Neuropharmacological Studies of the Serotonergic System

References

• Amin Crawford T. B.B., Gaddum J. H. The distribution of substance P and 5-hydroxytryptamine in the central nervous system of the dog. Journal of Physiology 1954; 12(6)596–618
   Google Scholar
• Andrade R, Nicoll R. A. Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded. in vitro, Journal of Physiology 1987; 394: 99–124
   PubMed Web of Science ®Google Scholar
• Arnt J, Hyttel J. Facilitation of 8-OHDPAT-induced forepaw treading of rats by the 5-HT2agonist DOI. European Journal of Pharmacology 1989; 16(1)45–51
   Google Scholar
• Battaglia G., Shannon M., Borgundvaag B., Titeler M. Guanyl nucleotide and divalent cation regulation of cortical 5-HT2serotonin receptors. Journal of Neurochemistry 1984; 4(3)1213–1219
   Google Scholar
• Barnes N. M., Costall B., Naylor R. J. [3H]zacopride: ligand for the identification of 5-HT3 recognition sites. Journal of Pharmacy and Pharmacology 1988; 40: 548–551
   PubMed Web of Science ®Google Scholar
• Bedard P, Pycock C. J. ‘Wet dog’ shake behaviour in the rat: a possible quantitative model of central 5-hydroxytryptamine activity. Neuropharmacology 1977; 1(6)663–670
   Google Scholar
• Berendsen H. H., Broekkamp C. L. Drug-induced penile erections in rats: indications of serotonin 1B receptor mediation. European Journal of Pharmacology 1987; 13(5)279–287
   Google Scholar
• Bill D. J., Knight M., Sutherland H., Forster E. A., Fletcher A. Evidence for an important species difference in the mechanism of 8-OH-DPAT-induced hypothermia. British Journal of Pharmacology 1989; 98: 920
   Google Scholar
• Blackshear M. A., Sanders-Bush E. Serotonin receptor sensitivity after acute and chronic treatment with mianserin. Journal of Pharmacology and Experimental Therapeutics 1982; 22(1)303–308
   Google Scholar
• Blandina P., Goldfarb J., Green J. P. Activation of a 5-HT3 receptor release dopamine from rat striatal slice. European Journal of Pharmacology 1988; 15(5)349–350
   Google Scholar
• Blier P., de Montigny C., Chaput Y. Electrophysiological assessments of the effects of anti-depressant treatments on the efficacy of 5-HT neurotransmission. Clinical Neuropharmacology 1988; 11(Suppl. 2)S1–S10
   PubMedGoogle Scholar
• Bouhelal R., Smounya L., Bockaert J. 5-HT1B receptors are negatively coupled with adenylate cyclase in rat substantia nigra. European Journal of Pharmacology 1988; 15(1)189–196
   Google Scholar
• Bradley P. B., Engel G., Fenuik W., Fozard J. R., Humphrey P. P. A., Middlemiss D. N., Mylecharane E. J., Richardson B. P., Saxena P. R. Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine. Neuropharmacology 1986; 2(5)563–576
   Google Scholar
• Brazell M. P., Marsden C. A., Nisbet A. P., Routledge C. The 5-HT1receptor agaonist RU 24969 decreases 5-hydroxytryptamine (5-HT) release and metabolism in the rat frontal cortexin vitroand. in vivo, British Journal of Pharmacology 1985; 86: 209–218
   PubMed Web of Science ®Google Scholar
• Broekkamp C. L. E., Berendsen H. H. G., Jenck F., van Delft A. M. L. Animal models for anxiety and response to serotonergic drugs. Psychopathology 1989; 22(Suppl. 1)2–12
   PubMedGoogle Scholar
• Buckholtz N. S., Zhou D., Freedman D. X. Serotonin2agonist administration down-regulates rat brain serotonin2receptors. Life Sciences 1988; 42: 2439–2445
   PubMed Web of Science ®Google Scholar
• Carboni E., Acquas E., Frau R., DiChiara G. Differential inhibitory effects of a 5-HT3 antagonist on drug-induced stimulation of dopamine release. European Journal of Pharmacology 1989; 16(4)515–519
   Google Scholar
• Carmichael J., Cantwell B. M., Edwards C. M., Zussman B. D., Thompson S., Rapeport W. G., Harris A. L. A pharmacokinetic study of granisetroin (BRL 43694A), a selective 5-HT3 receptor antagonist: correlation with anti-emetic response. Cancer Chemotherapy and Pharmacology 1989; 24: 45–49
   PubMed Web of Science ®Google Scholar
• Chaouloff F., Serrurrier B., Merino D., Laude D., Elghozi J. L. Feeding responses to a high dose of 8-OH-DPAT in young and adult rats: influence of food texture. European Journal of Pharmacology 1988; 15(1)267–273
   Google Scholar
• Chaput Y., de Montigny C. Effects of the 5-hydroxytryptamine1receptor antagonist, BMY 7378, on 5-hydroxytryptamine neurotransmission: electrophysiological studies in the rat central nervous system. Journal of Pharmacology and Experimental Therapeutics 1988; 246: 359–370
   PubMed Web of Science ®Google Scholar
• Cherqui C., Dabire H., Fournier B., Schmitt H. Participation of sympathetic and vagal tones in the hypotensive and bradycardic effects of some 5-HT1-like receptor agonists in the rat. Archives Internationales de Pharmacodynamie et de Therapie (Ghent) 1988; 29(6)18–28
   Google Scholar
• Closse A. [3H]mesulergine, a selective ligand for serotonin-2 receptors. Life Sciences 1983; 32: 2485–2495
   PubMed Web of Science ®Google Scholar
• Colino A, Halliwell J. V. 8-OHDPAT is a strong antagonist of 5-HT action in rat hippocampus. European Journal of Pharmacology 1986; 130: 151–152
