8
Views
1
CrossRef citations to date
0
Altmetric
Original Article

Biological markers of serotonin receptors in depression and animal models of depression

Pages 69-83 | Published online: 11 Jul 2009

References

  • Aghajanian G.K., de Montigny C. Tricyclic antidepressants: Long term treatment increases responsivity of rat forebrain neurons to serotonin. Science 1978; 202: 1303–1306
  • Agren H., Mefford I.N., Rudorfer M.V., et al. Interacting neurotransmitter systems. Journal of Psychiatric Research 1986; 20: 175–193
  • Arora R.C., Meltzer H.Y. Serotonin uptake by blood platelets by schizophrenic patients. Psychiatric Research 1982; 6: 327
  • Arora R.C., Meltzer H.Y. Serotonergic measures in brains of suicide victims: 5-HT2 binding sites in the frontal cortex of suicide victims and control subjects. American Journal of Psychiatry 1989; 146: 730–736
  • Arora R.C., Meltzer H.Y. Laterality and 3H-imipramine binding: studies in the frontal cortex of normal controls and suicide victims. Biological Psychiatry 1991; 29: 1016–1022
  • Ayd F.J., Blackwell B. Discoveries in Biological Psychiatry. Lippincot, Philadelphia 1970
  • Bayer S.M., McCoy E.E. A comparison of the 5-HT and ATP content in platelets from subjects with Down Syndrome. Biochemical Medicine 1974; 9: 225
  • Bizot J.C., Thebot M.H., Puech A.J. Effects of 5-HT-related drugs on waiting behaviour in rats. Psychopharmacology 1988; 96: 55
  • Blier P., Chaput Y., de Montigny C. Long term 5-HT reuptake blockade but not monoamine oxidase inhibition decreases the function of terminal 5-HT autoreceptors: an electrophysiological study in the rat brain. Naunyn Schmieldeberg's Archives of Pharmacology 1988; 337: 246–254
  • Blier P., de Montigny C., Chaput Y. A role for die serotonin systems in the mechanism of action of antidepressants. Journal of Clinical Psychiatry 1990; 51(suppl. 4)14–20
  • Bocknik S.E., Kulkarnia A.A. Effects of a decarboxylase inhibitor (R04–4602) on 5-HTP induced muricide blockade in rats. Neuropharmacology 1974; 13: 279–87
  • Boullin D.J., O'Brien P.A.M. Characterization of receptor mediating 5-HT and catecholamine induced platelet aggregation by alpha and beta blockers, butyrophenones, 5-HT antagonists and chlorpromazine. British Journal of Pharmacology 1971; 62: 537
  • Braddock L.E., Cowen P.J., Eliott J.M., Fraser S., Stamp K. Changes in the binding to platelets of 3H-imipramine and 3H-yohimbine in normal subjects taking amitriptyline. Neuropharmacology 1984; 23: 285
  • Briley M.S., Langer S.Z., Raisman R., Sechter D., Zarihan E. 3H-imipramine binding sites are decreased on platelets of untreated depressed patients. Science 1980; 303: 1209
  • Broekkamp C.L., Garrigon D., Lloyd K.G. Serotonin-mimetic and antidepressant drugs on passive avoidance learning by olfactory bulbectomized rats. Pharmacology Biochemistry of Behaviour 1980; 13: 643–649
  • Brunello N., Voltera A., Cagiano R., et al. Biochemical and behavioral changes in rats after prolonged treatment with desipramine: interaction with p-chlorophenylalanine. Naunyn Schmiedeberg's Archives of Pharmacology 1985; 331: 20–22
  • Brusov O.S., Beliaeve B.S., Katasonov A.B., Zlobina G.P., Factor M.I., Lideman R.R. Does platelet serotonin receptor supersensitivity accompany endogenous depression?. Biological Psychiatry 1989; 25: 375
