Serotonin receptor-specific mediation of antidepressant treatment effects in depressed patients

References

• Adham N., Kao H.T., Schecter L.E., et al. Cloning of another human serotonin receptor (5-HTIF): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. Proceedings of the National Academy of Sciences, USA 1993; 90: 408–412
   PubMed Web of Science ®Google Scholar
• Albert P.R., Zhou Q.Y., Van Tol H.H., et al. Cloning, functional expression, and mRNA tissue distribution of die rat 5-hydroxytryptamineIA receptor gene. Journal of Biological Chemistry 1990; 265: 5825–5832
   PubMed Web of Science ®Google Scholar
• Asakura M., Tsukamoto T., Kubota H., et al. Role of serotonin in the regulation of beta-adrenoceptors by antidepressants. European Journal of Pharmacology 1987; 141: 95–100
   PubMedGoogle Scholar
• Balon R. Biological predictors of antidepressant treatment outcome. Clinical Neuropharmacology 1989; 12: 195–214
   Google Scholar
• Bendersen H., Broekkamp H.G., Broekkamp C.L.E. Drug-induced penile erections in rats: indications of serotonin IB receptor mediation. European Journal of Pharmacology 1987; 135: 279–287
   Google Scholar
• Blackshear M.A., Martin L.L., Sanders-Bush E. Adaptive changes in the 5-HT2 binding site after chronic administration. Neuropharmacology 1986; 25: 1267–1271
   PubMedGoogle Scholar
• Blakely R.D., Berson H.E., Fremeau R. T., Jr., et al. Cloning and expression of a functional serotonin transporter from rat brain. Nature 1991; 354: 66–70
   PubMed Web of Science ®Google Scholar
• Blier P., de Montigny C. Serotoninergic but not adrenergic neurons in rat central nervous system adapt to long-term treatment with monoamine oxidase inhibitors. Neuroscience 1985; 16: 949–955
   PubMed Web of Science ®Google Scholar
• Blier P., de Montigny C. Electrophysiological investigation of the adaptive response of the 5-HT system to the administration of 5-HTIA receptor agonists. Journal of Cardiovascular Pharmacology 1990; 15(Suppl 7)S42–S48
   Google Scholar
• Blier P., de Montigny C., Chaput Y. A role for the serotonin system in the mechanism of action of antidepressant treatments: preclinical evidence. Journal of Clinical Psychiatry 1990; 51: 14–20, Suppl
   PubMed Web of Science ®Google Scholar
• Broqua P., Benyassi A., Grouselle D., et al. Antidepressant/anxiolytic ipsapirone inhibits cold-induced hypodialamic TRH release. Neuroreport 1993a; 4: 1200–1202
   Google Scholar
• Broqua P., Laude D., Bluet-Pajot M.T., et al. Are 5-HTIA autoreceptors involved in the inhibitory effect of ipsapirone on cold-elicited thyrotropin secretion?. Neuroendocrinology 1993b; 57: 640–647
   Google Scholar
• Buckholtz N.S., Freedman D.X., Middaugh L.D. Daily LSD administration selectively decreases serotonin2 receptor. European Journal of Pharmacology 1985; 109: 421–425
   PubMedGoogle Scholar
• Byerley W.F., McConnell E.J., McCabe R.T., et al. Decreased beta-adrenergic receptors in rat brain after chronic. Psychopharmacology 1988; 94: 141–143
   Google Scholar
• Cambell J.C., Marangos P.J., Murphy D.L. Neuron specific enolase (NSE) in human blood platelets: implications for the neuronal model. Advances in the Biosciences, B. Angrist, G.D. Burrows, M. Lader, O. Lingjaerde, G. Sedvall, D. Wheatley. Pergamon Press, New York 1993; 203–211
   Google Scholar
• Celada P., Dolera M., Alvarez E., et al. Effects of acute and chronic treatment with fluvoxamine on extracellular and platelet serotonin in the blood of major depressive patients. Relationship to clinical improvement. Journal of Affective Disorders 1992; 25: 243–249
   PubMed Web of Science ®Google Scholar
