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Research Article

The Cache County Study on Memory in Aging: Factors affecting risk of Alzheimer's disease and its progression after onset

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Pages 673-685 | Received 01 Jul 2013, Accepted 25 Sep 2013, Published online: 15 Jan 2014

References

  • Aalten, P., de Vugt, M.E., Lousberg, R., Korten, E., Jaspers, N., Senden, B., … Verhey, F.R. (2003). Behavioral problems in dementia: A factor analysis of the neuropsychiatric inventory. Dementia and Geriatric Cognitive Disorders, 15, 99–105.
  • Adak, S., Illouz, K., Gorman, W., Tandon, R., Zimmerman, E. A., Guariglia, R., … Kaye, J.A. (2004). Predicting the rate of cognitive decline in aging and early Alzheimer disease. Neurology, 63, 108–114.
  • ADAPT Research Group. (2006). Cardiovascular and cerebrovascular events in the randomized, controlled Alzheimer's disease anti-inflammatory prevention trial (ADAPT). PLoS Clinical Trials, 1, e33.
  • ADAPT Research Group, Lyketsos, C.G., Breitner, J.C., Green, R.C., Martin, B.K., Meinert, C., … Sabbagh, M. (2007). Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial. Neurology, 68, 1800–1808.
  • Aguero-Torres, H., Fratiglioni, L., Guo, Z., Viitanen, M. & Winblad, B. (1998a). Prognostic factors in very old demented adults: A seven-year follow-up from a population-based survey in Stockholm. Journal of the American Geriatrics Society46, 444–452.
  • Aguero-Torres, H., Fratiglioni, L. & Winblad, B. (1998b). Natural history of Alzheimer's disease and other dementias: Review of the literature in the light of the findings from the Kungsholmen Project. International Journal of Geriatric Psychiatry, 13, 755–766.
  • Aisen, P.S., Schmeidler, J. & Pasinetti, G.M. (2002). Randomized pilot study of nimesulide treatment in Alzheimer's disease. Neurology, 58, 1050–1054.
  • Aisen, P.S., Schafer, K.A., Grundman, M., Pfeiffer, E., Sano, M., Davis, K.L., … Thal, L.J. (2003). Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: A randomized controlled trial. Journal of the American Medical Association, 289, 2819–2826.
  • Andersen-Ranberg, K., Vasegaard, L. & Jeune, B. (2001). Dementia is not inevitable: A population-based study of Danish centenarians. Journal of Gerontology B Psychological Science, 56, P152–159.
  • Anthony, J.C., Breitner, J.C., Zandi, P.P., Meyer, M.R., Jurasova, I., Norton, M.C. & Stone, S.V. (2000). Reduced prevalence of AD in users of NSAIDs and H2 receptor antagonists: The Cache County Study. Neurology, 54, 2066–2071.
  • Asthana, S., Baker, L.D., Craft, S., Stanczyk, F.Z., Veith, R.C., Raskind, M.A. & Plymate, S.R. (2001). High-dose estradiol improves cognition for women with AD: Results of a randomized study. Neurology, 57, 605–612.
  • Barnhart, R.L., van Belle, G., Edland, S.D. & Larson, E. (1997). Referral bias in Alzheimer's disease. Journal of Clinical Epidemiology, 50, 365–366.
  • Behl, P., Stefurak, T.L. & Black, S.E. (2005). Progress in clinical neurosciences: Cognitive markers of progression in Alzheimer's disease. Canadian Journal of Neurological Sciences, 32, 140–151.
  • Borenstein, A.R., Wu, Y., Mortimer, J.A., Schellenberg, G.D., McCormick, W.C., Bowen, J.D., … Larson, E.B. (2005). Developmental and vascular risk factors for Alzheimer's disease. Neurobiolology of Aging, 26, 325–334.
  • Bosch, J., Yusuf, S., Pogue, J., Sleight, P., Lonn, E., Rangoonwala, B., … Probstfield, J. (2002). Use of ramipril in preventing stroke: Double blind randomised trial. British Medical Journal, 324, 699–702.
  • Bowler, J.V., Munoz, D.G., Merskey, H., & Hachinski, V. (1998). Factors affecting the age of onset and rate of progression of Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry, 65, 184–190.
  • Breitner, J.C. & Zandi, P.P. (2003). Effects of estrogen plus progestin on risk of dementia. Journal of the American Medical Association, 290, 1706–1707.
  • Breitner, J.C., Haneuse, S.J., Walker, R., Dublin, S., Crane, P.K., Gray, S. L., Larson, E.B. (2009). Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort. Neurology, 72, 1899–1905.
  • Breitner, J.C.S. & Miech, R.A. (2000). ApoE-E4 count predicts age when prevalence of AD increases, then declines – Correction. Neurology, 55, 161–162.