  • Burnstein K.L., Cidlowski J.A. Regulation of gene expression by glucocorticoids. Annual Review of Physiology 1989; 51: 683–699
  • Butler J., Tannian M., Leonard B.E. The chronic effects of desipramine and sertraline on platelet and synaptosomal 5-HT uptake in olfactory bulbectomized rats. Progress in Neuro-Psychopharmacology and Biological Psychiatry 1988; 12: 585–594
  • Cairncross K.D., Cox B., Forster C., Wren A.F. Olfactory projection system, drugs and behaviour a review. Psychoneuroendocrinology 1979; 4: 253–73
  • Chaput Y., Blier P., de Montigny C. In vivo electrophysiological evidence for die regulatory role of autoreceptors on serotongeric terminals. Journal of Neuroscience 1986; 6: 2796–2801
  • Charney D.S., Southwick S.M., Delgado P.L., . Current status of the receptor sensitivity hypothesis of antidepressant action. Pharmacotherapy of Depression, J.D. Amsterdam, et al. Marcel Dekker, New York, NY 1990
  • Coppen A. The biochemistry of affective disorders. British Journal of Psychiatry 1967; 133: 1237–1264
  • Coppen A., Swade C., Wood K. Platelet 5-hydroxytryptamine accumulation in depressive illness. Clinica Chimica Acta 1978; 87: 165
  • Davis A. Molecular aspects of the imipramine receptor. Experientia 1984; 40: 782
  • Deakin J.F.W., Guimaraes F.S., Wang M., Hensman R. Experimental tests of the 5-HT receptor imbalance theory of affective disorders. 5-Hydroxytryptamine In Psychiatry, M. Sandler, A. Coppen, S. Harnetts. Oxford Medical Publications, Oxford 1991
  • De Montigny C., Chaput Y., Buer P. Long term tricyclic and electroconvulsive treatment increases responsiveness of dorsal hippocampus 5-HTIA receptors: an electrophysiological study. Society of Neuroscience Abstracts 1989; 15: 854
  • De Montigny C., Chaput Y., Buer P. Modification of serotonergic neuron properties by long-term treatment with serotonin reuptake blockers. Journal of Clinical Psychiatry 1990; 51(Suppl. B)4–8
  • De Montigny C., Chaput Y., Buer P. Classical and novel targets of antidepressant drugs. New Pharmacological Approaches to the Therapy of Depressive Disorders, J. Mendlewicz, N. Brunello, S.Z. Langer, G. Racagni. Karger, Basel 1993
  • Dinan T.G. Glucocorticoids and the genesis of depressive illness. A psychobiological model. British Journal of Psychiatry 1994; 164: 365–371
  • Dray A., Gonge T.J., Oakley N.R. Evidence for the existence of a raphe projection to the substantia nigra in rat. Brain Research 1976; 113: 45–57
  • Earley B., Glennon M., Lally M., et al. Autoradiographic distribution of cholinergic muscarinic receptors in olfactory bulbectomized rat after chronic treatment with mianserin and desipramine. Proceedings of the Society for Neuroscience Abstracts No. 1. 1990
  • Eisenstein N., Iorid L.C., Cody D.E. Role of serotonin in the blockade of muricidal behaviour by tricyclic antidepressants. Pharmacology Biochemistry and Behavior 1982; 17: 847–9
  • Emrich H.M., Hollt V., Kissling W., et al. Beta endorphin-like immunoreactivity in cerebrospinal fluid and plasma of patients with schizophrenia and other neuropsychiatric disorders. Pharmacopsychiatry 1979; 2: 269–276
  • Everett G.M., Toman T.E.O. Mode of action of Rauwolfia Serpentina alkloids and motor activity. Biological Psychiatry, J. Massermann. Grune and Stratton, New York 1959
  • Finberg J.P.M., Tal A. Reduced peripheral pre-synaptic adrenoceptor sensitivity following chronic antidepressant treatment in rats. British Journal of Pharmacology 1985; 84: 609