• Chalmers D.T., Kwak S.P., Mansour A., et al. Corticosteroids regulate brain hippocampal 5-HTIA receptor mRNA expression. Journal of Neuroscience 1993; 13: 914–923
   PubMed Web of Science ®Google Scholar
• Chojnacka-Wojcik E., Tatarczy-Nska E., Goembiowska K., et al. Involvement of 5-HTIA receptors in the antidepressant-like activity of gepirone in the forced swimming test in rats. Neuropharmacology 1991; 30: 711–717
   Google Scholar
• Clement H.W., Schafer F., Ruwe C., et al. Stress-induced changes of extracellular 5-hydroxyin-doleacetic acid concentrations followed in the nucleus raphe dorsalis and the frontal cortex of the rat. Brain Research 1993; 614: 117–124
   PubMed Web of Science ®Google Scholar
• Cook E. H., Jr., Fletcher K.E., Wainwright M., et al. Primary structure of the human platelet serotonin 5-HT2A receptor: identify with frontal cortex serotonin 5-HT2A receptor. Journal of Neurochemistry 1994; 63: 465–469
   PubMedGoogle Scholar
• Curzon G. 5-Hydroxytryptamine and corticosterone in an animal model of depression. Progress in Neuropsychopharmacology and Biological Psychiatry 1989; 13: 305–310
   PubMedGoogle Scholar
• Da Prada M., Cesura A.M., Launay J.M., et al. Platelets as a model for neurons?. Experientia 1988; 44: 115–126
   PubMedGoogle Scholar
• Da Prada M., Picotti G.B. Content and subcellular localization of catecholamines and 5-hydroxytryptamine in human and animal blood platelets: Monoamine distribution between platelets and plasma. British Journal of Pharmacology 1979; 65: 653–662
   PubMed Web of Science ®Google Scholar
• De Montigny C., Chaput Y., Blier P. Modification of serotonergic neuron properties by long-term treatment with serotonin reuptake blockers. Journal of Clinical Psychiatry 1990; 51(Suppl B)4–8
   Google Scholar
• Delgado P.L., Charney D.S., Price L.H., et al. Serotonin function and the mechanism of antidepressant action. Archives of General Psychiatry 1990; 47: 411–418
   PubMed Web of Science ®Google Scholar
• DeSouza R.J., Goodwin G.M., Green A.R., et al. Effect of chronic treatment with 5-HT1 agonist (8-OH-DPAT and RU 24969). British Journal of Pharmacology 1986; 89: 377–384
   Google Scholar
• Fabre L.F. Buspirone in the management of major depression: a placebo-controlled comparison. Journal of Clinical Psychiatry 1990; 51: 55–61, Suppl
   Google Scholar
• Fargin A., Raymond J.R., Lohse M.J., et al. The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HTIA receptor. Nature 1988; 335: 358–360
   PubMed Web of Science ®Google Scholar
• Foguet M., Hartikka J.A., Schmuck K., et al. Long-term regulation of serotonergic activity in the rat brain via activation of protein kinase A. EMBO Journal 1993; 12: 903–910
   Google Scholar
• Gilbert F., Brazell C., Tricklebank M.D., et al. Activation of the 5-HTIA receptor subtype increases rat plasma ACTH concentration. European Journal of Pharmacology 1988; 147: 431–439
   Google Scholar
• Giral P., Martin P., Soubrie P., et al. Reversal of helpless behavior in rats by putative 5-HTIA agonists. Biological Psychiatry 1988; 23: 237–242
   PubMedGoogle Scholar
• Goodwin G.M., DeSouza R.J., Wood A.J., et al. Lithium decreases 5-HTIA and 5-HT2 receptor and alpha 2-adrenoceptor. Psychopharmacology (Berlin) 1986; 90: 482–487
   Google Scholar
• Goodwin G.M., DeSouza R.J., Green A.R. Attenuation by electro-convulsive shock and antidepressant drugs of the. Psychopharmacology (Berlin) 1987; 91: 500–505
   PubMed Web of Science ®Google Scholar
• Green A.R. Evolving concepts on the interactions between antidepressant treatments. Neuropharmacology 1987; 26: 815–822