  • Breitner, J.C., Welsh, K.A., Gau, B.A., McDonald, W.M., Steffens, D.C., Saunders, A.M., … Folstein, M.F. (1995). Alzheimer's disease in the National Academy of Sciences-National Research Council Registry of Aging Twin Veterans. III. Detection of cases, longitudinal results, and observations on twin concordance. Archives of Neurology, 52, 763–771.
  • Brenner, D.E., Kukull, W.A., Stergachis, A., van Belle, G., Bowen, J.D., McCormick, W.C., … Larson, E.B. (1994). Postmenopausal estrogen replacement therapy and the risk of Alzheimer's disease: A population-based case-control study. American Journal of Epidemiology, 140, 262–267.
  • Brinton, R.D. & Nilsen, J. (2003). Effects of estrogen plus progestin on risk of dementia. Journal of the American Medical Association, 290, 1706.
  • Carlson, M.C., Zandi, P.P., Plassman, B.L., Tschanz, J.T., Welsh-Bohmer, K.A., Steffens, D.C., … Breitner, J.C. (2001). Hormone replacement therapy and reduced cognitive decline in older women: The Cache County Study. Neurology, 57, 2210–2216.
  • Corrada, M.M., Brookmeyer, R., Paganini-Hill, A., Berlau, D. & Kawas, C.H. (2010). Dementia incidence continues to increase with age in the oldest old: The 90 + study. Annals of Neurolology, 67, 114–121.
  • Farrer, L.A., Cupples, L.A., Haines, J.L., Hyman, B., Kukull, W.A., Mayeux, R., … Van Duijn, C.M. (1997). Effects of age, sex, and ethnicity on the association between apolipoprotein e genotype and alzheimer disease. A meta-analysis. ApoE and Alzheimer disease meta analysis consortium. Journal of the American Medical Association, 278, 1349–1356.
  • Fauth, E., Hess, K., Piercy, K., Norton, M., Corcoran, C., Rabins, P., … Tschanz, J. (2012). Caregivers’ relationship closeness with the person with dementia predicts both positive and negative outcomes for caregivers’ physical health and psychological well-being. Aging and Mental Health, 16, 699–711.
  • Fauth, E.B., Schwartz, S., Tschanz, J.T., Ostbye, T., Corcoran, C. & Norton, M.C. (2013). Baseline disability in activities of daily living predicts dementia risk even after controlling for baseline global cognitive ability and depressive symptoms. International Journal of Geriatric Psychiatry, 28, 597–606.
  • Forette, F., Seux, M.L., Staessen, J.A., Thijs, L., Babarskiene, M.R., Babeanu, S., … Birkenhager, W.H. (2002). The prevention of dementia with antihypertensive treatment: New evidence from the systolic hypertension in Europe (Syst-Eur) study. Archives of Internal Medicine, 162, 2046–2052.
  • Forette, F., Seux, M.L., Staessen, J.A., Thijs, L., Birkenhager, W.H., Babarskiene, M.R., … Fagard, R. (1998). Prevention of dementia in randomised double-blind placebo-controlled systolic hypertension in Europe (Syst-Eur) trial. Lancet, 352, 1347–1351.
  • Frisoni, G.B., Rozzini, L., Gozzetti, A., Binetti, G., Zanetti, O., Bianchetti, A., … Cummings, J.L. (1999). Behavioral syndromes in alzheimer's disease: Description and correlates. Dementia and Geriatric Cognitive Disorders, 10, 130–138.
  • Ganguli, M., Snitz, B.E., Saxton, J.A., Chang, C.C., Lee, C.W., Vander Bilt, J., … Petersen, R.C. (2011). Outcomes of mild cognitive impairment by definition: A population study. Archives of Neurology, 68, 761–767.
  • Gao, S., Hendrie, H.C., Hall, K.S. & Hui, S. (1998). The relationships between age, sex, and the incidence of dementia and alzheimer disease: A meta-analysis. Archives of General Psychiatry, 55, 809–815.
  • Garre-Olmo, J., Lopez-Pousa, S., Vilalta-Franch, J., De Gracia Blanco, M. & Vilarrasa, A.B. (2010). Grouping and trajectories of the neuropsychiatric symptoms in patients with Alzheimer's disease, part I: Symptom clusters. Journal of Alzheimer's Disease, 22, 1157–1167.
  • Graham, J.E., Rockwood, K., Beattie, B.L., Eastwood, R., Gauthier, S., Tuokko, H. & Mcdowell, I. (1997). Prevalence and severity of cognitive impairment with and without dementia in an elderly population. Lancet, 349, 1793–1796.
  • Greene, D., Tschanz, J.T., Smith, K.R., Ostbye, T., Corcoran, C., Welsh-Bohmer, K.A. & Norton, M.C. (2013). Impact of offspring death on cognitive health in late life. The Cache County Study. American Journal of Geriatric Psychiatry, doi: 10.1016/j.jagp.2013.05.002.
  • Gustafson, D. (2008). A life course of adiposity and dementia. European Journal of Pharmacology, 585, 163–175.