   PubMed Web of Science ®Google Scholar
• Cohen M. L., Fuller R. W. Antagonism of vascular serotonin receptors by m-chlorophenylpiperazine and m-trifluoromethylphenylpiperazine. Life Sciences 1983; 3(2)711–718
   Google Scholar
• Colpaert F. C., Koek W., Lategan A. European Journal of Pharmacology 1989; 169: 175–178
   PubMed Web of Science ®Google Scholar
• Colpaert F. C., Niemegeers C. J.E., Janssen P. A. J. A drug discrimination analysis of lysergic acid diethylamide (LSD):in vivoagaonist and antagonist effects of purported 5-hydroxytryptamine antagonists and of pirenperone, a LSD-antagonist. Journal of Pharmacology and Experimental Therapeutics 1982; 221: 206–214
   PubMed Web of Science ®Google Scholar
• Conn P. J., Sanders-Bush E. Serotonin-stimulated phosphoinositide turnover: mediation by the S2binding site in rat cerebral cortex but not in subcortical regions. Journal of Pharmacology and Experimental Therapeutics 1985; 23(4)195–203
   Google Scholar
• Conn P. J., Sanders-Bush E. Agonist induced phosphoinositide hydrolysis in choroid plexus. Journal of Neurochemistry 1986; 4(7)1754–1760
   Google Scholar
• Conn P. J., Sanders-Bush E. Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT-2 and 5-HT-1c) receptors. Journal of Pharmacology and Experimental Therapeutics 1987; 24(2)552–557
   Google Scholar
• Connor H. E., Taylor G., Fenuik W. BMY 7378: antagonist effects of functional 5-H1Areceptors. British Journal of Pharmacology 1989; 98: 862
   Google Scholar
• Costall B., Domeney A. M., Naylor R. J., Tyers M. B. Effects of the 5-HT3receptor antagonist, GR 38032F, on raised dopaminergic activity in the mesolimbic system of the rat and marmoset brain. British Journal of Pharmacology 1987; 92: 881–894
   PubMed Web of Science ®Google Scholar
• Crews F. T., Scott J. A., Shorsten N. H. Rapid down-regulation of serotonin2receptor binding during combined administration of tricyclic antidepressant drugs and α2antagonists. Neuropharmacology 1983; 2(2)1203–1209
   Google Scholar
• Cunningham D., Pople A., Ford H. T., Hawthorn J., Gazet J. C., Challoner T. Prevention of emesis in patients receiving cytotoxic drugs by GR38032F, a selective 5-HT3receptor antagonist. Lancet 1987; i: 1461–1462
   Google Scholar
• Dabire H., Cherqui C., Fournier B., Schmitt H. Comparison of effects of some 5HT1agonists on blood pressure and heart rate of normotensive anaesthetized rats. European Journal of Pharmacology 1987; 140: 259–266
   PubMed Web of Science ®Google Scholar
• Davies M., Wilkinson L. S., Robert M. H. T. Evidence for excitatory 5-HT2receptors on rat brainstem neurones. British Journal of Pharmacology 1988a; 9(4)483–491
   Google Scholar
• Davies M., Wilkinson L. S., Robert M. H. T. Evidence for depressant 5-HT1-like receptors on brainstem neurones. British Journal of Pharmacology 1988b; 9(4)492–499
   Google Scholar
• Defrance R., Marey C., Kamoun A. Antide-pressant and anxiolytic activities of tianeptine: and overvies of clinical trials. Clinical Neuropharmcology 1988; 11(Suppl. 2)S74–S82
   Google Scholar
• de Keyser J., Walraevens H., Convents A., Ebinger G., Vauquelin G. [3H]SCH23390 labels a novel 5-hydroxytryptamine binding site in human blood platelet membranes. European Journal of Pharmacology 1989; 16(2)437–445
   Google Scholar
• Derkach V., Surprenant A., North R. A. 5-HT3receptors are membrane ion channels. Nature 1989; 33(9)706–709
   Google Scholar
• Dickinson S. L., Curzon G. Roles of dopamine and 5-hydroxytryptamine in stereotyped and non-stereotyped behaviour. Neuropharmacology 1983; 2(2)805–812
   Google Scholar
• Dimpfel W., Spüler M., Nichols D. E. Hallucinogenic and stimulating amphetamine derivatives: fingerprinting DOM, DOI, DOB, MDMA, and MBDB by spectral analysis of brain field potentials in the freely moving rat (Tele-Stereo-EEG). Psychopharmacology 1989; 98: 297–303
   PubMed Web of Science ®Google Scholar
• Dourish C. T., Hutson P. H., Curzon G. Low doses of the putative serotonin agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) elicit feeding in the rat. Psychopharmacology 1985; 8(6)197–204
   Google Scholar
• Dourish C. T., Clark M. L., Iversen S. D. 8-OH-DPAT elicits feeding and not chewing: evidence from liquid diet studies and a diet choice test. Psycho-pharmacology 1988; 9(5)185–188
   Google Scholar
• Dumuis A., Sebben M., Bockaert J. BRL 24924: a potent agonist at a non-classical 5-HT receptor positively coupled with adenylate cyclase in colliculi neurons. European Journal of Pharmacology 1989; 16(2)381–384
   Google Scholar
• Eison A. S., Eison M. S., Stanley M., Riblet L. A. Serotonergic mechanisms in the behavioral effects of buspirone and gepirone. Pharmacology, Biochemistry and Behaviour 1986; 2(4)701–707
   Google Scholar
• Engel G., Göthert M., Hoyer D., Schilicker E., Hillenbrand K. Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1Bbinding sites. Naunyn-Schmiedeberg's Archives of Pharmacology 1986; 33(2)1–7
   Google Scholar
