 452–455.
   PubMed Web of Science ®Google Scholar
• Tanofsky-Kraff, M., Han, J.C., Anandalingam, K., Shomaker, L.B., Columbo, K.M., Wolkoff, L.E., … Yanovski, J.A. (2009). The FTO gene rs9939609 obesity-risk allele and loss of control over eating. American Journal of Clinical Nutrition, 90, 1483–1488.
   PubMed Web of Science ®Google Scholar
• Temple, J.L., Legierski, C.M., Giacomelli, A.M., Salvy, S.J. & Epstein, L.H. (2008). Overweight children find food more reinforcing and consume more energy than do nonoverweight children. American Journal of Clinical Nutrition, 87, 1121–1127.
   PubMed Web of Science ®Google Scholar
• Timpson, N.J., Emmett, P.M., Frayling, T.M., Rogers, I., Hattersley, A.T., McCarthy, M.I. & Davey Smith, G (2008). The fat mass- and obesity-associated locus and dietary intake in children. American Journal of Clinical Nutrition, 88, 971–978.
   PubMed Web of Science ®Google Scholar
• Tonjes, A., Scholz, M., Loeffler, M. & Stumvoll, M (2006). Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with pre-diabetic phenotypes: Meta-analysis of 57 studies on nondiabetic individuals. Diabetes Care, 29, 2489–2497.
   PubMed Web of Science ®Google Scholar
• Tschritter, O., Preissl, H., Yokoyama, Y., Machicao, F., Haring, H.U. & Fritsche, A (2007). Variation in the FTO gene locus is associated with cerebrocortical insulin resistance in humans. Diabetologia, 50, 2602–2603.
   PubMed Web of Science ®Google Scholar
• Valladares, M., Dominguez-Vasquez, P., Obregon, A.M., Weisstaub, G., Burrows, R., Maiz, A. & Santos, J.L. (2010). Melanocortin-4 receptor gene variants in Chilean families: association with childhood obesity and eating behavior. Nutritional Neuroscience, 13, 71–78.
   PubMed Web of Science ®Google Scholar
• Valve, R., Sivenius, K., Miettinen, R., Pihlajamaki, J., Rissanen, A., Deeb, S.S., … Laakso, M (1999). Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women. Journal of Clinical Endocrinology & Metabolism, 84, 3708–3712.
   PubMed Web of Science ®Google Scholar
• van Strien, T., Snoek, H.M., van der Zwaluw, C.S. & Engels, R.C.M.E. (2010). Parental control and the dopamine D2 receptor gene (DRD2) interaction on emotional eating in adolescence. Appetite, 54, 255–261.
   PubMed Web of Science ®Google Scholar
• Vidal-Puig, A., Jimenez-Linan, M., Lowell, B.B., Hamann, A., Hu, E., Spiegelman, B., … Moller, D.E. (1996). Regulation of PPAR gamma gene expression by nutrition and obesity in rodents. Journal of Clinical Investigation, 97, 2553–2561.
   PubMed Web of Science ®Google Scholar
• Vidal-Puig, A.J., Considine, R.V., Jimenez-Linan, M., Werman, A., Pories, W.J., Caro, J.F. & Flier, J.S. (1997). Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids. Journal of Clinical Investigation, 99, 2416–2422.
   PubMed Web of Science ®Google Scholar
• Volkow, N.D., Wang, G.J., Telang, F., Fowler, J.S., Thanos, P.K., Logan, J., … Pradhan, K (2008). Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: Possible contributing factors. Neuroimage, 42, 1537–1543.
   PubMed Web of Science ®Google Scholar
• Wang, G., Volkow, N.D., Logan, J., Pappas, N.R., Wong, C.T., Zhu, W., … Fowler, J.S. (2001). Brain dopamine and obesity. Lancet, 357, 354–357.
   PubMed Web of Science ®Google Scholar
• Wang, X.L., Oosterhof, J. & Duarte, N (1999). Peroxisome proliferator-activated receptor gamma C161 → T polymorphism and coronary artery disease. Cardiovascular Research, 44, 588–594.
   PubMed Web of Science ®Google Scholar
• Wardle, J., Carnell, S., Haworth, C.M. & Plomin, R. (2008a). Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment. American Journal of Clinical Nutrition, 87, 398–404.
   PubMed Web of Science ®Google Scholar
• Wardle, J., Carnell, S., Haworth, C.M.A., Farooqi, I.S., O’Rahilly, S., & Plomin, R. (2008b). Obesity associated genetic variation in FTO is associated with diminished satiety. Journal of Clinical Endocrinology and Metabolism, 93, 3640–3643.
   PubMed Web of Science ®Google Scholar
• Wardle, J., Llewellyn, C., Sanderson, S. & Plomin, R (2009). The FTO gene and measured food intake in children. International Journal of Obesity, 33, 42–45.
   PubMed Web of Science ®Google Scholar
• Whitaker, R.C., Pepe, M.S., Wright, J.A., Seidel, K.D. & Dietz, W.H. (1998). Early adiposity rebound and the risk of adult obesity. Pediatrics, 101, E5.
   PubMed Web of Science ®Google Scholar
• Widen, E., Lehto, M., Kanninen, T., Walston, J., Shuldiner, A.R. & Groop, L.C. (1995). Association of a polymorphism in the beta 3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns. New England Journal of Medicine, 333, 348–351.
   PubMed Web of Science ®Google Scholar
• Wiegand, S., Dannemann, A., Krude, H. & Gruters, A (2005). Impaired glucose tolerance and type 2 diabetes mellitus: A new field for pediatrics in Europe. International Journal of Obesity, 29, S136–142.
   Web of Science ®Google Scholar
• Willer, C.J., Speliotes, E.K., Loos, R.J., Li, S., Lindgren, C.M., Heid, I.M., … Hirschhorn, J.N. (2009). Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet, 41, 25–34.
   PubMed Web of Science ®Google Scholar
• Wright, C.M., Cox, K.M. & Le Couteur, A (2011). How does infant behaviour relate to weight gain and adiposity? Proceedings of the Nutrition Society, 70, 485–493.
   PubMed Web of Science ®Google Scholar
• Xi, B., Shen, Y., Zhang, M., Liu, X., Zhao, X., Wu, L., … Wang, X (2010). The common rs9939609 variant of the fat mass and obesity-associated gene is associated with obesity risk in children and adolescents of Beijing, China. BMC Medical Genetics, 11, 107.
   PubMed Web of Science ®Google Scholar
• Xinli, W., Xiaomei, T., Meihua, P. & Song, L (2001). Association of a mutation in the beta3-adrenergic receptor gene with obesity and response to dietary intervention in Chinese children. Acta Paediatrica, 90, 1233–1237.
   PubMed Web of Science ®Google Scholar
• Zhang, B., Graziano, M.P., Doebber, T.W., Leibowitz, M.D., White-Carrington, S., Szalkowski, D.M., … Smith, R.G. (1996). Down-regulation of the expression of the obese gene by an antidiabetic thiazolidinedione in Zucker diabetic fatty rats and db/db mice. J Biol Chem, 271, 9455–9459.
   PubMed Web of Science ®Google Scholar
• Zimmet, P., Alberti, G., Kaufman, F., Tajima, N., Silink, M., Arslanian, S., … Caprio, S (2007). The metabolic syndrome in children and adolescents. Lancet, 369, 2059–2061.
   PubMed Web of Science ®Google Scholar