  • Hajjar, I., Schumpert, J., Hirth, V., Wieland, D. & Eleazer, G.P. (2002). The impact of the use of statins on the prevalence of dementia and the progression of cognitive impairment. Journals of Gerontology A Biological & Medical Science, 57, M414–418.
  • Hall, C.B., Verghese, J., Sliwinski, M., Chen, Z., Katz, M., Derby, C. & Lipton, R.B. (2005). Dementia incidence may increase more slowly after age 90: Results from the Bronx Aging Study. Neurology, 65, 882–886.
  • Hayden, K.M. & Welsh-Bohmer, K.A. (2012). Epidemiology of cognitive aging and Alzheimer's disease: Contributions of the Cache County Utah Study of Memory, Health and Aging. Current Topics in Behavioral Neuroscience. Berlin: Springer.
  • Hayden, K.M., Zandi, P.P., Khachaturian, A.S., Szekely, C.A., Fotuhi, M., Norton, M.C., … Welsh-Bohmer, K.A. (2007). Does NSAID use modify cognitive trajectories in the elderly? The Cache County Study. Neurology, 69, 275–282.
  • Hayden, K.M., Zandi, P.P., Lyketsos, C.G., Khachaturian, A.S., Bastian, L.A., Charoonruk, G., … Welsh-Bohmer, K.A. (2006). Vascular risk factors for incident Alzheimer disease and vascular dementia: The Cache County Study. Alzheimer Disease and Associated Disorders, 20, 93–100.
  • Henderson, V.W., Paganini-Hill, A., Miller, B.L., Elble, R.J., Reyes, P.F., Shoupe, D., … Farlow, M.R. (2000). Estrogen for Alzheimer's disease in women: Randomized, double-blind, placebo-controlled trial. Neurology, 54, 295–301.
  • Hofman, A., Ott, A., Breteler, M.M., Bots, M.L., Slooter, A.J., Van Harskamp, … Grobbee, D.E. (1997). Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study. Lancet, 349, 151–154.
  • Jellinger, K.A. (2006). Clinicopathological analysis of dementia disorders in the elderly – An update. Journal of Alzheimer's Disease, 9(Suppl.3), 61–70.
  • Jick, H., Zornberg, G.L., Jick, S.S., Seshadri, S. & Drachman, D.A. (2000). Statins and the risk of dementia. Lancet, 356, 1627–1631.
  • Kawas, C., Resnick, S., Morrison, A., Brookmeyer, R., Corrada, M., Zonderman, A., … Metter, E. (1997). A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: The Baltimore Longitudinal Study of Aging. Neurology, 48, 1517–1521.
  • Kawas, C.H. & Corrada, M.M. (2006). Alzheimer's and dementia in the oldest-old: A century of challenges. Current Alzheimer Research, 3, 411–419.
  • Khachaturian, A.S., Corcoran, C.D., Mayer, L.S., Zandi, P.P. & Breitner, J.C. (2004). Apolipoprotein E epsilon4 count affects age at onset of Alzheimer disease, but not lifetime susceptibility: The Cache County Study. Archives of General Psychiatry, 61, 518–524.
  • Khachaturian, A.S., Zandi, P.P., Lyketsos, C.G., Hayden, K.M., Skoog, I., Norton, M.C. … Breitner, J.C. (2006). Antihypertensive medication use and incident Alzheimer disease: The Cache County Study. Archives of Neurology, 63, 686–692.
  • Kivipelto, M., Helkala, E.L., Laakso, M.P., Hanninen, T., Hallikainen, M., Alhainen, K., … Nissinen, A. (2001). Midlife vascular risk factors and Alzheimer's disease in later life: Longitudinal, population based study. British Medical Journal, 322, 1447–1451.
  • Larrieu, S., Letenneur, L., Orgogozo, J.M., Fabrigoule, C., Amieva, H., Le Carret, N., … Dartigues, J.F. (2002). Incidence and outcome of mild cognitive impairment in a population-based prospective cohort. Neurology, 59, 1594–1599.
  • Launer, L.J., Ross, G.W., Petrovitch, H., Masaki, K., Foley, D., White, L.R. & Havlik, R.J. (2000). Midlife blood pressure and dementia: The Honolulu-Asia Aging Study. Neurobiology of Aging, 21, 49–55.
  • Leoutsakos, J.M., Han, D., Mielke, M.M., Forrester, S.N., Tschanz, J.T., Corcoran, C.D., … Lyketsos, C.G. (2012). Effects of general medical health on Alzheimer's progression: The Cache County Dementia Progression Study. International Psychogeriatrics, 24, 1561–1570.
  • Li, G., Higdon, R., Kukull, W.A., Peskind, E., Van Valen Moore, K., Tsuang, D., … Larson, E.B. (2004). Statin therapy and risk of dementia in the elderly: A community-based prospective cohort study. Neurology, 63, 1624–1628.