• Fargin A., Raymond J. R., Lohse M. J., Kobilka B. K., Caron M. G., Lefkowitz R. J. The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1Areceptor. Nature 1988; 33(5)358–360
   Google Scholar
• Fattaccini C. M., Bolaños-Jimenez F., Gozlan H., Hamon M. Tianeptine stimulates 5-hydroxytryptamine uptakein vivoin the rat brain. Neuropharmacology 1990; 29: 1–8
   PubMed Web of Science ®Google Scholar
• File S. E. Animal models for predicting efficacy of anxiolytic drugs: social behaviour. Neuropsychobiology 1985; 1(3)55–62
   Google Scholar
• File S. E., Johnston A. L. Lack of effects of 5HT3receptor antagonists in the social interaction and elevated plus-maze tests of anxiety in the rat. Psycho-pharmacology 1989; 9(9)248–251
   Google Scholar
• Fone K. C. F., Johnson J. V., Bennett G. W., Marsden C. A. Involvement of 5-HT2receptors in the behaviours produced by intrathecal administration of selected 5-HT agaonists and the TRH analogue (CG3509) to rats. British Journal of Pharmacology 1989; 9(6)599–608
   Google Scholar
• Fozard J. R., Mir A. K., Middlemiss D. N. The cardiovascular response to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the rat: site of action and pharmacological analysis. Journal of Cardiovascular Pharmacology 1987; 9: 328–347
   PubMed Web of Science ®Google Scholar
• Gaddum J. H. Antagonism between lysergic acid diethylamide and 5-hydroxytryptamine. Journal of Physiology 1953; 121: 15
   PubMed Web of Science ®Google Scholar
• Gaddum J. H. Serotonin-LSD interactions. Annals of the New York Academy of Sciences 1957; 6(6)643–647
   Google Scholar
• Gaddum J. H., Picarelli Z. P. Two kinds of tryptamine receptors. British Journal of Pharmacology 1957; 1(2)323–328
   Google Scholar
• Gandolfi O., Barbaccia M. L., Costa E. Different effects of serotonin antagonists on3H-mianserin and3H-ketanserin recognition sites. Life Sciences 1985; 3(6)713–721
   Google Scholar
• Garcha G. S., Smokcum R. W. J., Stephenson J. D., Weeramanthri T. B. Effects of some atypical antidepressants on β-adrenoceptor binding and adenylate cyclase in the rat forebrain. European Journal of Pharmacology 1985; 10(8)1–7
   Google Scholar
• Gardner C. R., Guy A. P. Pharmacological characterization of a modified social interaction model of anxiety in the rat. Neuropsychobiology 1985; 1(3)194–200
   Google Scholar
• Glennon R. A., Rosencrans J. A., Young R., Gaines J. Hallucinogens as discriminative stimuli: generalisation of DOM to a 5-methoxy-N,N-dimethyltryptamine stimulus. Life Sciences 1979; 24: 993–998
   PubMed Web of Science ®Google Scholar
• Glennon R. A., Young R., Rosencrans J. A. Antagonism of the effects of the hallucinogen DOM and the purported 5-HT agonist quipazine by 5-HT2antagonists. European Journal of Pharmacology 1983; 9(1)189–196
   Google Scholar
• Glennon R. A., Titeler M., McKenney J. D. Evidence for 5-HT2involvement in the mechanism of action of hallucinogenic agents. Life Sciences 1984; 3(5)2505–2511
   Google Scholar
• Glennon R. A., Pierson M. E., McKenney J. D. Stimulus generalization of 1-(3-trifluoromethylphenyl)piperazine (TFMPP) to propranolol, pindolol, and mesulergine. Pharmacology, Biochemistry and Behaviour 1988; 29: 197–199
   PubMed Web of Science ®Google Scholar
• Goodwin G. M. The effect of antidepressant treatments and lithium upon 5-HT1Areceptor function. Progress in Neuropsychopharmacology and Biological Psychiatry 1989; 13: 445–451
   PubMed Web of Science ®Google Scholar
• Goodwin G. M., Green A. R. A behavioural and biochemical study in mice and rats of putative selective agonists and antagonists for 5-HT1and 5-HT2receptors, British. Journal of Pharmacology 1985; 84: 743–753
   Google Scholar
• Goodwin G. M., de Souza R. J., Green A. R. Psychopharmacology 1987; 91: 506–511
   PubMed Web of Science ®Google Scholar
• Green A. R. 5-HT mediated behaviour: animal studies. Neuropharmacology 1984; 2(3)1521–1528
   Google Scholar
• Green A. R., O'Shaughnessy K., Hammond M., Schächter M., Grahame-smith D. G. Inhibition of 5-hydroxytryptamine-mediated behaviour by the putative 5-HT2antagonist pirenperone. Neuropharmacology 1983; 2(2)573–578
   Google Scholar
• Green A. R., Guy A. P., Gardner C. R. The behavioural effects of RU 24969, a suggested 5-HT1receptor agonist in rodents and the effects on the behaviour of treatments with antidepressants. Neuropharmacology 1984; 23: 655–661
   PubMed Web of Science ®Google Scholar
• Gudelsky G. A., Koenig J. I., Meltzer H. I. Thermoregulatory responses to serotonin (5HT) receptor stimulation in the rat: evidence for opposing roles of 5HT2and 5HT1Areceptors. Neuropharmacology 1986; 2(5)1307–1313
   Google Scholar
• Hall H, Wedel I. The effects of manipulation of presynaptic 5-HT nerve terminals on postsynaptic 5-HT1and 5-HT2binding sites of the rat brain. Journal of Neural Transmission 1985; 6(4)129–143
   Google Scholar
• Hamik A, Peroutka S. J. Differential intractions of traditional and novel antiemetics with dopamine D2 and 5-hydroxytryptamine 3 receptors. Cancer Chemotherapy and Pharmacology 1989; 2(4)307–310