  • Galzin A.M., Poirier M-F., Loo H., Sechter D., Zarifian E., Langer S.Z. 3H-paroxetine binding from healthy volunteers and depressed patients. British Journal of Pharmacology 1988; 93: 12
  • Gay C., Langer S.Z., Loo H., Raisman R., Sechter D., Zarifan E. 3H-imipramine binding to platelets: A state dependent or independent biological markers. British Journal of Pharmacology 1983; 78: 57
  • Gibbons J.L., Glusman M. Effects of quipazine, fluoxetine and fenfluramine on muricide in rats. Federation Proceedings of the Society for Experimentaql Biology 1978; 39: 257
  • Giller G.L., Yehuda R., O'Loughun M. Lymphocyte glucocorticoid receptors in PTSD, major depression, panic and schizophrenia. Proceedings of the American College of Neuropsychopharmacology. 1988; 179
  • Goodwin G.M., De Sousa R.J., Green A.R. Presynaptic serotonin receptor mediated response in mice attenuated by antidepressant drugs and electroconvulsive shock. Nature 1985; 317: 531–533
  • Gravel P., de Montigny C. Noradrenergic denervation prevents sensitization of rat forebrain neurons to serotonin by tricyclic antidepressant treatment. Synapse 1987; 1: 233–239
  • Hamon M., Emerit M.B., Mestikaws S., . Pharmacological, biochemical and functional properties of 5-HTIA binding sites labelled by 8-OH-DPAT in the rat brain. Brain 5-HTIA receptors, C.T. Dourish, S. Ahlenius, P.H. Hudson, et al. Ellis Horwood, Chichester 1987
  • Hannin I., Usdin E. Animal Models in Psychiatry and Neurology. Pergammon Press, Oxford 1977
  • Harfstand A., Fuxe K., Cintra A. Glucocorticoid receptor immunoreactivity in monoamine neurons of rat brain. Proceedings of the National Academy of Science USA 1986; 83: 9779–9783
  • Healy D., Carney P.A., Leonard B.E. Monoamine related markers of depression. Journal of Psychiatric Research 1983; 17: 251–258
  • Healy D., Carney P.A., O'Halloran A., Leonard B.E. Peripheral adrenoceptors and serotonin receptors in depression. Journal of Affective Disorders 1985; 17: 285–292
  • Healy D., O'Halloran A., Carney P.A., Leonard B.E. Peripheral adrenoceptors and serotonin receptors in depression. Journal of Psychiatric Research 1985; 20: 345
  • Hong K.W., Rion B.Y., Lee W.S. Enhancement of central and peripheral alpha T adrenoceptors sensitivity and reduction in alpha 2 adrenoceptor sensitivity following chronic imipramine treatment in rats. European Journal of Pharmacology 1986; 29: 275
  • Hrdina P.D. Differences between sodium dependent and desipramine denned 3H-imipramine binding intact human platelets. Biological Psychiatry 1989; 25: 576
  • Hyttel J. Pharmacological characterization of selective serotonin re-uptake inhibitors (SSRI's). International Journal of Psychopharmacology 1994; 9(Suppl. 1)19–26
  • Johnson A.M. The comparative pharmacological properties of selective serotonin re-uptake inhibition in animals. Perspectives in Psychiatry, J.P. Feighner, W.F. Boyer. John Wiley, & Sons, Chichester 1991; vol. 1: 37–70
  • Kendall D.A., Nahorski S.R. 5-Hydroxy-tryptamine stimulates inositol phospholipid hydrolysis in rat cerebral cortex slices: Pharmacological characterization and effects of antidepressants. Journal of Pharmacology and Experimental Therapeutics 1985; 23: 473–484
  • Kitayama I., Cintra A.M., Fuxe K., et al. Effects of chronic imipramine treatment on glucocorticoid receptor immunoreactivity in various regions of the rat brain. Journal of Neural Transmission 1988; 73: 191–203