   Google Scholar
• Green A.R. The mechanism of action of antidepressant treatments: basic aspects. Pharmacopsychiatry 1988; 21: 3–5
   Google Scholar
• Green A.R., Heal D.J., Goodwin G.M. The effects of electroconvulsive therapy and antidepressant drugs on monoamine receptors in rodent brain—similarities and differences. Ciba Foundation Symposia 1986; 123: 246–267
   Google Scholar
• Green A.R., Johnson P., Nimgaonkar V.L. Increased 5-HT2 receptor number in brain as a probable explanation for. British Journal of Pharmacology 1983; 80: 173–177
   Google Scholar
• Hamblin M.W., Metcalf M.A., McGuffin R.W., et al. Molecular cloning and functional characterization of a human 5-HTIB serotonin receptor: a homologue of the rat 5-HTIB receptor with 5-HTID-Hke pharmacological specificity. Biochemical and Biophysical Research Communications 1992; 184: 752–759
   Google Scholar
• Hamblin M.W., Metcalf M.A. Primary structure and functional characterization of a human 5-HTID-type serotonin receptor. Molecular Pharmacology 1991; 40: 143–148
   PubMed Web of Science ®Google Scholar
• Harrington M.A., Zhong P., Garlow S.J., et al. Molecular biology of serotonin receptors. Journal of Clinical Psychiatry 1992; 53: 8–27, Suppl
   PubMedGoogle Scholar
• Hartig P.R. Molecular pharmacology of serotonin receptors. EXS 1994; 71: 93–102
   Google Scholar
• Heller A.H., Beneke M., Kuemmel B., et al. Ipsapirone: evidence for efficacy in depression. Psychopharmacology Bulletin 1990; 26: 219–222
   Google Scholar
• Helmeste D.M. Rapid down-regulation of S2 serotonin receptors by antidepressants. Life Sciences 1986; 39: 223–227
   PubMedGoogle Scholar
• Hensler J.G., Kovachich G.B., Frazer A. A quantitative autoradiographic study of serotoninIA receptor regulation. Effect of 5,7-dihydroxytryptamine and antidepressant treatments. Neuropsychopharmacology 1991; 4: 131–144
   PubMed Web of Science ®Google Scholar
• Hoyer D., Pazos A., Probst A., et al. Serotonin receptors in the human brain. II. Characterization and autoradiographic localization of 5-HTIC and 5-HT2 recognition sites. Brain Research 1986; 376: 97–107
   PubMedGoogle Scholar
• Hsieh C.L., Bowcock A.M., Farrer L.A. The serotonin receptor subtype 2 locus HTR2 is on human chromosome 13 near genes for esterase D and retinoblastoma-I and on mouse chromosome 14. Somatic Cell, & Molecular Genetics 1990; 16(6)567–574
   Google Scholar
• Jenkins S.W., Robinson D.S., Fabre L. F., Jr., et al. Gepirone in the treatment of major depression. Journal of Clinical Psychopharmacology 1990; 10: 77S–85S
   PubMed Web of Science ®Google Scholar
• Kannengeiser M.H., Hunt P., Raynaud J.P. An in vitro model for the study of psychotropic drugs as a criterion of antidepressant activity. Biochemical Pharmacology 1973; 22: 73–84
   Google Scholar
• Kataoka Y., Shibata K., Miyazaki A., et al. Involvement of the dorsal hippocampus in mediation of the antianxiety action of tandospirone, a 5-hydroxytryptamineIA agonistic anxiolytic. Neuropharmacology 1991; 30: 475–480
   PubMed Web of Science ®Google Scholar
• Kaumann A.J., Murray K.J., Brown A.M., et al. A receptor for 5-HT in the human atrium. British Journal of Pharmacology 1989; 98: 664P
   Google Scholar
• Kellar K.J., Cascio S-C., Butler J.A., et al. Differential effects of electroconvulsive shock and antidepressant drugs. European Journal of Pharmacology 1981; 69: 515–518
   PubMed Web of Science ®Google Scholar
• Kennett G.A., Curzon G. Potencies of antagonists indicate that 5-HTIC receptors mediate 1–3 (chlorophenyl)piperazine-induced hypophagia. British Journal of Pharmacology 1991; 103: 2016–2020