   Google Scholar
• Herrick-Davis M., Titeler M. Detection and characterization of the serotonin 5-HT1Dreceptor in rat and human brain. Journal of Neurochemistry 1988; 50: 1624–1631
   PubMed Web of Science ®Google Scholar
• Hertting G., Axelrod J., Whitby L. G. Effects of drugs on the uptake and metabolism of [3H]-norepinephrine. Journal of Pharmacology and Experimental Therapeutics 1961; 13(4)146–153
   Google Scholar
• Heuring R. E., Peroutka S. J. Characterizetion of a novel3H-5-hydroxytryptamine binding site subtype in bovine brain membranes. Journal of Neurosciences 1987; 7: 894–903
   PubMed Web of Science ®Google Scholar
• Heym J, Jacobs B. L. Serotonergk mechanisms of hallucinogenic drug effects. Monographs in Neural Sciences 1987; 1(3)55–81
   Google Scholar
• Higgins G. A., Bradbury A. J., Jones B. J., Oakley N. R. Behavioural and biochemical consequences following activation of 5HT1-like and GABA receptors in the dorsal raphe nucleus of the rat. Neuropharmacology 1988; 2(7)993–1001
   Google Scholar
• Higgins G. A., Kilpatrick G. J., Bunce K. T., Jones B. J., Tyers M. B. 5-HT3receptor antagonists injected into the area postrema inhibit cisplatin-induced emesis in the ferret. British Journal of Pharmacology 1989; 9(7)247–255
   Google Scholar
• Hirschhorn I. D., Winter J. C. Mescaline and lysergic acid diethylamide (LSD) as discriminative stimuli. Psychopharmacology 1971; 2(2)64–71
   Google Scholar
• Hjorth S, Carlsson A. Buspirone: effects on central monoaminergic transmission—possible relevance to animal experiments and clinical findings. European Journal of Pharmacology 1982; 8(3)299–303
   Google Scholar
• Hjorth S, Carlsson A. Is pindolol a mixed agonist-antagonist at central serotonin (5-HT) receptors. European Journal of Pharmacology 1986; 12(9)131–138
   Google Scholar
• Hoyer D. Molecular pharmacology and biology of 5-HT1Creceptors. Trends in Pharmacological Sciences 1988a; 9: 89
   PubMed Web of Science ®Google Scholar
• Hoyer D. Functional correlates of serotonin 5-HT1recognition sites. Journal of Receptor Research 1988b; 8: 59–81
   PubMed Web of Science ®Google Scholar
• Hoyer D, Karpf A. [125I]SCH 23892, a ‘selective’ D-1 receptor antagonist, labels with high afinity 5-HT1Csites in pig choroid plexus. European Journal of Pharmacology 1988; 150: 181–184
   PubMed Web of Science ®Google Scholar
• Hoyer D, Neijt H. C. Identification of serotonin 5-HT3recognition sites by radioligand binding in NG108-15 neuroblastoma-glioma cells. European Journal of Pharmacology 1987; 14(3)291–292
   Google Scholar
• Hoyer D, Schoeffter P. 5-HT1Dreceptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in calf substantia nigra. European Journal of Pharmacology 1988; 14(7)145–147
   Google Scholar
• Hoyer D., Pazos A., Probst A., Palacios J. M. Serotonin receptors in the human brain. I. Characterization and autoradiographic localization of 5-HT1Arecognition sites: apparent absence of 5-HT1Brecognition sites. Brain Research 1986a; 37(6)85–96
   Google Scholar
• Hoyer D., Pazos A., Probst A., Palacios J. M. Biochemical effects and drug levels in rats after long-term treatment with the specific 5-HT-uptake inhibitor, citalopram. Psychopharmacology Serotonin receptors in the human brain. II. Characterization and autoradiographic localization of 5-HT_1Cand 5-HT₂recognition sites, apparent absence of 5-HT_1Brecognition sites. Brain Research 1986; 376: 97–107
   Google Scholar
• Hutson P. H., Donohoe T. P., Curzon G. Hypothermia induced by the putative 5-HT1Aagonists LY 165163 and 8-OH-DPAT is not prevented by 5-HT depletion. European Journal of Pharmacology 1987; 14(3)221–228
   Google Scholar
• Hutson P. H., Dourish C. T., Curzon G. Evidence that the hyperphagic response to 8-OH-DPAT is mediated by 5-HT1A receptors. European Journal of Pharmacology 1988a; 150: 361–366
   PubMed Web of Science ®Google Scholar
• Hutson P. H., Donohoe T. P., Curzon G. Infusion of the 5-hydroxytryptamine agonists RU24969 and TFMPP into the paraventricular nucleus of the hypothalamus causes hypophagia. Psychopharmacology 1988b; 9(5)550–552
   Google Scholar
• Hyttel J. SCH 23390—the first selective dopamine D-1 antagonist. European Journal of Pharmacology 1983; 9(1)153–154
   Google Scholar
• Hyttel J., Overo K. F., Arnt J. 83: 20–27
   Google Scholar
• Imperato A, Angelucci L. 5-HT3 receptors control dopamine release in the nucleus accumbens of freely moving rats. Neuroscience Letters 1989; 10(1)214–217
   Google Scholar
• Jacobs B. L. An animal behaviour model for studying central serotonergic synapses. Life Sciences 1976; 1(9)777–786
   Google Scholar
• Jenck F., Broekkamp C. L.E., van Delft A. M. L. Effects of serotonin receptor antagonists on PAG stimulation induced aversion: different contributions of 5-HT1, 5-HT2and 5-HT3receptors. Psychopharmacology 1984; 97: 489–495
   Google Scholar
• Johnson M. P., Hoffman A. J., Nichols D. E., Mathis C. A. Binding to the serotonin 5-HT2receptor by the enantiomers of [125I]DOI. Neuropharmacology 1987; 2(6)1803–1806