  • Langer S.Z., Shoemaker H. Effects of antidepressants on monoamine transporters. Progress in Neuropsychopharmacology and Biological Psychiatry 1988; 12: 193
  • Lapin I.P., Oxenkrug G.F. Intensification of central serotonergic processes as a possible determinant of the thymoleptic effect. Lancet 1969; i: 132–136
  • Lawrence K.M., De Paermentier F., Cheetha S.C., Crompton M.R., Katorna C.L., Horton R.W. Brain 5-HT uptake sites labelled with 3H-paroxetine in post-mortem samples from depressed suicide victims. British Journal of Pharmacology 1989; 98: 812
  • Leonard B.E. The comparative pharmacology of new antidepressants. Journal of Clinical Psychiatry 1993; 54: 3–15, Suppl
  • Leonard B.E. Second generation antidepressants: chemical diversity but unity of action?. Psychopharmacology of Depression, S.A. Montgomery, T.H. Corn. Oxford University Press, Oxford 1994a
  • Leonard B.E. Serotonin receptors—where are they going?. International Clinical Psychopharmacology 1994b; 9(Suppl. 1)7–18
  • Leysen J.E., Awontere F., Kennis L., et al. Receptor binding profile of R 414681, a novel antagonist at 5-HT2 receptors. Life Science 1981; 20: 1015–1018
  • Linnoila M., Virkkunen M. Monoamines, glucose metabolism and impulse control. 5-hydroxytryptamine in Psychiatry—a spectrum of ideas, M. Sandler, A. Coppen, S. Harnetts. Oxford University Press, Oxford 1991
  • McAdams C., Colohan F.J., Brophy J., Leonard B.E. Alteration by a plasma factor of platelet aggregation and 5-HT uptake in depression. Biological Psychiatry 1992; 32: 296
  • McLean D.R., Nihei T. Uptake of dopamine and 5-hydroxytryptamine by platelets from patients with Huntington's chorea. Lancet 1977; 1: 249
  • Marek G.J., Li A., Serden L.S. Selective 5-hydroxytryptamine 2 antagonists have antidepressant like effects on differential-reinforcement of low rate 72-s schedule. Journal of Pharmacological Experimental Therapy 1989; 250: 60–68
  • Martin P., Soubrie P., Simon P. Shuttle-box deficits induced by inescapable shocks in rats: reversal by the beta-adrenoceptor stimulants clenbuterol and salbutamol. Pharmacology, Biochemistry and Behavior 1986; 24: 177–181
  • Modai I., Apter A., Meltzer M., Tyano S., Walevski A., Jerushalm Z. Serotonin uptake by platelets of suicidal and aggressive adolescent psychiatric in-patients. Neuropsychobiology 1989; 21: 9
  • Nelson D.R., Palmer K.J., Johnson A.M. Pharmacological effects of paroxetine after repeated administration to animals. Acta Psychiatrica Scandinavia 1989; 80(Suppl. 350)21–23
  • Nestler E.J., Walaas S.T., Greengard P. Neuronal phosphoproteins: physiological and clinical implications. Science 1984; 225: 1357–1364
  • Ogren S.O., Fuxe K. Effects of antidepressant drugs on cerebral serotonin receptors. Neuropharmacology of Serotonin, A.R. Green. Oxford University Press, Oxford 1985
  • Oswald I., Brezinova V., Funleavy D.L. On the slowness of action of tricyclic antidepressants. British Journal of Psychiatry 1972; 120: 673–677
  • Paul S.M. Serotonin uptake sites in platelets and human brain: clinical implications. Proceedings of the Regional Symposium World Psychiatric Association. Copenhagen 1986, Abstract No. 293
  • Paul S.M., Rehavi M., Skolnick P. Demonstration of specific “high affinity” binding sites for 3H-imipramine on human platelets. Life Science 1980; 26: 953