  • Lopez, O.L., Kuller, L.H., Becker, J.T., Dulberg, C., Sweet, R.A., Gach, H.M. & Dekosky, S.T. (2007). Incidence of dementia in mild cognitive impairment in the Cardiovascular Health Study Cognition Study. Archives of Neurology, 64, 416–420.
  • Luchsinger, J.A., Reitz, C., Honig, L.S., Tang, M.X., Shea, S. & Mayeux, R. (2005). Aggregation of vascular risk factors and risk of incident Alzheimer disease. Neurology, 65, 545–551.
  • Luchsinger, J.A., Tang, M.X., Shea, S. & Mayeux, R. (2003). Antioxidant vitamin intake and risk of Alzheimer disease. Archives of Neurology, 60, 203–208.
  • Lyketsos, C.G., Carrillo, M.C., Ryan, J.M., Khachaturian, A.S., Trzepacz, P., Amatniek, J., … Miller, D.S. (2011). Neuropsychiatric symptoms in Alzheimer's Disease. Alzheimers & Dementia, 7, 532–9.
  • Lyketsos, C.G., Sheppard, J.M., Steinberg, M., Tschanz, J.A., Norton, M.C., Steffens, D.C. & Breitner, J.C. (2001). Neuropsychiatric disturbance in Alzheimer's disease clusters into three groups: The Cache County Study. International Journal of Geriatrric Psychiatry, 16, 1043–1053.
  • Lyketsos, C.G., Toone, L., Tschanz, J., Rabins, P.V., Steinberg, M., Onyike, C.U., … Williams, M. (2005). Population-based study of medical comorbidity in early dementia and ‘cognitive impairment, no dementia (CIND)’: Association with functional and cognitive impairment: The Cache County Study. American Journal of Geriatric Psychiatry, 13, 656–664.
  • Martin, B.K., Szekely, C., Brandt, J., Piantadosi, S., Breitner, J.C., Craft, S., … Mullan, M. (2008). Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): Results of a randomized, controlled trial of naproxen and celecoxib. Archives of Neurology, 65, 896–905.
  • Miech, R.A., Breitner, J.C., Zandi, P.P., Khachaturian, A.S., Anthony, J.C. & Mayer, L. (2002). Incidence of AD may decline in the early 90s for men, later for women: The Cache County Study. Neurology, 58, 209–218.
  • Mielke, M.M., Leoutsakos, J.M., Corcoran, C.D., Green, R.C., Norton, M.C., Welsh-Bohmer, K.A., … Lyketsos, C.G. (2012a). Effects of food and drug administration-approved medications for Alzheimer's Disease on clinical progression. Alzheimer's and Dementia, 8, 180–187.
  • Mielke, M.M., Leoutsakos, J.M., Tschanz, J.T., Green, R.C., Tripodis, Y., Corcoran, C.D., … Lyketsos, C.G., 2012b. Interaction between vascular factors and the ApoE epsilon4 allele in predicting rate of progression in Alzheimer's Disease. Journal of Alzheimer's Disease, 26, 127–134.
  • Mielke, M.M., Rosenberg, P.B., Tschanz, J., Cook, L., Corcoran, C., Hayden, K.M., … Lyketsos, C.G. (2007). Vascular factors predict rate of progression in Alzheimer Disease. Neurology, 69, 1850–1858.
  • Mitchell, A.J. & Shiri-Feshki, M. (2009). Rate of progression of mild cognitive impairment to dementia – Meta-analysis of 41 robust inception cohort studies. Acta Psychiatrica Scandinavica, 119, 252–265.
  • Moceri, V.M., Kukull, W.A., Emanual, I., Van Belle, G., Starr, J.R., Schellenberg, G.D., … Larson, E.B. (2001). Using census data and birth certificates to reconstruct the early-life socioeconomic environment and the relation to the development of Alzheimer's Disease. Epidemiology, 12, 383–389.
  • Moceri, V.M., Kukull, W.A., Emanuel, I., Van Belle, G. & Larson, E.B. (2000). Early-life risk factors and the development of Alzheimer's disease. Neurology, 54, 415–420.
  • Morris, M.C., Beckett, L.A., Scherr, P.A., Hebert, L.E., Bennett, D.A., Field, T.S. & Evans, D.A. (1998). Vitamin E and vitamin C supplement use and risk of incident Alzheimer disease. Alzheimer Disease and Associated Disorders, 12, 121–126.
  • Morris, M.C., Evans, D.A., Bienias, J.L., Tangney, C.C., Bennett, D.A., Wilson, R.S., … Schneider, J. (2003). Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Archives of Neurology, 60, 940–946.
  • Morris, M.C., Evans, D.A., Tangney, C.C., Bienias, J.L. & Wilson, R.S. (2005). Fish consumption and cognitive decline with age in a large community study. Archives of Neurology, 62, 1849–1853.
  • Mortimer, J.A., Ebbitt, B., Jun, S.P. & Finch, M.D. (1992). Predictors of cognitive and functional progression in patients with probable Alzheimer's disease. Neurology, 42, 1689–1696.