   Google Scholar
• Johnston A. L., File S. E. Effects of ligands for specific 5HT receptor sub-types in two animal tests of anxiety. Buspirone: a new introduction to the treatment of anxiety, M. H. Lader. RSM Services Ltd, London 1989; 31–41
   Google Scholar
• Jones B. J., Costall B., Domeney A. M., Kelly M. E., Naylor R. J., Oakley N. R., Tyers M. B. The potential anxiolytic activity of GR38032F, a 5-HT3receptor antagonist. British Journal of Pharmacology 1988; 93: 985–993
   PubMed Web of Science ®Google Scholar
• Julius D., MacDermott A. B., Axel R., Jessell T. M. Molecular characterization of a functional cDNA encoding the serotonin 1c receptor. Science 1988; 558–564
   PubMed Web of Science ®Google Scholar
• Kennett G. A., Dourish C T., Curzon G. 5-HT1Bagonists induce anorexia at a postsynaptic site. European Journal of Pharmacology 1987; 14(1)429–435
   Google Scholar
• Kennett G. A., Curzon G. Evidence that hypophagia induced by mCPP and TFMPP requires 5-HT1C and 5-HT1B receptors; hypophagia induced by RU 24969 only requires 5-HT1B receptors. Psychopharmcology 1988a; 9(6)93–100
   Google Scholar
• Kennett G. A., Curzon G. Evidence that mCPP may have behavioural effects mediated by 5-HT1Creceptors. British Journal of Pharmacology 1988b; 9(4)137–147
   Google Scholar
• Kennett G. A., Whitton P., Shah K., Curzon G. Anxiogenic-like effects of mCPP and TFMPP in animal models are opposed by 5-HT1Creceptor antagonists. European Journal of Pharmacology 1989; 16(4)445–454
   Google Scholar
• Kilpatrick G. J., Jones B. J., Tyers M. B. Identification and distribution of 5-HT3receptors in rat brain using radioligand binding. Nature 1987; 330: 746–748
   PubMed Web of Science ®Google Scholar
• Kilpatrick Jones G. B. J. J., Tyers M. B. The distribution of specific binding of the 5-HT3 receptor ligand [3H]GR65630 in rat brain using quantitative autoradiography. Neuroscience Letters 1988; 9(4)156–160
   Google Scholar
• Kilpatrick G. J., Jones B. J., Tyers M. B. Binding of the 5-HT3 ligand, [3H]GR65630, to rat area postrema, vagus nerve and the brains of several species. European Journal of Pharmacology 1988; 159: 157–164
   Web of Science ®Google Scholar
• Koshikawa N., Smokcum R. W.J., Stephenson J. D. Is waning of 5-hydroxytryptamine (5-HT)-mediated syndrome due to 5-HT2receptor down-regulation?. Neuroscience Letters 1989; 55: 279–282
   Google Scholar
• Koshikawa F., Koshikawa N., Stephenson J. D. Effects of antidepressant drug combinations on cortical 5-HT2receptors and wet-dog shakes in rats. European Journal of Pharmacology 1985a; 118: 273–281
   PubMed Web of Science ®Google Scholar
• Koshikawa N., Maruyama Y., Stephenson J. D. Production of wet-dog shakes in rats and down-regulation of spinal 5-HT2receptors. European Journal of Pharmacology 1989; 16(4)595–598
   Google Scholar
• Lambert J. J., Peters J. A., Hales T. G., Dempster J. The properties of 5-HT3 receptors in clonal cell lines studied by patch-clamp techniques. British Journal of Pharmacology 1989; 9(7)27–40
   Google Scholar
• Leonhardt S., Herrick-Davis K., Titeler M. Detection of a novel serotonin receptor subtype (5-HT1E) in human brain: interaction with a GTP-binding protein. Journal of Neurochemistry 1989; 5(3)465–471
   Google Scholar
• Leysen J. E., Niemegeers C. J. E., van Nueten J. M., Laduron P. M. [3H]Ketanserin, a selective3H-ligand for serotonin2receptor binding sites. Molecular Pharmacology 1985b; 21: 301–314
   Google Scholar
• Leysen J. E., van Gompel P., Gommeren W., Woestenborghs R., Janssen P. A. J. Down regulation of serotonin-S2receptor sites in rat brain by chronic treatment with the serotonin-S2antagonists: ritanserin and setoperone. Psychopharmacology 1986; 8(8)434–444
   Google Scholar
• Leysen J. E., Janssen P. F.M., Niemegeers C. J. E. Rapid desensitization and down-regulation of 5-HT2receptors by DOM treatment. European Journal of Pharmacology 1989; 16(3)145–149
   Google Scholar
• Lôo H., Benkalfat C., Galinowski A., Malka R. Les nouveaux antidépresseurs non IMAO. Psychological Medicine 1982; 8: 1221–1225
   Google Scholar
• Lucki I, Frazer A. Behavioural effects of indole and piperazine type serotonin receptor agonists. Society of Neurosciences Abstracts 1986; 8: 101
   Google Scholar
• Lucki I., Nobler M. S., Frazer A. Differential actions of serotonin antagonists on two behavioural models of serotonin receptor activation in the rat. Journal of Pharmacology and Experimental Therapeutics 1984; 22(8)133–139
   Google Scholar
• Lyon R. A., Davis K. H., Titeler M. 3H-DOB (4-bromo-2,5-dimethoxyphenylisopropylamine) labels a guanyl nucleotide sensitive state of cortical 5-HT2receptors. Molecular Pharmacology 1982; 31: 194–199
   Google Scholar
• Maj J., Chojnacka W.-E., Klodzinska A., Deren A., Moryl E. Hypothermia induced by m-trifluoro-methylphenylpiperazine or m-chlorphenylpiperazine: an effect mediated by 5-HT1B receptors?. Journal of Neural Transmission 1987; 73: 43–55