  • Paul S.M., Rehavi M., Skolnick P., Ballenger J.C., Goodwin F.K. Depressed patients have decreased binding of 3HT-imipramine to the platelet serotonin transporter. Archives of General Psychiatry 1981; 38: 1315
  • Pepin M.C., Beauluin S., Bardin N. Antidepressants regulate glucocorticoid receptor messenger RNA concentration in primary neuronal cultures. Molecular Brain Research 1989; 6: 77–83
  • Peroutka S.J., Snyder S.H. Long-term antidepressant treatment decreases spiroperidol-labelled serotonin receptor binding. Science 1980; 210: 88–90
  • Pinder R.M., Wieringa J.H. Third-generation antidepressants. Medical Research Reviews 1993; 13: 259–325
  • Poirier M.F., Glazin A.M., Loo H., Pimoule C., Segonacxz A., Benkeflat C., Sechter D., Carifian E., Schoemaker H., Langer S.Z. Changes in 3H-5-HT uptake and 3H imipramine binding in platelets after clomipramine in healthy volunteers: Comparison with maprotiline and amitriptyline. Biological Psychiatry 1987; 22: 287
  • Porsolt R.D., Anton G., Blavet N., Jalfre M. Behavioural despair in rats: a new model sensitive to antidepressant treatments. European Journal of Pharmacology 1978; 47: 379–85
  • Porsolt R.D., Chermat R., Siman P., Stern L. The tail suspension test: computerized device for evaluating psychotropic activity profile. Psychopharmacology 1986; 89: 528
  • Porsolt R.D., Lenegre A., McArthur R.A. Pharmacological models of depression. Animal Models of Depression in Psychopharmacology, B. Olivier, J. Mos, T.L. Slangen. Birkhanser, Basel 1991
  • Racagni G., Tinelu D., Bianchi E., . cAMP-dependent binding proteins and endogenous phosphorylation after anti-depressant treatment. 5-Hydroxytryptamine in Psychiatry, M. Sandler, A. Copper, S. Harnett, et al. Medical Publications, Oxford 1991; 116–123
  • Raisman R., Sette M., Pinnoule C., Brilely M., Langer S.Z. High affinity 3H-desipramine binding in the peripheral and central nervous system: a specific site associated with the neuronal uptake of noradrenaline. European Journal of Pharmacology 1982; 78: 345–351
  • Rehavi M., Sokolovsky M. Multiple binding sites of tricyclic antidepressants to mammalian brain receptors. Brain Research 1978; 149: 525
  • Rehavi M., Skolnick P., Hulihan B., Paul S.M. High affinity binding of 3H-desipramine to rat cerebral cortex: Relationship to tricyclic antidepressant induced inhibition of noradrenaline uptake. European Journal of Pharmacology 1981; 70: 597
  • Rehavi M., Skolnick P., Brownstein M.J., Paul S.M. High affinity binding of 3H-desipramine to rat brain: A pre-synaptic marker for NA uptake sites. Journal of Neurochemistry 1982; 38: 899
  • Rehavi M., Sepcuti H., Weizman A. Upregulation of imipramine binding and serotonin uptake by estradiol in female rat brain. Brain Research 1987; 410: 135
  • Richardson J.S. The olfactory bulbectomized rat as a model of major depressive disorder. Neuromethods Vol 19, Animal models in Psychiatry II, A. Boulton, G. Baker, M. Martin-Iverson. The Humana Press Inc, New Jersey 1991
  • Richelson E. Antidepressants and brain neurochemistry. Mayo Clinic Proceedings 1990; 65: 1227–1236
  • Sanders-Bush E., Breeding M., Knoth K., et al. Sertraline-induced desensitization of the serotonin 5-HT2 receptors transmembrane signalling system. Psychopharmacology 1989; 99: 64–69