  • MRC CFAS (Medical Research Council Cognitive Function and Aging Group). (2001). Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Lancet, 357, 169–175.
  • Mulnard, R.A., Cotman, C.W., Kawas, C., Van Dyck, C.H., Sano, M., Doody, R., … Thal, L.J. (2000). Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: A randomized controlled trial. Alzheimer's Disease Cooperative Study. Journal of the American Medical Association, 283, 1007–1015.
  • Murray, C., Michaud, C., Mckenna, M. & Marks, J. (1998). U.S. Patterns of mortality by county and race: 1965–1994. Cambridge, MA: Harvard School of Public Health.
  • Nelson, C., Wengreen, H.J., Munger, R.G. & Corcoran, C.D. (2009). Dietary folate, vitamin B12, vitamin B6 and incident Alzheimer's disease: The Cache County Memory, Health and Aging Study. Journal of Nutrition, Health and Aging, 13, 899–905.
  • Norton, M.C., Clark, C., Fauth, E.B., Piercy, K.W., Pfister, R., Green, R.C., … Tschanz, J.T. (2013a). Caregiver personality predicts rate of cognitive decline in a community sample of persons with Alzheimer's disease. The Cache County Dementia Progression Study. International Psychogeriatrics 25, 1629–1637.
  • Norton, M.C., Dew, J., Smith, H., Fauth, E., Piercy, K.W., Breitner, J.C., … Welsh-Bohmer, K. (2012). Lifestyle behavior pattern is associated with different levels of risk for incident dementia and Alzheimer's disease: The Cache County Study. Journal of the American Geriatrics Society, 60, 405–412.
  • Norton, M.C., Ostbye, T., Smith, K.R., Munger, R.G. & Tschanz, J.T. (2009a). Early parental death and late-life dementia risk: Findings from the Cache County Study. Age and Ageing, 38, 340–343.
  • Norton, M.C., Piercy, K.W., Rabins, P.V., Green, R.C., Breitner, J.C., Ostbye, T., … Tschanz, J.T. (2009b). Caregiver-recipient closeness and symptom progression in Alzheimer disease. The Cache County Dementia Progression Study. Journals of Gerontology B Psychological Sciences, 64, 560–568.
  • Norton, M.C., Smith, K.R., Ostbye, T., Tschanz, J.T., Corcoran, C., Schwartz, S., … Welsh-Bohmer, K.A. (2010). Greater risk of dementia when spouse has dementia? The Cache County Study. Journal of the American Geriatrics Society, 58, 895–900.
  • Norton, M.C., Smith, K.R., Ostbye, T., Tschanz, J.T., Corcoran, C., Schwartz, S., … Welsh-Bohmer, K.A. (2013b). Correction: Greater risk of dementia when spouse has dementia? The Cache County Study. Journal of the American Geriatric Society, 61, 1642.
  • Norton, M.C., Smith, K.R., Ostbye, T., Tschanz, J.T., Corcoran, C., Schwartz, S., … Breitner, J.C.S. (2011). Early parental death and remarriage of widowed parents as risk factors for Alzheimer's disease. American Journal of Geriatric Psychiatry, 19, 814–824.
  • Notkola, I.L., Sulkava, R., Pekkanen, J., Erkinjuntti, T., Ehnholm, C., Kivinen, P., … Nissinen, A. (1998). Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease. Neuroepidemiology, 17, 14–20.
  • Ott, A., Stolk, R.P., Van Harskamp, F., Pols, H.A., Hofman, A. & Breteler, M.M. (1999). Diabetes mellitus and the risk of dementia: The Rotterdam Study. Neurology, 53, 1937–1942.
  • Peltz, C.B., Corrada, M.M., Berlau, D.J. & Kawas, C.H. (2011). Incidence of dementia in oldest-old with amnestic MCI and other cognitive impairments. Neurology, 77, 1906–1912.
  • Persson, G. & Skoog, I. (1996). A prospective population study of psychosocial risk factors for late onset dementia. International Journal of Geriatric Psychiatry, 11, 15–22.
  • Peters, M.E., Rosenberg, P.B., Steinberg, M., Norton, M.C., Welsh-Bohmer, K.A., Hayden, K.M., … Lyketsos, C.G. (2013). Neuropsychiatric symptoms as risk factors for progression from cind to dementia: The Cache County Study. American Journal of Geriatric Psychiatry, 21, 1116–1124.
  • Peters, M.E., Rosenberg, P.B., Steinberg, M., Tschanz, J.T., Norton, M.C., Welsh-Bohmer, K.A., … Lyketsos, C.G. (2012). Prevalence of neuropsychiatric symptoms in CIND and its subtypes: The Cache County Study. American Journal of Geriatric Psychiatry, 20, 416–424.