   Google Scholar
• Marszalec W, Anderson E. G. Three putative 5-HT1A agonists act as 5-HT antagonists in frog sensory neurons. European Journal of Pharmacology 1988; 15(4)325–328
   Google Scholar
• Maura G., Ulvi M., Raiteri M. (-)-Propanolol and (±)-cyanopindolol are mixed agonists-antagonists at serotonin autoreceptors in the hippocampus of the rat brain. Neuropharmacology 1987; 2(6)713–717
   Google Scholar
• May P. C., Morgan D. G., Finch C. E. Regional serotonin receptor studies: chronic methysergide-treatment induces a selective and dose-dependent decrease in serotonin-2 receptors. Life Sciences 1986; 3(8)1741–1747
   Google Scholar
• McKenna D. J., Nazarali A. J., Hoffman A. J., Nichols D. E., Mathis C. A., Saavedra J. M. Common receptors for hallucinogens in rat brain: a comparative autoradiographic study using [125I]LSD and [125I]DOI, a new psychotomimetic radioligand. Brain Research 1988; 476: 45–56
   Web of Science ®Google Scholar
• Mendelson S. D., Gorzalka B. B. A facilitatory role for serotonin in the sexual behavior of the female rat, Pharmacology. Biochemistry and Behaviour 1989; 22: 1025–1033
   Google Scholar
• Middlemiss D. N. 8-hydroxy-2-(di-n-propyl-amino)tetralin is devoid of activity at the 5-hydroxytryptamine autoreceptor in rat brain. Implications for the proposed link between the autoreceptor and the [3H]-5-HT recognition site. Naunyn Schmiedeberg's Archives of Pharmacology 1984; 32(7)18–22
   Google Scholar
• Middlemiss D. N., Fozard J. R. 8-Hydroxy-(di-n-propylamino)tetralin discriminates between subtypes of the 5-HT1recognition site. European Journal of Pharmcology 1983; 90: 151–153
   PubMed Web of Science ®Google Scholar
• Middlemiss D. N., Bremer M. E., Smith S. M. A pharmacological analysis of the 5-HT receptor mediating inhibition of 5-HT release in the guinea-pig frontal cortex. European Journal of Pharmacology 1988; 15(7)101–107
   Google Scholar
• Milburn C. M., Peroutka S. J. Characterization of [3H]quipazine binding to 5-hydroxytryptamine3 receptors in rat brain membranes. Journal of Neurochemistry 1989; 5(2)1787–1792
   Google Scholar
• Mishra R., Janowsky A., Sulser F. Action of mianserin and zimeldine on the norepinephrine receptor coupled adenylate cyclase system in brain: subsensitivity without reduction in β-adrenergic binding. Neuropharmacology 1980; 1(9)983–987
   Google Scholar
• Mocaër E., Rettori M. C., Kamoun A. Pharmacological antidepressive effects and tianeptine-induced 5-HT uptake increase. Clinical Neuropharmacology 1988; 11(Suppl. 2)S32–S42
   Google Scholar
• Moser P. C. An evaluation of the elevated plusmaze using the novel anxiolytic buspirone. Psychopharmacology 1989; 9(9)48–53
   Google Scholar
• Moser P. C., Hibert M., Middlemiss D. N., Mir A. K., Tricklebank M. D., Fozard J. R. Effects of MDL 730005EF in animal models predictive of anxiolytic activity. British Journal of Pharmacology 1988; 93: 3
   PubMedGoogle Scholar
• Murphy R. M., Zemlan F. P. Selective 5-HT1B agonists identify the 5-HT autoreceptor in lumbar spinal cord of rat. Neuropharmacology 1988; 2(7)37–42
   Google Scholar
• Nash J. F., Meltzer H. Y. Effect of gepirone and ipsapirone on the stimulated and unstimulated secretion of prolactin in the rat. Journal of Pharmacology and Experimental Therapeutics 1989; 24(9)236–241
   Google Scholar
• Neale R. V. F., Fallon S. L., Boyar W. C., Wasley J. W., Martin L. L., Stone G. A., Glaeser B. S., Sinton C. M., Williams M. Biochemical and pharmacological characterization of CGS 12066B, a selective serotonin-1B agonist. European Journal of Pharmacology 1985; 136: 1–9
   Web of Science ®Google Scholar
• Neill J. C., Cooper S. J. Evidence for serotonergic modulation of sucrose sham-feeding in the gastric-fistulated rat. Physiology and Behaviour 1988a; 4(4)453–459
   Google Scholar
• Neill J. C., Cooper S. J. MDL 72832, a selective 5-HT1A receptor ligand, stereospecifically increases food intake. European Journal of Pharmacology 1987; 151: 329–332
   Web of Science ®Google Scholar
• Nelson D. R., Thomas D. R. [3H]-BRL 43694 (Granisetron), a specific ligand for 5-HT3 binding sites in rat brain cortical membranes. Biochemical Pharmacology 1988b; 38: 1693–1695
   Web of Science ®Google Scholar
• Nicoletti F., Meek J. L., Iadorala M. J., Chuang D.-M., Roth B. L., Costa E. Coupling of inositol phospholipid metabolism with excitatory amino acid recognition sites in rat hippocampus. Journal of Neurochemistry 1986; 4(6)40–46
   Google Scholar
• Offord S. J., Ordway G. A., Frazer A. Application of [125I]iodocyanopindolol to measure 5-hydroxytryptamine1B receptors in the brain of the rat. Journal of Pharmacology and Experimental Therapeutics 1988; 24(4)144–153
   Google Scholar
• Oksenberg D, Peroutka S. J. Antagonism of 5-hydroxytryptamine1A(5-HT1A) receptor-mediated modulation of adenylate cyclase activity by pindolol and propranolol isomers. Biochemical Pharmacology 1989; 37: 3429–3433
   Web of Science ®Google Scholar