  • Schildkraut J.J. The catecholamine hypothesis of affective disorders, a review of supporting evidence. American Journal of Psychiatry 1965; 122: 413–418
  • Scheffel V., Hartig P.R. In vitro labelling of serotonin uptake sites with 3H-paroxetine. Journal of Neurochemistry 1989; 52: 1602–1605
  • Seligman M.E.P. Helplessness. Freeman, San Francisco 1975
  • Sheard M. The effect of p-chlorophenylamine on behaviour of rats: relation to brain serotonin and 5-hydroxyindoleacetic acid. Brain Research 1969; 15: 524–8
  • Sherman A.D., Sacquitne J.L., Petty F. Specificity of die learned helpless model of depression. Pharmacology, Biochemistry, & Behavior 1982; 16: 449–454
  • Stanley M., Mann J.J. Increased Serotonin 2 binding sites in frontal cortex of suicide victims. Lancet 1983; 1: 214–216
  • Stockmeier C.A., Keller K.J. In vivo regulation of the serotonin 2 receptor in rat brain. Life Science 1986; 38: 117–127
  • Stolz J.F., Marsden C.A., Middlemiss D.M. Effect of chronic antidepressant treatment and subsequent withdrawal on 3H-5-HT and 3H-spiperone binding in rat frontal cortex and serotonin mediated behaviour. Psychopharmacology 1983; 80: 150–155
  • Strobel G.H., Calixto J.B., Ballejo G. Decreased GABA modulatory effect on rat vas deferens neurotransmission after chronic administration of imipramine. Cell Molecular Neurobiology 1989; 9: 469
  • Sulser F., Sanders-Bush E. The serotonin norepinephrine link hypothesis of affective disorders: receptor interactions in the brain. Molecular Basis of Neuronal Responsiveness, R.H. Erlich, E. Lennox, E. Kornecki, et al. Plenum, New York, NY 1987
  • Suranyi-Cadotte B.E., Wood P.L., Nair N.P., Schwartz G. Normalization of platelet 3H-imipramine binding in depressed patients during revision. European Journal of Pharmacology 1982; 85: 357
  • Tang S.W., Cheung S., Strijewski A., Chudzik J., Helmeste D. Anti-imipramine antibodies recognize endogenous serotonin and imipramine binding inhibitors. Psychiatric Research 1990; 34: 205
  • Tuomisto J., Tukiainen E. Decreased uptake of 5-hydroxytryptamine in blood platelet from depressed patients. Nature 1976; 262: 596
  • Van Riezen H., Leonard B.E. Effects of psychotropic drugs on the behaviour and neurochemistry of olfactory bulbectomized rats. Pharmacology and Therapeutics 1990; 47: 21–34
  • Vergnes M., Karli P. D'enclenchement du comportement, d'agression interspecifique. Rat et souris par ablation bilaterale des ulbes olfactifs. Comptes Rendus de Seances de la Sociéte de Biologie et de sesfiliales 1963; 157: 1061–3
  • Vergnes M., Kempf E. Effects of hypothalamic injections of 5,7 dihydroxytryptamine on elicitation of mouse killing in rats. Behavioural Brain Research 1982; 5: 387–97
  • Wennogle L.P., Meyerson L.R. Serotonin uptake inhibitors differently modulate high affinity imipramine dissociation in human platelet membranes. Life Science 1985; 36: 1541
  • Willner P. Depression: a Psychological Synthesis. John Wiley, & Sons, New York 1985
  • Willner P. Animal models of Depression. Handbook of Depression and Anxiety—a biological approach, J.A. den Boer, J.M.A. Sitsen. Marcel Dekker Inc., New York 1994
  • Wong K.L., Bruck R.C., Farabman I.A. Amitriptyline mediated inhibition of neurite outgrowth from chick embryonic cerebral explants involves a reduction in adenylate cyclase activity. Journal of Neurochemistry 1991; 57: 1223–1330

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.