   Google Scholar
• Kennett G.A., Whitton P., Shah K., et al. Anxiogenic-like effects of mCPP and TFMPP in animal models are opposed by 5-HTIC receptor antagonists. European Journal of Pharmacology 1988; 164: 445–454
   Google Scholar
• Kennett G.A., Dourish C.T., Curzon G. Antidepressant-like action of 5-HTIA agonists and conventional antidepressants in an animal model of depression. European Journal of Pharmacology 1987; 134: 265–274
   PubMedGoogle Scholar
• Kobilka B.K., Frielle T., Collins S., et al. An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. Nature 1987; 329: 75–79
   PubMed Web of Science ®Google Scholar
• Kursar J.D., Nelson D.L., Wainscott D.B., et al. Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxyrryptamine2B receptor. Molecular Pharmacology 1994; 46: 227–234
   PubMed Web of Science ®Google Scholar
• Lesch K.P., Wolozin B.L., Estler H.C., et al. Isolation of a cDNA encoding the human brain serotonin transporter. Journal of Neural Transmission General Section 1993a; 91: 67–72
   Web of Science ®Google Scholar
• Lesch K.P., Wolozin B.L., Murphy D.L., et al. Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter. Journal of Neurochemistry 1993b; 60: 2319–2322
   PubMed Web of Science ®Google Scholar
• Lesch K.P., Disselkamp-Tietze J., Schmidtke A. 5-HTIA receptor function in depression: Effect of chronic amitriptyline. Journal of Neural Transmission General Section 1990; 80: 157–161
   Google Scholar
• Lesch K.P., Lerer B. The 5-HT receptor—G-protein—effector system complex in depression. I. Effect of glucocorticoids. Journal of Neural Transmission General Section 1991; 84: 3–18
   Google Scholar
• Lingjaerde O. Inhibition of platelet uptake of serotonin in plasma from patients treated with clomipramine and amitripryline. European Journal of Clinical Pharmacology 1979; 15(5)335–340
   Google Scholar
• Lingjaerde O. Blood platelets as a model system for studying the biochemistry of depression. Biological and Pharmacological Research in Depression: Advances in Biochemical Psychopharmacology, E. Usdin, M. Asberg, L. Bertilsson, F. Sjoqvist. Raven Press, New York 1984a; 99–111
   Google Scholar
• Lingjaerde O. Platelet serotonin uptake inhibition as a basis for monitoring antidepressant drug treatment. Journal of Clinical Psychopharmacology 1984b; 4(2)76–81
   Google Scholar
• Lovenberg T.W., Baron B.M., de Lecea L., et al. A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms. Neuron 1993; 11: 449–458
   PubMed Web of Science ®Google Scholar
• Lucki I. Antidepressant-like activity of 5-HTIA agonists measured with the forced swim test. Psychopharmacology (Berlin) 1990; 101: 497–504
   Google Scholar
• Maitre L., Moser P., Baumann P.A., et al. Amine uptake inhibitors: Criteria of selectivity. Acta Psyciatrica Scandinavica 1980; 280: 97–110, suppl
   Google Scholar
• Mancinelli A., D'Aranno V., Stasi M.A., et al. Effect of enantiomers of propranolol on desipramine-induced anti-immobility in the forced swimming test in the rat. Pharmacology Research 1991; 23: 47–50
   Google Scholar
• Mann J.J., Stanley M., McBride P.A., et al. Increased serotonin 2 and beta-adrenergic receptor binding in the frontal cortices of suicide victims. Archives of General Psychiatry 1986; 43(10)954–959
   Google Scholar
• Mann J.J., McBride P.A., Anderson G.M., et al. Platelet and whole blood serotonin content in depressed inpatients: correlations with acute and life-time psychopathology. Biological Psychiatry 1992; 32: 243–257
   PubMed Web of Science ®Google Scholar