• Pazos A., Hoyer D., Palacios J. M. The binding of serotonergic ligands to the porcine choroid plexus: characterisation of a new type of serotonin recognition site. European Journal of Pharmacology 1984; 10(6)539–546
   Google Scholar
• Pazos A, Palacios J. M. Quantitative auto-radiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Research 1985; 34(6)205–230
   Google Scholar
• Pazos A., Cortés R., Palacios J. M. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors. Brain Research 1985; 34(6)231–249
   Google Scholar
• Pazos A., Probst A., Palacios J. M. Serotonin receptors in the human brain. IV. Autoradiographic mapping of serotonin-2 receptors. Neuroscience 1987; 2(1)123–139
   Google Scholar
• Pedigo N. W., Yamamura H. I., Nelson D. L. Discrimination of multiple [3H]5-hydroxytryptamine binding sites by the neuroleptic spiperone in rat brain. Journal of Neurochemistry 1981; 3(6)220–226
   Google Scholar
• Peroutka S. J. Species variations in 5-HT3 recognition sites labeled by 3H-quipazine in the central nervous system. Naunyn-Schmiedeberg's Archives of Pharmacology 1988; 338: 472–475
   PubMed Web of Science ®Google Scholar
• Peroutka S. J., Snyder S. H. Multiple serotonin receptors: differential binding of3H-serotonin3H-lysergic acid diethylamide and3H-spiroperidol. Molecular Pharmacology 1979; 1(6)687–699
   Google Scholar
• Peroutka S. J., Snyder S. H. Long-term antidepressant treatment decreases [3H]-spiroperidol-labeled serotonin receptor binding. Science 1980; 210: 88–90
   PubMed Web of Science ®Google Scholar
• Peroutka S. J., Snyder S. H. Multiple serotonin receptors and their physiological significance. Federation Proceedings 1983; 4(2)213–217
   Google Scholar
• Pierce P. A., Peroutka S. J. Hallucinogenic drug interactions with neurotransmitter receptor binding sites in human cortex. Psychopharmacology 1989; 9(7)118–122
   Google Scholar
• Piper D., Upton N., Thomas D., Nicholass J. The effects of the 5-HT3antagonists BRL 43694 and GR 38032F in animal behavioural models of anxiety. British Journal of Pharmacology 1988; 94: 314
   Web of Science ®Google Scholar
• Reiser G, Hamprecht B. Serotonin raises the cyclic GMP level in a neuronal cell line via 5-HT3 receptors. European Journal of Pharmacology 1989; 17(2)195–198
   Google Scholar
• Ross S. B., Renyi A. L. Inhibition of the uptake of tritiated 5-HT in brain tissue. European Journal of Pharmacology 1988; 4: 270–277
   Google Scholar
• Roth B. L., Chuang D.-M. Multiple mechanisms of serotonergic signal induction. Life Sciences 1987; 4(1)1051–1064
   Google Scholar
• Sanders-bush E., Breeding M., Knoth K., Tsutsumi M. Sertraline-induced desensitization of the serotonin 5HT-2 receptor transmembrane signaling system. Psychopharmacology 1989; 9(9)64–69
   Google Scholar
• Schuurman T, Spencer D. G. Behavioural effects of the 5-hydroxytryptamine 1a-receptor ligand ipsapirone TVX-Q-7821, a comparison with 8-hydroxy-2-di-N-propylaminotetralin and diazepam. Psychopharmacology 1969; 89: S54
   Google Scholar
• Segawa T, Uehara M. Effects of methiothepin on imipramine- or mianserin-induced subsensitivity of serotonergic receptors. Life Sciences 1982; 30: 809–812
   PubMed Web of Science ®Google Scholar
• Segawa T., Mizuta T., Nomura Y. Modifications of central 5-hydroxytryptamine binding sites in synaptic membranes from rat brain after long-term administration of tricyclic antidepressants. European Journal of Pharmacology 1979; 5(8)75–83
   Google Scholar
• Sharp T., Bramwell S. R., Grahame-smith D. G. 5-HT1 agonists reduce 5-hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysis. British Journal of Pharmacology 1989; 9(6)283–290
   Google Scholar
• Sigg E. B. Pharmacological studies with Torranil. Canadian Psychiatric Association Journal 1987; 4(Suppl.)S75–S85
   Google Scholar
• Sills M. A., Wolfe B. B., Frazer A. Determination of selective and non-selective compounds for the 5-HT1Aand 5-HT1Breceptor subtypes in rat frontal cortex. Journal of Pharmacology and Experimental Therapeutics 1984; 23(1)480–487
   Google Scholar
• Silverman P. B., Ho B. T. Stimulus properties of DOM: commonality with other hallucinogens. Stimulus Properties of Drugs: Ten Years of Progress, F. C. Colpaert, J. A. Rosecrans. Elsevier, Amsterdam 1959; 189–198
   Google Scholar
• Simansky K. J., Schecter L. E. Properties of some 1-arylpiperazines as antagonists of stereotyped behaviors mediated by central serotonergic receptors in rodents. Journal of Pharmacology and Experimental Therapeutics 1988; 24(7)1073–1081
   Google Scholar
• Sinton C. M., Fallon S. L. Electrophysiological evidence for a functional differentiation between subtypes of the 5-HT1 receptor. European Journal of Pharmacology 1988; 15(7)173–181
   Google Scholar
• Smith W. L., Callahan E. M., Alphin R. S. The emetic activity of centrally administered cisplatin in cats and its antagonism by zacopride. Journal of Pharmacy and Pharmacology 1988; 40: 142–143
   PubMed Web of Science ®Google Scholar