  • Peters, R., Beckett, N., Forette, F., Tuomilehto, J., Clarke, R., Ritchie, C., … Bulpitt, C. (2008). Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial Cognitive Function Assessment (HYVET-cog): A double-blind, placebo controlled trial. Lancet Neurology, 7, 683–689.
  • Petersen, R.C., Thomas, R.G., Grundman, M., Bennett, D., Doody, R., Ferris, S., … Thal, L.J. (2005). Vitamin E and donepezil for the treatment of mild cognitive impairment. New England Journal of Medicine, 352, 2379–2388.
  • Piercy, K.W., Fauth, E.B., Norton, M.C., Pfister, R., Corcoran, C.D., Rabins, P.V., … Tschanz, J.T. (2013). Predictors of dementia caregiver depressive symptoms in a population: The Cache County Dementia Progression Study. Journals of Gerontology B Psychological Sciences Social Sciences,68, 921–926.
  • Plassman, B.L., Langa, K.M., Fisher, G.G., Heeringa, S.G., Weir, D.R., Ofstedal, M.B., … Wallace, R.B. (2007). Prevalence of dementia in the United States: The Aging, Demographics, and Memory Study. Neuroepidemiology, 29, 125–132.
  • Quinn, J.F., Raman, R., Thomas, R.G., Yurko-Mauro, K., Nelson, E.B., Van Dyck, C., … Aisen, P.S. (2010). Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: A randomized trial. Journal of the American Medical Association, 304, 1903–1911.
  • Rabins, P.V., Schwartz, S., Black, B.S., Corcoran, C., Fauth, E., Mielke, M., … Tschanz, J. (2013). Predictors of progression to severe Alzheimer's disease in an incidence sample. Alzheimer's and Dementia, 9, 204–207.
  • Rapp, S.R., Espeland, M.A., Shumaker, S.A., Henderson, V.W., Brunner, R.L., Manson, J.E., … Bowen, D. (2003). Effect of estrogen plus progestin on global cognitive function in postmenopausal women: The Women's Health Initiative Memory Study: A randomized controlled trial. Journal of the American Medical Association, 289, 2663–2672.
  • Rea, T.D., Breitner, J.C., Psaty, B.M., Fitzpatrick, A.L., Lopez, O.L., Newman, A.B., … Kuller, L.H. (2005). Statin use and the risk of incident dementia: The Cardiovascular Health Study. Archives of Neurology, 62, 1047–1051.
  • Reines, S.A., Block, G.A., Morris, J.C., Liu, G., Nessly, M.L., Lines, C.R., … Baranak, C.C. (2004). Rofecoxib: No effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study. Neurology, 62, 66–71.
  • Reitz, C., Den Heijer, T., Van Duijn, C., Hofman, A. & Breteler, M.M. (2007). Relation between smoking and risk of dementia and Alzheimer disease: The Rotterdam Study. Neurology, 69, 998–1005.
  • Resnick, S.M. & Henderson, V.W. (2002). Hormone therapy and risk of Alzheimer disease: A critical time. Journal of the American Medical Association, 288, 2170–2172.
  • Rockwood, K., Kirkland, S., Hogan, D.B., Macknight, C., Merry, H., Verreault, R., … Mcdowell, I. (2002). Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people. Archives of Neurology, 59, 223–227.
  • Rosenberg, P.B., Mielke, M.M., Han, D., Leoutsakos, J.S., Lyketsos, C.G., Rabins, P.V., … Tschanz, J.T. (2012). The association of psychotropic medication use with the cognitive, functional, and neuropsychiatric trajectory of Alzheimer's disease. International Journal of Geriatric Psychiatry, 27, 1248–1257.
  • Rosenberg, P.B., Mielke, M.M., Tschanz, J., Cook, L., Corcoran, C., Hayden, K.M., … Lyketsos, C.G. (2008). Effects of cardiovascular medications on rate of functional decline in Alzheimer disease. American Journal of Geriatric Psychiatry, 16, 883–892.
  • Ruitenberg, A., Ott, A., Van Swieten, J.C., Hofman, A. & Breteler, M.M. (2001). Incidence of dementia: Does gender make a difference? Neurobiology of Aging, 22, 575–580.
  • Santanello, N.C., Barber, B.L., Applegate, W.B., Elam, J., Curtis, C., Hunninghake, D.B. & Gordon, D.J. (1997). Effect of pharmacologic lipid lowering on health-related quality of life in older persons: Results from the Cholesterol Reduction in Seniors Program (CRISP) pilot study. Journal of the American Geriatric Society, 45, 8–14.
  • Scarmeas, N., Stern, Y., Tang, M.X., Mayeux, R. & Luchsinger, J.A. (2006). Mediterranean diet and risk for Alzheimer's disease. Annals of Neurology, 59, 912–921.
  • Scharf, S., Mander, A., Ugoni, A., Vajda, F. & Christophidis, N. (1999). A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease. Neurology, 53, 197–201.