• Marek G.J., Li A.A., Setoen L.S. Evidence for involvement of 5-hydroxytryptamine 1 receptors in antidepressant-like drug effects on differential-reinforcement-of-low-rate 72-second behavior. Journal of Pharmacology and Experimental Therapeutics 1989; 250: 60–71
   Google Scholar
• May P.C., Morgan D.G., Finch C.E. Regional serotonin receptor studies: Chronic methysergide treatment. Life Science 1986; 38: 1741–1747
   Google Scholar
• Melmer G., Sherrington R., Mankoo B., et al. A cosmid clone for the 5-HTIA receptor (HTRIA) reveals a Taql RFLP that shows tight linkage to dna loci D5S6, D5S39, and D5S76. Genomics 1991; 11: 767–769
   PubMedGoogle Scholar
• Meltzer H.Y., Arora R.C. Genetic control of serotonin uptake in blood platelets: a twin study. Psychiatry Research 1988; 24: 263–269
   Google Scholar
• Mizuta T., Segawa T. Chronic effects of imipramine and lithium on postsynaptic 5-HTIA and 5-. Japanese Journal Pharmacology 1988; 47: 107–113
   PubMedGoogle Scholar
• Montgomery S.A., McAuley R., Rani S.J., et al. A double blind comparison of zimelidine and amitriptyline in endogenous. Acta Psychiatrica Scandinavica 1981; 290: 314–327, Suppl
   Google Scholar
• Moret C., Briley M. Platelet 3H-paroxetine binding to the serotonin transporter is insensitive to changes in central serotonergic innervation in the rat. Psychiatry Research 1991; 38: 97–104
   PubMed Web of Science ®Google Scholar
• Muck-Seler D., Jakovljevic M., Deanovic Z. Effect of antidepressant treatment on platelet 5-HT content and relation to therapeutic outcome in unipolar depressive patients. Journal of Affective Disorders 1991; 23: 157–164
   Google Scholar
• Muijen M., Roy D., Silverstone T., et al. A comparative clinical trial of fluoxetine, mianserin and placebo in depressed outpatients. Acta Psyciatrica Scandinavica 1988; 78: 384–390
   PubMedGoogle Scholar
• Orth D.N. Adrenocorticotropic hormone. Methods of Hormone Radioimmunoassay, R.M. Jaffee, H.R. Berman. Academic Press, Inc. 1979; 245–284
   Google Scholar
• Pandey G.N., Pandey S.C., Janicak P.G. Platelet serotonin-2 receptor binding sites in depression and suicide. Biological Psychiatry 1990; 28(3)215–222
   Google Scholar
• Pearse A.G.E. The diffuse neuroendocrine system: Peptides, amines, placodes and the APUD theory. Progress in Brain Research, I. Hokfelt, K. Fuxe, B. Pernow. Elsevier Science Publishers, Amsterdam 1986; 25–31
   Google Scholar
• Peatfield R.C., Fozard J.R., Rose F.C. Drug treatment of migraine. Handbook of Clinical Neurology, P.J. Vinken, G.W. Bruyn, H.L. Klawans. Elsevier Science Publishers, Amsterdam 1986; 173–216
   Google Scholar
• Peroutka S.J. 5-Hydroxytryptamine receptors. Journal of Neurochemistry 1993; 60: 408–416
   PubMed Web of Science ®Google Scholar
• Pletscher A., Affolter H., Cesura A.M., Erne P., Mueller K. Blood platelet as a model for neurons: Similarities for the 5-hydroxytryptamine systems. Progress in Tryptophan and Serotonin Research, H.G. Schlossenberger, W. Kochen, B. Linzen, H. Steinhart. Walter de Gruyter, & Co., Berlin-New York 1984; 231–239
   Google Scholar
• Pletscher A. Platelets as models: Use and limitations. Experientia 1988; 42: 152–155
   Google Scholar
• Pritchett D.B., Bach A.W., Wozny M., et al. Structure and functional expression of cloned rat serotonin 5-HT-2 receptor. EMBO Journal 1988; 7: 4135–4140
   PubMed Web of Science ®Google Scholar
• Quintana J. Platelet serotonin uptake dynamic changes in depression: effects of long-term imipramine treatment and clinical recovery. Journal of Affective Disorders 1989; 16(2–3)233–242
   Google Scholar