• Sprouse J. S., Aghajanian G. K. (-)-Propranolol blocks the inhibition of serotonergic dorsal raphé cell firing by 5-HT1Aselective agonists. European Journal of Pharmacology 1986; 12(8)295–298
   Google Scholar
• Sprouse J. S., Aghajanian G. K. Electro-physiological responses of serotonergic dorsal raphé neurons to 5-HT1Aand 5-HT1Bagonists. Synapse 1978; 1: 3–9
   Google Scholar
• Stables R., Andrews P. L. R., Baily H. E., Costall B., Gunning S. J., Hawthorn J., Naylor R. J., Tyers M. B. Anti-emetic properties of the 5-HT3antagonist, GR38032F. Cancer Treatment Reviews 1987; 14: 333–336
   PubMed Web of Science ®Google Scholar
• Taylor D. P., Allen L. E., Ashworth E. M., Becker J. A., Hyslop D. K., Riblet L. A. Treatment with trazadone plus phenoxybenzamine accelerates development of decreased type 2 serotonin binding in rat cortex. Neuropharmacology 1981; 20: 513–516
   PubMed Web of Science ®Google Scholar
• Titeler M., Herrick K., Lyon R. A., McKenney J. D., Glennon R. A. [3H]DOP: a specific agonist radioligand for 5-HT2receptors. European Journal of Pharmacology 1985; 11(7)145–146
   Google Scholar
• Titeler M., Lyon R. A., Glennon R. A. Radioligand binding evidence implicates the brain 5-HT2receptor as a site of action for LSD and phenyliso-propylamine halluncinogens. Psychopharmacology 1988; 9(4)213–216
   Google Scholar
• Tricklebank M. D., Forler C., Fozard J. R. The involvement of subtypes of the 5-HT1receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat. European Journal of Pharmacology 1984; 10(6)271–282
   Google Scholar
• Tricklebank M. D., Forler C., Middlemiss D. N., Fozard J. R. Subtypes of the 5-HT receptor mediating the behavioural responses to 5-methoxy-N,N-dimethyltryptamine in the rat. European Journal of Pharmacology 1987; 117: 15–24
   Web of Science ®Google Scholar
• Tricklebank M. D., Middlemiss D. N., Neill J. Pharmacological analysis of the behavioural and thermoregulatory effcts of the putative 5-HT1receptor agonist, RU 24969 in the rat. Neuropharmacology 1985; 25: 877–886
   Web of Science ®Google Scholar
• Trulson M. E., Keltch G. F. Development of tolerance to repeated administration of 5-methoxy-N,N-dimethyltryptamine in rats. European Journal of Pharmacology 1986; 108: 33–37
   Web of Science ®Google Scholar
• Trulson M. E., Preussler D. W., Trulson V. M. Differential effects of hallucinogenic drugs on the activity of serotonin-containing neurons in the nucleus centralis superior and nucleus raphé pallidus in freely moving cats. Journal of Pharmacology and Experimental Therapeutics 1984; 22(8)94–102
   Google Scholar
• Waddington J. L., Crow T. J. Rotational responses to serotonergic and dopaminergic agonists after unilateral dihydroxytryptamin lesions of the median forebrain bundle: co-operative interactions of serotonin and dopamine in neostriatum. Life Sciences 1979; 2(5)1307–1314
   Google Scholar
• Waeber C., Dietl M. M., Hoyer D., Probst A., Palacios J. M. Visualization of a novel serotonergic recognition site (5-HT1D) in the human brain by autoradiography. Neuroscience Letters 1988; 8(8)11–16
   Google Scholar
• Waldmeier P. C., Delina-stula A. A. Serotonin-dopamine interactions in the nigrostriatal system. European Journal of Pharmacology 1979; 5(5)363–373
   Google Scholar
• White F. J., Appel J. B. A neuropharmacological analysis of the discriminative stimulus properties of fenfluramine. Psychopharmacology 1981; 7(3)110–115
   Google Scholar
• Willner P. Antidepressants and sertotonergic neurotransmission: an integrative review. Psychopharmacology 1985; 8(5)387–404
   Google Scholar
• Wouters W., Tulp M, Th M., Bevan P. Flesinoxan lowers blood pressure and heart rate in cats via 5-HT1Areceptors. European Journal of Pharmacology 1988; 14(9)213–223
   Google Scholar
• Wright I. K., Garratt J. C., Marsden C. A. Effects of a selective 5-HT2agonist, DOI, on 5-HT neuronal firing in the dorsal raphé nucleus and 5-HT release and metabolism in the frontal cortex. British Journal of Pharmacology 1985; 99: 221–222
   Google Scholar
• Yagaloff K. A., Hartig P. R. 125I-Lysergic acid diethylamide binds to a novel serotonergic site on rat choroid plexus epithelial cells. Journal of Neuroscience 1990; 5: 3178–3183
   Google Scholar
• Yakel J. L., Jackson M. B. 5-HT3receptors mediate rapid responses in cultured hippocampus and a clonal cell line. Neuron 1985; 1: 615–621
   Google Scholar
• Yamada J., Sugimoto Y., Horisaka K. The behavioural effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in mice. European Journal of Pharmacology 1988; 15(4)299–304
   Google Scholar
• Yap C. Y., Taylor D. A. Involvement of 5-HT2receptors in the wet-dog shake behaviour induced by 5-hydroxytryptophan in the rat. Neuropharmacology 1983; 2(2)801–804
   Google Scholar
• Yocca F. D., Hyslop D. K., Smith D. W., Maayani S. BMY 7378, a buspirone analog with high affinity, selectivity, and low intrinsic activity at the 5-HT1Areceptor in rat and guinea pig hippocampal membranes. European Journal of Pharmacology 1988; 137: 293–294
   Web of Science ®Google Scholar