  • Schmeidler, J., Mohs, R.C. & Aryan, M. (1998). Relationship of disease severity to decline on specific cognitive and functional measures in Alzheimer disease. Alzheimer Disease and Associated Disorders, 12, 146–151.
  • Seshadri, S., Zornberg, G.L., Derby, L.E., Myers, M.W., Jick, H. & Drachman, D.A. (2001). Postmenopausal estrogen replacement therapy and the risk of Alzheimer disease. Archives of Neurology, 58, 435–440.
  • Shah, K., Qureshi, S.U., Johnson, M., Parikh, N., Schulz, P.E. & Kunik, M.E. (2009). Does use of antihypertensive drugs affect the incidence or progression of dementia? A systematic review. American Journal of Geriatric Pharmacotherapy, 7, 250–261.
  • Shao, H., Breitner, J.C., Whitmer, R.A., Wang, J., Hayden, K., Wengreen, H., … Zandi, P.P. (2012). Hormone therapy and Alzheimer disease dementia: New findings from the Cache County Study. Neurology, 79, 1846–1852.
  • Shepherd, J., Blauw, G.J., Murphy, M.B., Bollen, E.L., Buckley, B.M., Cobbe, S.M., … Westendorp, R.G. (2002). Pravastatin in elderly individuals at risk of vascular disease (prosper): A randomised controlled trial. Lancet, 360, 1623–1630.
  • Shumaker, S.A., Legault, C., Kuller, L., Rapp, S.R., Thal, L., Lane, D.S., … Coker, L.H. (2004). Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study. Journal of the American Medical Association, 291, 2947–2958.
  • Shumaker, S.A., Legault, C., Rapp, S.R., Thal, L., Wallace, R.B., Ockene, J.K., … Wactawski-Wende, J. (2003). Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: The Women's Health Initiative Memory Study: A randomized controlled trial. Journal of the American Medical Association, 289, 2651–2662.
  • Slavin, M.J., Brodaty, H. & Sachdev, P.S. (2013). Challenges of diagnosing dementia in the oldest old population. Journals of Gerontology A Bioliological Sciences Medical Sciences, 68, 1103–1111.
  • Soininen, H., West, C., Robbins, J. & Niculescu, L. (2007). Long-term efficacy and safety of celecoxib in Alzheimer's disease. Dementia, and Geriatric Cognnitive Disorders, 23, 8–21.
  • Steffens, D.C., Norton, M.C., Plassman, B.L., Tschanz, J.T., Wyse, B.W., Welsh-Bohmer, K.A., … Breitner, J.C. (1999). Enhanced cognitive performance with estrogen use in nondemented community-dwelling older women. Journal of the American Geriatrics Society47, 1171–1175.
  • Steinberg, M., Hess, K., Corcoran, C., Mielke, M.M., Norton, M., Breitner, J., … Tschanz, J. (2013). Vascular risk factors and neuropsychiatric symptoms in Alzheimer's disease: The Cache County Study. International Journal of Geriatric Psychiatry, doi: 10.1002/gps.3980
  • Steinberg, M., Shao, H., Zandi, P., Lyketsos, C.G., Welsh-Bohmer, K.A., Norton, M.C., … Tschanz, J.T. (2008). Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: The Cache County Study. International Journal of Geriatric Psychiatry, 23, 170–177.
  • Steinberg, M., Tschanz, J.T., Corcoran, C., Steffens, D.C., Norton, M.C., Lyketsos, C.G. & Breitner, J.C. (2004). The persistence of neuropsychiatric symptoms in dementia: The Cache County Study. International Journal of Geriatric Psychiatry, 19, 19–26.
  • Stern, Y., Albert, S., Tang, M.X. & Tsai, W.Y. (1999). Rate of memory decline in AD is related to education and occupation: Cognitive reserve? Neurology, 53, 1942–1947.
  • Swanwick, G.R., Coen, R.F., Coakley, D. & Lawlor, B.A. (1998). Assessment of progression and prognosis in ‘possible’ and ‘probable’ Alzheimer's disease. International Journal of Geriatric Psychiatry, 13, 331–335.
  • Tang, M.X., Jacobs, D., Stern, Y., Marder, K., Schofield, P., Gurland, B., … Mayeux, R. (1996). Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet, 348, 429–432.
  • Treiber, K.A., Carlson, M.C., Corcoran, C., Norton, M.C., Breitner, J.C., Piercy, K.W., … Tschanz, J.T. (2011). Cognitive stimulation and cognitive and functional decline in Alzheimer's disease: The Cache County Dementia Progression Study. Journals of Gerontology Psychological Sciences Social Sciences, 66, 416–425.
  • Treiber, K.A., Lyketsos, C.G., Corcoran, C., Steinberg, M., Norton, M., Green, R.C., … Tschanz, J.T. (2008). Vascular factors and risk for neuropsychiatric symptoms in Alzheimer's disease: The Cache County Study. International Psychogeriatrics, 20, 538–553.