• Ramamoorthy S., Bauman A.L., Moore K.R., et al. Antidepressant- and cocaine-sensitive human serotonin transporter molecular cloning, expression, and chromosomal localization. Proceeding of the National Academy of Sciences USA 1993; 90: 2542–2546
   PubMed Web of Science ®Google Scholar
• Rausch J.L., Moeller F.G. Platelet 5-HT transport affinity predicts early nortriptyline treatment. 1993, Submitted for publication
   Google Scholar
• Rausch J.L., Stahl S.M., Hauger R.L. Cortisol and growth hormone responses to the 5-HTIA agonist gepirone in depressed patients. Biological Psychiatry 1990a; 28: 73–78
   Google Scholar
• Rausch J.L., Stahl S.M., Hauger R.L. Cortisol and growth hormone responses to the 5-HTIA agonist gepirone. Biological Psychiatry 1990b; 28: 73–78
   Google Scholar
• Rickels K., Amsterdam J.D., Clary C., et al. Buspirone in major depression: a controlled study. Journal of Clinical Psychiatry 1991; 52: 34–38
   PubMedGoogle Scholar
• Risch S.C., Nemeroff C.B. Neurochemical alterations of serotonergic neuronal systems in depression. Journal of Clinical Psychiatry 1992; 53: 3–7, Suppl
   Google Scholar
• Robinson D.S., Rickels K., Feighner J., et al. Clinical effects of the 5-HTIA partial agonists in depression: a composite analysis of bus-pirone in the treatment of depression. Journal of Clinical Psychopharmacology 1990a; 10: 67S–76S
   PubMedGoogle Scholar
• Ross S.B., Aperia B., Beck-Friis J., et al. Inhibition of 5-hydroxytryptamine uptake in human platelets by antidepressant agents in vivo. Psychopharmacology 1980; 67: 1–7
   PubMed Web of Science ®Google Scholar
• Roth B.L., Craigo S.C., Choudhary M.S., et al. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. Journal of Pharmacology and Experimental Therapeutics 1994; 268: 1403–1410
   PubMed Web of Science ®Google Scholar
• Ruat M., Traiffort E., Arrang J.M., et al. A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation. Biochemical and Biophysical Research Communications 1993; 193: 268–276
   PubMed Web of Science ®Google Scholar
• Saito N., Guttart X., Hayward M., et al. Corticosterone differentially regulates the expression of Gs alpha and Proceeding of the National Academy of Sciences USA. 1989; 86: 3906–3910
   Google Scholar
• Saltzman A.G., Morse B., Whitman M.M., et al. Cloning of the human serotonin 5-HT2 and 5-HTIC receptor subtypes. Biochemical and Biophysical Research Communications 1991; 181: 1469–1478
   PubMed Web of Science ®Google Scholar
• Sanders-Bush E. 5-HT receptors coupled to phosphoinosiade hydrolysis. The Serotonin Receptors, E. Sanders-Bush. Humana Press, Clifton, NJ 1988; 181–195
   Google Scholar
• Satinoff E., Kent S., Li H., et al. Circadian rhythms of body temperature and drinking and responses to thermal challenge in rats after PCPA. Pharmacology, Biochemistry, & Behavior 1991; 38: 253–257
   PubMedGoogle Scholar
• Schoups A.A., de Potter W.P. Species dependence of adaptations at the pre- and postsynaptic serotonergic receptors following long-term antidepressant drug treatment. Biochemical Pharmacology 1988; 37: 4451–4460
   Google Scholar
• Scott J.A., Crews F.T. Down-regulation of serotonin2, but not of beta-adrenergic receptors. Neuropharmacology 1986; 25: 1301–1306
   PubMed Web of Science ®Google Scholar
• Seinen H., Zonnenberg B.A., Tijia P., et al. The effect of 3 dose levels of ICS 205–930 (a selective 5-HT3 receptor antagonist) on cisplatin-induced nausea and vomiting. European Journal of Cancer and Clinical Oncology 1989; 25: 1333–1335
   Google Scholar
• Shen Y., Monsma F. J., Jr., Metcalf M.A., et al. Molecular cloning and expression of a 5-hydroxytryptamine? serotonin receptor subtype. Journal of Biological Chemistry 1993; 268: 18200–18204
   PubMed Web of Science ®Google Scholar
• Shopsin B., Friedman E., Gershon S. Parachlorophenylalanine reversal of tranylcypromine effects in depressed patients. Archives of General Psychiatry 1976; 33: 811–819
   PubMed Web of Science ®Google Scholar
• Sleight A.J., Marsden C.A., Palfreyman M.G., et al. Chronic MAO A and MAO B inhibition decreases the 5-HT1A receptor-. European Journal of Pharmacology 1988; 154: 255–261
   Google Scholar
• Sprouse J.S., Aghajanian G.K. (-)-Propranolol blocks the inhibition of serotonergic dorsal raphe cell firing by 5-HTIA selective agonists. European Journal of Pharmacology 1986; 128: 295–298
   Google Scholar
• Stahl S.M., Hauger R.L., Rausch J.L., et al. Downregulation of serotonin receptor subtypes by nortriptyline and adinazolam in major depressive disorder: neuroendocrine and platelet markers. Clinical Neuropharmacology 1993; 16(Suppl 3)S19–S31
   Google Scholar
• Stam N.J., Van Hutzen F., Van Alebeek C., et al. Genomic organization, coding sequence and functional expression of human 5-HT2 and 5-HTIA receptor genes. European Journal of Pharmacology 1992; 227: 153–162
   Google Scholar
• Stockmeier C.A., Martino A.M., Kellar K.J. A strong influence of serotonin axons on β-adrenergic receptors in rat. Science 1985; 230: 323–325
   PubMed Web of Science ®Google Scholar
• Tang S.W., Seeman P., Kwan S. Differential effect of chronic desipramine and amitriptyline treatment. Psychiatry Research 1981; 4: 129–138
   PubMedGoogle Scholar
• Toivonen M., Mannisto P.T. Complex actions of serotonergic agonists on cold-stimulated TSH secretion in male rats. European Journal of Pharmacology 1990; 180: 91–102
   Google Scholar
• Trickelbank M.D., Middlemiss D.N., Neill J. Pharmacological analysis of the behavioral and thermoregulatory effects of the putative 5-HTi receptor agonist, RU 24969, in rat. Neuropharmacology 1986; 25: 877–S86
   Google Scholar
• Tukiainen E., Voutilainen R., Tuomainen P. Inhibition of 5-hydroxytryptamine and noradrenaline uptake in platelets and synaptosomes in plasma from human subjects treated with amitriptyline or nortriptyline: utilization of die principle for a bioassay method. Psychopharmacology 1980; 69: 137–142
   Google Scholar
• Vernier P., Philippe H., Samama P., et al. Bioamine receptors: evolutionary and functional variations of a structural leitmotiv. EXS 1993; 63: 297–337
   Google Scholar
• Waeber C., Schoeffter P., Palacios J.M., et al. Molecular pharmacology of 5-HTID recognition sites: radioligand binding studies in human, pig, and calf brains. Naunyn Schmiedebergs Archives of Pharmacology 1988; 337: 595–601
   PubMed Web of Science ®Google Scholar
• Wang H.Y., Friedman E. Central 5-hydroxytryptamine receptor-linked protein kinase C translocation: a functional postsynaptic signal transduction system. Molecular Pharmacology 1989; 37: 75–79
   Google Scholar
• Warren J. T., Jr., Peacock M.L., Fink J.K. An RsaI polymorphism in the human serotonin receptor gene (HTRIA): detection by DGGE and RFLP analysis. Human Molecular Genetics 1992; 1: 778
   Google Scholar
• Welner S.A., de Montigny C., Desroches J., et al. Autoradiographic quantification of serotonin 1A receptors in rat brain. Synapse 1989; 4: 347–352
   Google Scholar
• Wernicke J.F., Dunlop S.R., Dornseif B.E., et al. Low-dose fluoxetine therapy for depression. Psychopharmacology Bulletin 1988; 24: 183–188
   PubMed Web of Science ®Google Scholar
• Yates M., Leake A., Candy J.M. 5-HT2 receptor changes in major depression. Biological Psychiatry 1990; 27: 489–496
   PubMed Web of Science ®Google Scholar