  • Tschanz, J.T., Corcoran, C., Schwartz, S., Treiber, K., Green, R.C., Norton, M.C., … Lyketsos, C.G. (2011). Progression of cognitive, functional and neuropsychiatric symptom domains in a population cohort with Alzheimer dementia: The Cache County Dementia Progression Study. American Journal of Geriatric Psychiatry, 19, 532–542.
  • Tschanz, J.T., Pfister, R., Wanzek, J., Corcoran, C., Smith, K., Tschanz, B.T., … Norton, M.C. (2013a). Stressful life events and cognitive decline in late life: Moderation by education and age. The Cache County Study. International Journal of Geriatric Psychiatry, 28, 821–830.
  • Tschanz, J.T., Piercy, K., Corcoran, C.D., Fauth, E., Norton, M.C., Rabins, P.V., … Lyketsos, C.G. (2013b). Caregiver coping strategies predict cognitive and functional decline in dementia: The Cache County Dementia Progression Study. American Journal of Geriatric Psychiatry, 21, 57–66.
  • Tschanz, J.T., Treiber, K., Norton, M.C., Welsh-Bohmer, K.A., Toone, L., Zandi, P.P., … Breitner, J.C. (2005). A population study of Alzheimer's disease: Findings from the Cache County Study on Memory, Health, and Aging. Care Management Journal, 6, 107–114.
  • Tschanz, J.T., Welsh-Bohmer, K.A., Lyketsos, C.G., Corcoran, C., Green, R.C., Hayden, K., … Breitner, J.C. (2006). Conversion to dementia from mild cognitive disorder: The Cache County Study. Neurology, 67, 229–234.
  • Tuokko, H., Frerichs, R., Graham, J., Rockwood, K., Kristjansson, B., Fisk, J., … Mcdowell, I. (2003). Five-year follow-up of cognitive impairment with no dementia. Archives of Neurology, 60, 577–582.
  • Tzourio, C., Anderson, C., Chapman, N., Woodward, M., Neal, B., Macmahon, S. & Chalmers, J. (2003). Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease. Archives of Internal Medicine, 163, 1069–1075.
  • UN (United Nations). (2002). World population ageing: 1950–2050. Retrieved from http://www.un.org/esa/population/publications/worldageing19502050/
  • US Census. (1990). Retrieved from http://www.census.gov/population/cencoutns/
  • Wengreen, H.J., Munger, R.G., Corcoran, C.D., Zandi, P., Hayden, K.M., Fotuhi, M., … Welsh-Bohmer, K.A. (2007). Antioxidant intake and cognitive function of elderly men and women: The Cache County Study. Journal of Nutrition, Health and Aging, 11, 230–237.
  • Wengreen, H.J., Neilson, C., Munger, R. & Corcoran, C. (2009). Diet quality is associated with better cognitive test performance among aging men and women. Journal of Nutrition, 139, 1944–1949.
  • Whitmer, R.A., Quesenberry, C.P., Zhou, J. & Yaffe, K. (2011). Timing of hormone therapy and dementia: The critical window theory revisited. Annals of Neurology, 69, 163–169.
  • Whitmer, R.A., Sidney, S., Selby, J., Johnston, S.C. & Yaffe, K. (2005). Midlife cardiovascular risk factors and risk of dementia in late life. Neurology, 64, 277–281.
  • WHO–AD (Alzheimer's Disease) International (2012). Dementia: A Public Health Priority. Geneva: World Health Organization.
  • Wolozin, B., Kellman, W., Ruosseau, P., Celesia, G.G. & Siegel, G. (2000). Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Archives of Neurology, 57, 1439–1443.
  • Yip, A.G., Green, R.C., Huyck, M., Cupples, L.A. & Farrer, L.A. (2005).Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: The MIRAGE Study. British Medical Journal Geriatrics, 5, 2.
  • Zandi, P.P., Anthony, J.C., Hayden, K.M., Mehta, K., Mayer, L. & Breitner, J.C. (2002a). Reduced incidence of AD with NSAID but not H2 receptor antagonists: The Cache County Study. Neurology, 59, 880–886.
  • Zandi, P.P., Anthony, J.C., Khachaturian, A.S., Stone, S.V., Gustafson, D., Tschanz, J.T., … Breitner, J.C. (2004). Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: The Cache County Study. Archives of Neurology, 61, 82–88.
  • Zandi, P.P., Carlson, M.C., Plassman, B.L., Welsh-Bohmer, K.A., Mayer, L.S., Steffens, D.C. & Breitner, J.C. (2002b). Hormone replacement therapy and incidence of Alzheimer disease in older women: The Cache County Study. Journal of the American Medical Association, 288, 2123–2129.
  • Zandi, P.P., Sparks, D.L., Khachaturian, A.S., Tschanz, J., Norton, M., Steinberg, M., … Breitner, J.C. (2005). Do statins reduce risk of incident dementia and Alzheimer Disease? The Cache County Study. Archives of General Psychiatry, 62, 217–224.

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